2000
Enhancement of NMDA‐induced current by the putative NR2B selective antagonist ifenprodil
Zhang X, Bunney B, Shi W. Enhancement of NMDA‐induced current by the putative NR2B selective antagonist ifenprodil. Synapse 2000, 37: 56-63. PMID: 10842351, DOI: 10.1002/(sici)1098-2396(200007)37:1<56::aid-syn6>3.0.co;2-d.Peer-Reviewed Original ResearchMeSH Keywords2-Amino-5-phosphonovalerateAnimalsDizocilpine MaleateDose-Response Relationship, DrugDrug SynergismElectrophysiologyExcitatory Amino Acid AgonistsExcitatory Amino Acid AntagonistsGlycineKynurenic AcidMaleMembrane PotentialsN-MethylaspartateOrgan Culture TechniquesPiperidinesPrefrontal CortexPyramidal CellsRatsRats, Sprague-DawleyReceptors, N-Methyl-D-AspartateSpermineConceptsLow NMDA concentrationsNMDA currentsNMDA concentrationReceptor affinityNMDA receptor affinityEffects of ifenprodilNR2B-selective antagonist ifenprodilEnhancement of NMDARat brain slicesNMDA receptorsAntagonist selectiveBrain slicesSubcortical areasNR2B subunitNMDANoncompetitive antagonistIfenprodilCGP37849Same concentrationKynurenatePrevious studiesAntagonistReceptors
1999
Opposite modulation of cortical N-methyl-d-aspartate receptor-mediated responses by low and high concentrations of dopamine
Zheng P, Zhang X, Bunney B, Shi W. Opposite modulation of cortical N-methyl-d-aspartate receptor-mediated responses by low and high concentrations of dopamine. Neuroscience 1999, 91: 527-535. PMID: 10366010, DOI: 10.1016/s0306-4522(98)00604-6.Peer-Reviewed Original ResearchMeSH Keywords1-Methyl-3-isobutylxanthine2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepineAlpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidAnimalsBenzazepinesDizocilpine MaleateDopamineDopamine AgonistsDopamine AntagonistsDose-Response Relationship, DrugExcitatory Amino Acid AntagonistsIn Vitro TechniquesMaleMembrane PotentialsPrefrontal CortexPyramidal CellsQuinoxalinesQuinpiroleRatsRats, Sprague-DawleyReceptors, N-Methyl-D-AspartateConceptsN-methyl-D-aspartate functionN-methyl-D-aspartate currentsN-methyl-D-aspartate (NMDA) receptor-mediated transmissionN-methyl-D-aspartate receptor-mediated responsesN-methyl-D-aspartate receptorsHigh concentrations dopamineReceptor-mediated transmissionD2 agonist quinpiroleD1 agonist SKF38393D1-like receptorsD-aspartate antagonistGlutamate-mediated neurotransmissionD2-like receptorsPresence of tetrodotoxinEffects of dopamineReceptor-mediated responsesWhole-cell recordingsD-aspartate agonistMedial prefrontal cortexBrief local applicationDizocilpine maleateAgonist SKF38393Concentration of dopamineCortical dopamineGlutamate transmission
1997
Characterization of dopamine‐induced depolarization of prefrontal cortical neurons
Shi W, Zheng P, Liang X, Bunney B. Characterization of dopamine‐induced depolarization of prefrontal cortical neurons. Synapse 1997, 26: 415-422. PMID: 9215600, DOI: 10.1002/(sici)1098-2396(199708)26:4<415::aid-syn9>3.0.co;2-9.Peer-Reviewed Original ResearchConceptsEffects of dopaminePFC neuronsDA agonistsPrefrontal cortexAtypical antipsychotic drug clozapinePrefrontal cortical neuronsRat brain slicesAntipsychotic drug clozapineWhole-cell recordingsPFC pyramidal cellsSynaptic blockadeDA receptorsBeta antagonistDA antagonistsSubstantia nigraCortical neuronsPyramidal cellsBrain slicesDrug clozapineCell recordingsNeuronsAntagonistNonspecific mechanismsDopamineDepolarizationDopamine-cell depolarization block as a model for the therapeutic actions of antipsychotic drugs
Grace A, Bunney B, Moore H, Todd C. Dopamine-cell depolarization block as a model for the therapeutic actions of antipsychotic drugs. Trends In Neurosciences 1997, 20: 31-37. PMID: 9004417, DOI: 10.1016/s0166-2236(96)10064-3.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntipsychotic AgentsDopamineDopamine AgonistsMembrane PotentialsModels, NeurologicalConceptsDepolarization blockAntipsychotic drugsDopamine systemNigrostriatal dopamine systemWeeks of treatmentExtrapyramidal side effectsAntipsychotic drug efficacyDopamine receptor antagonistDrug treatment resultsMesolimbic dopamine neuronsTreatment of schizophreniaDopamine neuron firingReceptor blockadeDopamine neuronsTherapeutic impactSide effectsClinical actionsDrug AdministrationTherapeutic efficacyTreatment resultsDrug efficacyTherapeutic actionPotential mechanismsDrugsEfficacy
1991
Repetitive firing properties of putative dopamine-containing neurons in vitro: regulation by an apamin-sensitive Ca2+-activated K+ conductance
Shepard P, Bunney B. Repetitive firing properties of putative dopamine-containing neurons in vitro: regulation by an apamin-sensitive Ca2+-activated K+ conductance. Experimental Brain Research 1991, 86: 141-150. PMID: 1756785, DOI: 10.1007/bf00231048.Peer-Reviewed Original ResearchConceptsAction potentialsPutative dopamine-containing neuronsEffects of apaminDopamine-containing neuronsIntracellular recording techniquesPost-spike afterhyperpolarizationRepetitive firing propertiesTypes of Ca2Apamin-sensitive Ca2Adaptive neuronal responsesZona compactaSubstantia nigraBath applicationInhibitory periodNeuronal responsesAfterhyperpolarizationApaminFiring propertiesRecording techniquesCellular mechanismsElectroresponsive propertiesFrequency adaptationSelective inhibitorInterspike intervalsNeurons
1990
Effect ofl-glutamate on the release of striatal dopamine: in vivo dialysis and electrochemical studies
Moghaddam B, Gruen R, Roth R, Bunney B, Adams R. Effect ofl-glutamate on the release of striatal dopamine: in vivo dialysis and electrochemical studies. Brain Research 1990, 518: 55-60. PMID: 1975217, DOI: 10.1016/0006-8993(90)90953-9.Peer-Reviewed Original ResearchConceptsN-methyl-D-aspartate receptor antagonistVivo voltammetryExtracellular DA concentrationsMM GluDA outflowStriatal dopamineReceptor antagonistExtracellular dopamineRat striatumVivo dialysisMicrodialysis probeLocal applicationBasal levelsExtracellular concentrationPathophysiological conditionsVivo releaseDA concentrationDopamineL-glutamateField potentialsIonic changesSignificant increaseSelective microelectrodesDepressionStriatum
1988
Intracellular studies of dopamine neurons in vitro: pacemakers modulated by dopamine
Silva N, Bunney B. Intracellular studies of dopamine neurons in vitro: pacemakers modulated by dopamine. European Journal Of Pharmacology 1988, 149: 307-315. PMID: 3409955, DOI: 10.1016/0014-2999(88)90661-9.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDopamineIn Vitro TechniquesMaleMembrane PotentialsMesencephalonNeuronsRatsRats, Inbred StrainsSulpirideTetrodotoxinConceptsSensitive neuronsInput resistanceAdministration of DADA-sensitive neuronsSelective D2 antagonistPacemaker-like activityHigh input resistanceZona compactaDA actionD2 antagonistDopamine neuronsIntracellular recordingsFiring rateIntracellular studyNeuronsReversal potentialTissue slicesDopamineHyperpolarizationSulpirideAntagonistCompactaAdministration
1986
Induction of depolarization block in midbrain dopamine neurons by repeated administration of haloperidol: analysis using in vivo intracellular recording.
Grace A, Bunney B. Induction of depolarization block in midbrain dopamine neurons by repeated administration of haloperidol: analysis using in vivo intracellular recording. Journal Of Pharmacology And Experimental Therapeutics 1986, 238: 1092-100. PMID: 3746660.Peer-Reviewed Original ResearchConceptsAdministration of haloperidolDopamine neuronsVivo intracellular recordingsDepolarization blockIntracellular recordingsNigral dopamine neuronsAdministration of neurolepticsActive dopamine neuronsSpontaneous spike activityDopamine agonist apomorphineAntipsychotic drug haloperidolSpontaneous electrophysiological activityMidbrain dopamine neuronsAcute administrationAgonist apomorphineSubstantia nigraControl ratsExcitatory driveDepolarization blockadeDrug haloperidolSpontaneous activitySpike activityFiring rateHaloperidolNeurons
1985
Low doses of apomorphine elicit two opposing influences on dopamine cell electrophysiology
Grace A, Bunney B. Low doses of apomorphine elicit two opposing influences on dopamine cell electrophysiology. Brain Research 1985, 333: 285-298. PMID: 3995296, DOI: 10.1016/0006-8993(85)91582-3.Peer-Reviewed Original ResearchConceptsDA cell firingDA cellsLow dosesInput resistanceDA agonistsReversal potentialStriatonigral pathwayCell firingCell firing rateElectrophysiological actionsApomorphine effectApomorphine administrationSlow depolarizationIntracellular recordingsIntravenous administrationDopamine cellsInhibitory inputsApomorphineStriatal cellsAction potentialsFiring rateAgonistsDosesCell dischargeCell electrophysiologyOpposing effects of striatonigral feedback pathways on midbrain dopamine cell activity
Grace A, Bunney B. Opposing effects of striatonigral feedback pathways on midbrain dopamine cell activity. Brain Research 1985, 333: 271-284. PMID: 2986775, DOI: 10.1016/0006-8993(85)91581-1.Peer-Reviewed Original ResearchConceptsInhibitory postsynaptic potentialsDA cellsStriatal stimulationReticulata neuronsDA neuronsRebound depolarizationReversal potentialSubstantia nigra zona reticulata neuronsStriatonigral GABAergic pathwayMidbrain dopamine cell activityDopamine cell activitySame stimulation parametersChloride injectionChloride channel blockerChloride reversal potentialSimilar reversal potentialsSimilar time courseGABAergic pathwayGABAergic projectionsZona reticulataPostsynaptic potentialsSystemic injectionChannel blockersIntracellular recordingsStriatal cells
1980
Nigral Dopamine Neurons: Intracellular Recording and Identification with L-Dopa Injection and Histofluorescence
Grace A, Bunney B. Nigral Dopamine Neurons: Intracellular Recording and Identification with L-Dopa Injection and Histofluorescence. Science 1980, 210: 654-656. PMID: 7433992, DOI: 10.1126/science.7433992.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsDopamineHippocampusLevodopaMembrane PotentialsMicroscopy, FluorescenceNeuronsRatsSubstantia NigraConceptsL-DOPA injectionIntracellular recordingsAntidromic conduction velocitiesPutative dopaminergic neuronsDopamine-containing neuronsRat substantia nigraAntidromic activationDopaminergic neuronsSubstantia nigraSlow depolarizationBurst firingFluorescence histochemistryConduction velocityFast potentialsNeuronsExtracellular spikesInjectionHistofluorescenceRecordingsNigra
1975
Inhibition of both noradrenergic and serotonergic neurons in brain by the α-adrenergic agonist clonidine
Svensson T, Bunney B, Aghajanian G. Inhibition of both noradrenergic and serotonergic neurons in brain by the α-adrenergic agonist clonidine. Brain Research 1975, 92: 291-306. PMID: 1174954, DOI: 10.1016/0006-8993(75)90276-0.Peer-Reviewed Original ResearchConceptsNE neuronsAgonist clonidineHigh dosesMidbrain dorsal raphe nucleusAlpha-adrenergic agonist clonidineSingle-unit recording techniquesBrain NE neuronsClonidine-induced depressionDorsal raphe nucleusAdrenergic agonist clonidineBrain norepinephrineRaphe neuronsIntravenous clonidineAdrenergic transmissionSerotonergic neuronsDepressant effectDopaminergic neuronsRaphe nucleusSpontaneous firingLocus coeruleusClonidineLow doseL-amphetamineAdrenergic receptorsNeurons