2007
Clozapine Blocks D-Amphetamine-Induced Excitation of Dopamine Neurons in the Ventral Tegmental Area
Shi W, Zhang X, Pun C, Bunney B. Clozapine Blocks D-Amphetamine-Induced Excitation of Dopamine Neurons in the Ventral Tegmental Area. Neuropsychopharmacology 2007, 32: 1922-1928. PMID: 17299514, DOI: 10.1038/sj.npp.1301334.Peer-Reviewed Original ResearchConceptsD2-like receptorsDA neuronsVentral tegmental areaD-amphetamineDA receptorsExcitatory effectsTegmental areaΑ1 receptor antagonist prazosinAtypical antipsychotic drug clozapineChloral hydrate-anesthetized ratsTypical antipsychotic drug haloperidolCentral dopamine transmissionCurrent antipsychotic drugsReceptor antagonist prazosinAntipsychotic drug haloperidolAntipsychotic drug clozapineAntagonist prazosinExcitatory pathwaysDA transmissionDopamine neuronsΑ1 receptorsSystemic administrationAntipsychotic drugsExcitatory inputsIncomplete blockade
2000
Dual Effects of d-Amphetamine on Dopamine Neurons Mediated by Dopamine and Nondopamine Receptors
Shi W, Pun C, Zhang X, Jones M, Bunney B. Dual Effects of d-Amphetamine on Dopamine Neurons Mediated by Dopamine and Nondopamine Receptors. Journal Of Neuroscience 2000, 20: 3504-3511. PMID: 10777813, PMCID: PMC6773133, DOI: 10.1523/jneurosci.20-09-03504.2000.Peer-Reviewed Original ResearchConceptsD2-like receptorsD-amphetamineDA cellsSelective D2 antagonist racloprideVivo single-unit recordingsFiring rateAlpha1-antagonist prazosinAlpha2 antagonist idazoxanAlpha-antagonist phenoxybenzamineD2 antagonist racloprideDA cell firingSingle-unit recordingsRelated psychostimulantsAntagonist idazoxanAntagonist phenoxybenzamineDA receptorsAntagonist prazosinAntagonist racloprideExcitatory effectsAlpha1 receptorsDopamine neuronsDopamine releaseCell firingInhibitory effectReceptors
1999
Endogenous DA‐mediated feedback inhibition of DA neurons: Involvement of both D1‐ and D2‐like receptors
Shi W, Pun C, Smith P, Bunney B. Endogenous DA‐mediated feedback inhibition of DA neurons: Involvement of both D1‐ and D2‐like receptors. Synapse 1999, 35: 111-119. PMID: 10611636, DOI: 10.1002/(sici)1098-2396(200002)35:2<111::aid-syn3>3.0.co;2-7.Peer-Reviewed Original ResearchConceptsDA neuronsLike receptorsDA cellsEndogenous DAChloral hydrate-anesthetized ratsNigral DA cellsD2-like receptorsSingle-unit recordingsCerveau isolé preparationFeedback inhibitionParkinsonian animalsAntagonist racloprideAntagonist SCH23390DA releaseEndogenous dopamineD-amphetamineParkinson's diseaseUnit recordingsSCH23390Receptor activationBaseline activityReceptorsChloral hydrateNeuronsConcurrent activationOpposite modulation of cortical N-methyl-d-aspartate receptor-mediated responses by low and high concentrations of dopamine
Zheng P, Zhang X, Bunney B, Shi W. Opposite modulation of cortical N-methyl-d-aspartate receptor-mediated responses by low and high concentrations of dopamine. Neuroscience 1999, 91: 527-535. PMID: 10366010, DOI: 10.1016/s0306-4522(98)00604-6.Peer-Reviewed Original ResearchMeSH Keywords1-Methyl-3-isobutylxanthine2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepineAlpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidAnimalsBenzazepinesDizocilpine MaleateDopamineDopamine AgonistsDopamine AntagonistsDose-Response Relationship, DrugExcitatory Amino Acid AntagonistsIn Vitro TechniquesMaleMembrane PotentialsPrefrontal CortexPyramidal CellsQuinoxalinesQuinpiroleRatsRats, Sprague-DawleyReceptors, N-Methyl-D-AspartateConceptsN-methyl-D-aspartate functionN-methyl-D-aspartate currentsN-methyl-D-aspartate (NMDA) receptor-mediated transmissionN-methyl-D-aspartate receptor-mediated responsesN-methyl-D-aspartate receptorsHigh concentrations dopamineReceptor-mediated transmissionD2 agonist quinpiroleD1 agonist SKF38393D1-like receptorsD-aspartate antagonistGlutamate-mediated neurotransmissionD2-like receptorsPresence of tetrodotoxinEffects of dopamineReceptor-mediated responsesWhole-cell recordingsD-aspartate agonistMedial prefrontal cortexBrief local applicationDizocilpine maleateAgonist SKF38393Concentration of dopamineCortical dopamineGlutamate transmission
1997
Characterization of dopamine‐induced depolarization of prefrontal cortical neurons
Shi W, Zheng P, Liang X, Bunney B. Characterization of dopamine‐induced depolarization of prefrontal cortical neurons. Synapse 1997, 26: 415-422. PMID: 9215600, DOI: 10.1002/(sici)1098-2396(199708)26:4<415::aid-syn9>3.0.co;2-9.Peer-Reviewed Original ResearchConceptsEffects of dopaminePFC neuronsDA agonistsPrefrontal cortexAtypical antipsychotic drug clozapinePrefrontal cortical neuronsRat brain slicesAntipsychotic drug clozapineWhole-cell recordingsPFC pyramidal cellsSynaptic blockadeDA receptorsBeta antagonistDA antagonistsSubstantia nigraCortical neuronsPyramidal cellsBrain slicesDrug clozapineCell recordingsNeuronsAntagonistNonspecific mechanismsDopamineDepolarization
1994
5‐HT1a agonist ±‐ 8‐OH‐DPAT modulates basal and stress‐induced changes in medial prefrontal cortical dopamine
Rasmusson A, Goldstein L, Deutch A, Bunney B, Roth R. 5‐HT1a agonist ±‐ 8‐OH‐DPAT modulates basal and stress‐induced changes in medial prefrontal cortical dopamine. Synapse 1994, 18: 218-224. PMID: 7855734, DOI: 10.1002/syn.890180307.Peer-Reviewed Original ResearchConceptsDopamine utilizationMedial prefrontal cortexStress-induced changesClinical efficacyMedial prefrontal cortical dopamineMicrograms/Prefrontal cortexAnxiety disordersPrefrontal cortical dopamineFootshock-induced increaseObserved clinical efficacyDopamine terminal fieldsCortical dopamineFootshock stressExtracellular dopamineHuman anxiety disordersNucleus accumbensSame doseTerminal fieldsEx vivo brain tissueNeurochemical analysisDopamine systemDPATAgonistsBrain tissue
1989
Ionic Composition of Microdialysis Perfusing Solution Alters the Pharmacological Responsiveness and Basal Outflow of Striatal Dopamine
Moghaddam B, Bunney B. Ionic Composition of Microdialysis Perfusing Solution Alters the Pharmacological Responsiveness and Basal Outflow of Striatal Dopamine. Journal Of Neurochemistry 1989, 53: 652-654. PMID: 2568406, DOI: 10.1111/j.1471-4159.1989.tb07383.x.Peer-Reviewed Original ResearchConceptsPharmacological responsivenessNigrostriatal dopamine systemExtracellular dopamine levelsExtracellular fluidBasal outflowBasal releaseStriatal dopamineHigh calcium levelsVivo microdialysisIonic compositionDopamine levelsCalcium levelsDopamine systemPharmacological manipulationRinger's solutionPerfusionDopamineResponsivenessSolution altersAltersMicrodialysisThe effect of acute and chronic treatment with SCH 23390 on the spontaneous activity of midbrain dopamine neurons
Esposito E, Bunney B. The effect of acute and chronic treatment with SCH 23390 on the spontaneous activity of midbrain dopamine neurons. European Journal Of Pharmacology 1989, 162: 109-113. PMID: 2656273, DOI: 10.1016/0014-2999(89)90609-2.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBenzazepinesDopamineDopamine AntagonistsElectrophysiologyHaloperidolMaleMesencephalonNeuronsRatsRats, Inbred StrainsSubstantia NigraConceptsSubstantia nigra pars compactaVentral tegmental areaActive DA neuronsSCH 23390Chronic treatmentDA neuronsDopamine neuronsDepolarization blockSpontaneous activityDA receptor blockadeAcute subcutaneous injectionGroups of ratsMidbrain dopamine neuronsChronic haloperidolReceptor blockadeChronic administrationPars compactaTegmental areaAntipsychotic drugsSubcutaneous injectionChronic experimentsMarked reductionNeuronsTreatmentHaloperidol