Hepatotoxicity Score: A New Method to Adjust for Use of Potentially Hepatotoxic Medications by Chronic Liver Disease Status
Re V, Newcomb C, Carbonari D, Mezochow A, Hennessy S, Rentsch C, Park L, Tate J, Bräu N, Bhattacharya D, Lim J, Mezzacappa C, Njei B, Roy J, Taddei T, Justice A, Torgersen J. Hepatotoxicity Score: A New Method to Adjust for Use of Potentially Hepatotoxic Medications by Chronic Liver Disease Status. Pharmacoepidemiology And Drug Safety 2024, 33: e70069. PMID: 39662972, PMCID: PMC11634562, DOI: 10.1002/pds.70069.Peer-Reviewed Original ResearchConceptsProton pump inhibitor initiationHazard ratioVeterans Health AdministrationSevere acute liver injuryProton pump inhibitorsChronic liver diseaseAcute liver injuryRates of hospitalizationSafety of medicationsPPI initiativesHealth AdministrationLiver disease statusMedication exposurePharmacoepidemiological studiesMedicationConfoundingScoresReports of hepatotoxicityDisease statusHepatotoxic medicationsDrug exposurePump inhibitorsHepatotoxic drugsOutpatient initiationHepatic safetyThe burden of cirrhosis and other chronic liver disease in the middle east and North Africa (MENA) region over three decades
Al Ta’ani O, Aleyadeh W, Al-Ajlouni Y, Alnimer L, Ismail A, Natour B, Njei B. The burden of cirrhosis and other chronic liver disease in the middle east and North Africa (MENA) region over three decades. BMC Public Health 2024, 24: 2979. PMID: 39468483, PMCID: PMC11514855, DOI: 10.1186/s12889-024-20445-5.Peer-Reviewed Original ResearchConceptsAge-standardized incidence rateAge-standardized death ratesDisability-adjusted life yearsBurden of cirrhosisGlobal Burden of DiseaseDisability burdenDeath rateAge-standardized disability-adjusted life yearsPublic health effortsBurden of diseaseSignificant health challengesGender-specific interventionsLiver disease incidenceChronic liver diseaseIncident casesMENA regionHealth effortsCountry-specific trendsHealthcare systemGlobal burdenHealth challengesIncreasing burdenIncidence rateLife yearsEpidemiological trends
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