2025
Validity of Diagnostic Codes and Laboratory Tests to Identify Cholangiocarcinoma and Its Subtypes
Ferrante N, Hubbard R, Weinfurtner K, Mezina A, Newcomb C, Furth E, Bhattacharya D, Njei B, Taddei T, Singal A, Hoteit M, Park L, Kaplan D, Re V. Validity of Diagnostic Codes and Laboratory Tests to Identify Cholangiocarcinoma and Its Subtypes. Pharmacoepidemiology And Drug Safety 2025, 34: e70154. PMID: 40328444, PMCID: PMC12055315, DOI: 10.1002/pds.70154.Peer-Reviewed Original ResearchConceptsPositive predictive valueVeterans Health AdministrationExtrahepatic cholangiocarcinomaValidity of diagnostic codesInternational Classification of Diseases for OncologyUS Veterans Health AdministrationConfidence intervalsPharmacoepidemiological studiesICD-O-3Days of diagnosisVA dataHealth AdministrationIntrahepatic cholangiocarcinomaDiagnostic codesHistology codesCholangiocarcinomaUnique patientsInclusion criteriaCholangiocarcinoma subtypesTopography codesPredictive valuePatientsEvaluate medicationsSubtypesEvaluate determinantsMortality, Hepatic Decompensation, and Cardiovascular Outcomes in Lean vs. Non-lean MASLD Cirrhosis: A Veterans Affairs Cohort Study
Njei B, Mezzacappa C, John B, Serper M, Kaplan D, Taddei T, Mahmud N. Mortality, Hepatic Decompensation, and Cardiovascular Outcomes in Lean vs. Non-lean MASLD Cirrhosis: A Veterans Affairs Cohort Study. Digestive Diseases And Sciences 2025, 70: 802-813. PMID: 39779587, PMCID: PMC11839701, DOI: 10.1007/s10620-024-08764-4.Peer-Reviewed Original ResearchConceptsNon-lean individualsAll-cause mortalityMajor adverse cardiovascular eventsIncreased risk of all-cause mortalityRisk of all-cause mortalityVeterans Health AdministrationRisk of hepatic decompensationPrevalence of diabetesRisk of cardiovascular mortalityHepatic decompensationHigher mortality riskCardiovascular-related mortalityCox proportional hazards modelsCohort study of patientsCardiovascular outcomesIncident major adverse cardiovascular eventsRetrospective cohort study of patientsProportional hazards modelNon-HispanicRetrospective cohort studyCompeting risk regressionHealth AdministrationMultivariate Cox proportional hazards modelLean individualsAssessed associations
2024
Hepatotoxicity Score: A New Method to Adjust for Use of Potentially Hepatotoxic Medications by Chronic Liver Disease Status
Re V, Newcomb C, Carbonari D, Mezochow A, Hennessy S, Rentsch C, Park L, Tate J, Bräu N, Bhattacharya D, Lim J, Mezzacappa C, Njei B, Roy J, Taddei T, Justice A, Torgersen J. Hepatotoxicity Score: A New Method to Adjust for Use of Potentially Hepatotoxic Medications by Chronic Liver Disease Status. Pharmacoepidemiology And Drug Safety 2024, 33: e70069. PMID: 39662972, PMCID: PMC11634562, DOI: 10.1002/pds.70069.Peer-Reviewed Original ResearchConceptsProton pump inhibitor initiationHazard ratioVeterans Health AdministrationSevere acute liver injuryProton pump inhibitorsChronic liver diseaseAcute liver injuryRates of hospitalizationSafety of medicationsPPI initiativesHealth AdministrationLiver disease statusMedication exposurePharmacoepidemiological studiesMedicationConfoundingScoresReports of hepatotoxicityDisease statusHepatotoxic medicationsDrug exposurePump inhibitorsHepatotoxic drugsOutpatient initiationHepatic safetyThe impact of overweight and obesity on health outcomes in the United States from 1990 to 2021
Al Ta'ani O, Al‐Ajlouni Y, Aleyadeh W, Al‐Bitar F, Alsakarneh S, Saadeh A, Alhuneafat L, Njei B. The impact of overweight and obesity on health outcomes in the United States from 1990 to 2021. Diabetes Obesity And Metabolism 2024, 26: 5455-5465. PMID: 39261301, DOI: 10.1111/dom.15924.Peer-Reviewed Original ResearchConceptsDisability-adjusted life yearsAge-standardized death ratesSocio-demographic indexBody mass indexHigher body mass indexHealth outcomesDeath rateAge-standardized disability-adjusted life yearsComprehensive public health strategyGlobal Burden of Disease dataBurden of disease dataAge-standardized DALY rateAnnual percentage changePublic health strategiesSignificant public health challengeElevated body mass indexPublic health challengeUnited StatesImpact public healthHealth strategiesDALY ratesOlder adultsEnvironmental interventionsGlobal burdenHealth challengesAn explainable machine learning model for prediction of high-risk nonalcoholic steatohepatitis
Njei B, Osta E, Njei N, Al-Ajlouni Y, Lim J. An explainable machine learning model for prediction of high-risk nonalcoholic steatohepatitis. Scientific Reports 2024, 14: 8589. PMID: 38615137, PMCID: PMC11016071, DOI: 10.1038/s41598-024-59183-4.Peer-Reviewed Original ResearchConceptsNational Health and Nutrition Examination SurveyRisk of progression to cirrhosisClinical risk indexHealth and Nutrition Examination SurveyControlled attenuation parameter valuesNovel therapeutic optionsLiver stiffness measurementProgression to cirrhosisAspartate aminotransferase levelsNutrition Examination SurveyResource-limited settingsFIB-4Fibrosis scorePlatelet countAminotransferase levelsTherapeutic optionsWaist circumferenceClinically applicable modelExamination SurveyNonalcoholic steatohepatitisFAST scoreEarly identificationElastography measurementsStiffness measurementPatients
2023
Artificial intelligence in medical imaging for cholangiocarcinoma diagnosis: A systematic review with scientometric analysis
Njei B, Kanmounye U, Seto N, McCarty T, Mohan B, Fozo L, Navaneethan U. Artificial intelligence in medical imaging for cholangiocarcinoma diagnosis: A systematic review with scientometric analysis. Journal Of Gastroenterology And Hepatology 2023, 38: 874-882. PMID: 36919223, DOI: 10.1111/jgh.16180.Peer-Reviewed Original ResearchConceptsConvolutional neural networkArtificial intelligenceComputer visionMedical imagingRole of AIDeep learning algorithmsHigh performance metricsMachine learningSocial network analysisLearning algorithmNeural networkPerformance metricsRelational networksIntelligenceNetworkCholangiocarcinoma diagnosisScientometric analysisVisionNetwork analysisClassifierAlgorithmCollaborationLearningImagesMetrics
2022
Artificial intelligence–assisted cholangioscopy for automatic detection of malignant biliary strictures
Njei B, McCarty T, Navaneethan U. Artificial intelligence–assisted cholangioscopy for automatic detection of malignant biliary strictures. Gastrointestinal Endoscopy 2022, 96: 1092-1093. PMID: 36404092, DOI: 10.1016/j.gie.2022.07.005.Peer-Reviewed Original Research
2021
Chronic opioid use is associated with obstructive and spastic disorders in the esophagus
Sanchez MJ, Olivier S, Gediklioglu F, Almeida M, Gaeta M, Nigro M, de la Rosa R, Nguyen M, Lalehzari M, Regala F, Njei B, Deng Y, Ciarleglio M, Masoud A. Chronic opioid use is associated with obstructive and spastic disorders in the esophagus. Neurogastroenterology & Motility 2021, 34: e14233. PMID: 34532898, PMCID: PMC11152085, DOI: 10.1111/nmo.14233.Peer-Reviewed Original ResearchConceptsEsophagogastric junction outflow obstructionDistal esophageal spasmNon-opioid usersAchalasia type IIIIneffective esophageal motilityHigh-resolution manometryDistal latencyOpioid useEsophageal motilityOpioid usersMME groupChronic opioid effectsChronic opioid useDose of opioidsEsophageal motility disordersType IIIElectronic medical recordsManometric abnormalitiesSpastic disordersOpioid effectsOutflow obstructionEsophageal spasmMotility disordersRetrospective studyManometric resultsTreatment and prevention of viral hepatitis in pregnancy
Dionne-Odom J, Cozzi GD, Franco RA, Njei B, Tita ATN. Treatment and prevention of viral hepatitis in pregnancy. American Journal Of Obstetrics And Gynecology 2021, 226: 335-346. PMID: 34516961, PMCID: PMC8907340, DOI: 10.1016/j.ajog.2021.09.002.Peer-Reviewed Original ResearchConceptsHepatitis BViral hepatitisHepatitis AHepatitis CAntiviral therapyPregnant womenVertical transmissionImmunoglobulin GActive hepatitis BBirth dose vaccineChronic viral hepatitisHigh clinical suspicionBlood-borne transmissionElevated viral loadRisk of acquisitionVertical transmission riskMedical history reviewTenofovir disoproxil fumarateAcquisition of infectionFecal-oral transmissionRoutine prenatal screeningRoute of infectionHerpes simplex virusVaccine seriesCesarean delivery
2020
Role of Prophylactic Cholecystectomy After Endoscopic Sphincterotomy for Biliary Stone Disease: A Systematic Review and Meta-analysis.
McCarty TR, Farrelly J, Njei B, Jamidar P, Muniraj T. Role of Prophylactic Cholecystectomy After Endoscopic Sphincterotomy for Biliary Stone Disease: A Systematic Review and Meta-analysis. Annals Of Surgery 2020, 273: 667-675. PMID: 32590541, DOI: 10.1097/sla.0000000000003977.Peer-Reviewed Original ResearchConceptsRecurrent biliary painProphylactic cholecystectomyBile duct stonesMeta-AnalysisSystematic reviewBiliary painDuct stonesCommon bile duct stonesBiliary stone diseaseSubset of patientsCochrane Library databasesRisk of mortalityConfidence intervalsRate of pancreatitisPooled effect sizeSearch of PubMedPreferred Reporting ItemsRandom-effects modelWeb of ScienceBiliary complicationsEventual cholecystectomyComplication rateEndoscopic cholangiopancreatographyEndoscopic sphincterotomyBiliary sphincterotomy
2019
Rhythmic Fluctuations in Levels of Liver Enzymes During Menstrual Cycles of Healthy Women and Effects of Body Weight
Lai C, Jadhav S, Njei B, Ye A, Wactawski-Wende J, Mumford S, Schisterman E, Rotman Y. Rhythmic Fluctuations in Levels of Liver Enzymes During Menstrual Cycles of Healthy Women and Effects of Body Weight. Clinical Gastroenterology And Hepatology 2019, 18: 2055-2063.e2. PMID: 31811951, PMCID: PMC7269853, DOI: 10.1016/j.cgh.2019.11.047.Peer-Reviewed Original ResearchConceptsLevels of liver enzymesMenstrual cycleLevels of alanine aminotransferaseBody mass indexLiver enzymesAlanine aminotransferaseSex hormonesMenstruating womenMass indexAssociation of sex hormonesPost hoc analysis of dataPhases of menstrual cycleAlkaline phosphataseHealthy menstruating womenNormal menstrual cycleAlanine aminotransferase valuesFemale sex hormonesMid-follicular phaseAbstractText Label="RESULTS">Levels of estrogenMarkers of oxidative stressLiver enzyme measurementsLevels of progesteroneLevels of alkaline phosphataseNon-reproductive organsExpression of the type 3 InsP3 receptor is a final common event in the development of hepatocellular carcinoma
Guerra MT, Florentino RM, Franca A, Lima Filho AC, Dos Santos ML, Fonseca RC, Lemos FO, Fonseca MC, Kruglov E, Mennone A, Njei B, Gibson J, Guan F, Cheng YC, Ananthanarayanan M, Gu J, Jiang J, Zhao H, Lima CX, Vidigal PT, Oliveira AG, Nathanson MH, Leite MF. Expression of the type 3 InsP3 receptor is a final common event in the development of hepatocellular carcinoma. Gut 2019, 68: 1676-1687. PMID: 31315892, PMCID: PMC7087395, DOI: 10.1136/gutjnl-2018-317811.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsApoptosisCalcium SignalingCarcinogenesisCarcinoma, HepatocellularCell ProliferationCells, CulturedDNA MethylationFemaleGene Expression Regulation, NeoplasticHepatocytesHumansInositol 1,4,5-Trisphosphate ReceptorsLiverLiver NeoplasmsLiver RegenerationMaleMice, KnockoutMiddle AgedSurvival AnalysisConceptsChronic liver diseaseITPR3 expressionLiver cancer cellsLiver diseaseMouse modelFinal common eventCancer cellsSpecimens of patientsIndependent patient cohortsControl liver specimensHuman HCC cellsType 3 InsP3 receptorHuman liver samplesIncreased expression levelCancer deathPatient cohortCommon molecular eventPoor survivalHepatocellular carcinomaLiver specimensNormal liverHCC cellsAbstractTextHCCType 3 isoformResponse to Letter to the Editor: Impact of Bariatric Surgery on Outcomes of Patients with Sickle Cell Disease: a Nationwide Inpatient Sample Analysis, 2004–2014
McCarty T, Sharma P, Yadav S, Ngu J, Njei B. Response to Letter to the Editor: Impact of Bariatric Surgery on Outcomes of Patients with Sickle Cell Disease: a Nationwide Inpatient Sample Analysis, 2004–2014. Obesity Surgery 2019, 29: 2624-2624. PMID: 31123989, DOI: 10.1007/s11695-019-03956-8.Peer-Reviewed Original ResearchRegional and Rural-Urban Differences in the Use of Direct-acting Antiviral Agents for Hepatitis C Virus
Njei B, Esserman D, Krishnan S, Ohl M, Tate JP, Hauser RG, Taddei T, Lim J, Justice AC. Regional and Rural-Urban Differences in the Use of Direct-acting Antiviral Agents for Hepatitis C Virus. Medical Care 2019, 57: 279-285. PMID: 30807449, PMCID: PMC6436819, DOI: 10.1097/mlr.0000000000001071.Peer-Reviewed Original ResearchConceptsDirect-acting antiviral agentsHepatitis C virus infectionVeterans Affairs Healthcare SystemRural-Urban Commuting Area codesCurative HCV treatmentRural-urban designationC virus infectionElectronic health record dataHepatitis C virusPrior treatment experienceLower odds ratioHealth record dataZone improvement plan codeEligible patientsHCV treatmentAntiretroviral medicationsRural-urban residenceLiver diseaseUnadjusted analysesC virusRural-urban differencesOdds ratioMultivariable modelLower incidenceObservational studyImpact of Bariatric Surgery on Outcomes of Patients with Sickle Cell Disease: a Nationwide Inpatient Sample Analysis, 2004–2014
Sharma P, McCarty TR, Yadav S, Ngu JN, Njei B. Impact of Bariatric Surgery on Outcomes of Patients with Sickle Cell Disease: a Nationwide Inpatient Sample Analysis, 2004–2014. Obesity Surgery 2019, 29: 1789-1796. PMID: 30805858, DOI: 10.1007/s11695-019-03780-0.Peer-Reviewed Original ResearchConceptsSickle cell diseaseVaso-occlusive crisisAcute chest syndromeBariatric surgeryIncidence risk ratioChest syndromeMorbid obesityClinical outcomesHospitalization costsCell diseaseUnited States Nationwide Inpatient Sample databaseNationwide Inpatient Sample databaseOutcomes of patientsMulti-organ failureSurgery-related complicationsHigher hospitalization costsUrinary tract infectionWeight loss surgeryDisease-specific treatmentLength of staySickle cell patientsHospital mortalityRespiratory failureThromboembolic eventsConclusionsBariatric surgeryEffects of Endotoxin on Type 3 Inositol 1,4,5‐Trisphosphate Receptor in Human Cholangiocytes
Franca A, Filho A, Guerra MT, Weerachayaphorn J, dos Santos M, Njei B, Robert M, Lima C, Vidigal P, Banales JM, Ananthanarayanan M, Leite MF, Nathanson MH. Effects of Endotoxin on Type 3 Inositol 1,4,5‐Trisphosphate Receptor in Human Cholangiocytes. Hepatology 2019, 69: 817-830. PMID: 30141207, PMCID: PMC6351171, DOI: 10.1002/hep.30228.Peer-Reviewed Original ResearchConceptsToll-like receptor 4Alcoholic hepatitisEffect of endotoxinBile duct cellsNF-κBInhibition of TLR4Human cholangiocytesStimulation of TLR4Duct cellsSevere alcoholic hepatitisCholestasis of sepsisForms of cholestasisNF-κB subunitsP65/p50Trisphosphate receptorReceptor 4Clinical conditionsBicarbonate secretionHepatocellular changesITPR3 expressionCholestasisType 3 inositolLPS receptorAgonist stimulusSepsisEffects of Hypercholesterolemia and Statin Exposure on Survival in a Large National Cohort of Patients With Cirrhosis
Kaplan DE, Serper M, Mehta R, Fox R, John B, Aytaman A, Baytarian M, Hunt K, Albrecht J, Njei B, Taddei TH, Group V. Effects of Hypercholesterolemia and Statin Exposure on Survival in a Large National Cohort of Patients With Cirrhosis. Gastroenterology 2019, 156: 1693-1706.e12. PMID: 30660733, DOI: 10.1053/j.gastro.2019.01.026.Peer-Reviewed Original ResearchMeSH KeywordsAgedCarcinoma, HepatocellularCholesterolFemaleHeart FailureHumansHydroxymethylglutaryl-CoA Reductase InhibitorsHypercholesterolemiaLiver CirrhosisLiver NeoplasmsMaleMiddle AgedMyocardial InfarctionPropensity ScoreProportional Hazards ModelsRandomized Controlled Trials as TopicRetrospective StudiesStrokeSurvival RateUnited StatesConceptsRetrospective cohort studyStatin exposureLarge national cohortHepatic decompensationStatin useCohort studyHazard ratioNational cohortMultivariable Cox proportional hazards modelsCox proportional hazards modelBaseline total cholesterolPrior statin exposureStatin-naïve subjectsEffect of hypercholesterolemiaVeterans Health AdministrationProportional hazards modelHepatocellular carcinoma developmentDecrease of mortalityRisk-set matchingChild-TurcottePugh classStatin therapyDL increaseTotal cholesterolHepatic functionNational Trends in Use of Opioid Drugs Among Cirrhosis-related Hospitalizations in the United States, 2004 to 2012
McCarty TR, Haque L, Njei B. National Trends in Use of Opioid Drugs Among Cirrhosis-related Hospitalizations in the United States, 2004 to 2012. Journal Of Clinical Gastroenterology 2019, 53: 78-79. PMID: 27984400, DOI: 10.1097/mcg.0000000000000771.Peer-Reviewed Original Research
2018
Cannabis Use Is Associated With Increased Risk of Post–Endoscopic Retrograde Cholangiopancreatography Pancreatitis
Njei B, Sharma P, McCarty TR, Singh M, Haque L, Aslanian HR, Jamidar P, Muniraj T. Cannabis Use Is Associated With Increased Risk of Post–Endoscopic Retrograde Cholangiopancreatography Pancreatitis. Pancreas 2018, 47: 1142-1149. PMID: 30134357, DOI: 10.1097/mpa.0000000000001143.Peer-Reviewed Original ResearchConceptsPost-endoscopic retrograde cholangiopancreatography pancreatitisIncidence risk ratioCholangiopancreatography pancreatitisCannabis useRisk of PEPEndoscopic retrograde cholangiopancreatography pancreatitisUS Nationwide Inpatient SampleRate of PEPShorter hospital stayNationwide Inpatient SampleNinth Edition codesImpact of cannabisPoisson regression modelsHospital deathHospital stayIndependent predictorsEdition codesRisk ratioInpatient SampleInternational ClassificationMultivariate analysisPancreatitisPatientsCannabisSignificant increaseImpact of bariatric surgery in patients with HIV infection
Sharma P, McCarty TR, Ngu JN, O'Donnell M, Njei B. Impact of bariatric surgery in patients with HIV infection. AIDS 2018, 32: 1959-1965. PMID: 30157083, PMCID: PMC6126912, DOI: 10.1097/qad.0000000000001915.Peer-Reviewed Original ResearchConceptsBariatric surgeryIncidence risk ratioMorbid obesityRespiratory failureObese patientsRenal failureClinical outcomesUnited States Nationwide Inpatient Sample databaseNationwide Inpatient Sample databaseObese HIV patientsLife-threatening morbidityUrinary tract infectionWeight loss surgeryRelevant clinical outcomesLength of stayRates of obesityHospital mortalityHIV patientsThromboembolic eventsSecondary outcomesTract infectionsHIV infectionPrimary outcomeMultivariable analysisDischarge diagnosis
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply