2025
Validity of Diagnostic Codes and Laboratory Tests to Identify Cholangiocarcinoma and Its Subtypes
Ferrante N, Hubbard R, Weinfurtner K, Mezina A, Newcomb C, Furth E, Bhattacharya D, Njei B, Taddei T, Singal A, Hoteit M, Park L, Kaplan D, Re V. Validity of Diagnostic Codes and Laboratory Tests to Identify Cholangiocarcinoma and Its Subtypes. Pharmacoepidemiology And Drug Safety 2025, 34: e70154. PMID: 40328444, PMCID: PMC12055315, DOI: 10.1002/pds.70154.Peer-Reviewed Original ResearchConceptsPositive predictive valueVeterans Health AdministrationExtrahepatic cholangiocarcinomaValidity of diagnostic codesInternational Classification of Diseases for OncologyUS Veterans Health AdministrationConfidence intervalsPharmacoepidemiological studiesICD-O-3Days of diagnosisVA dataHealth AdministrationIntrahepatic cholangiocarcinomaDiagnostic codesHistology codesCholangiocarcinomaUnique patientsInclusion criteriaCholangiocarcinoma subtypesTopography codesPredictive valuePatientsEvaluate medicationsSubtypesEvaluate determinantsMortality, Hepatic Decompensation, and Cardiovascular Outcomes in Lean vs. Non-lean MASLD Cirrhosis: A Veterans Affairs Cohort Study
Njei B, Mezzacappa C, John B, Serper M, Kaplan D, Taddei T, Mahmud N. Mortality, Hepatic Decompensation, and Cardiovascular Outcomes in Lean vs. Non-lean MASLD Cirrhosis: A Veterans Affairs Cohort Study. Digestive Diseases And Sciences 2025, 70: 802-813. PMID: 39779587, PMCID: PMC11839701, DOI: 10.1007/s10620-024-08764-4.Peer-Reviewed Original ResearchConceptsNon-lean individualsAll-cause mortalityMajor adverse cardiovascular eventsIncreased risk of all-cause mortalityRisk of all-cause mortalityVeterans Health AdministrationRisk of hepatic decompensationPrevalence of diabetesRisk of cardiovascular mortalityHepatic decompensationHigher mortality riskCardiovascular-related mortalityCox proportional hazards modelsCohort study of patientsCardiovascular outcomesIncident major adverse cardiovascular eventsRetrospective cohort study of patientsProportional hazards modelNon-HispanicRetrospective cohort studyCompeting risk regressionHealth AdministrationMultivariate Cox proportional hazards modelLean individualsAssessed associations
2024
Impact of Recipient and Donor Body Mass Index on Survival Outcomes After Intestinal Transplantation: A United Network for Organ Sharing Database Analysis
Ameyaw A, Boateng S, Annor E, Njei B. Impact of Recipient and Donor Body Mass Index on Survival Outcomes After Intestinal Transplantation: A United Network for Organ Sharing Database Analysis. Annals Of Transplantation 2024, 29: e943994-1-e943994-13. PMID: 38978263, PMCID: PMC11299477, DOI: 10.12659/aot.943994.Peer-Reviewed Original ResearchConceptsBody mass indexDonor body mass indexIncreased risk of mortalityIntestinal transplantationRisk of mortalityIT recipientsSurvival outcomesMass indexIncreased riskLong-term patient survivalImpact of body mass indexRecipient body mass indexMultivariate Cox regression analysisKaplan-Meier survival curvesBody mass index categoriesLower body mass indexImprove survival outcomesCox regression analysisRetrospective cohort studyAssociation of recipientPost-transplant mortalityImpact of recipientUnderweight patientsPatient survivalObesity class
2021
Chronic opioid use is associated with obstructive and spastic disorders in the esophagus
Sanchez MJ, Olivier S, Gediklioglu F, Almeida M, Gaeta M, Nigro M, de la Rosa R, Nguyen M, Lalehzari M, Regala F, Njei B, Deng Y, Ciarleglio M, Masoud A. Chronic opioid use is associated with obstructive and spastic disorders in the esophagus. Neurogastroenterology & Motility 2021, 34: e14233. PMID: 34532898, PMCID: PMC11152085, DOI: 10.1111/nmo.14233.Peer-Reviewed Original ResearchConceptsEsophagogastric junction outflow obstructionDistal esophageal spasmNon-opioid usersAchalasia type IIIIneffective esophageal motilityHigh-resolution manometryDistal latencyOpioid useEsophageal motilityOpioid usersMME groupChronic opioid effectsChronic opioid useDose of opioidsEsophageal motility disordersType IIIElectronic medical recordsManometric abnormalitiesSpastic disordersOpioid effectsOutflow obstructionEsophageal spasmMotility disordersRetrospective studyManometric results
2019
Effects of Hypercholesterolemia and Statin Exposure on Survival in a Large National Cohort of Patients With Cirrhosis
Kaplan DE, Serper M, Mehta R, Fox R, John B, Aytaman A, Baytarian M, Hunt K, Albrecht J, Njei B, Taddei TH, Group V. Effects of Hypercholesterolemia and Statin Exposure on Survival in a Large National Cohort of Patients With Cirrhosis. Gastroenterology 2019, 156: 1693-1706.e12. PMID: 30660733, DOI: 10.1053/j.gastro.2019.01.026.Peer-Reviewed Original ResearchMeSH KeywordsAgedCarcinoma, HepatocellularCholesterolFemaleHeart FailureHumansHydroxymethylglutaryl-CoA Reductase InhibitorsHypercholesterolemiaLiver CirrhosisLiver NeoplasmsMaleMiddle AgedMyocardial InfarctionPropensity ScoreProportional Hazards ModelsRandomized Controlled Trials as TopicRetrospective StudiesStrokeSurvival RateUnited StatesConceptsRetrospective cohort studyStatin exposureLarge national cohortHepatic decompensationStatin useCohort studyHazard ratioNational cohortMultivariable Cox proportional hazards modelsCox proportional hazards modelBaseline total cholesterolPrior statin exposureStatin-naïve subjectsEffect of hypercholesterolemiaVeterans Health AdministrationProportional hazards modelHepatocellular carcinoma developmentDecrease of mortalityRisk-set matchingChild-TurcottePugh classStatin therapyDL increaseTotal cholesterolHepatic function
2018
Impact of bariatric surgery in patients with HIV infection
Sharma P, McCarty TR, Ngu JN, O'Donnell M, Njei B. Impact of bariatric surgery in patients with HIV infection. AIDS 2018, 32: 1959-1965. PMID: 30157083, PMCID: PMC6126912, DOI: 10.1097/qad.0000000000001915.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBariatric SurgeryFemaleHIV InfectionsHumansMaleMiddle AgedObesityRetrospective StudiesSurvival AnalysisTreatment OutcomeUnited StatesConceptsBariatric surgeryIncidence risk ratioMorbid obesityRespiratory failureObese patientsRenal failureClinical outcomesUnited States Nationwide Inpatient Sample databaseNationwide Inpatient Sample databaseObese HIV patientsLife-threatening morbidityUrinary tract infectionWeight loss surgeryRelevant clinical outcomesLength of stayRates of obesityHospital mortalityHIV patientsThromboembolic eventsSecondary outcomesTract infectionsHIV infectionPrimary outcomeMultivariable analysisDischarge diagnosis
2016
Prevalence of hepatitis delta infection in the United States: National Health and Nutrition Examination Survey, 1999‐2012
Njei B, Do A, Lim JK. Prevalence of hepatitis delta infection in the United States: National Health and Nutrition Examination Survey, 1999‐2012. Hepatology 2016, 64: 681-682. PMID: 26453027, PMCID: PMC4826621, DOI: 10.1002/hep.28279.Peer-Reviewed Original ResearchTrends in esophageal cancer survival in United States adults from 1973 to 2009: A SEER database analysis
Njei B, McCarty TR, Birk JW. Trends in esophageal cancer survival in United States adults from 1973 to 2009: A SEER database analysis. Journal Of Gastroenterology And Hepatology 2016, 31: 1141-1146. PMID: 26749521, PMCID: PMC4885788, DOI: 10.1111/jgh.13289.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAge FactorsAgedCarcinoma, Squamous CellEarly Detection of CancerEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaEsophagectomyFemaleHumansKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisNeoplasm StagingPredictive Value of TestsProportional Hazards ModelsRetrospective StudiesRisk FactorsSEER ProgramSurvival RateTime FactorsTreatment OutcomeUnited StatesConceptsSquamous cell carcinomaEsophageal cancerEsophageal adenocarcinomaMedian survivalBetter long-term survival outcomesLong-term survival outcomesOverall median survivalEnd Results (SEER) databaseProportion of patientsSEER database analysisSignificant survival improvementProportional hazards regressionEsophageal cancer survivalLong-term survivalIndependent mortality factorsLocalized diseaseCurative stageSurgical treatmentSurvival improvementHazards regressionResults databaseSurvival outcomesCell carcinomaTreatment modalitiesCancer survival
2015
Emerging trends in hepatocellular carcinoma incidence and mortality
Njei B, Rotman Y, Ditah I, Lim JK. Emerging trends in hepatocellular carcinoma incidence and mortality. Hepatology 2015, 61: 191-199. PMID: 25142309, PMCID: PMC4823645, DOI: 10.1002/hep.27388.Peer-Reviewed Original ResearchMeSH KeywordsAgedCarcinoma, HepatocellularFemaleHumansIncidenceLiver NeoplasmsMaleMiddle AgedProportional Hazards ModelsRetrospective StudiesSEER ProgramUnited StatesConceptsIB mortalityHCC incidenceHepatocellular carcinomaIncidence of HCCMultivariable Cox regression analysisOverall median survivalCox regression analysisEnd Results (SEER) dataSignificant survival improvementAge-adjusted incidenceU.S. populationHepatocellular carcinoma incidenceJoinpoint Regression ProgramIncidence-based mortalityRegression analysisSignificant increaseCurative modalityLiver transplantCurative stageMedian survivalSurvival improvementCarcinoma incidenceTumor sizeVascular invasionPrimary tumor
2013
Increased mortality with peptic ulcer bleeding in patients with both compensated and decompensated cirrhosis
Venkatesh P, Parasa S, Njei B, Sanaka M, Navaneethan U. Increased mortality with peptic ulcer bleeding in patients with both compensated and decompensated cirrhosis. Gastrointestinal Endoscopy 2013, 79: 605-614.e3. PMID: 24119507, DOI: 10.1016/j.gie.2013.08.026.Peer-Reviewed Original ResearchConceptsInternational Classification of DiseasesPopulation-based studyHospital costsImpact of cirrhosisClassification of DiseasesPeptic ulcer bleedingIncreased mortalityAssociated with increased mortalityLength of stayInternational ClassificationIn-hospital mortalityControl groupStratified analysisAdministrative dataDecompensated cirrhosisHigher mortalityCompensated cirrhosisProportion of patientsAssociated with worse outcomesUlcer bleedingMortalityHospitalOutcomesOutcomes of patientsPresence of cirrhosisTiming of colonoscopy and outcomes in patients with lower GI bleeding: a nationwide population-based study
Navaneethan U, Njei B, Venkatesh P, Sanaka M. Timing of colonoscopy and outcomes in patients with lower GI bleeding: a nationwide population-based study. Gastrointestinal Endoscopy 2013, 79: 297-306.e12. PMID: 24060518, DOI: 10.1016/j.gie.2013.08.001.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overColonoscopyConfidence IntervalsCross-Sectional StudiesFemaleFollow-Up StudiesGastrointestinal HemorrhageHemostasis, EndoscopicHospital MortalityHumansInpatientsLength of StayMaleMiddle AgedOdds RatioOhioOperative TimePopulation SurveillancePrognosisRetrospective StudiesSurvival RateYoung AdultConceptsTime of colonoscopyPopulation-based studyDelayed colonoscopyEarly colonoscopyLength of hospital stayHospital costsNationwide population-based studyHospital stayInternational Classification of DiseasesAssociated with decreased length of hospital stayClinical Modification codesClassification of DiseasesMultivariate analysisShorter length of hospital stayAssociated with decreased lengthLength of stayInternational ClassificationModification codesIn-hospital mortalityOutcomes of patientsColonoscopyHospitalBlood transfusionGI bleedingLGIB
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