2022
Inflammatory stress signaling via NF-kB alters accessible cholesterol to upregulate SREBP2 transcriptional activity in endothelial cells
Fowler JWM, Zhang R, Tao B, Boutagy NE, Sessa WC. Inflammatory stress signaling via NF-kB alters accessible cholesterol to upregulate SREBP2 transcriptional activity in endothelial cells. ELife 2022, 11: e79529. PMID: 35959888, PMCID: PMC9395194, DOI: 10.7554/elife.79529.Peer-Reviewed Original ResearchConceptsAcute inflammatory responseEndothelial cellsCholesterol homeostasisInflammatory stressInflammatory responsePro-inflammatory cytokinesSite of injuryCholesterol biosynthetic gene expressionNF-κB DNA bindingHuman endothelial cellsMultiple sclerosisInflammatory activationPrimary human endothelial cellsVascular endotheliumNF-κB-inducible genesTissue damageInducible targetAberrant activationRole of cholesterolSREBP2 activationMicrobial infectionsCholesterolKey transcription regulatorHomeostasisLeukocytes
2021
Characterization of a Novel Caveolin Modulator That Reduces Vascular Permeability and Ocular Inflammation
Bernatchez PN, Tao B, Bradshaw RA, Eveleth D, Sessa WC. Characterization of a Novel Caveolin Modulator That Reduces Vascular Permeability and Ocular Inflammation. Translational Vision Science & Technology 2021, 10: 21-21. PMID: 34111267, PMCID: PMC8132009, DOI: 10.1167/tvst.10.6.21.Peer-Reviewed Original ResearchMeSH KeywordsCapillary PermeabilityCaveolin 1Endothelial CellsHumansInflammationVascular Endothelial Growth Factor AConceptsOcular inflammationCell-permeable peptideRetinal damageVascular permeabilityModel of uveitisVascular endothelial growth factorNitric oxide releaseEndothelial growth factorNovel cell-permeable peptideEndothelial cell signalingVascular leakageClinical developmentInflammationOxide releaseEndothelial cellsNO releaseGrowth factorUveitisVEGFDistinct assaysPhage display technologyPresent studyVivoCell signalingPeptides
2016
Chromium alters lipopolysaccharide-induced inflammatory responses both in vivo and in vitro
Jin Y, Liu L, Zhang S, Tao B, Tao R, He X, Qu L, Huang J, Wang X, Fu Z. Chromium alters lipopolysaccharide-induced inflammatory responses both in vivo and in vitro. Chemosphere 2016, 148: 436-443. PMID: 26841286, DOI: 10.1016/j.chemosphere.2016.01.057.Peer-Reviewed Original ResearchConceptsInducible nitric oxide synthaseInterleukin-6Inflammatory responseCyclooxygenase-2 mRNA levelsLipopolysaccharide-induced inflammatory responsesRelease of TNFαNitric oxide synthaseTumor necrosis factorCell linesRAW264.7 cell lineConcentration-dependent mannerSerum levelsInflammatory cellsInterleukin-1βLiver weightOxide synthaseMacrophage cell lineNecrosis factorInterleukin-1αCR pretreatmentCytokine genesPeritoneal macrophagesSerious infiltrationLipopolysaccharideMRNA levels
2014
Myeloid-Specific Disruption of Tyrosine Phosphatase Shp2 Promotes Alternative Activation of Macrophages and Predisposes Mice to Pulmonary Fibrosis
Tao B, Jin W, Xu J, Liang Z, Yao J, Zhang Y, Wang K, Cheng H, Zhang X, Ke Y. Myeloid-Specific Disruption of Tyrosine Phosphatase Shp2 Promotes Alternative Activation of Macrophages and Predisposes Mice to Pulmonary Fibrosis. The Journal Of Immunology 2014, 193: 2801-2811. PMID: 25127857, DOI: 10.4049/jimmunol.1303463.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArginaseBleomycinBronchoalveolar Lavage FluidCells, CulturedChitinInflammationInterleukin-13Interleukin-4Interleukin-5Janus Kinase 1LungMacrophage ActivationMacrophages, AlveolarMiceMice, KnockoutProtein Tyrosine Phosphatase, Non-Receptor Type 11Pulmonary FibrosisReceptors, Cell SurfaceRNA InterferenceRNA, Small InterferingSchistosoma japonicumSchistosomiasis japonicaSignal TransductionSTAT6 Transcription FactorConceptsPulmonary fibrosisIL-4RAM2 polarizationAlternative activation of macrophagesBleomycin-induced inflammationActivation of M2 macrophagesM2 polarization in vitroActivation of macrophagesPolarization in vitroTyrosine phosphatase SHP2Association of Jak1Loss of Shp2Enhanced M2 polarizationM2 macrophagesMacrophage skewingAlveolar macrophagesCre recombinaseFibrosisPhosphatase SHP2M2 phenotypeM2 skewingMacrophagesSHP2Predisposed mice
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