2025
Neurobiological fingerprints of negative symptoms in schizophrenia identified by connectome‐based modeling
Gao Z, Xiao Y, Zhu F, Tao B, Zhao Q, Yu W, Bishop J, Gong Q, Lui S. Neurobiological fingerprints of negative symptoms in schizophrenia identified by connectome‐based modeling. Psychiatry And Clinical Neurosciences 2025, 79: 108-116. PMID: 39815736, DOI: 10.1111/pcn.13782.Peer-Reviewed Original ResearchConceptsConnectome-based predictive modelingNegative symptomsResting-state functional connectivity dataSeverity of negative symptomsDevelopment of novel treatment interventionsPrediction of negative symptomsDrug-naive schizophrenia patientsFirst-episode drug-naive schizophrenia patientsUnique neural substratesNovel treatment interventionsFunctional connectivity dataConnectome-based modelsSchizophrenia psychopathologySchizophrenia patientsNeurobiological mechanismsNeural substratesSymptom-specificSchizophreniaIndependent validation sampleError processNeural fingerprintsTreatment interventionsConnectivity patternsFunctional networksConnectivity data
2024
Multilayer network analysis reveals instability of brain dynamics in untreated first-episode schizophrenia
Gao Z, Xiao Y, Zhu F, Tao B, Zhao Q, Yu W, Sweeney J, Gong Q, Lui S. Multilayer network analysis reveals instability of brain dynamics in untreated first-episode schizophrenia. Cerebral Cortex 2024, 34: bhae402. PMID: 39375878, DOI: 10.1093/cercor/bhae402.Peer-Reviewed Original ResearchConceptsDorsal attention networkFirst-episode schizophreniaNetwork switching rateAntipsychotic treatmentSchizophrenia patientsReduction of negative symptomsResting-state functional magnetic resonance imaging dataUntreated first-episode schizophreniaDrug-naive schizophrenia patientsHealthy controlsFunctional magnetic resonance imaging dataEarly-stage schizophreniaFirst-episode drug-naive schizophrenia patientsInferior parietal lobuleFunctional network activityBrain network activityMagnetic resonance imaging dataNetwork activityAntipsychotic medicationNegative symptomsParietal lobuleAcute psychosisParietal regionsSchizophreniaMultilayer network analysisAltered cerebral white matter network topology and cognition in children with obstructive sleep apnea
Chen F, Fu Y, Tang B, Tao B, Wang Y, Huang Y, Chen T, Yu C, Jiang C, Lui S, Cai X, Lu Y, Yan Z. Altered cerebral white matter network topology and cognition in children with obstructive sleep apnea. Sleep Medicine 2024, 118: 63-70. PMID: 38613858, DOI: 10.1016/j.sleep.2024.03.038.Peer-Reviewed Original ResearchConceptsObstructive apnea-hypopnea indexWhite matter networksVerbal Comprehension IndexNon-OSA childrenEvidence of impaired cognitive functionRight temporal poleSuperior temporal gyrusImpaired cognitive functionBrain white matter networkHierarchical linear regressionApnea-hypopnea indexObstructive sleep apneaNeuroimaging evidenceTemporal gyrusTemporal poleBrain regionsCognitive testsCognitive functionMediation analysisTemporal lobeCognitive impairmentChild's brainNetwork propertiesSleep apneaComprehensive index
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