2017
Macrophage-Restricted Shp2 Tyrosine Phosphatase Acts as a Rheostat for MMP12 through TGF-β Activation in the Prevention of Age-Related Emphysema in Mice
Xu J, Tao B, Guo X, Zhou S, Li Y, Zhang Y, Zhou Z, Cheng H, Zhang X, Ke Y. Macrophage-Restricted Shp2 Tyrosine Phosphatase Acts as a Rheostat for MMP12 through TGF-β Activation in the Prevention of Age-Related Emphysema in Mice. The Journal Of Immunology 2017, 199: 2323-2332. PMID: 28814604, DOI: 10.4049/jimmunol.1601696.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsLungMacrophage ActivationMatrix Metalloproteinase 12MiceMice, KnockoutPhosphorylationProtein Tyrosine Phosphatase, Non-Receptor Type 11Pulmonary EmphysemaSignal TransductionSmad2 ProteinSmad3 ProteinTransforming Growth Factor beta1ConceptsMatrix metalloproteinasesActivation of alveolar macrophagesLevels of matrix metalloproteinasesElevated levels of matrix metalloproteinasesChronic lung disordersFunction of Shp2Activation of macrophagesProtein tyrosine phosphatase 2Development of emphysemaLong-term observation periodAttenuated Smad2/3 phosphorylationElevation of matrix metalloproteinasesProduction of matrix metalloproteinasesLoss of Shp2Tyrosine phosphatase 2MMP12 expressionPotential etiologiesAged miceLung disordersDestruction of alveolar wallsPulmonary emphysemaSmad2/3 phosphorylationAlveolar macrophagesAlveolar morphologyExtracellular matrix degradation
2014
Myeloid-Specific Disruption of Tyrosine Phosphatase Shp2 Promotes Alternative Activation of Macrophages and Predisposes Mice to Pulmonary Fibrosis
Tao B, Jin W, Xu J, Liang Z, Yao J, Zhang Y, Wang K, Cheng H, Zhang X, Ke Y. Myeloid-Specific Disruption of Tyrosine Phosphatase Shp2 Promotes Alternative Activation of Macrophages and Predisposes Mice to Pulmonary Fibrosis. The Journal Of Immunology 2014, 193: 2801-2811. PMID: 25127857, DOI: 10.4049/jimmunol.1303463.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArginaseBleomycinBronchoalveolar Lavage FluidCells, CulturedChitinInflammationInterleukin-13Interleukin-4Interleukin-5Janus Kinase 1LungMacrophage ActivationMacrophages, AlveolarMiceMice, KnockoutProtein Tyrosine Phosphatase, Non-Receptor Type 11Pulmonary FibrosisReceptors, Cell SurfaceRNA InterferenceRNA, Small InterferingSchistosoma japonicumSchistosomiasis japonicaSignal TransductionSTAT6 Transcription FactorConceptsPulmonary fibrosisIL-4RAM2 polarizationAlternative activation of macrophagesBleomycin-induced inflammationActivation of M2 macrophagesM2 polarization in vitroActivation of macrophagesPolarization in vitroTyrosine phosphatase SHP2Association of Jak1Loss of Shp2Enhanced M2 polarizationM2 macrophagesMacrophage skewingAlveolar macrophagesCre recombinaseFibrosisPhosphatase SHP2M2 phenotypeM2 skewingMacrophagesSHP2Predisposed mice
2012
Loss of Shp2 in alveoli epithelia induces deregulated surfactant homeostasis, resulting in spontaneous pulmonary fibrosis
Zhang X, Zhang Y, Tao B, Teng L, Li Y, Cao R, Gui Q, Ye M, Mou X, Cheng H, Hu H, Zhou R, Wu X, Xie Q, Ning W, Lai M, Shen H, Feng G, Ke Y. Loss of Shp2 in alveoli epithelia induces deregulated surfactant homeostasis, resulting in spontaneous pulmonary fibrosis. The FASEB Journal 2012, 26: 2338-2350. PMID: 22362894, DOI: 10.1096/fj.11-200139.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsATP-Binding Cassette TransportersFibroblast Growth FactorsHomeostasisMiceMice, KnockoutNuclear ProteinsProtein Tyrosine Phosphatase, Non-Receptor Type 11Pulmonary AlveoliPulmonary FibrosisPulmonary Surfactant-Associated ProteinsPulmonary SurfactantsThyroid Nuclear Factor 1Transcription FactorsConceptsATP-binding cassette subfamily A member 3Thyroid transcription factor-1Spontaneous pulmonary fibrosisPulmonary fibrosisSurfactant homeostasisTyrosine phosphatase SHP2Expression of thyroid transcription factor-1Surfactant proteinsAlveolar epithelial apoptosisInterstitial pulmonary fibrosisPhosphatase SHP2Investigate in vivo functionsTranscription factor 1Lung branching morphogenesisEpithelial apoptosisPulmonary surfactant proteinsAlveolar epitheliaLung injuryIneffective repairLoss of Shp2Minimal inflammationAT-IIEpithelial budsAlveolar functionFibrosis
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