2016
Genome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells
Kraehling JR, Chidlow JH, Rajagopal C, Sugiyama MG, Fowler JW, Lee MY, Zhang X, RamĂrez CM, Park EJ, Tao B, Chen K, Kuruvilla L, LarriveĂ© B, Folta-Stogniew E, Ola R, Rotllan N, Zhou W, Nagle MW, Herz J, Williams KJ, Eichmann A, Lee WL, Fernández-Hernando C, Sessa WC. Genome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells. Nature Communications 2016, 7: 13516. PMID: 27869117, PMCID: PMC5121336, DOI: 10.1038/ncomms13516.Peer-Reviewed Original ResearchConceptsActivin-like kinase 1Wide RNAi screenGWA data setsLDL uptakeEndothelial cellsIdentification of pathwaysLDL receptorRNAi screenEndocytic pathwayLysosomal degradationKinase 1LDL transcytosisPhysiological roleGenetic ablationUptake of LDLPathwayFunctional LDL receptorsCellsLow affinityTranscytosisUptakeALK1Unique opportunityAortic endotheliumAnimals
2013
Loss of Shp2 phosphatase favors alternative activation of macrophages, contributing to pulmonary fibrosis in mice
Tao B, Zhang X, Jin W, Zhang Y, Cheneg H, Ke Y. Loss of Shp2 phosphatase favors alternative activation of macrophages, contributing to pulmonary fibrosis in mice. The FASEB Journal 2013, 27: 835.7-835.7. DOI: 10.1096/fasebj.27.1_supplement.835.7.Peer-Reviewed Original ResearchPulmonary fibrosisAlternative activation of macrophagesArginase 1 activityBleomycin-induced inflammationAlveolar macrophage activationM2 polarization in vitroActivation of macrophagesPolarization in vitroSHP2 phosphataseIL-4Expressed cytoplasmic tyrosine phosphataseInflammatory diseasesMacrophage activationIL-4RFibrosisCytoplasmic tyrosine phosphataseMiceAlternative activationM2 polarizationCritical signal transducerPhenotypic changesPhysiological roleCatalytic domainNegative regulatorTyrosine phosphatase
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