2023
Genetic or therapeutic neutralization of ALK1 reduces LDL transcytosis and atherosclerosis in mice
Lee S, Schleer H, Park H, Jang E, Boyer M, Tao B, Gamez-Mendez A, Singh A, Folta-Stogniew E, Zhang X, Qin L, Xiao X, Xu L, Zhang J, Hu X, Pashos E, Tellides G, Shaul P, Lee W, Fernandez-Hernando C, Eichmann A, Sessa W. Genetic or therapeutic neutralization of ALK1 reduces LDL transcytosis and atherosclerosis in mice. Nature Cardiovascular Research 2023, 2: 438-448. PMID: 39196046, PMCID: PMC11358031, DOI: 10.1038/s44161-023-00266-2.Peer-Reviewed Original ResearchLDL transcytosisLDL receptor knockout miceReceptor knockout miceAtherosclerotic cardiovascular diseaseLow-density lipoprotein accumulationHigh-fat dietPromising therapeutic strategyTherapeutic neutralizationMacrophage infiltrationTriglyceride levelsLDL entryCardiovascular diseaseSelective monoclonal antibodiesLipoprotein accumulationTherapeutic strategiesKnockout micePlaque formationAtherosclerosis initiationType 1Genetic deletionArterial wallMonoclonal antibodiesEndothelial cellsLDL accumulationMice
2013
Loss of Shp2 phosphatase favors alternative activation of macrophages, contributing to pulmonary fibrosis in mice
Tao B, Zhang X, Jin W, Zhang Y, Cheneg H, Ke Y. Loss of Shp2 phosphatase favors alternative activation of macrophages, contributing to pulmonary fibrosis in mice. The FASEB Journal 2013, 27: 835.7-835.7. DOI: 10.1096/fasebj.27.1_supplement.835.7.Peer-Reviewed Original ResearchPulmonary fibrosisAlternative activation of macrophagesArginase 1 activityBleomycin-induced inflammationAlveolar macrophage activationM2 polarization in vitroActivation of macrophagesPolarization in vitroSHP2 phosphataseIL-4Expressed cytoplasmic tyrosine phosphataseInflammatory diseasesMacrophage activationIL-4RFibrosisCytoplasmic tyrosine phosphataseMiceAlternative activationM2 polarizationCritical signal transducerPhenotypic changesPhysiological roleCatalytic domainNegative regulatorTyrosine phosphatase
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply