2024
Single-cell CAR T atlas reveals type 2 function in 8-year leukaemia remission
Bai Z, Feng B, McClory S, de Oliveira B, Diorio C, Gregoire C, Tao B, Yang L, Zhao Z, Peng L, Sferruzza G, Zhou L, Zhou X, Kerr J, Baysoy A, Su G, Yang M, Camara P, Chen S, Tang L, June C, Melenhorst J, Grupp S, Fan R. Single-cell CAR T atlas reveals type 2 function in 8-year leukaemia remission. Nature 2024, 634: 702-711. PMID: 39322664, PMCID: PMC11485231, DOI: 10.1038/s41586-024-07762-w.Peer-Reviewed Original ResearchChimeric antigen receptorChimeric antigen receptor T cellsT cellsIL-4CAR T-cell dysfunctionChimeric antigen receptor T-cell productsCAR-T cell persistenceProteomic profiling of seraCAR-T cellsT cell persistenceT-cell therapyLong-term remissionT cell dysfunctionCAR-T productsType 2 cytokinesAntigen-specific activationT cell productionAssociated with patientsType 2 cellsDysfunctional subsetPotential therapeutic strategyCellular immunotherapyLeukemia remissionPatients relapseType 2 functions
2013
Loss of Shp2 phosphatase favors alternative activation of macrophages, contributing to pulmonary fibrosis in mice
Tao B, Zhang X, Jin W, Zhang Y, Cheneg H, Ke Y. Loss of Shp2 phosphatase favors alternative activation of macrophages, contributing to pulmonary fibrosis in mice. The FASEB Journal 2013, 27: 835.7-835.7. DOI: 10.1096/fasebj.27.1_supplement.835.7.Peer-Reviewed Original ResearchPulmonary fibrosisAlternative activation of macrophagesArginase 1 activityBleomycin-induced inflammationAlveolar macrophage activationM2 polarization in vitroActivation of macrophagesPolarization in vitroSHP2 phosphataseIL-4Expressed cytoplasmic tyrosine phosphataseInflammatory diseasesMacrophage activationIL-4RFibrosisCytoplasmic tyrosine phosphataseMiceAlternative activationM2 polarizationCritical signal transducerPhenotypic changesPhysiological roleCatalytic domainNegative regulatorTyrosine phosphatase
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