2020
BMP-9 and LDL crosstalk regulates ALK-1 endocytosis and LDL transcytosis in endothelial cells
Tao B, Kraehling JR, Ghaffari S, Ramirez C, Lee S, Fowler JW, Lee WL, Fernandez-Hernando C, Eichmann A, Sessa WC. BMP-9 and LDL crosstalk regulates ALK-1 endocytosis and LDL transcytosis in endothelial cells. Journal Of Biological Chemistry 2020, 295: 18179-18188. PMID: 33097593, PMCID: PMC7939458, DOI: 10.1074/jbc.ra120.015680.Peer-Reviewed Original ResearchConceptsBone morphogenetic protein 9Dynamin 2Caveolin-1LDL transcytosisGene expressionActivin-like kinase 1Endothelial cellsEndothelial cell quiescenceCell surface levelsSmad1/5 phosphorylationExtensive endocytosisUnbiased screenProtein 9Cell quiescenceKinase 1ALK-1BMP-9 levelsEssential roleEndocytosisEndothelial homeostasisHeavy chainSignalingInternalizationTranscytosisCells
2012
Docking protein Gab2 regulates mucin expression and goblet cell hyperplasia through TYK2/STAT6 pathway
Zhang X, Zhang Y, Tao B, Wang D, Cheng H, Wang K, Zhou R, Xie Q, Ke Y. Docking protein Gab2 regulates mucin expression and goblet cell hyperplasia through TYK2/STAT6 pathway. The FASEB Journal 2012, 26: 4603-4613. PMID: 22859374, DOI: 10.1096/fj.12-211755.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsEpithelial CellsGene Expression RegulationGoblet CellsHumansHyperplasiaHypersensitivityInterleukin-13LungLung NeoplasmsMiceMice, KnockoutMucinsMucusOvalbuminPhosphoproteinsPulmonary Disease, Chronic ObstructiveRespiratory MucosaSTAT6 Transcription FactorTYK2 KinaseConceptsGoblet cell hyperplasiaChronic obstructive pulmonary diseaseExpression of mucin genesKnockdown of Gab2Mucin gene expressionGab2 knockoutIn vivo roleCell hyperplasiaGab2Lung cancerRegulate growthMucin genesMolecular basisGene expressionPulmonary diseaseChronic pulmonary diseaseAirway inflammatory diseasesAnalysis of lungPotential involvementObstructive pulmonary diseaseAirway epitheliaMucin expressionAllergy modelCystic fibrosisInflammatory diseases
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply