2025
Morphological alterations of the thymus gland in individuals with schizophrenia
Zhao Q, Wei X, Yu W, Li X, Gao Z, Liu S, Liu Z, Wang K, Bishop J, Hu H, Luo C, Xiao Y, Hu N, Tao B, Zhu F, Gong Q, Lui S. Morphological alterations of the thymus gland in individuals with schizophrenia. Molecular Psychiatry 2025, 1-11. PMID: 40038543, DOI: 10.1038/s41380-025-02946-w.Peer-Reviewed Original ResearchAverage CT attenuationChest computed tomographyCT attenuationImmunometabolic profileThymic morphologySubtype 1Subtype 2Evidence of immunological abnormalitiesMaximal thicknessAnteroposterior distancePatient subtypesLow CT attenuationMorphological alterationsCase-control comparisonImmunological abnormalitiesThymic sizeLymphocyte countSchizophreniaComputed tomographyLipid measurementsThymus glandImmune hypothesisPatientsImmune systemSubtypesNeurobiological fingerprints of negative symptoms in schizophrenia identified by connectome‐based modeling
Gao Z, Xiao Y, Zhu F, Tao B, Zhao Q, Yu W, Bishop J, Gong Q, Lui S. Neurobiological fingerprints of negative symptoms in schizophrenia identified by connectome‐based modeling. Psychiatry And Clinical Neurosciences 2025, 79: 108-116. PMID: 39815736, DOI: 10.1111/pcn.13782.Peer-Reviewed Original ResearchConceptsConnectome-based predictive modelingNegative symptomsResting-state functional connectivity dataSeverity of negative symptomsDevelopment of novel treatment interventionsPrediction of negative symptomsDrug-naive schizophrenia patientsFirst-episode drug-naive schizophrenia patientsUnique neural substratesNovel treatment interventionsFunctional connectivity dataConnectome-based modelsSchizophrenia psychopathologySchizophrenia patientsNeurobiological mechanismsNeural substratesSymptom-specificSchizophreniaIndependent validation sampleError processNeural fingerprintsTreatment interventionsConnectivity patternsFunctional networksConnectivity data
2024
Multilayer network analysis reveals instability of brain dynamics in untreated first-episode schizophrenia
Gao Z, Xiao Y, Zhu F, Tao B, Zhao Q, Yu W, Sweeney J, Gong Q, Lui S. Multilayer network analysis reveals instability of brain dynamics in untreated first-episode schizophrenia. Cerebral Cortex 2024, 34: bhae402. PMID: 39375878, DOI: 10.1093/cercor/bhae402.Peer-Reviewed Original ResearchConceptsDorsal attention networkFirst-episode schizophreniaNetwork switching rateAntipsychotic treatmentSchizophrenia patientsReduction of negative symptomsResting-state functional magnetic resonance imaging dataUntreated first-episode schizophreniaDrug-naive schizophrenia patientsHealthy controlsFunctional magnetic resonance imaging dataEarly-stage schizophreniaFirst-episode drug-naive schizophrenia patientsInferior parietal lobuleFunctional network activityBrain network activityMagnetic resonance imaging dataNetwork activityAntipsychotic medicationNegative symptomsParietal lobuleAcute psychosisParietal regionsSchizophreniaMultilayer network analysisThe type 2 cytokine Fc–IL-4 revitalizes exhausted CD8+ T cells against cancer
Feng B, Bai Z, Zhou X, Zhao Y, Xie Y, Huang X, Liu Y, Enbar T, Li R, Wang Y, Gao M, Bonati L, Peng M, Li W, Tao B, Charmoy M, Held W, Melenhorst J, Fan R, Guo Y, Tang L. The type 2 cytokine Fc–IL-4 revitalizes exhausted CD8+ T cells against cancer. Nature 2024, 634: 712-720. PMID: 39322665, PMCID: PMC11485240, DOI: 10.1038/s41586-024-07962-4.Peer-Reviewed Original ResearchCD8+ T cellsMammalian target of rapamycinCancer immunotherapyT cellsNext-generation cancer immunotherapyAdoptive T-cell transferImmune checkpoint blockade therapyLong-term complete remissionCurrent cancer immunotherapiesCheckpoint blockade therapyInduce durable remissionsT-cell transferCD8+ TCytokine-based immunotherapyType 2 cytokinesXenograft tumor modelBlockade therapyDurable remissionsComplete remissionAntitumour efficacyTumor modelTarget of rapamycinInterleukin-4Immune responseCD8Single-cell CAR T atlas reveals type 2 function in 8-year leukaemia remission
Bai Z, Feng B, McClory S, de Oliveira B, Diorio C, Gregoire C, Tao B, Yang L, Zhao Z, Peng L, Sferruzza G, Zhou L, Zhou X, Kerr J, Baysoy A, Su G, Yang M, Camara P, Chen S, Tang L, June C, Melenhorst J, Grupp S, Fan R. Single-cell CAR T atlas reveals type 2 function in 8-year leukaemia remission. Nature 2024, 634: 702-711. PMID: 39322664, PMCID: PMC11485231, DOI: 10.1038/s41586-024-07762-w.Peer-Reviewed Original ResearchChimeric antigen receptorChimeric antigen receptor T cellsT cellsIL-4CAR T-cell dysfunctionChimeric antigen receptor T-cell productsCAR-T cell persistenceProteomic profiling of seraCAR-T cellsT cell persistenceT-cell therapyLong-term remissionT cell dysfunctionCAR-T productsType 2 cytokinesAntigen-specific activationT cell productionAssociated with patientsType 2 cellsDysfunctional subsetPotential therapeutic strategyCellular immunotherapyLeukemia remissionPatients relapseType 2 functionsProgressive alterations of resting-state hypothalamic dysconnectivity in schizophrenia
Li X, Zeng J, Liu N, Yang C, Tao B, Sun H, Gong Q, Zhang W, Li C, Lui S. Progressive alterations of resting-state hypothalamic dysconnectivity in schizophrenia. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2024, 135: 111127. PMID: 39181307, DOI: 10.1016/j.pnpbp.2024.111127.Peer-Reviewed Original ResearchHypothalamic functional connectivityBilateral anterior cingulate cortexAnterior cingulate cortexFunctional connectivityFES patientsCingulate cortexFC decreaseRight thalamusChronically treated schizophrenia patientsHealthy controlsSeed-based functional connectivityFirst-episode patientsPathogenesis of schizophreniaNature of schizophreniaAge-related declineAntipsychotic treatmentAntipsychotic medicationRight caudateLeft putamenIllness durationAnalysis of covarianceSchizophreniaDiagnostic groupsHC groupHypothalamus dysfunctionMultivariate associations between neuroanatomy and cognition in unmedicated and medicated individuals with schizophrenia
Zhao Q, Gao Z, Yu W, Xiao Y, Hu N, Wei X, Tao B, Zhu F, Li S, Lui S. Multivariate associations between neuroanatomy and cognition in unmedicated and medicated individuals with schizophrenia. Schizophrenia 2024, 10: 62. PMID: 39004627, PMCID: PMC11247086, DOI: 10.1038/s41537-024-00482-0.Peer-Reviewed Original ResearchFirst-episode schizophreniaCortical surface areaSubcortical volumesMedicated individualsFirst-episode schizophrenia sampleCortical thicknessBrain-behavior profilesAnterior cingulate cortexRight parahippocampal gyrusVerbal fluency testInferior parietal lobuleMultiple cognitive domainsVerbal memory performanceSample of individualsAntipsychotic doseAntipsychotic medicationPsychopathological symptomsCingulate cortexNeurobiological basisFluency testRight caudateMemory performanceParietal lobuleCognitive domainsIllness durationApplications of MRI in Schizophrenia: Current Progress in Establishing Clinical Utility
Sun H, Liu N, Qiu C, Tao B, Yang C, Tang B, Li H, Zhan K, Cai C, Zhang W, Lui S. Applications of MRI in Schizophrenia: Current Progress in Establishing Clinical Utility. Journal Of Magnetic Resonance Imaging 2024, 61: 616-633. PMID: 38946400, DOI: 10.1002/jmri.29470.Peer-Reviewed Original ResearchMagnetic resonance imagingTreatment outcome of schizophreniaOutcome of schizophreniaSevere mental illnessSchizophrenia patientsSchizophreniaIllness onsetPredicting symptomsBrain abnormalitiesClinical utilityMental illnessTreatment outcomesDecades of researchFindings of magnetic resonance imagingScreening high-risk individualsLife of affected individualsHigh-risk individualsPromote clinical translationResonance imagingIncreased mortality rateResponse processApplication of magnetic resonance imagingSymptomsPrognostic toolResearch findingsAltered cerebral white matter network topology and cognition in children with obstructive sleep apnea
Chen F, Fu Y, Tang B, Tao B, Wang Y, Huang Y, Chen T, Yu C, Jiang C, Lui S, Cai X, Lu Y, Yan Z. Altered cerebral white matter network topology and cognition in children with obstructive sleep apnea. Sleep Medicine 2024, 118: 63-70. PMID: 38613858, DOI: 10.1016/j.sleep.2024.03.038.Peer-Reviewed Original ResearchConceptsObstructive apnea-hypopnea indexWhite matter networksVerbal Comprehension IndexNon-OSA childrenEvidence of impaired cognitive functionRight temporal poleSuperior temporal gyrusImpaired cognitive functionBrain white matter networkHierarchical linear regressionApnea-hypopnea indexObstructive sleep apneaNeuroimaging evidenceTemporal gyrusTemporal poleBrain regionsCognitive testsCognitive functionMediation analysisTemporal lobeCognitive impairmentChild's brainNetwork propertiesSleep apneaComprehensive indexIs unilateral cerebellum sufficient? Insights from new cases of cerebellar agenesis and literature review
Deng D, Tao B, Yuan Y, Ao Y, Qiu L. Is unilateral cerebellum sufficient? Insights from new cases of cerebellar agenesis and literature review. Psychoradiology 2024, 4: kkae012. PMID: 39022191, PMCID: PMC11253423, DOI: 10.1093/psyrad/kkae012.Peer-Reviewed Original ResearchCerebellar agenesisFunctional magnetic resonance imagingCerebellar diseaseNon-motor functionsCase of cerebellar agenesisNon-motor domainsMild cognitive impairmentMotor functionSocial behaviorCognitive impairmentPrevent deficitsMild depressionClinical manifestationsSevere autismMotor deficitsCerebellumMagnetic resonance imagingStructural imagingDeficitsImpairmentBrainResonance imagingMotorCerebellar developmentReview pertinent literature
2023
CT Hyperdense Lesions after Endovascular Therapy in Acute Ischemic Stroke: Imaging Findings and Clinical Significance
Yu W, Xia C, Tao B, Xiao Y, Gao Z, Zhu F, Zhao Q, Lui S. CT Hyperdense Lesions after Endovascular Therapy in Acute Ischemic Stroke: Imaging Findings and Clinical Significance. Cerebrovascular Diseases 2023, 53: 607-617. PMID: 37989121, DOI: 10.1159/000535369.Peer-Reviewed Original ResearchNon-contrast CTAcute ischemic strokeFollow-up protocolEndovascular therapyContrast extravasationHyperdense lesionHemorrhagic transformationTreated with endovascular therapyStandardized follow-up protocolIschemic strokeDual-energy CTSusceptibility weighted imagingClinical outcomesImaging findingsClinical significanceRadiographic findingsClinical evaluationPostoperative phenomenonExtravasationLesionsAn optogenetic-phosphoproteomic study reveals dynamic Akt1 signaling profiles in endothelial cells
Zhou W, Li W, Wang S, Salovska B, Hu Z, Tao B, Di Y, Punyamurtula U, Turk B, Sessa W, Liu Y. An optogenetic-phosphoproteomic study reveals dynamic Akt1 signaling profiles in endothelial cells. Nature Communications 2023, 14: 3803. PMID: 37365174, PMCID: PMC10293293, DOI: 10.1038/s41467-023-39514-1.Peer-Reviewed Original ResearchConceptsPhosphorylation sitesSerine/threonine kinase AktMass spectrometry-based phosphoproteomicsThreonine kinase AktAkt-dependent phosphorylationAberrant Akt activationEndothelial cellsKinase substrateKinase AktCell signalingPhosphorylation profilePhenotypic outcomesDownstream signalingAkt activationAkt1 phosphorylationHuman diseasesSystem-level analysisAKT1Vascular endothelial cellsRich resourcePhosphorylationSignalingGrowth factorAktCellsGenetic or therapeutic neutralization of ALK1 reduces LDL transcytosis and atherosclerosis in mice
Lee S, Schleer H, Park H, Jang E, Boyer M, Tao B, Gamez-Mendez A, Singh A, Folta-Stogniew E, Zhang X, Qin L, Xiao X, Xu L, Zhang J, Hu X, Pashos E, Tellides G, Shaul P, Lee W, Fernandez-Hernando C, Eichmann A, Sessa W. Genetic or therapeutic neutralization of ALK1 reduces LDL transcytosis and atherosclerosis in mice. Nature Cardiovascular Research 2023, 2: 438-448. PMID: 39196046, PMCID: PMC11358031, DOI: 10.1038/s44161-023-00266-2.Peer-Reviewed Original ResearchLDL transcytosisLDL receptor knockout miceReceptor knockout miceAtherosclerotic cardiovascular diseaseLow-density lipoprotein accumulationHigh-fat dietPromising therapeutic strategyTherapeutic neutralizationMacrophage infiltrationTriglyceride levelsLDL entryCardiovascular diseaseSelective monoclonal antibodiesLipoprotein accumulationTherapeutic strategiesKnockout micePlaque formationAtherosclerosis initiationType 1Genetic deletionArterial wallMonoclonal antibodiesEndothelial cellsLDL accumulationMice
2022
Molecular determinants of peri‐apical targeting of inositol 1,4,5‐trisphosphate receptor type 3 in cholangiocytes
Rodrigues MA, Gomes DA, Fiorotto R, Guerra MT, Weerachayaphorn J, Bo T, Sessa WC, Strazzabosco M, Nathanson MH. Molecular determinants of peri‐apical targeting of inositol 1,4,5‐trisphosphate receptor type 3 in cholangiocytes. Hepatology Communications 2022, 6: 2748-2764. PMID: 35852334, PMCID: PMC9512452, DOI: 10.1002/hep4.2042.Peer-Reviewed Original ResearchConceptsLipid raftsCaveolin-1Intact lipid raftsType 3 inositol trisphosphate receptorApical regionC-terminal amino acidsTrisphosphate receptor type 3Madin-Darby canine kidney cellsCanine kidney cellsFluorescence microscopy techniquesInositol trisphosphate receptorApical localizationTrisphosphate receptorHeavy chain 9Molecular determinantsChemical disruptionAmino acidsITPR3RaftsKidney cellsIntracellular CaFinal common eventReceptor type 3Release channelMYH9Inflammatory stress signaling via NF-kB alters accessible cholesterol to upregulate SREBP2 transcriptional activity in endothelial cells
Fowler JWM, Zhang R, Tao B, Boutagy NE, Sessa WC. Inflammatory stress signaling via NF-kB alters accessible cholesterol to upregulate SREBP2 transcriptional activity in endothelial cells. ELife 2022, 11: e79529. PMID: 35959888, PMCID: PMC9395194, DOI: 10.7554/elife.79529.Peer-Reviewed Original ResearchConceptsAcute inflammatory responseEndothelial cellsCholesterol homeostasisInflammatory stressInflammatory responsePro-inflammatory cytokinesSite of injuryCholesterol biosynthetic gene expressionNF-κB DNA bindingHuman endothelial cellsMultiple sclerosisInflammatory activationPrimary human endothelial cellsVascular endotheliumNF-κB-inducible genesTissue damageInducible targetAberrant activationRole of cholesterolSREBP2 activationMicrobial infectionsCholesterolKey transcription regulatorHomeostasisLeukocytes
2021
Characterization of a Novel Caveolin Modulator That Reduces Vascular Permeability and Ocular Inflammation
Bernatchez PN, Tao B, Bradshaw RA, Eveleth D, Sessa WC. Characterization of a Novel Caveolin Modulator That Reduces Vascular Permeability and Ocular Inflammation. Translational Vision Science & Technology 2021, 10: 21-21. PMID: 34111267, PMCID: PMC8132009, DOI: 10.1167/tvst.10.6.21.Peer-Reviewed Original ResearchConceptsOcular inflammationCell-permeable peptideRetinal damageVascular permeabilityModel of uveitisVascular endothelial growth factorNitric oxide releaseEndothelial growth factorNovel cell-permeable peptideEndothelial cell signalingVascular leakageClinical developmentInflammationOxide releaseEndothelial cellsNO releaseGrowth factorUveitisVEGFDistinct assaysPhage display technologyPresent studyVivoCell signalingPeptidesLoss of endothelial glucocorticoid receptor promotes angiogenesis via upregulation of Wnt/β-catenin pathway
Liu B, Zhou H, Zhang T, Gao X, Tao B, Xing H, Zhuang Z, Dardik A, Kyriakides TR, Goodwin JE. Loss of endothelial glucocorticoid receptor promotes angiogenesis via upregulation of Wnt/β-catenin pathway. Angiogenesis 2021, 24: 631-645. PMID: 33650028, PMCID: PMC8292305, DOI: 10.1007/s10456-021-09773-x.Peer-Reviewed Original ResearchConceptsWnt/β-catenin signalingWnt/β-catenin pathwayΒ-catenin signalingΒ-catenin pathwayAutophagy fluxKey biological processesGlucocorticoid receptorNuclear receptor familyTube formation assaysEndothelial cellsBiological processesCanonical WntP62 degradationReceptor familyFormation assaysAbsence of GRCell viability assaysProcess of angiogenesisWntGR regulationSignalingVivo assaysQuantitative PCRKey receptorPathway
2020
BMP-9 and LDL crosstalk regulates ALK-1 endocytosis and LDL transcytosis in endothelial cells
Tao B, Kraehling JR, Ghaffari S, Ramirez C, Lee S, Fowler JW, Lee WL, Fernandez-Hernando C, Eichmann A, Sessa WC. BMP-9 and LDL crosstalk regulates ALK-1 endocytosis and LDL transcytosis in endothelial cells. Journal Of Biological Chemistry 2020, 295: 18179-18188. PMID: 33097593, PMCID: PMC7939458, DOI: 10.1074/jbc.ra120.015680.Peer-Reviewed Original ResearchConceptsBone morphogenetic protein 9Dynamin 2Caveolin-1LDL transcytosisGene expressionActivin-like kinase 1Endothelial cellsEndothelial cell quiescenceCell surface levelsSmad1/5 phosphorylationExtensive endocytosisUnbiased screenProtein 9Cell quiescenceKinase 1ALK-1BMP-9 levelsEssential roleEndocytosisEndothelial homeostasisHeavy chainSignalingInternalizationTranscytosisCells
2017
Macrophage-Restricted Shp2 Tyrosine Phosphatase Acts as a Rheostat for MMP12 through TGF-β Activation in the Prevention of Age-Related Emphysema in Mice
Xu J, Tao B, Guo X, Zhou S, Li Y, Zhang Y, Zhou Z, Cheng H, Zhang X, Ke Y. Macrophage-Restricted Shp2 Tyrosine Phosphatase Acts as a Rheostat for MMP12 through TGF-β Activation in the Prevention of Age-Related Emphysema in Mice. The Journal Of Immunology 2017, 199: 2323-2332. PMID: 28814604, DOI: 10.4049/jimmunol.1601696.Peer-Reviewed Original ResearchConceptsMatrix metalloproteinasesActivation of alveolar macrophagesLevels of matrix metalloproteinasesElevated levels of matrix metalloproteinasesChronic lung disordersFunction of Shp2Activation of macrophagesProtein tyrosine phosphatase 2Development of emphysemaLong-term observation periodAttenuated Smad2/3 phosphorylationElevation of matrix metalloproteinasesProduction of matrix metalloproteinasesLoss of Shp2Tyrosine phosphatase 2MMP12 expressionPotential etiologiesAged miceLung disordersDestruction of alveolar wallsPulmonary emphysemaSmad2/3 phosphorylationAlveolar macrophagesAlveolar morphologyExtracellular matrix degradation
2016
Genome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells
Kraehling JR, Chidlow JH, Rajagopal C, Sugiyama MG, Fowler JW, Lee MY, Zhang X, Ramírez CM, Park EJ, Tao B, Chen K, Kuruvilla L, Larriveé B, Folta-Stogniew E, Ola R, Rotllan N, Zhou W, Nagle MW, Herz J, Williams KJ, Eichmann A, Lee WL, Fernández-Hernando C, Sessa WC. Genome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells. Nature Communications 2016, 7: 13516. PMID: 27869117, PMCID: PMC5121336, DOI: 10.1038/ncomms13516.Peer-Reviewed Original ResearchConceptsActivin-like kinase 1Wide RNAi screenGWA data setsLDL uptakeEndothelial cellsIdentification of pathwaysLDL receptorRNAi screenEndocytic pathwayLysosomal degradationKinase 1LDL transcytosisPhysiological roleGenetic ablationUptake of LDLPathwayFunctional LDL receptorsCellsLow affinityTranscytosisUptakeALK1Unique opportunityAortic endotheliumAnimals
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