2015
Biologic Activity of Autologous, Granulocyte–Macrophage Colony-Stimulating Factor Secreting Alveolar Soft-Part Sarcoma and Clear Cell Sarcoma Vaccines
Goldberg J, Fisher D, Demetri G, Neuberg D, Allsop S, Fonseca C, Nakazaki Y, Nemer D, Raut C, George S, Morgan J, Wagner A, Freeman G, Ritz J, Lezcano C, Mihm M, Canning C, Hodi F, Dranoff G. Biologic Activity of Autologous, Granulocyte–Macrophage Colony-Stimulating Factor Secreting Alveolar Soft-Part Sarcoma and Clear Cell Sarcoma Vaccines. Clinical Cancer Research 2015, 21: 3178-3186. PMID: 25805798, PMCID: PMC4506240, DOI: 10.1158/1078-0432.ccr-14-2932.Peer-Reviewed Original ResearchConceptsAlveolar soft part sarcomaClear cell sarcomaGranulocyte-macrophage colony-stimulating factorColony-stimulating factorSoft part sarcomaTissue-type plasminogen activatorMicrophthalmia transcription factorGM-CSFReplication-defective adenoviral vector encoding GM-CSFSecrete granulocyte-macrophage colony-stimulating factorCCS patientsImmune-mediated tumor destructionT-cell-mediated delayed-type hypersensitivity reactionCD8(+) T cellsAdenoviral-mediated gene transferPhase I clinical trialDelayed-type hypersensitivity reactionAutologous tumor cellsPD-ligand 1Sarcoma cellsNo tumor regressionRare mesenchymal malignancySingle-cell suspensionsTumor regressionMetastatic tumors
2012
Ca2+/calmodulin-dependent protein kinase II is associated with pelvic pain of neurogenic cystitis
Yang W, Rudick C, Hoxha E, Allsop S, Dimitrakoff J, Klumpp D. Ca2+/calmodulin-dependent protein kinase II is associated with pelvic pain of neurogenic cystitis. American Journal Of Physiology. Renal Physiology 2012, 303: f350-f356. PMID: 22647634, PMCID: PMC3433862, DOI: 10.1152/ajprenal.00077.2012.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBehavior, AnimalCalcium-Calmodulin-Dependent Protein Kinase Type 2CystitisDose-Response Relationship, DrugFemaleHerpesvirus 1, SuidHyperalgesiaImage Processing, Computer-AssistedImmunohistochemistryInjections, SpinalIsoenzymesMiceMice, Inbred C57BLMicroarray AnalysisPelvic PainPhosphorylationPosterior Horn CellsReal-Time Polymerase Chain ReactionRNARNA, MessengerSpinal CordTranscription, GeneticConceptsSacral spinal cordPelvic painNeurogenic cystitisProtein kinase IISpinal cordDorsal hornAssociated with urothelial lesionsChronic bladder inflammatory diseaseDevelopment of pelvic painMurine neurogenic cystitis modelCaMKII inhibitor KN-93Interstitial cystitis/painful bladder syndromeAssociated with pelvic painCa(2+)/calmodulin-dependent protein kinase IIAbductor caudalis dorsalisProgressive pelvic painPostinfection dayKinase IIInhibitor KN-93Pain-signaling pathwaysFemale C57BL/6J miceCa2+/calmodulin-dependent protein kinase IIPostinfection day 2Pelvic/perineal areaCystitis model