Overexpression of Malat1 drives metastasis through inflammatory reprogramming of the tumor microenvironment
Martinez-Terroba E, Plasek-Hegde L, Chiotakakos I, Li V, de Miguel F, Robles-Oteiza C, Tyagi A, Politi K, Zamudio J, Dimitrova N. Overexpression of Malat1 drives metastasis through inflammatory reprogramming of the tumor microenvironment. Science Immunology 2024, 9: eadh5462. PMID: 38875320, DOI: 10.1126/sciimmunol.adh5462.Peer-Reviewed Original ResearchConceptsTumor microenvironmentLung adenocarcinomaMetastatic diseasePromoting metastatic diseaseGlobal chromatin accessibilityMetastasis-associated lung adenocarcinoma transcript 1Overexpression of MALAT1Lung adenocarcinoma transcript 1Lung adenocarcinoma metastasisCCL2 blockadeInflammatory reprogrammingEnhanced cell mobilityMacrophage depletionMechanism of actionTumor typesTumor progressionMouse modelCell mobilizationTumorLong noncoding RNAsParacrine secretionMetastasisCell linesTranscript 1MicroenvironmentA scalable and cost-efficient rRNA depletion approach to enrich RNAs for molecular biology investigations
Singh A, Xue A, Tai J, Mbadugha F, Obi P, Mascarenhas R, Tyagi A, Siena A, Chen Y. A scalable and cost-efficient rRNA depletion approach to enrich RNAs for molecular biology investigations. RNA 2024, 30: rna.079761.123. PMID: 38485192, PMCID: PMC11098455, DOI: 10.1261/rna.079761.123.Peer-Reviewed Original ResearchConceptsDepleting rRNACellular processesAbundance of rRNAMolecular biological investigationsNon-rRNA transcriptsComplex regulatory networkInvestigate gene expressionRRNA removalRRNA moleculesHistone mRNARegulatory networksSmall RNAsPositive selectionRRNARNA inputBiological investigationsTranscriptome analysisLong noncoding RNAsGene expressionRegulatory mechanismsRNAOff-target effectsNoncoding RNAsCircular RNAsTranscription
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