2022
The Effect of Black Cohosh on Ki67 expression and Tumor Volume: A Pilot Study of Ductal Carcinoma in Situ Patients
Trant A, Chagpar A, Wei W, Neumeister V, Rimm D, Stavris K, Lurie B, Frederick C, Andrejeva L, Raghu M, Killelea B, Horowitz N, Lannin D, Knill-Selby E, Sturrock T, Hofstatter E. The Effect of Black Cohosh on Ki67 expression and Tumor Volume: A Pilot Study of Ductal Carcinoma in Situ Patients. Integrative Cancer Therapies 2022, 21: 15347354221137290. PMID: 36444764, PMCID: PMC9716631, DOI: 10.1177/15347354221137290.Peer-Reviewed Original ResearchConceptsTumor volumeBlack cohoshSitu patientsDuctal carcinomaAnti-inflammatory effectsTumor cellular proliferationBreast cancer treatmentCellular proliferationWilcoxon signed-rank testDCIS patientsAdverse eventsEligible subjectsWindow trialsCore biopsyInvasive diseaseKi67 expressionSigned-rank testBreast cancerGrade 3Hormone changesPatientsQuantitative immunofluorescenceBC extractSignificant toxicityCancer treatment
2021
ASO Visual Abstract: Assessing Interobserver Variability of Cosmetic Outcome Assessment in Breast Cancer Patients Undergoing Breast Conservation Surgery
Chagpar A, Berger E, Alperovich M, Zanieski G, Avraham T, Lannin D. ASO Visual Abstract: Assessing Interobserver Variability of Cosmetic Outcome Assessment in Breast Cancer Patients Undergoing Breast Conservation Surgery. Annals Of Surgical Oncology 2021, 28: 632-632. DOI: 10.1245/s10434-021-10584-z.Peer-Reviewed Original ResearchHow did the COVID crisis affect use of neoadjuvant therapy for patients with breast cancer?
Chagpar A, Lannin D, Mougalian S, Berger E, Gross C, Horowitz N, Sanft T, DiGiovanna M, Golshan M, Pusztai L. How did the COVID crisis affect use of neoadjuvant therapy for patients with breast cancer? Journal Of Clinical Oncology 2021, 39: e18708-e18708. DOI: 10.1200/jco.2021.39.15_suppl.e18708.Peer-Reviewed Original ResearchUse of NTNeoadjuvant therapyEarly pandemic periodBreast cancerNon-metastatic breast cancerPractice settingsEarly pandemicFlatiron Health databaseNeoadjuvant endocrine therapyTechnology-enabled abstractionSame period one yearSimilar clinicopathologic featuresLongitudinal electronic health recordsPeriod one yearElectronic health recordsTNBC subsetEndocrine therapyPatient ageTN patientsClinicopathologic featuresContemporary cohortClinical stageCancer clinicCancer managementHigh risk
2018
Durvalumab (MEDI4736) concurrent with nab-paclitaxel and dose dense doxorubicin cyclophosphamide (ddAC) as neoadjuvant therapy for triple negative breast cancer (TNBC).
Pusztai L, Hofstatter E, Chung G, Horowitz N, Lannin D, Killelea B, Chagpar A, DiGiovanna M, Frederick C, Burello T, Harigopal M. Durvalumab (MEDI4736) concurrent with nab-paclitaxel and dose dense doxorubicin cyclophosphamide (ddAC) as neoadjuvant therapy for triple negative breast cancer (TNBC). Journal Of Clinical Oncology 2018, 36: 586-586. DOI: 10.1200/jco.2018.36.15_suppl.586.Peer-Reviewed Original ResearchThe effect of black cohosh on Ki67 levels in DCIS patients.
Hofstatter E, Trant A, Stavris K, Horowitz N, Killelea B, Lannin D, Neumeister V, Rimm D, Chagpar A. The effect of black cohosh on Ki67 levels in DCIS patients. Journal Of Clinical Oncology 2018, 36: e13541-e13541. DOI: 10.1200/jco.2018.36.15_suppl.e13541.Peer-Reviewed Original Research
2017
Safety of MEDI4736 (anti-PD-L1 antibody) administered concomitant with weekly nab-paclitaxel and dose dense doxorubicin/cyclophosphamide (ddAC) as neoadjuvant chemotherapy for stage I-III triple negative breast cancer (TNBC): A Phase I/II trial.
Pusztai L, Silber A, Hofstatter E, Chung G, Horowitz N, Lannin D, Killelea B, Chagpar A, Szekely B, Frederick C, Rispoli L, DiGiovanna M. Safety of MEDI4736 (anti-PD-L1 antibody) administered concomitant with weekly nab-paclitaxel and dose dense doxorubicin/cyclophosphamide (ddAC) as neoadjuvant chemotherapy for stage I-III triple negative breast cancer (TNBC): A Phase I/II trial. Journal Of Clinical Oncology 2017, 35: 572-572. DOI: 10.1200/jco.2017.35.15_suppl.572.Peer-Reviewed Original ResearchImmune related adverse eventsTriple-negative breast cancerWeekly nab-paclitaxelWeeks of therapyNeoadjuvant chemotherapyDose levelsNab-paclitaxelPhase I/II trialPathologic complete response rateChest X-ray abnormalitiesDoxorubicin/cyclophosphamidePhase I toxicityComplete response rateImmune checkpoint inhibitorsPhase I portionRelated adverse eventsPhase II portionPhase I partX-ray abnormalitiesNegative breast cancerSequential taxaneAnthracycline chemotherapyCheckpoint inhibitorsII trialAdverse eventsPathologic complete response (pCR) rates after neoadjuvant pertuzumab (P) and trastuzumab (H) administered concomitantly with weekly paclitaxel (T) and 5-fluorouracil/epirubicin/cyclophosphamide (FEC) chemotherapy for clinical stage I-III HER2-positive breast cancer.
Foldi J, Mougalian S, Silber A, Lannin D, Killelea B, Chagpar A, Horowitz N, Frederick C, Rispoli L, Abu-Khalaf M, Sabbath K, Sanft T, Fischbach N, Brandt D, Hofstatter E, DiGiovanna M, Pusztai L. Pathologic complete response (pCR) rates after neoadjuvant pertuzumab (P) and trastuzumab (H) administered concomitantly with weekly paclitaxel (T) and 5-fluorouracil/epirubicin/cyclophosphamide (FEC) chemotherapy for clinical stage I-III HER2-positive breast cancer. Journal Of Clinical Oncology 2017, 35: 577-577. DOI: 10.1200/jco.2017.35.15_suppl.577.Peer-Reviewed Original ResearchPathologic complete response rateHER2-positive breast cancerDual HER2 blockadeComplete response ratePCR rateEstrogen receptorHER2 blockadeBreast cancerStage IResponse rateGrade 3/4 adverse eventsSymptomatic congestive heart failureClinical stage ICompletion of chemotherapyPhase II studyTaxane-based chemotherapyCongestive heart failureEfficacy of anthracyclinesPositive breast cancerNormal cardiac functionEntire treatment durationER- cancersER cohortNeoadjuvant pertuzumabWeekly paclitaxel
2015
Characteristics and treatment of Her2 positive breast cancer: 43,485 cases from the National Cancer Database (NCDB) treated in 2010 and 2011
Killelea B, Chagpar A, Horowitz N, Lannin D. Characteristics and treatment of Her2 positive breast cancer: 43,485 cases from the National Cancer Database (NCDB) treated in 2010 and 2011. Journal Of The American College Of Surgeons 2015, 221: e4. DOI: 10.1016/j.jamcollsurg.2015.08.310.Peer-Reviewed Original Research
2014
Does three-dimensional intraoperative specimen imaging reduce the need for re-excision in breast cancer patients?
Chagpar A, Butler M, Killelea B, Horowitz N, Stavris K, Lannin D. Does three-dimensional intraoperative specimen imaging reduce the need for re-excision in breast cancer patients? Journal Of Clinical Oncology 2014, 32: 107-107. DOI: 10.1200/jco.2014.32.30_suppl.107.Peer-Reviewed Original ResearchMargin statusIntraoperative imagingFinal margin statusMedian tumor sizeBreast cancer patientsRe-excision ratesIntraoperative specimen radiographyCohort of interestIntraoperative marginsResidual tumorPartial mastectomyPositive marginsProspective studyTumor sizeCancer patientsInvasive cancerFurther excisionPathology resultsIntraoperative resectionPatientsDefinitive specimenSpecimen radiographyIntraoperative specimenSurgeons
2013
Does removal of DCIS decrease the incidence of invasive breast cancer?
Killelea B, Christy C, Horowitz N, Tsangaris T, Dixon M, Chagpar A, Grube B, Lannin D. Does removal of DCIS decrease the incidence of invasive breast cancer? Journal Of Clinical Oncology 2013, 31: 2-2. DOI: 10.1200/jco.2013.31.26_suppl.2.Peer-Reviewed Original ResearchHigh-grade DCISInvasive cancerDCIS componentSEER dataInvasive tumorsHigh-grade invasive cancerLow-grade DCISNon-calcified DCISProportion of DCISPure invasive tumorsInvasive breast cancerPresence of necrosisGrade of DCISLow-grade cancerPresence of calcificationLow gradeDCIS extentMicropapillary histologyGrade DCISPure DCISRetrospective reviewBreast cancerDCISBreast screeningCancer decreasesA pilot chemoprevention study of isopropanolic black cohosh extract in women with ductal carcinoma in situ.
Hofstatter E, Stavris K, Horowitz N, Killelea B, Tsangaris T, Lannin D, Andrejeva L, Cong X, Yao X, Rimm D, Chagpar A. A pilot chemoprevention study of isopropanolic black cohosh extract in women with ductal carcinoma in situ. Journal Of Clinical Oncology 2013, 31: tps1609-tps1609. DOI: 10.1200/jco.2013.31.15_suppl.tps1609.Peer-Reviewed Original ResearchIsopropanolic black cohosh extractBlack cohosh extractBlack cohoshDuctal carcinomaBreast cancerBreast epithelial cell proliferationPre-operative courseTwo-sided significance levelDisease-free survivalLiver function testsBreast cancer preventionSerum hormone levelsAnti-inflammatory effectsBreast cancer patientsPost-menopausal womenCohort of womenRecent preclinical dataSignificant protective effectKi-67 stainingBreast core biopsyLevels of Ki67Years of ageEpithelial cell proliferationWilcoxon signed-rank testEligible subjectsMulticenter phase II trial of neoadjuvant carboplatin, weekly nab-paclitaxel, and trastuzumab in stage II-III HER2+ breast cancer: A BrUOG study.
Sinclair N, Sakr B, Abu-Khalaf M, Somlo G, Black R, Chung G, Rizack T, Strenger R, Fenton M, DiGiovanna M, Constantinou M, Lannin D, Legare R, Chagpar A, Sambandam S, Bossuyt V, Rosati K, Harris L, Sikov W. Multicenter phase II trial of neoadjuvant carboplatin, weekly nab-paclitaxel, and trastuzumab in stage II-III HER2+ breast cancer: A BrUOG study. Journal Of Clinical Oncology 2013, 31: 619-619. DOI: 10.1200/jco.2013.31.15_suppl.619.Peer-Reviewed Original ResearchPathologic complete responseResidual cancer burdenNeoadjuvant chemotherapyT regimenNab-paclitaxelBreast cancerMulticenter phase II trialHuman epidermal growth factor receptor 2Epidermal growth factor receptor 2Median age 51Weekly nab-paclitaxelPhase II trialGrowth factor receptor 2Factor receptor 2Adjuvant chemotherapyFebrile neutropeniaNeoadjuvant carboplatinAdjuvant treatmentII trialDose intensityExcellent prognosisPathologic responseResearch biopsiesComplete responseResidual tumorThe Prognostic Implications of Histologic Subtype of Ductal Carcinoma in Situ
Sue G, Lannin D, Killelea B, Horowitz N, Tsangaris T, Chagpar A. The Prognostic Implications of Histologic Subtype of Ductal Carcinoma in Situ. Journal Of Surgical Research 2013, 179: 193. DOI: 10.1016/j.jss.2012.10.224.Peer-Reviewed Original Research
2012
Predictors of residual disease after breast-conserving surgery.
Aneja S, Lannin D, Killelea B, Horowitz N, Chagpar A. Predictors of residual disease after breast-conserving surgery. Journal Of Clinical Oncology 2012, 30: 168-168. DOI: 10.1200/jco.2012.30.27_suppl.168.Peer-Reviewed Original ResearchResidual invasive diseaseResidual invasive cancerResidual DCISInvasive cancerInvasive diseaseResidual diseaseMargin distanceSitu diseaseTumor sizeBreast cancerRetrospective cohort studyInvasive breast cancerBreast-conserving surgerySitu breast cancerCavity shave marginsMain outcome variablesCohort of interestLocoregional failureChart reviewCohort studyLymphovascular invasionPathologic factorsAdditional resectionPostoperative managementRisk stratificationPredictors of microinvasion and its prognostic role in ductal carcinoma in situ.
Sue G, Lannin D, Killelea B, Horowitz N, Chagpar A. Predictors of microinvasion and its prognostic role in ductal carcinoma in situ. Journal Of Clinical Oncology 2012, 30: 188-188. DOI: 10.1200/jco.2012.30.27_suppl.188.Peer-Reviewed Original ResearchPossible microinvasionPrognostic roleDuctal carcinomaActuarial overall survivalRetrospective cohort studyHigh-grade DCISRisk of recurrenceLikelihood of recurrenceSPSS software version 19DCIS sizeSolid histologyChart reviewFinal pathologyGrade DCISOverall survivalSoftware version 19Cohort studyConsecutive patientsIndependent predictorsMedian ageSurgical excisionBreast centerMicroinvasionDCISPatientsAccuracy of breast MRI in predicting pathologic tumor size.
Caprio K, Chagpar A, Hooley R, Tavassoli F, Honarpishe H, Lannin D, Killelea B, Horowitz N. Accuracy of breast MRI in predicting pathologic tumor size. Journal Of Clinical Oncology 2012, 30: 1109-1109. DOI: 10.1200/jco.2012.30.15_suppl.1109.Peer-Reviewed Original ResearchPathologic tumor sizeTumor sizeAccuracy of MRIMRI sizePathologic sizePathology sizeBreast cancerMRI lesion sizeSitu breast cancerPreoperative planning toolFinal pathologyNeoadjuvant chemotherapyPatient agePathologic findingsTumor histologyPreoperative MRILesion sizeLesionsBreast MRISpearman's rho coefficientPatientsMRICancerModest correlationSpearman coefficientCan primary tumor markers of cancer-initiating cells predict lymph node positivity in breast cancer patients?
Chagpar A, Neumeister V, Lannin D, Rimm D. Can primary tumor markers of cancer-initiating cells predict lymph node positivity in breast cancer patients? Journal Of Clinical Oncology 2012, 30: 1121-1121. DOI: 10.1200/jco.2012.30.15_suppl.1121.Peer-Reviewed Original ResearchBreast cancer patientsLN statusCancer patientsLymphovascular invasionTumor sizeTumor markersPositive LNsPoor prognosisMedian numberPrimary tumor markersMedian patient ageMedian tumor sizeLymph node positivityLN-positive patientsLymph node statusOnly factorCancer initiating cellsCancer-initiating cellsLevels of CD44Axillary surgeryLN positivityNode positivityPatient agePositive patientsClinicopathologic data
2011
P3-05-08: Hormone Receptor Heterogeneity in Ductal Intraepithelial Neoplasia (Ductal Carcinoma In Situ) of the Breast.
Sowden M, Flynn C, Bossuyt V, Lannin D, Chagpar A. P3-05-08: Hormone Receptor Heterogeneity in Ductal Intraepithelial Neoplasia (Ductal Carcinoma In Situ) of the Breast. Cancer Research 2011, 71: p3-05-08-p3-05-08. DOI: 10.1158/0008-5472.sabcs11-p3-05-08.Peer-Reviewed Original ResearchDuctal intraepithelial neoplasiaHormone receptor statusReceptor statusNuclear gradeIntraepithelial neoplasiaSame tumorHormonal therapyDifferent nuclear gradesHospital tumor registryMedian patient ageMajority of patientsLobular intraepithelial neoplasiaDin-2DIN 1Cohort of interestDIN patientsPR positivityPatient ageER statusPR statusTumor RegistrySingle pathologistInvasive tumorsSame patientPatientsP3-07-26: How Generalizable Is the Patient Population Enrolled in ACOSOG Z11?
Lannin D, Killelea B, Grube B, Horowitz N, Chagpar A. P3-07-26: How Generalizable Is the Patient Population Enrolled in ACOSOG Z11? Cancer Research 2011, 71: p3-07-26-p3-07-26. DOI: 10.1158/0008-5472.sabcs11-p3-07-26.Peer-Reviewed Original ResearchPositive sentinel nodesSentinel node biopsySentinel nodesPositive nodesAxillary dissectionNode biopsyLower axillary recurrence ratePositive sentinel lymph nodesAxillary recurrence rateNode-positive patientsNeo-adjuvant chemotherapyPercentage of patientsNegative sentinel nodesBreast cancer patientsSentinel lymph nodesEligibility requirementsLumpectomy patientsZ11 trialT4 tumorsPositive patientsLymph nodesRecurrence ratePatient populationCancer patientsInstitutional database
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