Andrew Tan

PhD
Associate Research Scientist in Neurology

Contact Information

Andrew Tan, PhD

Mailing Address

  • Neurology

    950 Campbell Avenue, Bldg 34 (127A)

    West Haven, CT, 06516

    United States

Appointments

Biography

My research interests focus on spinal cord injury (SCI) pathology, particularly mechanisms underlying neuropathic pain and spastic movement disorders. My long-term goal is to identify potential therapeutic targets and assess strategies to restore normal function after SCI, and provide useful information that may guide the development of more effective clinical therapies.

I’m particularly intrigued by the functional contribution of maladaptive plasticity and structural reorganization in the injured spinal cord. Though much of what we know about fiber and synaptic plasticity emerge from cortical learning and memory studies, little is known about the role of spinal memory mechanisms in pathologies that arise after injury.

Our recent work has demonstrated that maladaptive dendritic spine remodeling occurs in wide dynamic range (WDR) neurons located in the spinal cord dorsal horn. We have further shown that abnormal dendritic spine plasticity can contribute to neuropathic pain in models of SCI, peripheral nerve injury, and type I diabetes. Importantly, we identified for the first time Rac1-GTPase as a key regulatory signaling molecule of injury-induced dendritic spine remodeling and neuropathic pain phenotype. These in vitro and in vivo studies have employed a combination of technical expertise in anatomical analysis (e.g., fiber tract tracing, digital 3D reconstruction techniques, etc.), and behavioral and electrophysiological assessment techniques.

Education & Training

  • PhD
    Stony Brook University (2006)
  • BS
    University of Rochester, Neuroscience (2001)
  • Postdoctoral Associate
    Columbia University/The City College (CUNY)
  • Postdoctoral Fellow
    Yale University

Honors & Recognition

AwardAwarding OrganizationDate
Travel Award, 12th World Congress on PainInternational Association for the Study of Pain (IASP)2008
Research Work Award, Public Education/Communication CommitteeSociety for Neuroscience2008
Keystone Symposia ScholarshipNINDS2005

Professional Service

OrganizationRoleDate
International Scholarly Research NetworkBoard Member2012 - Present
AVI Publishing Inc.Journalist and editorial service for commercial magazine2009 - 2012
Phase Five Communications Inc./Grey Healthcare GroupAuthor2008 - 2010

Departments & Organizations