2025
Integrated Stepped Alcohol Treatment With Contingency Management for Unhealthy Alcohol Use Among People With HIV: A Randomized Controlled Trial
Edelman E, Dziura J, Deng Y, DePhilippis D, Ferguson T, Brown S, Marconi V, Goetz M, Rodriguez-Barradas M, Simberkoff M, Molina P, Weintrob A, Maisto S, Paris M, Justice A, Bryant K, Fiellin D. Integrated Stepped Alcohol Treatment With Contingency Management for Unhealthy Alcohol Use Among People With HIV: A Randomized Controlled Trial. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2025, 98: 72-81. PMID: 39321757, DOI: 10.1097/qai.0000000000003534.Peer-Reviewed Original ResearchUnhealthy alcohol useSelf-reported abstinenceAlcohol useLost to follow-upContingency managementAlcohol use disorderRandomized controlled trialsSubstance use treatmentAlcohol abstinenceFollow-upUse disorderControlled trialsPWHAlcohol treatmentAbstinenceUse treatmentEvidence of abstinenceHIVWeeksMean proportionTreatmentTrialsAlcoholDaysParticipants
2024
Hepatotoxicity Score: A New Method to Adjust for Use of Potentially Hepatotoxic Medications by Chronic Liver Disease Status
Re V, Newcomb C, Carbonari D, Mezochow A, Hennessy S, Rentsch C, Park L, Tate J, Bräu N, Bhattacharya D, Lim J, Mezzacappa C, Njei B, Roy J, Taddei T, Justice A, Torgersen J. Hepatotoxicity Score: A New Method to Adjust for Use of Potentially Hepatotoxic Medications by Chronic Liver Disease Status. Pharmacoepidemiology And Drug Safety 2024, 33: e70069. PMID: 39662972, PMCID: PMC11634562, DOI: 10.1002/pds.70069.Peer-Reviewed Original ResearchConceptsProton pump inhibitor initiationHazard ratioVeterans Health AdministrationSevere acute liver injuryProton pump inhibitorsChronic liver diseaseAcute liver injuryRates of hospitalizationSafety of medicationsPPI initiativesHealth AdministrationLiver disease statusMedication exposurePharmacoepidemiological studiesMedicationConfoundingScoresReports of hepatotoxicityDisease statusHepatotoxic medicationsDrug exposurePump inhibitorsHepatotoxic drugsOutpatient initiationHepatic safetyThe Association of Anemia With Survival Among People With HIV Following Antiretroviral Initiation in the NA-ACCORD 2007–2016
Lang R, Coburn S, Gill M, Grossman J, Gebo K, Horberg M, Mayor A, Justice A, Bosch R, Silverberg M, Rabkin C, Sterling T, Thorne J, Moore R, Althoff K, AIDS F. The Association of Anemia With Survival Among People With HIV Following Antiretroviral Initiation in the NA-ACCORD 2007–2016. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2024, 97: 334-343. PMID: 39118208, PMCID: PMC11732725, DOI: 10.1097/qai.0000000000003502.Peer-Reviewed Original ResearchConceptsMortality riskAntiretroviral therapyNA-ACCORDSevere anemiaMacrocytic anemiaMicrocytic anemiaInitiation of antiretroviral therapyMortality hazard ratioWorld Health Organization criteriaHIV clinical markersDecreased mortality riskIncreased mortality riskMedian hemoglobin levelHemoglobin measurementsAssociation of anemiaPredictors of mortalityTime-to-event analysisAntiretroviral initiationHazard ratioOrganization criteriaPredictive markerNormocytic anemiaModerate anemiaHemoglobin levelsMild anemiaMultiomic Network Analysis Identifies Dysregulated Neurobiological Pathways in Opioid Addiction
Sullivan K, Kainer D, Lane M, Cashman M, Miller J, Garvin M, Townsend A, Quach B, Willis C, Kruse P, Gaddis N, Mathur R, Corradin O, Maher B, Scacheri P, Sanchez-Roige S, Palmer A, Troiani V, Chesler E, Kember R, Kranzler H, Justice A, Xu K, Aouizerat B, Hancock D, Johnson E, Jacobson D, Program V. Multiomic Network Analysis Identifies Dysregulated Neurobiological Pathways in Opioid Addiction. Biological Psychiatry 2024, 98: 11-22. PMID: 39615775, PMCID: PMC12119972, DOI: 10.1016/j.biopsych.2024.11.013.Peer-Reviewed Original ResearchGenome-wide association studiesSubstance use disordersOpioid use disorderAddiction treatmentOpioid addictionDorsolateral prefrontal cortexOpioid addiction treatmentMulti-omics network analysisPrefrontal cortexPrescription opioid misuseSystems biology approachNeurobiological pathwaysOpioid overdose victimsUse disorderOverdose victimsAddictionAssociation studiesEpigenetic dataOpioid misuseOpioidDlPFCERK pathwayBiology approachMulti-omicsGene targetingSevere Acute Liver Injury After Hepatotoxic Medication Initiation in Real-World Data
Torgersen J, Mezochow A, Newcomb C, Carbonari D, Hennessy S, Rentsch C, Park L, Tate J, Bräu N, Bhattacharya D, Lim J, Mezzacappa C, Njei B, Roy J, Taddei T, Justice A, Re V. Severe Acute Liver Injury After Hepatotoxic Medication Initiation in Real-World Data. JAMA Internal Medicine 2024, 184: 943-952. PMID: 38913369, PMCID: PMC11197444, DOI: 10.1001/jamainternmed.2024.1836.Peer-Reviewed Original ResearchIncidence rateUS Department of Veterans AffairsMedication initiationDepartment of Veterans AffairsInitiation of medicationVeterans AffairsMain OutcomesPotential of medicationsOutpatient settingDischarge diagnosisCohort studyDay of admissionCase reportReal World DataReport countsMedicationMedical cohortSevere acute liver injuryUS DepartmentFollow-upAcute liver injuryHospitalCohortHepatotoxic medicationsIncidenceIdentification of hepatic steatosis among persons with and without HIV using natural language processing
Torgersen J, Skanderson M, Kidwai-Khan F, Carbonari D, Tate J, Park L, Bhattacharya D, Lim J, Taddei T, Justice A, Re V. Identification of hepatic steatosis among persons with and without HIV using natural language processing. Hepatology Communications 2024, 8: e0468. PMID: 38896066, PMCID: PMC11186806, DOI: 10.1097/hc9.0000000000000468.Peer-Reviewed Original ResearchConceptsImaging ReportingSteatotic liver diseaseHIV statusHepatic steatosisPrevalence of metabolic comorbiditiesImaging studiesVeterans Aging Cohort StudyCompare patient characteristicsPositive predictive valueAlcohol use disorderAging Cohort StudyIdentification of hepatic steatosisHIV infectionHepatitis BMetabolic comorbiditiesNatural language processing algorithmsRadiological studiesCohort studyPatient characteristicsClinical reviewLiver diseaseHIVPredictive valueUse disorderClinical image reportsAuthor Correction: A multi-ancestry genetic study of pain intensity in 598,339 veterans
Toikumo S, Vickers-Smith R, Jinwala Z, Xu H, Saini D, Hartwell E, Pavicic M, Sullivan K, Xu K, Jacobson D, Gelernter J, Rentsch C, Stahl E, Cheatle M, Zhou H, Waxman S, Justice A, Kember R, Kranzler H. Author Correction: A multi-ancestry genetic study of pain intensity in 598,339 veterans. Nature Medicine 2024, 30: 2088-2088. PMID: 38714900, DOI: 10.1038/s41591-024-03024-4.Peer-Reviewed Original ResearchDNA methylation‐based telomere length is associated with HIV infection, physical frailty, cancer, and all‐cause mortality
Liang X, Aouizerat B, So‐Armah K, Cohen M, Marconi V, Xu K, Justice A. DNA methylation‐based telomere length is associated with HIV infection, physical frailty, cancer, and all‐cause mortality. Aging Cell 2024, 23: e14174. PMID: 38629454, PMCID: PMC11258465, DOI: 10.1111/acel.14174.Peer-Reviewed Original ResearchCancer prevalenceAll-cause mortalityVeterans Aging Cohort Study Biomarker CohortMortality riskPhysiological frailtyVACS IndexIncreased risk of all-cause mortalityRisk of all-cause mortalityCancer registry dataHigher cancer prevalenceHIV infectionElectronic medical recordsSelf-reported raceCoronary heart diseaseAssociated with HIV infectionIndicator of cellular agingPhysical frailtyRegistry dataSmoking statusWomen's Interagency HIV Study cohortAlcohol consumptionShorter TLTelomere lengthMedical recordsPeripheral blood mononuclear cellsImpact of Decarceration Plus Alcohol, Substance Use, and Mental Health Screening on Life Expectancies of Black Sexual Minority Men and Black Transgender Women Living With HIV in the United States: A Simulation Study Based on HPTN 061
Feelemyer J, Bershteyn A, Scheidell J, Brewer R, Dyer T, Cleland C, Hucks-Ortiz C, Justice A, Mayer K, Grawert A, Kaufman J, Braithwaite S, Khan M. Impact of Decarceration Plus Alcohol, Substance Use, and Mental Health Screening on Life Expectancies of Black Sexual Minority Men and Black Transgender Women Living With HIV in the United States: A Simulation Study Based on HPTN 061. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2024, 95: 283-290. PMID: 38032748, PMCID: PMC10922416, DOI: 10.1097/qai.0000000000003354.Peer-Reviewed Original ResearchConceptsLower life expectancyBlack sexual minority menBlack transgender womenReduce incarcerationSubstance useTransgender WomenIncreased LEVeterans Aging Cohort StudyPsychiatric conditionsMental health screeningLinkage to treatmentDisproportionate rates of incarcerationLife expectancyAging Cohort StudyRates of incarcerationHistory of incarcerationSexual minority menImplementing screeningHealth screeningSubstance use disordersTreatment of psychiatric conditionsPositive screenImprove screeningCohort studyDisproportionate ratesA multi-ancestry genetic study of pain intensity in 598,339 veterans
Toikumo S, Vickers-Smith R, Jinwala Z, Xu H, Saini D, Hartwell E, Pavicic M, Sullivan K, Xu K, Jacobson D, Gelernter J, Rentsch C, Stahl E, Cheatle M, Zhou H, Waxman S, Justice A, Kember R, Kranzler H. A multi-ancestry genetic study of pain intensity in 598,339 veterans. Nature Medicine 2024, 30: 1075-1084. PMID: 38429522, PMCID: PMC12105102, DOI: 10.1038/s41591-024-02839-5.Peer-Reviewed Original ResearchPain intensityChronic painTreat chronic painCalcium channel blockersCross-ancestry meta-analysisGenome-wide association studiesExperience of painSamples of European ancestryPain phenotypesFunctional genomics dataGABAergic neuronsCalcium channelsAnalgesic effectB-blockersDrug groupMillion Veteran ProgramPainSubstance use disordersQuality of lifeDrug repurposing analysisOpioid crisisGenetic architectureCausal genesGenetic lociGenomic dataHypertension Control During the Coronavirus Disease 2019 Pandemic
Korves C, Peixoto A, Lucas B, Davies L, Weinberger D, Rentsch C, Vashi A, Young-Xu Y, King J, Asch S, Justice A. Hypertension Control During the Coronavirus Disease 2019 Pandemic. Medical Care 2024, 62: 196-204. PMID: 38284412, PMCID: PMC10922611, DOI: 10.1097/mlr.0000000000001971.Peer-Reviewed Original ResearchConceptsHypertension controlFollow-up intervalPrimary care clinic visitsFollow-up lengthVeterans Health AdministrationControlled hypertensionUncontrolled hypertensionGeneralized estimating equationsCohort of individualsStudy inclusion criteriaHealth careHealth AdministrationLonger follow-up intervalsBlood pressure measurementsAssessed associationsClinic visitsInclusion criteriaDecreased likelihoodEstimating equationsPrepandemic periodLow likelihoodCoronavirus diseaseFollow-upHypertensionIndividualsThe forecasted prevalence of comorbidities and multimorbidity in people with HIV in the United States through the year 2030: A modeling study.
Althoff K, Stewart C, Humes E, Gerace L, Boyd C, Gebo K, Justice A, Hyle E, Coburn S, Lang R, Silverberg M, Horberg M, Lima V, Gill M, Karris M, Rebeiro P, Thorne J, Rich A, Crane H, Kitahata M, Rubtsova A, Wong C, Leng S, Marconi V, D'Souza G, Kim H, Napravnik S, McGinnis K, Kirk G, Sterling T, Moore R, Kasaie P. The forecasted prevalence of comorbidities and multimorbidity in people with HIV in the United States through the year 2030: A modeling study. PLOS Medicine 2024, 21: e1004325. PMID: 38215160, PMCID: PMC10833859, DOI: 10.1371/journal.pmed.1004325.Peer-Reviewed Original ResearchConceptsHistory of injection drug useInjection drug useHealthcare needsPrevalence of comorbiditiesHIV diagnosisNorth American AIDS Cohort CollaborationDrug useAntiretroviral therapyHIV surveillance dataGuideline-recommended careNon-Hispanic whitesPrevalence of anxietyChronic kidney diseaseMyocardial infarctionPrevalence of cancerEnd-stage liver diseaseResearch and DesignMultimorbidity prevalenceRisk of comorbiditiesUnited StatesBlack MSMNon-HispanicSubspecialty careClinical capacityHIV cliniciansAdaption and National Validation of a Tool for Predicting Mortality from Other Causes Among Men with Nonmetastatic Prostate Cancer
Justice A, Tate J, Howland F, Gaziano J, Kelley M, McMahon B, Haiman C, Wadia R, Madduri R, Danciu I, Leppert J, Leapman M, Thurtle D, Gnanapragasam V. Adaption and National Validation of a Tool for Predicting Mortality from Other Causes Among Men with Nonmetastatic Prostate Cancer. European Urology Oncology 2024, 7: 923-932. PMID: 38171965, DOI: 10.1016/j.euo.2023.11.023.Peer-Reviewed Original ResearchVeterans Health AdministrationCharlson Comorbidity IndexNon-prostate cancer mortalityProstate cancer mortalityNonmetastatic prostate cancerComorbidity indexCancer mortalityProvider estimationProstate cancerHealth AdministrationUS Veterans Health AdministrationElectronic health record-based toolsYear of diagnosisRisk of deathObservational cohortMedian ageNonmetastatic cancerPredicting MortalityC-statisticHispanic ethnicityTreatment groupsMortalityCancerNational validationAge
2023
9. THE GENETIC ARCHITECTURE OF PAIN INTENSITY IN THE MILLION VETERAN PROGRAM
Toikumo S, Vickers-Smith R, Jinwala Z, Xu H, Saini D, Hartwell E, Pavicic M, Sullivan K, Jacobson D, Cheatle M, Zhou H, Waxman S, Justice A, Kember R, Kranzler H. 9. THE GENETIC ARCHITECTURE OF PAIN INTENSITY IN THE MILLION VETERAN PROGRAM. European Neuropsychopharmacology 2023, 75: s60-s61. DOI: 10.1016/j.euroneuro.2023.08.120.Peer-Reviewed Original ResearchIndependent lociGenetic architectureMillion Veteran ProgramGenome-wide association testingIndependent genetic lociLinkage disequilibrium score regressionDrug-gene interaction databaseDisequilibrium score regressionNovel genetic variantsPotential drug targetsComplex traitsGWAS resultsCausal genesDruggable genomeDrug repurposing analysisGenetic lociDruggable genesInteraction databasesDrug targetsGenetic correlationsMolecular contributorsAssociation testingLociPsychiatric traitsScore regressionMULTI-ANCESTRY META-ANALYSIS OF TOBACCO USE DISORDERS PRIORITIZES NOVEL CANDIDATE RISK GENES AND REVEALS ASSOCIATIONS WITH NUMEROUS HEALTH OUTCOMES
Sanchez-Roige S, Toikumo S, Jennings M, Pham B, Lee H, Mallard T, Bianchi S, Meredith J, Smoller J, Davis L, Justice A, Kranzler H, Kember R, Sanchez-Roige S. MULTI-ANCESTRY META-ANALYSIS OF TOBACCO USE DISORDERS PRIORITIZES NOVEL CANDIDATE RISK GENES AND REVEALS ASSOCIATIONS WITH NUMEROUS HEALTH OUTCOMES. European Neuropsychopharmacology 2023, 75: s8-s9. DOI: 10.1016/j.euroneuro.2023.08.024.Peer-Reviewed Original ResearchTobacco use disorderUse disordersPrevalent substance use disordersSubstance use disordersRisk genesNumerous health outcomesHIV infectionHeart diseaseSmoking behaviorMedical outcomesGenome-wide association studiesNicotine consumptionHealth outcomesCandidate risk genesPotential risk genesGenetic factorsIndependent risk lociDisordersRisk variantsNovel candidate risk genesRisk lociOutcomesMajority of variantsFunctional genomics toolsPsychiatric traitsPerspectives on contingency management for alcohol use and alcohol‐associated conditions among people in care with HIV
Cohen S, DePhilippis D, Deng Y, Dziura J, Ferguson T, Fucito L, Justice A, Maisto S, Marconi V, Molina P, Paris M, Rodriguez‐Barradas M, Simberkoff M, Petry N, Fiellin D, Edelman E. Perspectives on contingency management for alcohol use and alcohol‐associated conditions among people in care with HIV. Alcohol Clinical And Experimental Research 2023, 47: 1783-1797. PMID: 37524371, PMCID: PMC10828101, DOI: 10.1111/acer.15159.Peer-Reviewed Original ResearchUnhealthy alcohol useAlcohol useContingency managementPrimary care settingSubset of participantsReward structureEvidence-based approachHIV clinicImplementation science frameworkTreatment trialsClinical trialsIntervention feasibilityCare settingsPromoting ActionAlcohol consumptionRelated conditionsBiochemical testingClinical contextHIVReward schedulePatientsReward processesInterventionTrialsBehavior changeDo Polygenic Risk Scores Add to Clinical Data in Predicting Pancreatic Cancer? A Scoping Review.
Wang L, Grimshaw A, Mezzacappa C, Rahimi Larki N, Yang Y, Justice A. Do Polygenic Risk Scores Add to Clinical Data in Predicting Pancreatic Cancer? A Scoping Review. Cancer Epidemiology Biomarkers & Prevention 2023, 32: 1490-1497. PMID: 37610426, PMCID: PMC10873036, DOI: 10.1158/1055-9965.epi-23-0468.Peer-Reviewed Original ResearchConceptsRoutine risk factorsPancreatic cancerRisk factorsPolygenic risk scoresClinical dataRisk scoreAddition of PRSClinical risk factorsRoutine clinical dataCancer risk predictionDatabase inceptionCancerClinical applicabilityRelevant exposuresGenetic riskRisk predictionCancer-specific polygenic risk scoresScoping ReviewRiskEuropean ancestryPopulation representativeScoresMost studiesAppropriate controlsFactorsEffect of image resolution on automated classification of chest X-rays
Haque I, Dubey A, Danciu I, Justice A, Ovchinnikova O, Hinkle J. Effect of image resolution on automated classification of chest X-rays. Journal Of Medical Imaging 2023, 10: 044503-044503. PMID: 37547812, PMCID: PMC10403240, DOI: 10.1117/1.jmi.10.4.044503.Peer-Reviewed Original ResearchGenetic Underpinnings of the Transition From Alcohol Consumption to Alcohol Use Disorder: Shared and Unique Genetic Architectures in a Cross-Ancestry Sample
Kember R, Vickers-Smith R, Zhou H, Xu H, Jennings M, Dao C, Davis L, Sanchez-Roige S, Justice A, Gelernter J, Vujkovic M, Kranzler H. Genetic Underpinnings of the Transition From Alcohol Consumption to Alcohol Use Disorder: Shared and Unique Genetic Architectures in a Cross-Ancestry Sample. American Journal Of Psychiatry 2023, 180: 584-593. PMID: 37282553, PMCID: PMC10731616, DOI: 10.1176/appi.ajp.21090892.Peer-Reviewed Original ResearchConverging Evidence from Rodent and Human Studies on the Role of Spironolactone as a Potential Pharmacotherapy for Alcohol Use Disorder
Farokhnia M, Rentsch C, Chuong V, McGinn M, Elvig S, Douglass E, Gonzalez L, Sanfilippo J, Marchette R, Tunstall B, Fiellin D, Koob G, Justice A, Leggio L, Vendruscolo L. Converging Evidence from Rodent and Human Studies on the Role of Spironolactone as a Potential Pharmacotherapy for Alcohol Use Disorder. Alcohol 2023, 109: 83-84. DOI: 10.1016/j.alcohol.2023.03.071.Peer-Reviewed Original Research
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