2014
Guanfacine extended release for the treatment of attention-deficit/hyperactivity disorder in children and adolescents
Connor DF, Arnsten A, Pearson GS, Greco GF. Guanfacine extended release for the treatment of attention-deficit/hyperactivity disorder in children and adolescents. Expert Opinion On Pharmacotherapy 2014, 15: 1601-1610. PMID: 24992513, DOI: 10.1517/14656566.2014.930437.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderHyperactivity disorderSymptoms of ADHDEvidence-based treatmentsTraumatic stressBehavioral dysregulationADHD studiesSmall effect sizesPrefrontal cortexAdolescents 6Behavioral conditionsAdolescentsEffect sizeGXRPsycINFO databasesGuanfacinePsychostimulantsShire PharmaceuticalsOpen trialChildrenPotential promiseSecond-line treatmentDisordersAntihypertensive agentsAdrenoreceptor agonist
2000
Genetics of Childhood Disorders: XVIII. ADHD, Part 2: Norepinephrine Has a Critical Modulatory Influence on Prefrontal Cortical Function
ARNSTEN A, Lombroso P. Genetics of Childhood Disorders: XVIII. ADHD, Part 2: Norepinephrine Has a Critical Modulatory Influence on Prefrontal Cortical Function. Journal Of The American Academy Of Child & Adolescent Psychiatry 2000, 39: 1201-1203. PMID: 10986819, DOI: 10.1097/00004583-200009000-00022.Peer-Reviewed Original Research
1999
Development of the Cerebral Cortex: XIV. Stress Impairs Prefrontal Cortical Function
Lombroso P, ARNSTEN A. Development of the Cerebral Cortex: XIV. Stress Impairs Prefrontal Cortical Function. Journal Of The American Academy Of Child & Adolescent Psychiatry 1999, 38: 220-222. PMID: 9951224, DOI: 10.1097/00004583-199902000-00024.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
1997
Pathogenesis of Tourette's Syndrome
Leckman J, Peterson B, Anderson G, Arnsten A, Pauls D, Cohen D. Pathogenesis of Tourette's Syndrome. Journal Of Child Psychology And Psychiatry 1997, 38: 119-142. PMID: 9232461, DOI: 10.1111/j.1469-7610.1997.tb01508.x.Peer-Reviewed Original Research
1995
Guanfacine Treatment of Comorbid Attention-Deficit Hyperactivity Disorder and Tourette's Syndrome: Preliminary Clinical Experience
CHAPPELL P, RIDDLE M, SCAHILL L, LYNCH K, SCHULTZ R, ARNSTEN A, LECKMAN J, COHEN D. Guanfacine Treatment of Comorbid Attention-Deficit Hyperactivity Disorder and Tourette's Syndrome: Preliminary Clinical Experience. Journal Of The American Academy Of Child & Adolescent Psychiatry 1995, 34: 1140-1146. PMID: 7559307, DOI: 10.1097/00004583-199509000-00010.Peer-Reviewed Original ResearchConceptsYale Global Tic Severity ScaleAttention deficit hyperactivity disorderTourette syndromeContinuous Performance TestHyperactivity disorderOpen-label studyCommon side effectsSeverity of motorComorbid attention deficit hyperactivity disorderSafe alternative therapySignificant decreaseTic Severity ScalePreliminary clinical experienceMajority of subjectsConners' Parent Rating ScaleTransient sedationControlled TrialsAlternative therapiesSedative effectsGuanfacine treatmentPhonic ticsSeverity ScaleSide effectsStimulant medicationTic severityAn Open Trial of Guanfacine in the Treatment of Attention-Deficit Hyperactivity Disorder
Hunt R, Arnsten A, Asbell M. An Open Trial of Guanfacine in the Treatment of Attention-Deficit Hyperactivity Disorder. Journal Of The American Academy Of Child & Adolescent Psychiatry 1995, 34: 50-54. PMID: 7860456, DOI: 10.1097/00004583-199501000-00013.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderGreater attentional abilityConners' Parent RatingUse of guanfacineAttentional abilitiesConners' hyperactivityParent ratingsHyperactivity disorderFrustration tolerancePatients' mean scoresSelective binding profileHyperactive childrenLonger excretionGuanfacine treatmentADHDHyperactive behaviorMean scoreSide effectsAlpha-2 noradrenergic agonistPsychiatric outpatientsGuanfacineDouble-blind studyBehavioral changesSedative side effectsOpen trial