Sleep-Disordered Breathing in Children With Metabolic Syndrome: The Role of Leptin and Sympathetic Nervous System Activity and the Effect of Continuous Positive Airway Pressure
Nakra N, Bhargava S, Dzuira J, Caprio S, Bazzy-Asaad A. Sleep-Disordered Breathing in Children With Metabolic Syndrome: The Role of Leptin and Sympathetic Nervous System Activity and the Effect of Continuous Positive Airway Pressure. Pediatrics 2008, 122: e634-e642. PMID: 18762497, PMCID: PMC5117807, DOI: 10.1542/peds.2008-0154.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressureSleep-disordered breathingSympathetic nervous system activityPositive airway pressureNervous system activityWhole-body insulin sensitivityMetabolic syndromeAirway pressureLeptin levelsInsulin sensitivitySystem activityExact testContinuous positive airway pressure (CPAP) treatmentPositive airway pressure treatmentC-reactive protein levelsOral glucose tolerance testGlucose tolerance testRole of leptinBMI z-scoreFisher's exact testOvernight polysomnographyBreathing groupMetabolic derangementsInsulin resistanceSleep QuestionnaireA Role for Macrophage Migration Inhibitory Factor in the Neonatal Respiratory Distress Syndrome
Kevill KA, Bhandari V, Kettunen M, Leng L, Fan J, Mizue Y, Dzuira JD, Reyes-Mugica M, McDonald CL, Baugh JA, O’Connor C, Aghai ZH, Donnelly SC, Bazzy-Asaad A, Bucala RJ. A Role for Macrophage Migration Inhibitory Factor in the Neonatal Respiratory Distress Syndrome. The Journal Of Immunology 2008, 180: 601-608. PMID: 18097062, DOI: 10.4049/jimmunol.180.1.601.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBronchopulmonary DysplasiaCorticosteroneDisease Models, AnimalHumansInfant, NewbornIntramolecular OxidoreductasesLungMacrophage Migration-Inhibitory FactorsMiceMice, KnockoutNeovascularization, PhysiologicPneumoniaPulmonary Surfactant-Associated ProteinsRespiratory Distress Syndrome, NewbornVascular Endothelial Growth Factor AConceptsMacrophage migration inhibitory factorRespiratory distress syndromeNeonatal respiratory distress syndromeMigration inhibitory factorEmbryonic day 18Lung maturationDistress syndromeHuman neonatesDay 18Inhibitory factorEarly saccular stageLungs of pupsNewborn lung diseaseFetal lung maturationVascular endothelial growth factorEmbryonic day 19.5Pulmonary epithelial cellsEndothelial growth factorMIF deficiencyMIF levelsWild-type controlsBronchopulmonary dysplasiaLung diseasePulmonary developmentHistological evaluation
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