Classification of psychedelics and psychoactive drugs based on brain-wide imaging of cellular c-Fos expression
Aboharb F, Davoudian P, Shao L, Liao C, Rzepka G, Wojtasiewicz C, Indajang J, Dibbs M, Rondeau J, Sherwood A, Kaye A, Kwan A. Classification of psychedelics and psychoactive drugs based on brain-wide imaging of cellular c-Fos expression. Nature Communications 2025, 16: 1590. PMID: 39939591, PMCID: PMC11822132, DOI: 10.1038/s41467-025-56850-6.Peer-Reviewed Original ResearchConceptsAcute fluoxetinePsychoactive drugsMarkers of neural plasticityImmediate early gene expressionC-fos expressionChronic fluoxetineNative brain tissueBehavioral effectsPsychedelic propertiesBrain regionsChance levelEarly gene expressionPsychoactive compoundsNeural plasticityFluoxetinePsilocybinMDMAMeasuring drug actionTested malesPsychedelicsPreclinical assaysDrug actionKetamineFemale miceDrug classificationNovel Approaches for Treating Anxiety and Trauma-Related Disorders
Kaye A, Jefferson S, Krystal J. Novel Approaches for Treating Anxiety and Trauma-Related Disorders. 2025, 583-598. DOI: 10.1093/med/9780197640654.003.0043.Peer-Reviewed Original ResearchNeural plasticityNeural circuitsAnxiety spectrum disordersTreatment-resistant populationModulation of neural circuitsExtinction learningFear extinctionBurden of anxietyThreat responsesTreat anxietyPsychedelic drugsSpectrum disorderImprove anxietyAnxietyPathological perceptionCurrent treatmentReceptor targetsPsychotherapyAntidepressantsAnxiolyticsExtinctionDisordersKetaminePlasticityTreatment
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