2006
A limited number of genes are involved in the differentiation of germinal center B cells
Nakayama Y, Stabach P, Maher SE, Mahajan MC, Masiar P, Liao C, Zhang X, Ye Z, Tuck D, Bothwell AL, Newburger PE, Weissman SM. A limited number of genes are involved in the differentiation of germinal center B cells. Journal Of Cellular Biochemistry 2006, 99: 1308-1325. PMID: 16795035, DOI: 10.1002/jcb.20952.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsB-LymphocytesCell DifferentiationCell LineChildChild, PreschoolDithiothreitolDNA-Binding ProteinsGene Expression ProfilingGerminal CenterHumansMolecular Sequence DataNuclear ProteinsOligonucleotide Array Sequence AnalysisPalatine TonsilProtein FoldingRegulatory Factor X Transcription FactorsTranscription FactorsTunicamycinX-Box Binding Protein 1ConceptsUnfolded protein responseX-box binding protein 1Interferon regulatory factor 4Protein 1B lymphocyte-induced maturation protein-1Transcription factor B lymphocyte-induced maturation protein-1Post-transcriptional changesBinding protein 1Maturation protein-1Mature B cellsDisulfide isomeraseTranscription factorsLevel of expressionPlasmacytoma cell lineProtein responseGene expressionRegulatory factor 4GenesGerminal center B cellsLymphoblastoid cellsLimited inductionCell linesB cellsFactor 4Germinal center centroblasts
2004
B cell–specific loss of histone 3 lysine 9 methylation in the VH locus depends on Pax5
Johnson K, Pflugh DL, Yu D, Hesslein DG, Lin KI, Bothwell AL, Thomas-Tikhonenko A, Schatz DG, Calame K. B cell–specific loss of histone 3 lysine 9 methylation in the VH locus depends on Pax5. Nature Immunology 2004, 5: 853-861. PMID: 15258579, PMCID: PMC1635547, DOI: 10.1038/ni1099.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceB-LymphocytesCell LineageCells, CulturedDNA-Binding ProteinsFlow CytometryGene Rearrangement, B-LymphocyteHematopoietic Stem CellsHistonesImmunoglobulin Heavy ChainsImmunoglobulin Variable RegionLysineMethylationMiceModels, ImmunologicalMolecular Sequence DataPAX5 Transcription FactorPrecipitin TestsReverse Transcriptase Polymerase Chain ReactionTranscription FactorsConceptsH3-K9 methylationDJH recombinationVH locusHistone 3 lysine 9 methylationLysine 9 methylationFunction of Pax5Non-B lineage cellsB cell-specific lossB cell commitmentHistone exchangeInactive chromatinLysine 9Histone H3Transcription factorsCell commitmentCell-specific lossInhibitory modificationMethylationLineage cellsLociPAX5B cellsHeavy chain rearrangementRecombinationChain rearrangement
2003
Class II transactivator promoter activity is suppressed through regulation by a trophoblast noncoding RNA1
Geirsson A, Paliwal I, Lynch RJ, Bothwell AL, Hammond GL. Class II transactivator promoter activity is suppressed through regulation by a trophoblast noncoding RNA1. Transplantation 2003, 76: 387-394. PMID: 12883198, DOI: 10.1097/01.tp.0000073612.04525.46.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceDNA MethylationDNA, ComplementaryHeLa CellsHumansLuciferasesMajor Histocompatibility ComplexMolecular Sequence DataNuclear ProteinsNucleic Acid ConformationPromoter Regions, GeneticProtein Structure, TertiaryRNA, UntranslatedSuppression, GeneticTrans-ActivatorsTranscription, GeneticTransfectionTrophoblastsConceptsClass II expressionMHC class IICIITA promoter IVPromoter IVQuantitative polymerase chain reactionMajor histocompatibility complexAllograft tolerancePolymerase chain reactionFluorescence-activated cell sortingCIITA expressionHuman leukocyte antigen-DRClass IIMHC class II expressionClassic major histocompatibility complexChain reactionCell sortingPurposes of transplantationLack expressionHistocompatibility complexNoncoding RNAsII-deficient cellsSelective suppressionPromoter-reporter constructsCIITA promoterInhibitory domain
1996
Porcine endothelial CD86 is a major costimulator of xenogeneic human T cells: cloning, sequencing, and functional expression in human endothelial cells.
Maher SE, Karmann K, Min W, Hughes CC, Pober JS, Bothwell AL. Porcine endothelial CD86 is a major costimulator of xenogeneic human T cells: cloning, sequencing, and functional expression in human endothelial cells. The Journal Of Immunology 1996, 157: 3838-44. PMID: 8892613, DOI: 10.4049/jimmunol.157.9.3838.Peer-Reviewed Original ResearchAbataceptAmino Acid SequenceAnimalsAntigens, CDAntigens, DifferentiationAortaB7-2 AntigenBase SequenceCells, CulturedCHO CellsCloning, MolecularCricetinaeCricetulusCTLA-4 AntigenDNA, ComplementaryEndothelium, VascularHumansImmunoconjugatesInterleukin-2Lymphocyte ActivationMembrane GlycoproteinsMolecular Sequence DataSequence AlignmentSequence Homology, Amino AcidSpecies SpecificitySwineT-LymphocytesTransfectionUmbilical Veins