2009
Differential roles of migratory and resident DCs in T cell priming after mucosal or skin HSV-1 infection
Lee HK, Zamora M, Linehan MM, Iijima N, Gonzalez D, Haberman A, Iwasaki A. Differential roles of migratory and resident DCs in T cell priming after mucosal or skin HSV-1 infection. Journal Of Experimental Medicine 2009, 206: 359-370. PMID: 19153243, PMCID: PMC2646574, DOI: 10.1084/jem.20080601.Peer-Reviewed Original ResearchConceptsResident dendritic cellsCD8 T cellsDendritic cellsHSV-1 infectionT cellsEpicutaneous infectionAntigen presentationLymph node-resident dendritic cellsHSV-specific T cellsCD4 T cell responsesNeedle injectionHerpes simplex virus 1 (HSV-1) infectionSimplex virus 1 infectionT cell primingT cell responsesVirus-1 infectionMode of infectionDC populationsCell primingVaginal infectionsImmune responseMucosal tissuesMucosal surfacesHSV-1Cell responses
1999
Epitope-specific cytotoxic T lymphocyte induction by minigene DNA immunization
Iwasaki A, Dela Cruz C, Young A, Barber B. Epitope-specific cytotoxic T lymphocyte induction by minigene DNA immunization. Vaccine 1999, 17: 2081-2088. PMID: 10217610, DOI: 10.1016/s0264-410x(98)00411-3.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, ViralAntigen PresentationBiolisticsCytokinesEpitopes, T-LymphocyteFemaleGenes, ViralHistocompatibility Antigens Class IInjections, IntramuscularMiceMice, Inbred StrainsNucleocapsid ProteinsNucleoproteinsOrthomyxoviridaeOrthomyxoviridae InfectionsPeptide FragmentsPlasmidsProtein Sorting SignalsRecombinant ProteinsRNA-Binding ProteinsT-Lymphocytes, CytotoxicTumor Cells, CulturedVaccines, DNAViral Core ProteinsConceptsCTL responsesCytotoxic T lymphocyte inductionEpitope-specific CTL responsesT lymphocyte responsesT lymphocyte inductionPlasmid DNA vaccineFull-length antigenLymphocyte responsesIL-12Lymphocyte inductionAntibody responseDNA immunizationDNA vaccineGene gun bombardmentPotent antibodiesGM-CSFCytokine combinationsNeedle injectionInfluenza virusSkeletal muscleSkin epidermisNucleoproteinMinimal effectResponseImmunization