2024
Randomized Phase II Trial of Imiquimod with or without 9-Valent HPV Vaccine versus Observation in Patients with High-grade Pre-neoplastic Cervical Lesions (NCT02864147)
Sheth S, Oh J, Bellone S, Siegel E, Greenman M, Mutlu L, McNamara B, Pathy S, Clark M, Azodi M, Altwerger G, Andikyan V, Huang G, Ratner E, Kim D, Iwasaki A, Levi A, Buza N, Hui P, Flaherty S, Schwartz P, Santin A. Randomized Phase II Trial of Imiquimod with or without 9-Valent HPV Vaccine versus Observation in Patients with High-grade Pre-neoplastic Cervical Lesions (NCT02864147). Clinical Cancer Research 2024, 30: of1-of10. PMID: 38592381, DOI: 10.1158/1078-0432.ccr-23-3639.Peer-Reviewed Original ResearchConceptsRandomized phase II trialCD4/CD8 T cellsT cellsHPV clearanceArm BNo significant differenceClinical surveillanceRate of HPV clearanceSecondary outcomesPre-neoplastic cervical lesionsCervical intraepithelial neoplasiaT cell infiltrationT cell responsesSignificant differenceCIN3 patientsIntraepithelial neoplasiaArm ACervical lesionsImiquimod groupSurveillance armVaginal suppositoriesProspective trialsArm CHPV vaccinationImiquimod
2015
No Viral Association Found in a Set of Differentiated Vulvar Intraepithelial Neoplasia Cases by Human Papillomavirus and Pan-Viral Microarray Testing
Saglam O, Samayoa E, Somasekar S, Naccache S, Iwasaki A, Chiu CY. No Viral Association Found in a Set of Differentiated Vulvar Intraepithelial Neoplasia Cases by Human Papillomavirus and Pan-Viral Microarray Testing. PLOS ONE 2015, 10: e0125292. PMID: 25894343, PMCID: PMC4404153, DOI: 10.1371/journal.pone.0125292.Peer-Reviewed Original ResearchConceptsVulvar squamous cell carcinomaVulvar intraepithelial neoplasiaDVIN casesHuman papillomavirusHigh-grade vulvar intraepithelial neoplasiaUsual-type vulvar intraepithelial neoplasiaUsual-type VINSquamous cell carcinomaHPV infectionIntraepithelial neoplasiaCell carcinomaPrecursor lesionsSmall biopsiesInfectious agentsDifferentiated typeGermline mutationsP53 geneInfectionDVINBiopsyCarcinomaPapillomavirusNeoplasiaLesionsCases