2025
Assessment of the relationship between synaptic density and metabotropic glutamate receptors in early Alzheimer’s disease: a multi-tracer PET study
Salardini E, O’Dell R, Tchorz E, Nabulsi N, Huang Y, Carson R, van Dyck C, Mecca A. Assessment of the relationship between synaptic density and metabotropic glutamate receptors in early Alzheimer’s disease: a multi-tracer PET study. Alzheimer's Research & Therapy 2025, 17: 98. PMID: 40329311, PMCID: PMC12054321, DOI: 10.1186/s13195-025-01739-1.Peer-Reviewed Original ResearchConceptsDistribution volume ratioMedial temporal lobePositron emission tomographyTemporal lobeSynaptic densityMetabotropic glutamate receptor subtype 5Multi-tracer PET studiesAlzheimer's diseaseCerebellum reference regionAmyloid-positive participantsSynaptic lossSynaptic vesicle glycoprotein 2AMetabotropic glutamate receptorsPositron emission tomography scanNeocortical regionsSubtype 5MGluR5Entorhinal cortexAD groupReference regionGlutamate receptorsExploratory analysisWidespread reductionsLongitudinal studyReceptor binding
2024
Validation of a Simplified Tissue-to-Reference Ratio Measurement Using SUVR to Assess Synaptic Density Alterations in Alzheimer Disease with [11C]UCB-J PET
Young J, O’Dell R, Naganawa M, Toyonaga T, Chen M, Nabulsi N, Huang Y, Cooper E, Miller A, Lam J, Bates K, Ruan A, Nelsen K, Salardini E, Carson R, van Dyck C, Mecca A. Validation of a Simplified Tissue-to-Reference Ratio Measurement Using SUVR to Assess Synaptic Density Alterations in Alzheimer Disease with [11C]UCB-J PET. Journal Of Nuclear Medicine 2024, 65: jnumed.124.267419. PMID: 39299782, PMCID: PMC11533916, DOI: 10.2967/jnumed.124.267419.Peer-Reviewed Original ResearchDistribution volume ratioSUV ratioSynaptic densityEffect sizeAlzheimer's diseaseLongitudinal study of Alzheimer's diseaseMethods:</b> ParticipantsLongitudinal studyMeasure synaptic densityAD participantsStudy of Alzheimer's diseaseNormal cognitionReference regionOlder adultsMulticenterDensity alterations
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