2025
Lower slow wave sleep and rapid eye movement sleep are associated with brain atrophy of AD-vulnerable regions.
Cho G, Mecca A, Buxton O, Liu X, Miner B. Lower slow wave sleep and rapid eye movement sleep are associated with brain atrophy of AD-vulnerable regions. Journal Of Clinical Sleep Medicine 2025 PMID: 40110600, DOI: 10.5664/jcsm.11630.Peer-Reviewed Original ResearchRapid eye movementSlow wave sleepSleep architectureArousal indexAssociated with smaller volumesCerebral microbleedsLobar cerebral microbleedsProportion of rapid eye movementBaseline sleep architectureRapid eye movement sleepProportion of slow wave sleepAssociated with cerebral microbleedsEye movement sleepSleep architecture variablesModifiable risk factorsAtrophy of hippocampusSleep deficiencyMedian ageParietal regionsMovement sleepMRI outcomesAssociated with brain atrophyAnatomical featuresRisk factorsCuneus regions
2024
Lower slow wave sleep and rapid eye‐movement sleep are associated with brain atrophy of AD‐vulnerable regions
Cho G, Mecca A, Buxton O, Liu X, Miner B. Lower slow wave sleep and rapid eye‐movement sleep are associated with brain atrophy of AD‐vulnerable regions. Alzheimer's & Dementia 2024, 20: e093827. PMCID: PMC11713325, DOI: 10.1002/alz.093827.Peer-Reviewed Original ResearchInferior parietal regionsSlow wave sleepAD-vulnerable regionsAssociated with smaller volumesParietal regionsPresence of cerebral microbleedsSleep architectureAlzheimer's diseaseCerebral microbleedsIncreased risk of Alzheimer's diseaseProportion of timeRisk of Alzheimer's diseaseBaseline cognitive functionLobar cerebral microbleedsModifiable risk factorsAssociated with lower volumesAssociated with brain atrophyBaseline sleep architectureSleep architecture variablesSleep deficiencyAssociated with ADFalse discovery rateAtherosclerosis RiskAD pathogenesisEye-movement sleepLower slow wave sleep and rapid eye‐movement sleep are associated with brain atrophy of AD‐vulnerable regions
Cho G, Mecca A, Buxton O, Liu X, Miner B. Lower slow wave sleep and rapid eye‐movement sleep are associated with brain atrophy of AD‐vulnerable regions. Alzheimer's & Dementia 2024, 20: e089369. PMCID: PMC11716384, DOI: 10.1002/alz.089369.Peer-Reviewed Original ResearchInferior parietal regionsSlow wave sleepAD-vulnerable regionsAssociated with smaller volumesParietal regionsPresence of cerebral microbleedsSleep architectureAlzheimer's diseaseCerebral microbleedsIncreased risk of Alzheimer's diseaseProportion of timeRisk of Alzheimer's diseaseBaseline cognitive functionLobar cerebral microbleedsModifiable risk factorsAssociated with lower volumesAssociated with brain atrophyBaseline sleep architectureSleep architecture variablesSleep deficiencyAssociated with ADFalse discovery rateAtherosclerosis RiskAD pathogenesisEye-movement sleepSelf‐reported hearing loss is associated with faster cognitive and functional decline but not diagnostic conversion in the ADNI cohort
Miller A, Sharp E, Wang S, Zhao Y, Mecca A, van Dyck C, O'Dell R, Initiative F. Self‐reported hearing loss is associated with faster cognitive and functional decline but not diagnostic conversion in the ADNI cohort. Alzheimer's & Dementia 2024, 20: 7847-7858. PMID: 39324520, PMCID: PMC11567835, DOI: 10.1002/alz.14252.Peer-Reviewed Original ResearchSelf-reported hearing lossFunctional Activities QuestionnaireHearing lossMild cognitive impairmentModifiable risk factorsMild cognitive impairment participantsFunctional declineImpairment diagnosisModified Preclinical Alzheimer Cognitive CompositeRate of functional declineRate of cognitive declinePreclinical Alzheimer Cognitive CompositeRisk factorsCognitive impairmentSignificant longitudinal associationsActivity QuestionnaireLongitudinal associationsAlzheimer's Disease Neuroimaging InitiativeLongitudinal relationshipCognitive compositeCN participantsIncreased riskCognitive declineParticipantsDiagnostic conversion
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