2021
Direct targeting of amplified gene loci for proapoptotic anticancer therapy
Kaushik Tiwari M, Colon-Rios DA, Tumu HCR, Liu Y, Quijano E, Krysztofiak A, Chan C, Song E, Braddock DT, Suh HW, Saltzman WM, Rogers FA. Direct targeting of amplified gene loci for proapoptotic anticancer therapy. Nature Biotechnology 2021, 40: 325-334. PMID: 34711990, PMCID: PMC8930417, DOI: 10.1038/s41587-021-01057-5.Peer-Reviewed Original ResearchConceptsDNA double-strand breaksTriplex-forming oligonucleotidesDNA damage responseDouble-strand breaksDrug resistanceGene amplificationP53-independent apoptosisHER2-positive breastOvarian cancer modelHuman tumor xenograftsInduction of apoptosisGenomic lociNumber of drugsCellular functionsDamage responseGene locusProtein productsHER2-positive cancer cellsDriver genesClinical efficacyCombat drug resistanceDNA damageHER2 amplificationTherapeutic strategiesTumor xenografts
2015
When defense becomes dangerous--transcription factor Nrf2 and cancer.
Krysztofiak A, Krajka-Kuźniak V. When defense becomes dangerous--transcription factor Nrf2 and cancer. Postępy Higieny I Medycyny Doświadczalnej 2015, 69: 140-52. PMID: 25614681.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsTranscription factor Nrf2Factor Nrf2Significance of Nrf2Expression of genesProtein Keap1Upstream kinaseRole of Nrf2Activation of Nrf2Nrf2 phosphorylationConformational changesBiotransformation of drugsTreatment of cancerTherapeutic effectCytoprotective enzymesDrug resistanceNrf2Adverse effectsEnzymatic systemsPhase IICancerPotential carcinogensActivationKinaseGenesPhosphorylation
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply