2024
Post-traumatic stress disorder symptoms following exposure to acute psychological trauma in children aged 8–16 years in South Africa: protocol for the Sinethemba longitudinal study
Sharp T, Chideya Y, Giuliani A, Hunt X, Tomlinson M, Seedat S, Creswell C, Fearon P, Hamilton-Giachritsis C, Hiller R, Meiser-Stedman R, Du Toit S, Stewart J, Halligan S. Post-traumatic stress disorder symptoms following exposure to acute psychological trauma in children aged 8–16 years in South Africa: protocol for the Sinethemba longitudinal study. BMJ Open 2024, 14: e085129. PMID: 38991675, DOI: 10.1136/bmjopen-2024-085129.Peer-Reviewed Original ResearchConceptsMental health outcomesPost-traumatic stress disorderChildren aged 8Caregiver supportHealth outcomesAssociation of psychosocial factorsAdverse mental health outcomesAged 8Traumatic eventsChildren’s post-traumatic stress disorderDepartment of HealthMiddle-income countriesTrauma-related mental healthPsychological risk factorsHigh-income countriesStress disorder symptomsFollow-up assessmentPost-traumatic stress disorder symptomsCape TownMotor vehicle accidentsHealthcare clinicsPsychosocial factorsMental healthPsychological recoveryEthical approvalImplementing and evaluating group interpersonal therapy for postnatal depression in Lebanon and Kenya—individually randomised superiority trial
Fonagy P, Chammay R, Ngunu C, Kumar M, Verdeli L, Allison E, Anani G, Fearon P, Fouad F, Hoare Z, Koyio L, Moore H, Nyandigisi A, Pilling S, Sender H, Skordis J, Evans R, Jaoude G, Madeghe B, Maradian S, O’Donnell C, Simes E, Truscott A, Wambua G, Yator O. Implementing and evaluating group interpersonal therapy for postnatal depression in Lebanon and Kenya—individually randomised superiority trial. Trials 2024, 25: 217. PMID: 38532432, PMCID: PMC10964704, DOI: 10.1186/s13063-024-08039-3.Peer-Reviewed Original ResearchConceptsPostnatal depressionInterpersonal psychotherapyChild developmental outcomesMulti-site randomised controlled trialWomen's mental health needsStandard careEfficacy of interpersonal psychotherapyMaternal postnatal depressionMental health needsMental health concernsMiddle-income countriesRandomised controlled trialsDevelopmental outcomesHigh-income countriesAntenatal servicesChildbearing womenMother-child bondingRandomised superiority trialChildren's developmental progressHealth needsOffspring of womenMaternal depressionCommunity settingsLMIC contextsInterpersonal therapy
2022
Measuring Antenatal Depressive Symptoms Across the World: A Validation and Cross-Country Invariance Analysis of the Patient Health Questionnaire-9 (PHQ-9) in Eight Diverse Low-Resource Settings
Murray A, Hemady C, Do H, Dunne M, Foley S, Osafo J, Sikander S, Madrid B, Baban A, Taut D, Ward C, Fernando A, Van Thang V, Eisner M, Hughes C, Fearon P, Valdebenito S, Tomlinson M, Pathmeswaran A, Walker S. Measuring Antenatal Depressive Symptoms Across the World: A Validation and Cross-Country Invariance Analysis of the Patient Health Questionnaire-9 (PHQ-9) in Eight Diverse Low-Resource Settings. Psychological Assessment 2022, 34: 993-1007. PMID: 36227303, DOI: 10.1037/pas0001154.Peer-Reviewed Original ResearchAssociations Between ADHD Symptoms and Maternal and Birth Outcomes: An Exploratory Analysis in a Multi-Country Cohort of Expectant Mothers
Murray A, Taut D, Baban A, Hemady C, Walker S, Osafo J, Sikander S, Tomlinson M, Du Toit S, Marlow M, Ward C, Fernando A, Madrid B, Van Thang V, Tuyen H, Dunne M, Hughes C, Fearon P, Valdebenito S, Eisner M. Associations Between ADHD Symptoms and Maternal and Birth Outcomes: An Exploratory Analysis in a Multi-Country Cohort of Expectant Mothers. Journal Of Attention Disorders 2022, 26: 1882-1894. PMID: 35815439, PMCID: PMC9597155, DOI: 10.1177/10870547221105064.Peer-Reviewed Original ResearchConceptsADHD symptomsSignificant associationLongitudinal birth cohort studyLow birth weightBirth cohort studyGreater mental health supportLow social supportMental health difficultiesMental health supportCohort studyBirth outcomesPremature birthThird trimesterRegular screeningBirth weightUnplanned pregnancyTobacco useDepressive symptomsExpectant mothersPregnancyFetal developmentUnwanted pregnancyHealth difficultiesSymptomsAlcohol usePatterns of adverse childhood experiences and associations with prenatal substance use and poor infant outcomes in a multi-country cohort of mothers: a latent class analysis
Hemady C, Speyer L, Murray A, Brown R, Meinck F, Fry D, Do H, Sikander S, Madrid B, Fernando A, Walker S, Dunne M, Foley S, Hughes C, Osafo J, Baban A, Taut D, Ward C, Van Thang V, Fearon P, Tomlinson M, Valdebenito S, Eisner M. Patterns of adverse childhood experiences and associations with prenatal substance use and poor infant outcomes in a multi-country cohort of mothers: a latent class analysis. BMC Pregnancy And Childbirth 2022, 22: 505. PMID: 35733125, PMCID: PMC9215006, DOI: 10.1186/s12884-022-04839-0.Peer-Reviewed Original ResearchConceptsPrenatal substance usePoor infant outcomesAdverse childhood experiencesInfant outcomesHousehold dysfunctionSubstance useLatent class analysisPrenatal drug useMother-infant dyadsLow-risk classMultilevel logistic regressionChildhood experiencesAntenatal supportHigh-risk classMiddle-income countriesStudy cohortLow birthweightPerinatal periodDrug useConclusionOur resultsChildhood adversityClass analysisLogistic regressionViolence exposureDysfunctionPerceived stress during the prenatal period: assessing measurement invariance of the Perceived Stress Scale (PSS-10) across cultures and birth parity
Katus L, Foley S, Murray A, Luong-Thanh B, Taut D, Baban A, Madrid B, Fernando A, Sikander S, Ward C, Osafo J, Marlow M, Du Toit S, Walker S, Van Vo T, Fearon P, Valdebenito S, Eisner M, Hughes C. Perceived stress during the prenatal period: assessing measurement invariance of the Perceived Stress Scale (PSS-10) across cultures and birth parity. Archives Of Women's Mental Health 2022, 25: 633-640. PMID: 35420323, PMCID: PMC9072510, DOI: 10.1007/s00737-022-01229-5.Peer-Reviewed Original ResearchAdapting and testing a brief intervention to reduce maternal anxiety during pregnancy (ACORN): report of a feasibility randomized controlled trial
O’Mahen H, Ramchandani P, King D, Lee-Carbon L, Wilkinson E, Thompson-Booth C, Ericksen J, Milgrom J, Dunkley-Bent J, Halligan S, Fearon P. Adapting and testing a brief intervention to reduce maternal anxiety during pregnancy (ACORN): report of a feasibility randomized controlled trial. BMC Psychiatry 2022, 22: 129. PMID: 35177019, PMCID: PMC8851863, DOI: 10.1186/s12888-022-03737-1.Peer-Reviewed Original ResearchConceptsPregnant individualsBrief interventionPrimary care servicesPublic health benefitsNew brief interventionLarge-scale trialsMaternal prenatal anxietyUsual careIntervention armPrenatal clinicsLevel of anxietyMaternal anxietyTreatment groupsMaternity servicesCare servicesElevated symptomsPrenatal anxietyFurther evaluationMore sessionsHealth benefitsInterventionPregnancyMindfulness exercisesGroup sessionsAnxietyDevelopmental pathways from toddler difficult temperament to child generalized psychopathology and adult functioning
Wu T, Meehan A, Rijlaarsdam J, Maughan B, Fearon P, Barker E. Developmental pathways from toddler difficult temperament to child generalized psychopathology and adult functioning. Journal Of Affective Disorders 2022, 301: 14-22. PMID: 34990631, DOI: 10.1016/j.jad.2022.01.012.Peer-Reviewed Original ResearchConceptsEarly difficult temperamentLate childhood/early adolescenceChildhood/early adolescenceDifficult temperamentMental health symptomsPositive parentingEarly adolescenceChild mental health symptomsDepressive symptomsLater mental health difficultiesRisk community sampleLow-risk community sampleChild mental health problemsImpaired psychosocial functioningMother-child dyadsMental health difficultiesOwn depressive symptomsChild difficult temperamentMental health problemsNegative parentingChildhood/adolescenceGeneral psychopathology factorGeneralized psychopathologyPsychosocial functioningAdult functioning
2021
Intranasal oxytocin administration improves mood in new mothers with moderate low mood but not in mothers with elevated symptoms of postnatal depression: A randomised controlled trial
Lindley Baron-Cohen K, Feldman R, Fearon P, Fonagy P. Intranasal oxytocin administration improves mood in new mothers with moderate low mood but not in mothers with elevated symptoms of postnatal depression: A randomised controlled trial. Journal Of Affective Disorders 2021, 300: 358-365. PMID: 34843839, DOI: 10.1016/j.jad.2021.11.062.Peer-Reviewed Original ResearchConceptsEdinburgh Postnatal Depression ScalePostnatal depressionOT administrationNew mothersLow moodPostnatal Depression ScaleCross-over designAntidepressant effectsMonths postpartumSevere scoresPND casesPND scoresSub-clinical levelsTreatment benefitDepression ScaleMood spectrumClinical diagnosisElevated symptomsAdministrationMood scoresMothersNegative moodWomenNeuropeptide hormoneDepressionEarly manifestations of intellectual performance: Evidence that genetic effects on later academic test performance are mediated through verbal performance in early childhood
Austerberry C, Fearon P, Ronald A, Leve LD, Ganiban JM, Natsuaki MN, Shaw DS, Neiderhiser JM, Reiss D. Early manifestations of intellectual performance: Evidence that genetic effects on later academic test performance are mediated through verbal performance in early childhood. Child Development 2021, 93: e188-e206. PMID: 34783370, PMCID: PMC10861934, DOI: 10.1111/cdev.13706.Peer-Reviewed Original ResearchMaternal caregiving moderates the impact of antenatal maternal cortisol on infant stress regulation
Nazzari S, Fearon P, Rice F, Molteni M, Frigerio A. Maternal caregiving moderates the impact of antenatal maternal cortisol on infant stress regulation. Journal Of Child Psychology And Psychiatry 2021, 63: 871-880. PMID: 34787327, DOI: 10.1111/jcpp.13532.Peer-Reviewed Original ResearchConceptsInfant stress regulationInfant cortisol reactivityC-reactive proteinMaternal sensitive caregivingAntenatal stressMaternal cortisolCortisol responseInfant stress response systemsInfant cortisol regulationMaternal antenatal stressMaternal caregivingInfant cortisol responseCortisol reactivityGreater cortisol responseAntenatal exposureMaternal ageMaternal levelsInterleukin-6Late pregnancyMaternal stress signalsPostnatal depressionSensitive caregivingAnimal studiesStress regulationCortisol regulationA mediation meta‐analysis of the role of maternal responsivity in the association between socioeconomic risk and children’s language
Borairi S, Fearon P, Madigan S, Plamondon A, Jenkins J. A mediation meta‐analysis of the role of maternal responsivity in the association between socioeconomic risk and children’s language. Child Development 2021, 92: 2177-2193. PMID: 34664260, DOI: 10.1111/cdev.13695.Peer-Reviewed Original ResearchConceptsPreschool language abilitiesLanguage developmentChildren's language developmentChild languageLanguage abilityFamily homeLanguageMaternal responsivityMeta-analytic structural equation modelingEnglishSocioeconomic riskMediationRiskHomeParentingIndirect effectsAssociationSensitive parentingModerator analysesChild‐father attachment in early childhood and behavior problems: A meta‐analysis
Deneault A, Bakermans‐Kranenburg M, Groh A, Fearon P, Madigan S. Child‐father attachment in early childhood and behavior problems: A meta‐analysis. New Directions For Child And Adolescent Development 2021, 2021: 43-66. PMID: 34651413, DOI: 10.1002/cad.20434.Peer-Reviewed Original ResearchThe impact of maternal adverse childhood experiences and prenatal depressive symptoms on foetal attachment: Preliminary evidence from expectant mothers across eight middle-income countries
Brown R, Eisner M, Walker S, Tomlinson M, Fearon P, Dunne M, Valdebenito S, Hughes C, Ward C, Sikander S, Osafo J, Madrid B, Baban A, Van Thang V, Fernando A, Murray A. The impact of maternal adverse childhood experiences and prenatal depressive symptoms on foetal attachment: Preliminary evidence from expectant mothers across eight middle-income countries. Journal Of Affective Disorders 2021, 295: 612-619. PMID: 34509077, DOI: 10.1016/j.jad.2021.08.066.Peer-Reviewed Original ResearchConceptsMaternal adverse childhood experiencesAdverse childhood experiencesPrenatal depressive symptomsMiddle-income countriesPrenatal depressionDepressive symptomsMaternal health careChildhood experiencesAntenatal careThird trimesterCohort evidenceACE exposureHigh-income countriesPostnatal periodExpectant mothersBaseline measurementsPostnatal attachmentSymptomsPath mediation analysisRelevant covariatesDepressionHealth careMothers' feelingsMothersPregnancyFirst 1,000 days: enough for mothers but not for children? Long‐term outcomes of an early intervention on maternal depressed mood and child cognitive development: follow‐up of a randomised controlled trial
Tomlinson M, Skeen S, Melendez‐Torres G, Hunt X, Desmond C, Morgan B, Murray L, Cooper P, Rathod S, Marlow M, Fearon P. First 1,000 days: enough for mothers but not for children? Long‐term outcomes of an early intervention on maternal depressed mood and child cognitive development: follow‐up of a randomised controlled trial. Journal Of Child Psychology And Psychiatry 2021, 63: 261-272. PMID: 34227113, DOI: 10.1111/jcpp.13482.Peer-Reviewed Original ResearchConceptsChildren's cognitive developmentChild cognitive outcomesCognitive developmentCognitive outcomesMaternal moodMother-infant relationship qualityDepressed moodEarly interventionKaufman Assessment BatteryEarly mother-infant relationshipLong-term child outcomesCapacity of parentsYears of ageMother-infant relationshipMaternal depressed moodAttachment interventionsMaternal mental healthPsychological distressAssessment BatteryChild developmentChild outcomesRelationship qualityNull findingsMental healthMoodDevelopmental trajectories of autistic social traits in the general population
Pender R, Fearon P, St Pourcain B, Heron J, Mandy W. Developmental trajectories of autistic social traits in the general population. Psychological Medicine 2021, 53: 814-822. PMID: 34154678, DOI: 10.1017/s0033291721002166.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderGrowth mixture modellingAutistic traitsSocial difficultiesCommunication Disorders ChecklistTrajectory groupsMajority-male groupsSCDC scoresAutistic peopleASD diagnosisSpectrum disorderDevelopmental trajectoriesCommunication traitsExternalising difficultiesAvon Longitudinal StudyTrait continuumGeneral population sampleAge 7Social traitsMental healthLongitudinal studyAdolescenceExternal validityPersistent lowYoung peopleDecision-making ability, psychopathology, and brain connectivity
Moutoussis M, Garzón B, Neufeld S, Bach D, Rigoli F, Goodyer I, Bullmore E, Consortium N, Fonagy P, Jones P, Hauser T, Romero-Garcia R, St Clair M, Vértes P, Whitaker K, Inkster B, Prabhu G, Ooi C, Toseeb U, Widmer B, Bhatti J, Villis L, Alrumaithi A, Birt S, Bowler A, Cleridou K, Dadabhoy H, Davies E, Firkins A, Granville S, Harding E, Hopkins A, Isaacs D, King J, Kokorikou D, Maurice C, McIntosh C, Memarzia J, Mills H, O’Donnell C, Pantaleone S, Scott J, Fearon P, Suckling J, van Harmelen A, Kievit R, Guitart-Masip M, Dolan R. Decision-making ability, psychopathology, and brain connectivity. Neuron 2021, 109: 2025-2040.e7. PMID: 34019810, PMCID: PMC8221811, DOI: 10.1016/j.neuron.2021.04.019.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAffectAntisocial Personality DisorderAnxietyBrainCognitionDecision MakingDepressionDepressive Disorder, MajorFactor Analysis, StatisticalFemaleFunctional NeuroimagingHumansIntelligence TestsMagnetic Resonance ImagingMaleNeural PathwaysNeuropsychological TestsPsychosocial FunctioningSelf ConceptSocial InteractionYoung AdultConceptsDecision-making abilityFunctional connectivityResting-state functional connectivityGeneral social functioningDecision-making measuresPoor social functionCognitive constructsCognitive processesBrain signaturesSocial functioningThought patternsBrain connectivityMental healthMultiple domainsSocial functionIQBrain dataCommon factorsYoung peopleConstructsIndividuals 18Neural networkConnectivityAbilityPsychopathologyAn expanding manifold in transmodal regions characterizes adolescent reconfiguration of structural connectome organization
Park B, Bethlehem R, Paquola C, Larivière S, Rodríguez-Cruces R, de Wael R, Bullmore E, Dolan R, Goodyer I, Fonagy P, Jones P, Moutoussis M, Hauser T, Neufeld S, Romero-Garcia R, St Clair M, Vértes P, Whitaker K, Inkster B, Prabhu G, Ooi C, Toseeb U, Widmer B, Bhatti J, Villis L, Alrumaithi A, Birt S, Bowler A, Cleridou K, Dadabhoy H, Davies E, Firkins A, Granville S, Harding E, Hopkins A, Isaacs D, King J, Kokorikou D, Maurice C, McIntosh C, Memarzia J, Mills H, O’Donnell C, Pantaleone S, Scott J, Kiddle B, Polek E, Fearon P, Suckling J, van Harmelen A, Kievit R, Chamberlain S, Bullmore E, Bernhardt B. An expanding manifold in transmodal regions characterizes adolescent reconfiguration of structural connectome organization. ELife 2021, 10: e64694. PMID: 33787489, PMCID: PMC8087442, DOI: 10.7554/elife.64694.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdolescent BehaviorAdolescent DevelopmentAdultAge FactorsBrainCognitionConnectomeFemaleGene Expression ProfilingGene Expression Regulation, DevelopmentalHumansLongitudinal StudiesMagnetic Resonance ImagingMaleModels, NeurologicalNerve Tissue ProteinsNeural PathwaysNeurogenesisTranscriptomeYoung AdultConceptsTransmodal regionsHigher-order association networksStructural connectome organizationMeasures of intelligenceLarge longitudinal sampleAdolescent developmentCognitive outcomesConnectome developmentBrain networksLongitudinal sampleStatistical learningConnectome organizationYoung adulthoodModule connectivityConnectivity patternsStructural connectomeEmpirical gapMaturational changesAdolescencePrenatal attachment: using measurement invariance to test the validity of comparisons across eight culturally diverse countries
Foley S, Hughes C, Murray A, Baban A, Fernando A, Madrid B, Osafo J, Sikander S, Abbasi F, Walker S, Luong-Thanh B, Vo T, Tomlinson M, Fearon P, Ward C, Valdebenito S, Eisner M. Prenatal attachment: using measurement invariance to test the validity of comparisons across eight culturally diverse countries. Archives Of Women's Mental Health 2021, 24: 619-625. PMID: 33559754, PMCID: PMC8266779, DOI: 10.1007/s00737-021-01105-8.Peer-Reviewed Original ResearchConceptsMaternal-fetal attachmentMiddle-income countriesHigh-income countriesExpectant mothersProspective birth cohort studyBirth cohort studyFirst-time mothersPrenatal Attachment InventoryCohort studyThird trimesterPregnant womenMaternal healthFirst infantMaternal behaviorGroup comparisonsMean levelsMothersInfantsSingle latent factorFuture studiesPlace childrenChildrenChild outcomesSimilar informationPAI
2020
Antisocial cognition as a mediator of the peer influence effect and peer selection effect in antisocial adolescents
Brewer A, Saunders R, Fearon P, Fonagy P, Cottrell D, Kraam A, Pilling S, Simes E, Anokhina A, Butler S. Antisocial cognition as a mediator of the peer influence effect and peer selection effect in antisocial adolescents. European Child & Adolescent Psychiatry 2020, 31: 177-187. PMID: 33330952, PMCID: PMC8816781, DOI: 10.1007/s00787-020-01695-1.Peer-Reviewed Original ResearchConceptsPeer selection effectsDelinquent peer associationPeer conflictAntisocial behaviorPeer influenceSerious antisocial behaviorPeer associationAntisocial cognitionSelf-reported antisocial behaviorPeer influence effectsAntisocial adolescentsBritish adolescentsInfluence effectsPredictive relationshipAdolescentsCognitionCriminological literatureBeliefsAttitudesSelection effectsTotal effectCausal mechanismsConflictBehaviorFindings