2024
Heightened response to positive facial cues as a potential marker of resilience following childhood adversity
Gerin M, Viding E, Neil L, Armbruster-Genc D, Freeman Z, Sharp M, Phillips H, McCrory E. Heightened response to positive facial cues as a potential marker of resilience following childhood adversity. European Journal Of Psychotraumatology 2024, 15: 2309783. PMID: 38318813, PMCID: PMC10849006, DOI: 10.1080/20008066.2024.2309783.Peer-Reviewed Original ResearchConceptsFacial cuesMaltreatment experiencesPresence of social supportSocial supportLow symptomsAssociated with lower symptomsThreat-related cuesPositive social cuesIncreased psychiatric riskPerceived emotional intensityMarkers of resilienceChildhood maltreatment experiencesNo group differencesMental health symptomsLevels of social supportPerceived social supportAssociated with better mental healthMental health vulnerabilitiesMental health outcomesBetter mental healthExperiences of abusePerceived intensityHappy facesChildhood maltreatmentImplicit processesAtypical Interpersonal Problem-Solving and Resting-state Functional Connectivity in Adolescents with Maltreatment Experience
Gerin M, Viding E, Puetz V, Armbruster-Genc D, Rankin G, McCrory E. Atypical Interpersonal Problem-Solving and Resting-state Functional Connectivity in Adolescents with Maltreatment Experience. Current Neuropharmacology 2024, 22: 290-301. PMID: 37818587, PMCID: PMC10788892, DOI: 10.2174/1570159x22666231002145440.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityPosterior cingulate cortexMedial prefrontal cortexMental health symptomsMaltreatment experiencesSocial functioningLingual gyrusFunctional connectivityHealth symptomsInterpersonal problem-solving skillsRetrosplenial cortexElevated mental health symptomsDefault mode network hubInterpersonal problem solvingPoor social functioningAdverse environmental experiencesProblem-solving performanceNon-maltreated peersProblem-solving skillsExperiences of abuseSeed-based analysisNeurocognitive processingNeurocognitive functioningMental health disordersEarly adversity
2023
A systematic review of childhood maltreatment and resting state functional connectivity
Gerin M, Viding E, Herringa R, Russell J, McCrory E. A systematic review of childhood maltreatment and resting state functional connectivity. Developmental Cognitive Neuroscience 2023, 64: 101322. PMID: 37952287, PMCID: PMC10665826, DOI: 10.1016/j.dcn.2023.101322.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityAnterior cingulate cortexFunctional connectivityCingulate cortexChildhood maltreatmentAltered functional connectivityState functional connectivityDorsal anterior cingulate cortexNegative psychiatric outcomesVentral anterior cingulate cortexDorsolateral prefrontal cortexRsFC alterationsAltered connectivityInclusion criteriaAmygdala connectivityNineteen studiesPsychiatric outcomesFuture symptomsSystematic reviewBrain regionsClinical disordersBrain circuitsAnterior insulaPrefrontal cortexMaltreatment exposure
2022
A genetically informed Registered Report on adverse childhood experiences and mental health
Baldwin J, Sallis H, Schoeler T, Taylor M, Kwong A, Tielbeek J, Barkhuizen W, Warrier V, Howe L, Danese A, McCrory E, Rijsdijk F, Larsson H, Lundström S, Karlsson R, Lichtenstein P, Munafò M, Pingault J. A genetically informed Registered Report on adverse childhood experiences and mental health. Nature Human Behaviour 2022, 7: 269-290. PMID: 36482079, PMCID: PMC7614239, DOI: 10.1038/s41562-022-01482-9.Peer-Reviewed Original ResearchConceptsMental health problemsAdverse childhood experiencesHealth problemsElevated riskMental healthGenetic confoundingChildhood experiencesPsychiatric vulnerabilityGenetic riskHigher polygenic scoresConfoundingChildrenPrevious associationsRiskGene-environment correlationSmall increaseAssociationHealthReportPolygenic scoresParenting boys with conduct problems and callous-unemotional traits: parent and child perspectives
Roberts R, McCrory E, Joffe H, Phillips H, Gaule A, Viding E. Parenting boys with conduct problems and callous-unemotional traits: parent and child perspectives. European Child & Adolescent Psychiatry 2022, 32: 2547-2555. PMID: 36374342, PMCID: PMC10682176, DOI: 10.1007/s00787-022-02109-0.Peer-Reviewed Original ResearchConceptsCP/HCUCallous-unemotional traitsConduct problemsParents/caregiversTD boysInconsistent disciplineChildren’s perspectivesAlabama Parenting QuestionnaireParenting QuestionnaireChild monitoringMore difficultyLittle researchParentingQualitative reportsFamily engagementParentsSame perceptionCaregiversChild safetyBoysChildrenQualitative methodsDifficultiesExperienceCP interventionSocial thinning and stress generation after childhood maltreatment: a neurocognitive social transactional model of psychiatric vulnerability
McCrory E, Foulkes L, Viding E. Social thinning and stress generation after childhood maltreatment: a neurocognitive social transactional model of psychiatric vulnerability. The Lancet Psychiatry 2022, 9: 828-837. PMID: 35926524, DOI: 10.1016/s2215-0366(22)00202-4.Peer-Reviewed Original ResearchConceptsTransactional modelChildhood maltreatmentNeurocognitive alterationsPsychiatric disordersQuantity of relationshipsIndividual's social networkSocial functioningSocial architecturePsychiatric vulnerabilityMaltreatmentSocial environmentExtant evidencePsychiatric riskNeurocognitive sequelaeSocial processesStress generationSocial networksDisordersPrescribing of antipsychotics among people with recorded personality disorder in primary care: a retrospective nationwide cohort study using The Health Improvement Network primary care database
Hardoon S, Hayes J, Viding E, McCrory E, Walters K, Osborn D. Prescribing of antipsychotics among people with recorded personality disorder in primary care: a retrospective nationwide cohort study using The Health Improvement Network primary care database. BMJ Open 2022, 12: e053943. PMID: 35264346, PMCID: PMC8968526, DOI: 10.1136/bmjopen-2021-053943.Peer-Reviewed Original ResearchConceptsSevere mental illnessPrimary care databasePersonality disorderSuch prescribingCohort studyCare databasePrimary careGeneral practiceHealth Improvement Network primary care databaseRetrospective nationwide cohort studyGeneral practice notesNationwide cohort studyRetrospective cohort studyGeneral practice recordsUK primary careCurrent UK guidelinesAdverse childhood experiencesMetabolic complicationsAntipsychotic prescribingAntipsychotic prescriptionsMedian timePractice recordsAntipsychoticsUK guidelinesClinical practiceAltered reward and effort processing in children with maltreatment experience: a potential indicator of mental health vulnerability
Armbruster-Genç D, Valton V, Neil L, Vuong V, Freeman Z, Packer K, Kiffin M, Roiser J, Viding E, McCrory E. Altered reward and effort processing in children with maltreatment experience: a potential indicator of mental health vulnerability. Neuropsychopharmacology 2022, 47: 1063-1070. PMID: 35149765, PMCID: PMC8832084, DOI: 10.1038/s41386-022-01284-7.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingInternalizing symptomsHistory of maltreatmentAnterior cingulate cortexEffort processingEffort-based decision-making taskDecision-making taskEffort-based decisionElevated internalizing symptomsNon-maltreated childrenImpact of maltreatmentMental health vulnerabilitiesFuture internalizing symptomsNeural indicesACC activationAltered rewardBehavioral indicesMaltreatment experiencesLatent vulnerabilityCingulate cortexEffort sensitivityGroup differencesRewardMaltreatmentLongitudinal study
2021
Functional brain plasticity following childhood maltreatment: A longitudinal fMRI investigation of autobiographical memory processing.
Puetz V, Viding E, Maguire E, Mechelli A, Armbruster-Genç D, Sharp M, Rankin G, Gerin M, McCrory E. Functional brain plasticity following childhood maltreatment: A longitudinal fMRI investigation of autobiographical memory processing. Development And Psychopathology 2021, 35: 1382-1389. PMID: 34924093, DOI: 10.1017/s0954579421001292.Peer-Reviewed Original ResearchConceptsChildhood maltreatmentAutobiographical memory processingCortical midline structuresValenced cue wordsPotential developmental plasticityCue wordsMemory processingFMRI studyBOLD signal changesNeural functioningPsychological assessmentBrain networksMaltreatmentMidline structuresMaturational changesLongitudinal analysisProcessingSignal changesFMRIPsychopathologyRecallAdolescentsFunctioningWordsDevelopmental plasticityTrust and childhood maltreatment: evidence of bias in appraisal of unfamiliar faces
Neil L, Viding E, Armbruster‐Genc D, Lisi M, Mareschal I, Rankin G, Sharp M, Phillips H, Rapley J, Martin P, McCrory E. Trust and childhood maltreatment: evidence of bias in appraisal of unfamiliar faces. Journal Of Child Psychology And Psychiatry 2021, 63: 655-662. PMID: 34500497, DOI: 10.1111/jcpp.13503.Peer-Reviewed Original ResearchConceptsTrust processingUnfamiliar facesChildhood maltreatmentPoor social functioningMental health difficultiesMental health problemsFacial stimuliCognitive abilitiesTrust judgmentsTrust attributionTrustworthiness dimensionsCommunity-based sampleSocial service recordsSocial functioningMaltreatment experiencesHealth difficultiesChild maltreatmentMaltreatmentSocial bondsAtypical patternsPeersEvidence of biasChildrenSocioeconomic statusProcessingChild Maltreatment, Peer Victimization, and Mental Health: Neurocognitive Perspectives on the Cycle of Victimization
Goemans A, Viding E, McCrory E. Child Maltreatment, Peer Victimization, and Mental Health: Neurocognitive Perspectives on the Cycle of Victimization. Trauma Violence & Abuse 2021, 24: 530-548. PMID: 34355601, PMCID: PMC10009486, DOI: 10.1177/15248380211036393.Peer-Reviewed Original ResearchConceptsMental healthMental health careMental health outcomesAdverse childhood experiencesMental health vulnerabilitiesSystematic scoping reviewInpatient populationChild maltreatmentHealth outcomesGoogle ScholarHealth careNeurocognitive functioningPutative mechanismsRisk of revictimizationScoping ReviewHealth vulnerabilityChildrenNeurocognitive findingsPreventative modelAdditive effectChildhood experiencesRiskPeer victimizationHealthMaltreatmentModulation of Amygdala Response by Cognitive Conflict in Adolescents with Conduct Problems and Varying Levels of CU Traits
Sebastian C, Stafford J, McCrory E, Sethi A, De Brito S, Lockwood P, Viding E. Modulation of Amygdala Response by Cognitive Conflict in Adolescents with Conduct Problems and Varying Levels of CU Traits. Research On Child And Adolescent Psychopathology 2021, 49: 1043-1054. PMID: 33728508, PMCID: PMC8222043, DOI: 10.1007/s10802-021-00787-z.Peer-Reviewed Original ResearchConceptsCallous-unemotional traitsNegative emotional stimuliAmygdala responseConduct problemsEmotional stimuliCognitive conflictTask demandsCognitive task demandsCognitive conflict tasksLow callous-unemotional traitsCP/HCUHealthy adult sampleCognitive controlEmotional facesReactive aggressionAtypical modulationConflict taskNeurocognitive responsesAffect regulationCU traitsPotential translational relevanceConflict conditionsPrefrontal areasHigh conflictAdult samples
2020
Individual differences in sensitivity to the early environment as a function of amygdala and hippocampus volumes: An exploratory analysis in 12-year-old boys
Pluess M, De Brito S, Bartoli A, McCrory E, Viding E. Individual differences in sensitivity to the early environment as a function of amygdala and hippocampus volumes: An exploratory analysis in 12-year-old boys. Development And Psychopathology 2020, 34: 901-910. PMID: 33342453, DOI: 10.1017/s0954579420001698.Peer-Reviewed Original ResearchConceptsIndividual differencesLeft amygdalaEnvironmental influencesLeft amygdala volumeNeurobiological sensitivityImportant brain regionsChild behaviorBrain regionsEarly environmentContextual factorsPositive experiencesBrain structuresAmygdala volumePreliminary evidenceAmygdalaGeneral environmental qualityHippocampus volumeExploratory analysisBoysExploratory studyEnvironmental featuresDisruptive Behavior Disorders: The Challenge of Delineating Mechanisms in the Face of Heterogeneity
Viding E, McCrory E. Disruptive Behavior Disorders: The Challenge of Delineating Mechanisms in the Face of Heterogeneity. American Journal Of Psychiatry 2020, 177: 811-817. PMID: 32867523, DOI: 10.1176/appi.ajp.2020.20070998.Peer-Reviewed Original ResearchFacial recognition during early motherhood: Investigating the persistence of age and affect biases
Bunderson M, Armstrong K, Mayes LC, McCrory EJ, Thompson-Booth C, Rutherford HJV. Facial recognition during early motherhood: Investigating the persistence of age and affect biases. Acta Psychologica 2020, 210: 103136. PMID: 32768610, DOI: 10.1016/j.actpsy.2020.103136.Peer-Reviewed Original ResearchConceptsInfant facesFacial recognitionOwn-age biasHappy face advantageFacial processingHappy facesSad facesFace advantageAdult facesSad expressionsNeutral expressionsSample of mothersNeurobiological changesAdult literatureProcessing literatureCurrent studyEarly motherhoodAppropriate caregivingFaceRecognitionPrior studiesMothersCaregivingBiasesParenthoodThinking about Others’ Minds: Mental State Inference in Boys with Conduct Problems and Callous-Unemotional Traits
Roberts R, McCrory E, Bird G, Sharp M, Roberts L, Viding E. Thinking about Others’ Minds: Mental State Inference in Boys with Conduct Problems and Callous-Unemotional Traits. Research On Child And Adolescent Psychopathology 2020, 48: 1279-1290. PMID: 32632744, PMCID: PMC7445196, DOI: 10.1007/s10802-020-00664-1.Peer-Reviewed Original ResearchConceptsMental state inferencesSocial judgment taskConduct problemsState inferenceMental statesCP/HCUCallous-unemotional traitsMind-related commentsSocial cognitionJudgment taskIntact abilityAntisocial actionsUnemotional TraitsPeople's thoughtsDifferent mindsGroup differencesMore difficultyBest friendTaskMindBoysNew measureDifferent aspectsThoughtCognitionAutobiographical memory as a latent vulnerability mechanism following childhood maltreatment: Association with future depression symptoms and prosocial behavior
Puetz V, Viding E, Hoffmann F, Gerin M, Sharp M, Rankin G, Maguire E, Mechelli A, McCrory E. Autobiographical memory as a latent vulnerability mechanism following childhood maltreatment: Association with future depression symptoms and prosocial behavior. Development And Psychopathology 2020, 33: 1300-1307. PMID: 32573399, DOI: 10.1017/s0954579420000504.Peer-Reviewed Original ResearchConceptsOvergeneral memoryProsocial behaviorChildhood maltreatmentAutobiographical memory recallAutobiographical Memory TestSocio-emotional functioningPsycho-social functioningValenced cue wordsPoor social functioningSample of adolescentsFuture depression symptomsDepressive symptomsChildhood maltreatment historyTrend-level associationCognitive mechanismsCue wordsNeural reactivityAutobiographical memoryMemory testMemory recallVulnerability mechanismsBrain activitySocial functioningElevated depressive symptomsMaltreatment history
2019
Ghosts in the Nursery: An Experimental Investigation of a Parent’s Own Maltreatment Experience, Attention to Infant Faces, and Dyadic Reciprocity
Thompson-Booth C, Viding E, Puetz VB, Rutherford HJV, Mayes LC, McCrory EJ. Ghosts in the Nursery: An Experimental Investigation of a Parent’s Own Maltreatment Experience, Attention to Infant Faces, and Dyadic Reciprocity. Emotion 2019, 19: 1093-1102. PMID: 30234333, DOI: 10.1037/emo0000464.Peer-Reviewed Original ResearchConceptsInfant facesChildhood maltreatmentAttentional processingDyadic reciprocityLower attentional biasVisual search taskAttentional biasEmotional cuesCognitive processingPreferential processingInfant affectParenting behaviorsInfant cuesSearch taskAn Experimental InvestigationCommunity sampleMaltreatment experiencesMaltreatmentPreferential biasOwn childrenCuesExploratory analysisProcessingFaceImportant implicationsMulti–Polygenic Score Approach to Identifying Individual Vulnerabilities Associated With the Risk of Exposure to Bullying
Schoeler T, Choi S, Dudbridge F, Baldwin J, Duncan L, Cecil C, Walton E, Viding E, McCrory E, Pingault J. Multi–Polygenic Score Approach to Identifying Individual Vulnerabilities Associated With the Risk of Exposure to Bullying. JAMA Psychiatry 2019, 76: 730-738. PMID: 30942833, PMCID: PMC6583782, DOI: 10.1001/jamapsychiatry.2019.0310.Peer-Reviewed Original ResearchConceptsMental health vulnerabilitiesMAIN OUTCOMEPopulation-based birth cohort studyHealth vulnerabilityIndividual vulnerabilityBody mass indexBirth cohort studyDiagnosis of depressionYears of ageDate of deliveryAttention-deficit/hyperactivity disorderAvon Longitudinal StudyMental health problemsPolygenic score approachLast followCohort studyMass indexMultivariable analysisRisk of exposureAssessment of exposureRisk factorsPrevention strategiesHealth problemsSignificant associationALSPAC dataInvestigating patterns of neural response associated with childhood abuse v. childhood neglect
Puetz V, Viding E, Gerin M, Pingault J, Sethi A, Knodt A, Radtke S, Brigidi B, Hariri A, McCrory E. Investigating patterns of neural response associated with childhood abuse v. childhood neglect. Psychological Medicine 2019, 50: 1398-1407. PMID: 31190662, DOI: 10.1017/s003329171900134x.Peer-Reviewed Original ResearchConceptsNeural reactivityThreat reactivityMaltreatment experiencesChildhood abuseChildhood maltreatmentHigher-order cortical regionsFronto-parietal networkEffects of abuseChildhood abuse experiencesExperiences of neglectPoor mental health outcomesEffects of neglectChildhood maltreatment experiencesMental health outcomesExperiences of abuseCognitive processingBrain imaging analysisFacial cuesNeural responsesNeglect experiencesDifferential effectsAbuse experiencesChildhood neglectDorsal amygdalaVentral amygdala