2024
Causal and common risk pathways linking childhood maltreatment to later intimate partner violence victimization
Pezzoli P, Pingault J, Eley T, McCrory E, Viding E. Causal and common risk pathways linking childhood maltreatment to later intimate partner violence victimization. Molecular Psychiatry 2024, 1-11. PMID: 39488656, DOI: 10.1038/s41380-024-02813-0.Peer-Reviewed Original ResearchIntimate partner violence victimizationIntimate partner violenceChildhood maltreatmentTwins Early Development StudyPartner violence victimizationSmall-to-moderate rangeNonshared environmental influencesEnvironmental influencesEarly Development StudyPsychiatric risk factorsEffects of maltreatmentRetrospective self-reportsRetrospective self-reports of maltreatmentIndividual-level riskPartner violenceViolence victimizationDevelopment studiesMaltreatmentVictimsIntimate relationshipsGenetic influencesCo-twinQuantitative genetic methodsRisk pathwaysModerating effectHeightened response to positive facial cues as a potential marker of resilience following childhood adversity
Gerin M, Viding E, Neil L, Armbruster-Genc D, Freeman Z, Sharp M, Phillips H, McCrory E. Heightened response to positive facial cues as a potential marker of resilience following childhood adversity. European Journal Of Psychotraumatology 2024, 15: 2309783. PMID: 38318813, PMCID: PMC10849006, DOI: 10.1080/20008066.2024.2309783.Peer-Reviewed Original ResearchConceptsFacial cuesMaltreatment experiencesPresence of social supportSocial supportLow symptomsAssociated with lower symptomsThreat-related cuesPositive social cuesIncreased psychiatric riskPerceived emotional intensityMarkers of resilienceChildhood maltreatment experiencesNo group differencesMental health symptomsLevels of social supportPerceived social supportAssociated with better mental healthMental health vulnerabilitiesMental health outcomesBetter mental healthExperiences of abusePerceived intensityHappy facesChildhood maltreatmentImplicit processes
2023
A systematic review of childhood maltreatment and resting state functional connectivity
Gerin M, Viding E, Herringa R, Russell J, McCrory E. A systematic review of childhood maltreatment and resting state functional connectivity. Developmental Cognitive Neuroscience 2023, 64: 101322. PMID: 37952287, PMCID: PMC10665826, DOI: 10.1016/j.dcn.2023.101322.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityAnterior cingulate cortexFunctional connectivityCingulate cortexChildhood maltreatmentAltered functional connectivityState functional connectivityDorsal anterior cingulate cortexNegative psychiatric outcomesVentral anterior cingulate cortexDorsolateral prefrontal cortexRsFC alterationsAltered connectivityInclusion criteriaAmygdala connectivityNineteen studiesPsychiatric outcomesFuture symptomsSystematic reviewBrain regionsClinical disordersBrain circuitsAnterior insulaPrefrontal cortexMaltreatment exposure
2022
Social thinning and stress generation after childhood maltreatment: a neurocognitive social transactional model of psychiatric vulnerability
McCrory E, Foulkes L, Viding E. Social thinning and stress generation after childhood maltreatment: a neurocognitive social transactional model of psychiatric vulnerability. The Lancet Psychiatry 2022, 9: 828-837. PMID: 35926524, DOI: 10.1016/s2215-0366(22)00202-4.Peer-Reviewed Original ResearchConceptsTransactional modelChildhood maltreatmentNeurocognitive alterationsPsychiatric disordersQuantity of relationshipsIndividual's social networkSocial functioningSocial architecturePsychiatric vulnerabilityMaltreatmentSocial environmentExtant evidencePsychiatric riskNeurocognitive sequelaeSocial processesStress generationSocial networksDisorders
2021
Functional brain plasticity following childhood maltreatment: A longitudinal fMRI investigation of autobiographical memory processing.
Puetz V, Viding E, Maguire E, Mechelli A, Armbruster-Genç D, Sharp M, Rankin G, Gerin M, McCrory E. Functional brain plasticity following childhood maltreatment: A longitudinal fMRI investigation of autobiographical memory processing. Development And Psychopathology 2021, 35: 1382-1389. PMID: 34924093, DOI: 10.1017/s0954579421001292.Peer-Reviewed Original ResearchConceptsChildhood maltreatmentAutobiographical memory processingCortical midline structuresValenced cue wordsPotential developmental plasticityCue wordsMemory processingFMRI studyBOLD signal changesNeural functioningPsychological assessmentBrain networksMaltreatmentMidline structuresMaturational changesLongitudinal analysisProcessingSignal changesFMRIPsychopathologyRecallAdolescentsFunctioningWordsDevelopmental plasticityTrust and childhood maltreatment: evidence of bias in appraisal of unfamiliar faces
Neil L, Viding E, Armbruster‐Genc D, Lisi M, Mareschal I, Rankin G, Sharp M, Phillips H, Rapley J, Martin P, McCrory E. Trust and childhood maltreatment: evidence of bias in appraisal of unfamiliar faces. Journal Of Child Psychology And Psychiatry 2021, 63: 655-662. PMID: 34500497, DOI: 10.1111/jcpp.13503.Peer-Reviewed Original ResearchConceptsTrust processingUnfamiliar facesChildhood maltreatmentPoor social functioningMental health difficultiesMental health problemsFacial stimuliCognitive abilitiesTrust judgmentsTrust attributionTrustworthiness dimensionsCommunity-based sampleSocial service recordsSocial functioningMaltreatment experiencesHealth difficultiesChild maltreatmentMaltreatmentSocial bondsAtypical patternsPeersEvidence of biasChildrenSocioeconomic statusProcessing
2020
The case for a preventative approach to mental health: Childhood maltreatment, neuroimaging, and the theory of latent vulnerability
McCrory E. The case for a preventative approach to mental health: Childhood maltreatment, neuroimaging, and the theory of latent vulnerability. 2020, 175-189. DOI: 10.1093/med/9780198789697.003.0011.Peer-Reviewed Original ResearchPsychiatric disordersChildhood maltreatmentFuture psychiatric disordersMagnetic resonance imaging researchClinical studiesLatent vulnerabilityClinical approachFunctional magnetic resonance imaging (fMRI) researchEarly adverse environmentsAltered functioningMental healthDisordersPreventative approachMaltreatmentImaging researchAutobiographical memory as a latent vulnerability mechanism following childhood maltreatment: Association with future depression symptoms and prosocial behavior
Puetz V, Viding E, Hoffmann F, Gerin M, Sharp M, Rankin G, Maguire E, Mechelli A, McCrory E. Autobiographical memory as a latent vulnerability mechanism following childhood maltreatment: Association with future depression symptoms and prosocial behavior. Development And Psychopathology 2020, 33: 1300-1307. PMID: 32573399, DOI: 10.1017/s0954579420000504.Peer-Reviewed Original ResearchConceptsOvergeneral memoryProsocial behaviorChildhood maltreatmentAutobiographical memory recallAutobiographical Memory TestSocio-emotional functioningPsycho-social functioningValenced cue wordsPoor social functioningSample of adolescentsFuture depression symptomsDepressive symptomsChildhood maltreatment historyTrend-level associationCognitive mechanismsCue wordsNeural reactivityAutobiographical memoryMemory testMemory recallVulnerability mechanismsBrain activitySocial functioningElevated depressive symptomsMaltreatment history
2019
A review of childhood maltreatment, latent vulnerability and the brain: implications for clinical practice and prevention
Gerin M, Hanson E, Viding E, McCrory E. A review of childhood maltreatment, latent vulnerability and the brain: implications for clinical practice and prevention. Adoption & Fostering 2019, 43: 310-328. DOI: 10.1177/0308575919865356.Peer-Reviewed Original ResearchMental health problemsLatent vulnerabilityNeurocognitive alterationsChildhood maltreatmentFuture mental health problemsEarly adverse environmentsCommon mental health problemsEmotion regulationThreat processingExecutive controlNeurocognitive systemsHealth problemsPoor mental healthReward processingMaltreated childrenFunctional neuroimagingFuture psychopathologyChild maltreatmentMental healthMaltreatmentLong-term outcomesSuch experiencesFunctioningClinical implicationsChildrenGhosts in the Nursery: An Experimental Investigation of a Parent’s Own Maltreatment Experience, Attention to Infant Faces, and Dyadic Reciprocity
Thompson-Booth C, Viding E, Puetz VB, Rutherford HJV, Mayes LC, McCrory EJ. Ghosts in the Nursery: An Experimental Investigation of a Parent’s Own Maltreatment Experience, Attention to Infant Faces, and Dyadic Reciprocity. Emotion 2019, 19: 1093-1102. PMID: 30234333, DOI: 10.1037/emo0000464.Peer-Reviewed Original ResearchConceptsInfant facesChildhood maltreatmentAttentional processingDyadic reciprocityLower attentional biasVisual search taskAttentional biasEmotional cuesCognitive processingPreferential processingInfant affectParenting behaviorsInfant cuesSearch taskAn Experimental InvestigationCommunity sampleMaltreatment experiencesMaltreatmentPreferential biasOwn childrenCuesExploratory analysisProcessingFaceImportant implicationsInvestigating patterns of neural response associated with childhood abuse v. childhood neglect
Puetz V, Viding E, Gerin M, Pingault J, Sethi A, Knodt A, Radtke S, Brigidi B, Hariri A, McCrory E. Investigating patterns of neural response associated with childhood abuse v. childhood neglect. Psychological Medicine 2019, 50: 1398-1407. PMID: 31190662, DOI: 10.1017/s003329171900134x.Peer-Reviewed Original ResearchConceptsNeural reactivityThreat reactivityMaltreatment experiencesChildhood abuseChildhood maltreatmentHigher-order cortical regionsFronto-parietal networkEffects of abuseChildhood abuse experiencesExperiences of neglectPoor mental health outcomesEffects of neglectChildhood maltreatment experiencesMental health outcomesExperiences of abuseCognitive processingBrain imaging analysisFacial cuesNeural responsesNeglect experiencesDifferential effectsAbuse experiencesChildhood neglectDorsal amygdalaVentral amygdalaHeightened amygdala reactivity and increased stress generation predict internalizing symptoms in adults following childhood maltreatment
Gerin M, Viding E, Pingault J, Puetz V, Knodt A, Radtke S, Brigidi B, Swartz J, Hariri A, McCrory E. Heightened amygdala reactivity and increased stress generation predict internalizing symptoms in adults following childhood maltreatment. Journal Of Child Psychology And Psychiatry 2019, 60: 752-761. PMID: 30933355, PMCID: PMC6594878, DOI: 10.1111/jcpp.13041.Peer-Reviewed Original ResearchConceptsMajor stressful life eventsStressful life eventsAmygdala reactivityChildhood maltreatmentLife eventsInternalizing disordersBaseline internalizing symptomsInternalizing symptomsHistory of maltreatmentThreat-related amygdala reactivityDevelopmental insultsPsychiatric riskPropensity scoreSymptomsFuture internalizing symptomsStress exposureMental healthYoung adultsSeverity 1Socioeconomic statusFuture psychopathologyPotent predictorSuch alterationsNonmaltreated peersMaltreatment statusEvidence of concurrent and prospective associations between early maltreatment and ADHD through childhood and adolescence
González R, Vélez-Pastrana M, McCrory E, Kallis C, Aguila J, Canino G, Bird H. Evidence of concurrent and prospective associations between early maltreatment and ADHD through childhood and adolescence. Social Psychiatry And Psychiatric Epidemiology 2019, 54: 671-682. PMID: 30903235, DOI: 10.1007/s00127-019-01659-0.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderADHD diagnosisEarly maltreatmentFoster placementPhysical abuseADHD medication statusRole of maltreatmentLongitudinal studyProspective associationsLikelihood of ADHDPuerto Rican backgroundHyperactivity disorderChildren-IVBoricua Youth StudyParental psychopathologyFamily environmentMaltreatment experiencesEmotional abuseMaltreatment exposureRisk of ADHDSexual abuseDisorder persistenceChildhood maltreatmentDiagnostic Interview ScheduleInitial evidenceNeurocognitive Adaptation and Mental Health Vulnerability Following Maltreatment: The Role of Social Functioning
McCrory E, Ogle J, Gerin M, Viding E. Neurocognitive Adaptation and Mental Health Vulnerability Following Maltreatment: The Role of Social Functioning. Child Maltreatment 2019, 24: 435-451. PMID: 30897955, DOI: 10.1177/1077559519830524.Peer-Reviewed Original ResearchConceptsSocial functioningEarly maltreatment experiencesMental health vulnerabilitiesMental health problemsNeurocognitive adaptationsEmotion regulationThreat processingStudy of childrenReward processingComputational psychiatryMental health disordersMaltreatment experiencesLatent vulnerabilityChildhood maltreatmentSocial supportFunctioningHealth disordersNeural functionMaltreatmentHealth vulnerabilityProcessingHealth problemsVulnerabilityKey findingsAdolescents
2017
Characterising youth with callous–unemotional traits and concurrent anxiety: evidence for a high-risk clinical group
Cecil C, McCrory E, Barker E, Guiney J, Viding E. Characterising youth with callous–unemotional traits and concurrent anxiety: evidence for a high-risk clinical group. European Child & Adolescent Psychiatry 2017, 27: 885-898. PMID: 29222633, PMCID: PMC6013514, DOI: 10.1007/s00787-017-1086-8.Peer-Reviewed Original ResearchConceptsCallous-unemotional traitsTrauma historyHigh callous-unemotional traitsCo-occurring anxietyGreater attachment insecurityLevels of irritabilityHigh-risk youthSevere childhood maltreatmentAttachment insecurityADHD symptomatologyAttachment styleAffective functioningCU traitsPsychological distressAntisocial behaviorCommunity sampleAffective dysregulationHigh anxietyChildhood maltreatmentConcurrent anxietyClinical groupsSubstance useAnxietyPsychiatric symptomatologyYouthThe Neuroscience and Genetics of Childhood Maltreatment
McCrory E, Puetz V, Viding E. The Neuroscience and Genetics of Childhood Maltreatment. 2017, 187-194. DOI: 10.1002/9781119170235.ch22.Peer-Reviewed Original ResearchPost-traumatic stress disorderChildhood maltreatmentHigher cognitive abilitiesStudy of childrenCognitive abilitiesEmotional processesInter-hemispheric communicationBody of researchAspects of behaviorStress disorderPrefrontal cortexSmaller hippocampal volumesBrain functionMaltreatmentBrain structuresSubcortical regionsNeural structuresHippocampal volumeCorpus callosumHost of processesWhite matter structuresLargest white matter structureNumber of studiesMatter structuresEmotionsThe Neurobiology and Genetics of Childhood Maltreatment
McCrory E, Palmer A, Puetz V. The Neurobiology and Genetics of Childhood Maltreatment. 2017, 85-96. DOI: 10.1002/9781118976111.ch6.Peer-Reviewed Original ResearchChildhood maltreatmentMaladaptive outcomesMagnetic resonance imagingBrain structuresKey brain structuresEmotion processingStudy of childrenPoor physical healthMaltreatment experiencesPhysical healthRegulation processesBrain functionMaltreatmentIndividual's lifePsychiatric disordersResonance imagingClinical implicationsGenetic factorsOutcomesMemoryNeurobiologyFindingsChildrenProcessingAnnual Research Review: Childhood maltreatment, latent vulnerability and the shift to preventative psychiatry – the contribution of functional brain imaging
McCrory E, Gerin M, Viding E. Annual Research Review: Childhood maltreatment, latent vulnerability and the shift to preventative psychiatry – the contribution of functional brain imaging. Journal Of Child Psychology And Psychiatry 2017, 58: 338-357. PMID: 28295339, PMCID: PMC6849838, DOI: 10.1111/jcpp.12713.Peer-Reviewed Original ResearchConceptsAnterior cingulate cortexLatent vulnerabilityEmotion regulationThreat processingReward processingChildhood maltreatmentActive emotion regulationDorsal ACC activityReceipt of rewardAdverse caregiving environmentsFuture psychiatric disordersPsychiatric disordersFunctional brain imagingEffective preventative approachesEffortful processingExecutive controlStudy of childrenError monitoringPoor mental healthNeurocognitive domainsNeurocognitive functioningCaregiving environmentNeural responsesEarly neglectNeural responsiveness
2015
Exploring the Relationship Between Childhood Maltreatment and Addiction: A Review of the Neurocognitive Evidence
Puetz V, McCrory E. Exploring the Relationship Between Childhood Maltreatment and Addiction: A Review of the Neurocognitive Evidence. Current Addiction Reports 2015, 2: 318-325. PMID: 26550550, PMCID: PMC4628081, DOI: 10.1007/s40429-015-0073-8.Peer-Reviewed Original ResearchSubstance use disordersChildhood maltreatmentSeverity of illnessSevere clinical presentationClinical presentationPsychiatric disordersUse disordersBrain structuresHistory of maltreatmentDisordersAdultsRiskExecutive functioningMaltreatmentAlterationsNeurocognitive systemsSalient stimuliLatent vulnerabilityIllnessRisk environmentImpairmentThe theory of latent vulnerability: Reconceptualizing the link between childhood maltreatment and psychiatric disorder
McCrory E, Viding E. The theory of latent vulnerability: Reconceptualizing the link between childhood maltreatment and psychiatric disorder. Development And Psychopathology 2015, 27: 493-505. PMID: 25997767, DOI: 10.1017/s0954579415000115.Peer-Reviewed Original ResearchConceptsPsychiatric disordersMental health problemsLatent vulnerabilityPsychiatric riskHealth problemsClinical interventionsDisordersNeurocognitive domainsPrevention approachesChildhood maltreatmentIntervention opportunitiesRisk trajectoriesPsychiatry approachMemory processingInterventionThreat processingChildrenRiskVulnerable childrenMaltreatmentLong termLife spanRisk environmentMaltreating environment