2023
A systematic review of childhood maltreatment and resting state functional connectivity
Gerin M, Viding E, Herringa R, Russell J, McCrory E. A systematic review of childhood maltreatment and resting state functional connectivity. Developmental Cognitive Neuroscience 2023, 64: 101322. PMID: 37952287, PMCID: PMC10665826, DOI: 10.1016/j.dcn.2023.101322.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityAnterior cingulate cortexFunctional connectivityCingulate cortexChildhood maltreatmentAltered functional connectivityState functional connectivityDorsal anterior cingulate cortexNegative psychiatric outcomesVentral anterior cingulate cortexDorsolateral prefrontal cortexRsFC alterationsAltered connectivityInclusion criteriaAmygdala connectivityNineteen studiesPsychiatric outcomesFuture symptomsSystematic reviewBrain regionsClinical disordersBrain circuitsAnterior insulaPrefrontal cortexMaltreatment exposure
2018
An fMRI investigation of empathic processing in boys with conduct problems and varying levels of callous-unemotional traits
Sethi A, O'Nions E, McCrory E, Bird G, Viding E. An fMRI investigation of empathic processing in boys with conduct problems and varying levels of callous-unemotional traits. NeuroImage Clinical 2018, 18: 298-304. PMID: 29876250, PMCID: PMC5987797, DOI: 10.1016/j.nicl.2018.01.027.Peer-Reviewed Original ResearchConceptsCP/HCUMedial prefrontal cortexCallous-unemotional traitsConduct problemsOwn emotionsAnterior cingulate cortexAnterior insulaEmpathic processingAffective experienceConjunction analysisACC/medial prefrontal cortexBrain areasBayes factor analysisEmpathy deficitsFMRI investigationTD groupNeural responsesConjunction effectOne's feelingsLess empathyEmotionsPrefrontal cortexNeutral scenarioCingulate cortexOccipital cortex
2017
Risk-taking, peer-influence and child maltreatment: A neurocognitive investigation
Hoffmann F, Puetz V, Viding E, Sethi A, Palmer A, McCrory E. Risk-taking, peer-influence and child maltreatment: A neurocognitive investigation. Social Cognitive And Affective Neuroscience 2017, 13: nsx124-. PMID: 29069467, PMCID: PMC5793726, DOI: 10.1093/scan/nsx124.Peer-Reviewed Original ResearchConceptsRight anterior insulaMT groupBalloon Analogue Risk TaskMore anxiety symptomsPsychiatric disordersAnterior insulaFuture psychopathologyAnxiety symptomsChildrenDifferential effectsNeural correlatesNeurocognitive investigationsRisk-taking behaviorPeer influenceChild maltreatmentRiskGroupNeural levelMaltreatmentRisk TaskSymptomsInsulaReduced Laughter Contagion in Boys at Risk for Psychopathy
O’Nions E, Lima C, Scott S, Roberts R, McCrory E, Viding E. Reduced Laughter Contagion in Boys at Risk for Psychopathy. Current Biology 2017, 27: 3049-3055.e4. PMID: 28966092, PMCID: PMC5640510, DOI: 10.1016/j.cub.2017.08.062.Peer-Reviewed Original ResearchConceptsAntisocial behaviorNeural responsesAnterior insula responseAuditory-motor processingImportance of affiliationSupplementary motor areaAtypical processingNeurocognitive processesAction tendenciesInsula responseEmotional experienceHuman laughterAnterior insulaSocial reciprocityMotor readinessPsychopathic traitsAffiliative bondsSocial affiliationPremotor regionsEmotional resonanceSocial behaviorMotor areaSubjective feelingsBehavioral profileSocial animals
2016
Anticipation of guilt for everyday moral transgressions: The role of the anterior insula and the influence of interpersonal psychopathic traits
Seara-Cardoso A, Sebastian C, McCrory E, Foulkes L, Buon M, Roiser J, Viding E. Anticipation of guilt for everyday moral transgressions: The role of the anterior insula and the influence of interpersonal psychopathic traits. Scientific Reports 2016, 6: 36273. PMID: 27808160, PMCID: PMC5093734, DOI: 10.1038/srep36273.Peer-Reviewed Original ResearchConceptsAnticipation of guiltEveryday moral transgressionsPsychopathic traitsAnterior insulaMoral transgressionsInterpersonal psychopathic traitsPattern of findingsNeurocognitive mechanismsMotivational processingMoral emotionsNeural responsesAntisocial behaviorMoral behaviorSocial normsGuiltInsulaPersonality disorderSecond sampleAnticipationHigh levelsSignificant interactionWrongnessTransgressionEmotionsTraits
2013
Association of Callous Traits with Reduced Neural Response to Others’ Pain in Children with Conduct Problems
Lockwood P, Sebastian C, McCrory E, Hyde Z, Gu X, De Brito S, Viding E. Association of Callous Traits with Reduced Neural Response to Others’ Pain in Children with Conduct Problems. Current Biology 2013, 23: 901-905. PMID: 23643836, PMCID: PMC3918856, DOI: 10.1016/j.cub.2013.04.018.Peer-Reviewed Original ResearchConceptsAnterior cingulate cortexFunctional magnetic resonance imagingConduct problemsNeural responsesAnterior insulaCallous traitsAdult psychopathyReduced blood oxygen level-dependent responsesAtypical neural responsesBlood oxygen level-dependent (BOLD) responseInferior frontal gyrusBilateral anterior insulaLevel-dependent responsesConsiderable societal costsEmpathic processingEmpathic deficitsEmpathic responsesFrontal gyrusAntisocial behaviorCingulate cortexACC responseEmpathyLarge samplePsychopathyNegative association
2012
Neural Responses to Affective and Cognitive Theory of Mind in Children With Conduct Problems and Varying Levels of Callous-Unemotional Traits
Sebastian C, McCrory E, Cecil C, Lockwood P, De Brito S, Fontaine N, Viding E. Neural Responses to Affective and Cognitive Theory of Mind in Children With Conduct Problems and Varying Levels of Callous-Unemotional Traits. JAMA Psychiatry 2012, 69: 814-822. PMID: 22868935, DOI: 10.1001/archgenpsychiatry.2011.2070.Peer-Reviewed Original ResearchConceptsCallous-unemotional traitsAffective processing taskConduct problemsNeural responsesCognitive theoryMind judgmentsUnique varianceAffective profilesAmygdala reactivityEmpathy componentsProcessing tasksAffective neural responsesDepression/anxiety symptomsConduct problem symptomsFunctional magnetic resonancePotential neural substratesConduct problem groupChildhood conduct problemsAffective stimuliNeural processingNeural substratesAnterior insulaUnemotional TraitsAnxiety symptomsRight amygdala
2011
Heightened neural reactivity to threat in child victims of family violence
McCrory E, De Brito S, Sebastian C, Mechelli A, Bird G, Kelly P, Viding E. Heightened neural reactivity to threat in child victims of family violence. Current Biology 2011, 21: r947-r948. PMID: 22153160, DOI: 10.1016/j.cub.2011.10.015.Peer-Reviewed Original ResearchConceptsAnterior insulaFamily violenceFunctional magnetic resonance imaging studyFunctional magnetic resonance imaging (fMRI) researchNeurobiological risk factorsMagnetic resonance imaging researchAngry cuesMagnetic resonance imaging studyAngry facesThreat cuesSad facesNeural reactivityResonance imaging studyEmotional processingNeural correlatesAmygdala reactivityLater psychopathologyChild victimsAnxiety disordersMaltreatment experiencesPhysical abuseImaging researchPsychopathologyCuesAnxiety