2003
The Effects of the Potassium Channel Opener Minoxidil on Renal Electrolytes Transport in the Loop of Henle
Wang T. The Effects of the Potassium Channel Opener Minoxidil on Renal Electrolytes Transport in the Loop of Henle. Journal Of Pharmacology And Experimental Therapeutics 2003, 304: 833-840. PMID: 12538840, DOI: 10.1124/jpet.102.043380.Peer-Reviewed Original ResearchConceptsLoop of HenleUrine volumePotassium channel opener minoxidilATP-sensitive potassium channelsChannel opener minoxidilK channel openerGlomerular filtration rateRenal electrolyte transportAddition of minoxidilThick ascending limbVivo microperfusion techniquesAntinatriuretic actionNatriuretic effectBlood pressureUrinary excretionFiltration rateChannel openersIntravenous injectionRenal clearanceAscending limbK cotransporterPerfusion fluidMinoxidilMicroperfusion techniqueHenle
2002
Role of iNOS and eNOS in modulating proximal tubule transport and acid-base balance
Wang T. Role of iNOS and eNOS in modulating proximal tubule transport and acid-base balance. American Journal Of Physiology. Renal Physiology 2002, 283: f658-f662. PMID: 12217856, DOI: 10.1152/ajprenal.00243.2001.Peer-Reviewed Original ResearchConceptsNeuronal nitric oxide synthaseInducible NOSEndothelial NOSProximal tubulesKnockout miceRole of iNOSNOS knockout miceENOS knockout miceINOS knockout miceIsoforms of NOSNitric oxide synthaseProximal tubule transportAcid-base statusAcid-base balanceINOS knockoutWild-type controlsKidney proximal tubulesMetabolic acidosisOxide synthaseTubule transportInhibitor LMiceFluid absorptionNOSTubules
2000
Defective fluid and HCO3 − absorption in proximal tubule of neuronal nitric oxide synthase-knockout mice
Wang T, Inglis F, Kalb R. Defective fluid and HCO3 − absorption in proximal tubule of neuronal nitric oxide synthase-knockout mice. American Journal Of Physiology. Renal Physiology 2000, 279: f518-f524. PMID: 10966931, DOI: 10.1152/ajprenal.2000.279.3.f518.Peer-Reviewed Original ResearchMeSH KeywordsAcid-Base EquilibriumAnimalsBicarbonatesBiological TransportBlood Gas AnalysisBody FluidsElectrolytesEnzyme InhibitorsInjections, IntravenousKidney Tubules, ProximalMiceMice, Inbred C57BLMice, KnockoutNG-Nitroarginine Methyl EsterNitric Oxide SynthaseNitric Oxide Synthase Type IPotassiumSodiumConceptsWild-type miceNNOS knockout miceL-NAMEProximal tubulesBlood pressureMetabolic acidosisNeuronal nitric oxide synthase knockout miceNitric oxide synthase knockout miceAbsorption of fluidFluid absorptionNeuronal nitric oxide synthaseRenal clearance techniquesMean blood pressureSignificant metabolic acidosisSynthase knockout miceMonomethyl-L-arginine methyl esterNitric oxide synthaseWild-type control animalsProximal tubule transportLuminal perfusion solutionAcid-base balanceIntravenous bolusUrinary excretionUrine volumeClearance technique
1996
Effects of angiotensin II on electrolyte transport in the early and late distal tubule in rat kidney
Wang T, Giebisch G. Effects of angiotensin II on electrolyte transport in the early and late distal tubule in rat kidney. American Journal Of Physiology 1996, 271: f143-f149. PMID: 8760255, DOI: 10.1152/ajprenal.1996.271.1.f143.Peer-Reviewed Original ResearchConceptsLate distal tubuleEarly distal tubuleAng IIDistal tubulesRat kidneyAng II receptor antagonistsAngiotensin II stimulatesAngiotensin receptor blockersII receptor antagonistsInitial collecting tubuleLuminal administrationCortical nephronsAngiotensin IIIntravenous infusionReceptor antagonistTubular perfusateDistal nephronLuminal applicationCollecting tubuleProximal tubulesSeparate perfusionHigh dosesLow dosesHormone effectsNephron segments
1995
Effects of chronic hyperfiltration on proximal tubule bicarbonate transport and cell electrolytes
Ohno A, Beck F, Pfaller W, Giebisch G, Wang T. Effects of chronic hyperfiltration on proximal tubule bicarbonate transport and cell electrolytes. Kidney International 1995, 48: 712-721. PMID: 7474656, DOI: 10.1038/ki.1995.342.Peer-Reviewed Original ResearchConceptsNa/H exchangeProximal tubulesUNX ratsK-ATPase activityBicarbonate absorptionBicarbonate transportChronic hyperfiltrationRemnant kidneyUnilateral nephrectomyFiltration rateCortical tubulesRenal clearanceBicarbonate levelsH secretionFluid absorptionMaximal transport rateBasolateral ion transportCompensatory responseMarked stimulationRubidium uptakeSimilar stimulationCell ion concentrationsBasolateral NaTubulesUNX