2021
Sex difference in kidney electrolyte transport III: Impact of low K intake on thiazide-sensitive cation excretion in male and female mice
Xu S, Li J, Yang L, Wang CJ, Liu T, Weinstein AM, Palmer LG, Wang T. Sex difference in kidney electrolyte transport III: Impact of low K intake on thiazide-sensitive cation excretion in male and female mice. Pflügers Archiv - European Journal Of Physiology 2021, 473: 1749-1760. PMID: 34455480, PMCID: PMC8528772, DOI: 10.1007/s00424-021-02611-5.Peer-Reviewed Original ResearchConceptsGlomerular filtration rateFemale miceUrine volumeNaCl cotransporterLow K intakeMeasurement of functionSex differencesNatriuretic responseFractional excretionK intakeTransport protein expressionFiltration rateNCC abundanceNCC expressionRenal clearanceDistal nephronLK dietCation excretionPlasma KNCC proteinNKCC2 expressionWestern blottingProtein expressionMiceFENa
2011
GENDER DIFFERENCE IN MODULATION OF ANGIOTENSIN II TYPE 2 RECEPTOR (AT2) FUNCTION AND EXPRESSION IN AT1A RECEPTOR‐DEFICIENT MICE
Yan Q, Wan L, Du Z, Gotoh N, Wang T. GENDER DIFFERENCE IN MODULATION OF ANGIOTENSIN II TYPE 2 RECEPTOR (AT2) FUNCTION AND EXPRESSION IN AT1A RECEPTOR‐DEFICIENT MICE. The FASEB Journal 2011, 25: 835.9-835.9. DOI: 10.1096/fasebj.25.1_supplement.835.9.Peer-Reviewed Original ResearchGlomerular filtration rateUrine volumeAT2 receptorsProximal tubulesAT1A receptor-deficient miceNull miceExpression levelsReceptor-deficient miceKidneys of malesFemale null miceMale null miceAT2 inhibitorNatriuretic effectRenal functionAT2 expressionWT miceFiltration rateBolus injectionReal-time PCRRenal clearancePD123319ENaC expressionReceptor functionMiceReceptors
2010
Altered renal proximal tubular endocytosis and histology in mice lacking myosin‐VI
Gotoh N, Yan Q, Du Z, Biemesderfer D, Kashgarian M, Mooseker MS, Wang T. Altered renal proximal tubular endocytosis and histology in mice lacking myosin‐VI. Cytoskeleton 2010, 67: 178-192. PMID: 20175219, PMCID: PMC3468331, DOI: 10.1002/cm.20435.Peer-Reviewed Original ResearchMeSH KeywordsActinsAdaptor Proteins, Signal TransducingAdaptor Proteins, Vesicular TransportAnimalsApoptosis Regulatory ProteinsCell TransdifferentiationEndocytosisHorseradish PeroxidaseKidney Tubules, ProximalLow Density Lipoprotein Receptor-Related Protein-2MiceMice, Neurologic MutantsMicrofilament ProteinsMicrovilliMyosin Heavy ChainsVesicular Transport ProteinsConceptsProximal tubule cellsAlbumin excretionSv miceTubule cellsProximal tubule brush borderGlomerular flow rateProximal tubular dilationUrinary albumin excretionElevated blood pressureReduced body weightProximal tubular endocytosisRenal proximal tubule brush borderTubule brush borderProximal tubular uptakeBlood acid-base parametersMouse kidney proximal tubulesKidney proximal tubulesBlood pressureUrine volumeUrinary excretionAcid-base parametersRenal homogenatesTubular dilationPlasma concentrationsRenal clearance
2007
Blocking angiotensin II type 2 receptor (AT2) induces diuresis and natriuresis in AT1A receptor‐deficient mice
Yan Q, Du Z, Duan Y, Weinbaum S, Weinstein A, Wang T. Blocking angiotensin II type 2 receptor (AT2) induces diuresis and natriuresis in AT1A receptor‐deficient mice. The FASEB Journal 2007, 21: a1246-a1246. DOI: 10.1096/fasebj.21.6.a1246-c.Peer-Reviewed Original ResearchMean arterial blood pressureGlomerular filtration rateAT1A receptor-deficient miceReceptor-deficient miceUrine volumeAT2 receptorsLower mean arterial blood pressureAngiotensin II type 2 receptorAdministration of PD123319Renin-angiotensin systemArterial blood pressureType 2 receptorBlocker PD123319Blood pressureIntravenous bolusFiltration rateKO miceRenal handlingRenal clearancePD123319Receptor functionFluid homeostasisWater handlingReceptorsMice
2003
The Effects of the Potassium Channel Opener Minoxidil on Renal Electrolytes Transport in the Loop of Henle
Wang T. The Effects of the Potassium Channel Opener Minoxidil on Renal Electrolytes Transport in the Loop of Henle. Journal Of Pharmacology And Experimental Therapeutics 2003, 304: 833-840. PMID: 12538840, DOI: 10.1124/jpet.102.043380.Peer-Reviewed Original ResearchConceptsLoop of HenleUrine volumePotassium channel opener minoxidilATP-sensitive potassium channelsChannel opener minoxidilK channel openerGlomerular filtration rateRenal electrolyte transportAddition of minoxidilThick ascending limbVivo microperfusion techniquesAntinatriuretic actionNatriuretic effectBlood pressureUrinary excretionFiltration rateChannel openersIntravenous injectionRenal clearanceAscending limbK cotransporterPerfusion fluidMinoxidilMicroperfusion techniqueHenle
1997
Nitric oxide regulates HCO3- and Na+ transport by a cGMP-mediated mechanism in the kidney proximal tubule
Wang T. Nitric oxide regulates HCO3- and Na+ transport by a cGMP-mediated mechanism in the kidney proximal tubule. American Journal Of Physiology 1997, 272: f242-f248. PMID: 9124402, DOI: 10.1152/ajprenal.1997.272.2.f242.Peer-Reviewed Original ResearchConceptsSodium nitroprussideProximal tubulesKidney proximal tubulesBlood pressureL-NAMENitric oxideNitro-L-arginine methyl esterNitric oxide synthase inhibitorGlomerular filtration rateOxide synthase inhibitorGuanylate cyclase inhibitorUrine flow rateMicroM sodium nitroprussideRenal hemodynamicsFiltration rateRenal excretionRenal clearanceSynthase inhibitorCyclase inhibitorLuminal perfusateRat kidneyMicroperfusion techniqueStimulatory effectSimilar stimulationCyclic monophosphate
1995
Effects of chronic hyperfiltration on proximal tubule bicarbonate transport and cell electrolytes
Ohno A, Beck F, Pfaller W, Giebisch G, Wang T. Effects of chronic hyperfiltration on proximal tubule bicarbonate transport and cell electrolytes. Kidney International 1995, 48: 712-721. PMID: 7474656, DOI: 10.1038/ki.1995.342.Peer-Reviewed Original ResearchConceptsNa/H exchangeProximal tubulesUNX ratsK-ATPase activityBicarbonate absorptionBicarbonate transportChronic hyperfiltrationRemnant kidneyUnilateral nephrectomyFiltration rateCortical tubulesRenal clearanceBicarbonate levelsH secretionFluid absorptionMaximal transport rateBasolateral ion transportCompensatory responseMarked stimulationRubidium uptakeSimilar stimulationCell ion concentrationsBasolateral NaTubulesUNXEffects of Glyburide on Renal Tubule Transport and Potassium-Channel Activity
Wang T, Wang W, Klein-Robbenhaar G, Giebisch G. Effects of Glyburide on Renal Tubule Transport and Potassium-Channel Activity. Kidney & Blood Pressure Research 1995, 18: 169-182. PMID: 7481068, DOI: 10.1159/000173914.Peer-Reviewed Original ResearchConceptsThick ascending limbRenal tubule transportEffects of glyburideCortical collecting tubuleK channel activityPatch-clamp techniqueApical K channelsPotassium channel activityElectrolyte excretionRenal clearanceK secretionTubule transportCollecting tubuleAscending limbGlyburideApical membraneK channelsK recyclingTransport of NaKaliuresis