Secondary Faculty Publications

Seo YE, Suh HW, Bahal R, Josowitz A, Zhang J, Song E, Cui J, Noorbakhsh S, Jackson C, Bu T, Piotrowski-Daspit A, Bindra R, Saltzman WM: Nanoparticle-mediated intratumoral inhibition of miR-21 for improved survival in glioblastoma. Biomaterials. 2019 May; 2019 Feb 14. PMID: 30802686

Barahona MJ, Baratta V, Ollodart J, Mulligan D, Geibel JP: Design and implementation of novel nutraceuticals and derivatives for treating intestinal disorders. Future Med Chem. 2019 Apr 17; 2019 Apr 17. PMID: 30994367

Ferreira MA, Gamazon ER, Al-Ejeh F, Aittomäki K, Andrulis IL, Anton-Culver H, Arason A, Arndt V, Aronson KJ, Arun BK, Asseryanis E, Azzollini J, Balmaña J, Barnes DR, Barrowdale D, Beckmann MW, Behrens S, Benitez J, Bermisheva M, Białkowska K, Blomqvist C, Bogdanova NV, Bojesen SE, Bolla MK, Borg A, Brauch H, Brenner H, Broeks A, Burwinkel B, Caldés T, Caligo MA, Campa D, Campbell I, Canzian F, Carter J, Carter BD, Castelao JE, Chang-Claude J, Chanock SJ, Christiansen H, Chung WK, Claes KBM, Clarke CL, EMBRACE Collaborators., GC-HBOC Study Collaborators., GEMO Study Collaborators., Couch FJ, Cox A, Cross SS, Czene K, Daly MB, de la Hoya M, Dennis J, Devilee P, Diez O, Dörk T, Dunning AM, Dwek M, Eccles DM, Ejlertsen B, Ellberg C, Engel C, Eriksson M, Fasching PA, Fletcher O, Flyger H, Friedman E, Frost D, Gabrielson M, Gago-Dominguez M, Ganz PA, Gapstur SM, Garber J, García-Closas M, García-Sáenz JA, Gaudet MM, Giles GG, Glendon G, Godwin AK, Goldberg MS, Goldgar DE, González-Neira A, Greene MH, Gronwald J, Guénel P, Haiman CA, Hall P, Hamann U, He W, Heyworth J, Hogervorst FBL, Hollestelle A, Hoover RN, Hopper JL, Hulick PJ, Humphreys K, Imyanitov EN, ABCTB Investigators., HEBON Investigators., BCFR Investigators., Isaacs C, Jakimovska M, Jakubowska A, James PA, Janavicius R, Jankowitz RC, John EM, Johnson N, Joseph V, Karlan BY, Khusnutdinova E, Kiiski JI, Ko YD, Jones ME, Konstantopoulou I, Kristensen VN, Laitman Y, Lambrechts D, Lazaro C, Leslie G, Lester J, Lesueur F, Lindström S, Long J, Loud JT, Lubiński J, Makalic E, Mannermaa A, Manoochehri M, Margolin S, Maurer T, Mavroudis D, McGuffog L, Meindl A, Menon U, Michailidou K, Miller A, Montagna M, Moreno F, Moserle L, Mulligan AM, Nathanson KL, Neuhausen SL, Nevanlinna H, Nevelsteen I, Nielsen FC, Nikitina-Zake L, Nussbaum RL, Offit K, Olah E, Olopade OI, Olsson H, Osorio A, Papp J, Park-Simon TW, Parsons MT, Pedersen IS, Peixoto A, Peterlongo P, Pharoah PDP, Plaseska-Karanfilska D, Poppe B, Presneau N, Radice P, Rantala J, Rennert G, Risch HA, Saloustros E, Sanden K, Sawyer EJ, Schmidt MK, Schmutzler RK, Sharma P, Shu XO, Simard J, Singer CF, Soucy P, Southey MC, Spinelli JJ, Spurdle AB, Stone J, Swerdlow AJ, Tapper WJ, Taylor JA, Teixeira MR, Terry MB, Teulé A, Thomassen M, Thöne K, Thull DL, Tischkowitz M, Toland AE, Torres D, Truong T, Tung N, Vachon CM, van Asperen CJ, van den Ouweland AMW, van Rensburg EJ, Vega A, Viel A, Wang Q, Wappenschmidt B, Weitzel JN, Wendt C, Winqvist R, Yang XR, Yannoukakos D, Ziogas A, Kraft P, Antoniou AC, Zheng W, Easton DF, Milne RL, Beesley J, Chenevix-Trench G: Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer. Nat Commun. 2019 Apr 15; 2019 Apr 15. PMID: 30988301

Zhao L, Pascual F, Bacudio L, Suchanek AL, Young PA, Li LO, Martin SA, Camporez JP, Perry RJ, Shulman GI, Klett EL, Coleman RA: Defective fatty acid oxidation in mice with muscle-specific acyl-CoA synthetase 1-deficiency increases amino acid use and impairs muscle function. J Biol Chem. 2019 Apr 11; 2019 Apr 11. PMID: 30975900

Pfau D, Thorn SL, Zhang J, Mikush N, Renaud JM, Klein R, deKemp RA, Wu X, Hu X, Sinusas AJ, Young LH, Tirziu D: Angiotensin Receptor Neprilysin Inhibitor Attenuates Myocardial Remodeling and Improves Infarct Perfusion in Experimental Heart Failure. Sci Rep. 2019 Apr 8; 2019 Apr 8. PMID: 30962467

Nguyen LH, Mahadeo T, Bordey A: mTOR Hyperactivity Levels Influence the Severity of Epilepsy and Associated Neuropathology in an Experimental Model of Tuberous Sclerosis Complex and Focal Cortical Dysplasia. J Neurosci. 2019 Apr 3; 2019 Jan 30. PMID: 30700531

Siefert AL, Cartiera MS, Khalid AN, Nantel MC, Loose CR, Schulam PG, Saltzman WM, Dempsey MK: The Yale Center for Biomedical Innovation and Technology (CBIT): One Model to Accelerate Impact From Academic Health Care Innovation. Acad Med. 2019 Apr. PMID: 30520807

Nouws J, Fitch M, Mata M, Santoro N, Galuppo B, Kursawe R, Narayan D, Vash-Margita A, Pierpont B, Shulman GI, Hellerstein M, Caprio S: Altered in vivo Lipid Fluxes and Cell Dynamics in Subcutaneous Adipose Tissues are Associated with the Unfavorable Pattern of Fat Distribution in Obese Adolescent Girls. Diabetes. 2019 Apr 1; 2019 Apr 1. PMID: 30936147

Apasu JE, Schuette D, LaRanger R, Steinle JA, Nguyen LD, Grosshans HK, Zhang M, Cai WL, Yan Q, Robert ME, Mak M, Ehrlich BE: Neuronal calcium sensor 1 (NCS1) promotes motility and metastatic spread of breast cancer cells in vitro and in vivo. FASEB J. 2019 Apr; 2018 Dec 28. PMID: 30592625

El-Hassar L, Song L, Winston TJT, Large CH, Alvaro G, Santos-Sacchi J, Kaczmarek LK: Modulators of Kv3 potassium channels rescue the auditory function of Fragile X mice. J Neurosci. 2019 Apr 1; 2019 Apr 1. PMID: 30936239

Abulizi A, Camporez JP, Zhang D, Samuel VT, Shulman GI, Vatner DF: Ectopic lipid deposition mediates insulin resistance in adipose specific 11β-hydroxysteroid dehydrogenase type 1 transgenic mice. Metabolism. 2019 Apr; 2018 Dec 19. PMID: 30576689

Abulizi A, Camporez JP, Jurczak MJ, Høyer KF, Zhang D, Cline GW, Samuel VT, Shulman GI, Vatner DF: Adipose glucocorticoid action influences whole-body metabolism via modulation of hepatic insulin action. FASEB J. 2019 Mar 28; 2019 Mar 28. PMID: 30922125

Zhang X, Fan L, Wu J, Xu H, Leung WY, Fu K, Wu J, Liu K, Kwan M, Yang X, Han J, Ren J, Yu J: Macrophage p38α promotes nutritional steatohepatitis through M1 polarization. J Hepatol. 2019 Mar 23; 2019 Mar 23. PMID: 30914267

Li X, Gong W, Wang H, Li T, Attri KS, Lewis RE, Kalil AC, Bhinderwala F, Powers R, Yin G, Herring LE, Asara JM, Lei YL, Yang X, Rodriguez DA, Yang M, Green DR, Singh PK, Wen H: O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3. Immunity. 2019 Mar 19; 2019 Feb 12. PMID: 30770249

Mancini G, Pirruccio K, Yang X, Blüher M, Rodeheffer M, Horvath TL: Mitofusin 2 in Mature Adipocytes Controls Adiposity and Body Weight. Cell Rep. 2019 Mar 12. PMID: 30865877

Santos-Sacchi J: The speed limit of outer hair cell electromechanical activity. HNO. 2019 Mar. PMID: 30747242

Madiraju AK, Qiu Y, Perry RJ, Rahimi Y, Zhang XM, Zhang D, Camporez JG, Cline GW, Butrico GM, Kemp BE, Casals G, Steinberg GR, Vatner DF, Petersen KF, Shulman GI: Author Correction: Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo. Nat Med. 2019 Mar. PMID: 30733621

Xiong X, Yang X, Li X, Yue G, Xing Y, Cho WC: Efficacy and safety of Chinese herbal medicine for patients with postmenopausal hypertension: A systematic review and meta-analysis. Pharmacol Res. 2019 Mar; 2019 Jan 11. PMID: 30639372

Dearborn JL, Viscoli CM, Young LH, Gorman MJ, Furie KL, Kernan WN: Achievement of Guideline-Recommended Weight Loss Among Patients With Ischemic Stroke and Obesity. Stroke. 2019 Mar. PMID: 30786849

Spence JD, Viscoli CM, Inzucchi SE, Dearborn-Tomazos J, Ford GA, Gorman M, Furie KL, Lovejoy AM, Young LH, Kernan WN, IRIS Investigators.: Pioglitazone Therapy in Patients With Stroke and Prediabetes: A Post Hoc Analysis of the IRIS Randomized Clinical Trial. JAMA Neurol. 2019 Feb 7; 2019 Feb 7. PMID: 30734043

Yu F, Guo S, Li T, Ran J, Zhao W, Li D, Liu M, Yan X, Yang X, Zhu X, Zhou J: Ciliary defects caused by dysregulation of O-GlcNAc modification are associated with diabetic complications. Cell Res. 2019 Feb; 2018 Nov 14. PMID: 30429527

Li Y, Hu C, Wang P, Liu Y, Wang L, Pi Q, Gong Z, Yang X, Mak M, Wu Y: Indoor nanoscale particulate matter-induced coagulation abnormality based on a human 3D microvascular model on a microfluidic chip. J Nanobiotechnology. 2019 Feb 1; 2019 Feb 1. PMID: 30709410

Zhong S, Rivera-Molina F, Rivetta A, Toomre D, Santos-Sacchi J, Navaratnam D: Seeing the long tail: A novel green fluorescent protein, SiriusGFP, for ultra long timelapse imaging. J Neurosci Methods. 2019 Feb 1; 2018 Dec 19. PMID: 30578868

Martin DT, Shen H, Steinbach-Rankins JM, Zhu X, Johnson KK, Syed J, Saltzman WM, Weiss RM: Glycoprotein-130 Expression Is Associated with Aggressive Bladder Cancer and Is a Potential Therapeutic Target. Mol Cancer Ther. 2019 Feb; 2018 Oct 31. PMID: 30381445

Perry RJ, Rabin-Court A, Song JD, Cardone RL, Wang Y, Kibbey RG, Shulman GI: Dehydration and insulinopenia are necessary and sufficient for euglycemic ketoacidosis in SGLT2 inhibitor-treated rats. Nat Commun. 2019 Feb 1; 2019 Feb 1. PMID: 30710078

Baro M, Lopez Sambrooks C, Quijano A, Saltzman WM, Contessa J: Oligosaccharyltransferase Inhibition Reduces Receptor Tyrosine Kinase Activation and Enhances Glioma Radiosensitivity. Clin Cancer Res. 2019 Jan 15; 2018 Jul 2. PMID: 29967251

Goedeke L, Perry RJ, Shulman GI: Emerging Pharmacological Targets for the Treatment of Nonalcoholic Fatty Liver Disease, Insulin Resistance, and Type 2 Diabetes. Annu Rev Pharmacol Toxicol. 2019 Jan 6. PMID: 30625285

Knauf F, Velazquez H, Pfann V, Jiang Z, Aronson PS: Characterization of renal NaCl and oxalate transport in Slc26a6-/- mice. Am J Physiol Renal Physiol. 2019 Jan 1; 2018 Nov 14. PMID: 30427220

Beaudoin DL, Kupershtok M, Demb JB: Selective synaptic connections in the retinal pathway for night vision. J Comp Neurol. 2019 Jan 1; 2017 Sep 15. PMID: 28856684

Farrelly JS, Bianchi AH, Ricciardi AS, Buzzelli GL, Ahle SL, Freedman-Weiss MR, Luks VL, Saltzman WM, Stitelman DH: Alginate microparticles loaded with basic fibroblast growth factor induce tissue coverage in a rat model of myelomeningocele. J Pediatr Surg. 2019 Jan; 2018 Oct 5. PMID: 30414695

Jiang M, Xu B, Li X, Shang Y, Chu Y, Wang W, Chen D, Wu N, Hu S, Zhang S, Li M, Wu K, Yang X, Liang J, Nie Y, Fan D: O-GlcNAcylation promotes colorectal cancer metastasis via the miR-101-O-GlcNAc/EZH2 regulatory feedback circuit. Oncogene. 2019 Jan; 2018 Aug 9. PMID: 30093632

Suh HW, Lewis J, Fong L, Ramseier JY, Carlson K, Peng ZH, Yin ES, Saltzman WM, Girardi M: Biodegradable bioadhesive nanoparticle incorporation of broad-spectrum organic sunscreen agents. Bioeng Transl Med. 2019 Jan; 2018 Jul 6. PMID: 30680324

Bleckert A, Zhang C, Turner MH, Koren D, Berson DM, Park SJH, Demb JB, Rieke F, Wei W, Wong RO: GABA release selectively regulates synapse development at distinct inputs on direction-selective retinal ganglion cells. Proc Natl Acad Sci U S A. 2018 Dec 18; 2018 Dec 3. PMID: 30509993

Viscoli CM, Kent DM, Conwit R, Dearborn JL, Furie KL, Gorman M, Guarino PD, Inzucchi SE, Stuart A, Young LH, Kernan WN, IRIS Trial Investigators.: Scoring System to Optimize Pioglitazone Therapy After Stroke Based on Fracture Risk. Stroke. 2018 Dec 10; 2018 Dec 10. PMID: 30580725

Dearborn JL, Viscoli CM, Inzucchi SE, Young LH, Kernan WN: Metabolic syndrome identifies normal weight insulin-resistant stroke patients at risk for recurrent vascular disease. Int J Stroke. 2018 Dec 3; 2018 Dec 3. PMID: 30507360

Goedeke L, Bates J, Vatner DF, Perry RJ, Wang T, Ramirez R, Li L, Ellis MW, Zhang D, Wong KE, Beysen C, Cline GW, Ray AS, Shulman GI: Acetyl-CoA Carboxylase Inhibition Reverses NAFLD and Hepatic Insulin Resistance but Promotes Hypertriglyceridemia in Rodents. Hepatology. 2018 Dec. PMID: 29790582

Li MD, Vera NB, Yang Y, Zhang B, Ni W, Ziso-Qejvanaj E, Ding S, Zhang K, Yin R, Wang S, Zhou X, Fang EX, Xu T, Erion DM, Yang X: Adipocyte OGT governs diet-induced hyperphagia and obesity. Nat Commun. 2018 Nov 30; 2018 Nov 30. PMID: 30504766

Tian DC, Shi K, Zhu Z, Yao J, Yang X, Su L, Zhang S, Zhang M, Gonzales RJ, Liu Q, Huang D, Waters MF, Sheth KN, Ducruet AF, Fu Y, Lou M, Shi FD: Fingolimod enhances the efficacy of delayed alteplase administration in acute ischemic stroke by promoting anterograde reperfusion and retrograde collateral flow. Ann Neurol. 2018 Nov; 2018 Nov 2. PMID: 30295338

Boeckel GR, Ehrlich BE: NCS-1 is a regulator of calcium signaling in health and disease. Biochim Biophys Acta Mol Cell Res. 2018 Nov; 2018 May 8. PMID: 29746899

Cheng H, Yang X, Si H, Saleh AD, Xiao W, Coupar J, Gollin SM, Ferris RL, Issaeva N, Yarbrough WG, Prince ME, Carey TE, Van Waes C, Chen Z: Genomic and Transcriptomic Characterization Links Cell Lines with Aggressive Head and Neck Cancers. Cell Rep. 2018 Oct 30. PMID: 30380422

Ong Q, Han W, Yang X: O-GlcNAc as an Integrator of Signaling Pathways. Front Endocrinol (Lausanne). 2018; 2018 Oct 16. PMID: 30464755

Haghighat L, Brandt EJ, Proctor DD, Garcia-Tsao G, Pollak J, Young LH: Evolution of Intrahepatic Shunts in a Patient With Hereditary Hemorrhagic Telangiectasia. Ann Intern Med. 2018 Oct 2; 2018 Jun 5. PMID: 29868721

Khare S, Galeano K, Zhang Y, Nick JA, Nick HS, Subramony SH, Sampson J, Kaczmarek LK, Waters MF: C-terminal proline deletions in KCNC3 cause delayed channel inactivation and an adult-onset progressive SCA13 with spasticity. Cerebellum. 2018 Oct. PMID: 29949095

Yang X, Chen C, Tian H, Chi H, Mu Z, Zhang T, Yang K, Zhao Q, Liu X, Wang Z, Ji X, Yang H: Mechanism of ATP hydrolysis by the Zika virus helicase. FASEB J. 2018 Oct; 2018 Apr 17. PMID: 29913559

Cassini MF, Kakade VR, Kurtz E, Sulkowski P, Glazer P, Torres R, Somlo S, Cantley LG: Mcp1 Promotes Macrophage-Dependent Cyst Expansion in Autosomal Dominant Polycystic Kidney Disease. J Am Soc Nephrol. 2018 Oct; 2018 Sep 12. PMID: 30209078

Calub CA, Furtak SC, Brown TH: Revisiting the autoconditioning hypothesis for acquired reactivity to ultrasonic alarm calls. Physiol Behav. 2018 Oct 1; 2018 Jun 19. PMID: 29933032

Petersen MC, Shulman GI: Mechanisms of Insulin Action and Insulin Resistance. Physiol Rev. 2018 Oct 1. PMID: 30067154

Yang F, Choi YJ, Misch A, Yang X, Dunham Y: In Defense of the Commons: Young Children Negatively Evaluate and Sanction Free Riders. Psychol Sci. 2018 Oct; 2018 Jul 16. PMID: 30010493

McCollister KE, Yang X, Murphy SM, Leff JA, Kronmal RA, Crane HM, Chandler RK, Taxman FS, Feaster DJ, Metsch LR, Cunningham WE, Altice FL, Schackman BR: Criminal justice measures for economic data harmonization in substance use disorder research. Health Justice. 2018 Sep 21; 2018 Sep 21. PMID: 30242561

Young LH, Viscoli CM, Schwartz GG, Inzucchi SE, Curtis JP, Gorman MJ, Furie KL, Conwit R, Spatz ES, Lovejoy A, Abbott JD, Jacoby DL, Kolansky DM, Ling FS, Pfau SE, Kernan WN, IRIS Investigators.: Heart Failure After Ischemic Stroke or Transient Ischemic Attack in Insulin-Resistant Patients Without Diabetes Mellitus Treated With Pioglitazone. Circulation. 2018 Sep 18. PMID: 29934374

Gassaway BM, Petersen MC, Surovtseva YV, Barber KW, Sheetz JB, Aerni HR, Merkel JS, Samuel VT, Shulman GI, Rinehart J: PKCε contributes to lipid-induced insulin resistance through cross talk with p70S6K and through previously unknown regulators of insulin signaling. Proc Natl Acad Sci U S A. 2018 Sep 18; 2018 Sep 4. PMID: 30181290

Qian K, Wang S, Fu M, Zhou J, Singh JP, Li MD, Yang Y, Zhang K, Wu J, Nie Y, Ruan HB, Yang X: Transcriptional regulation of O-GlcNAc homeostasis is disrupted in pancreatic cancer. J Biol Chem. 2018 Sep 7; 2018 Jul 23. PMID: 30037904

Chen EM, Quijano AR, Seo YE, Jackson C, Josowitz AD, Noorbakhsh S, Merlettini A, Sundaram RK, Focarete ML, Jiang Z, Bindra RS, Saltzman WM: Biodegradable PEG-poly(ω-pentadecalactone-co-p-dioxanone) nanoparticles for enhanced and sustained drug delivery to treat brain tumors. Biomaterials. 2018 Sep; 2018 Jun 18. PMID: 29936153

Jiang Y, Gaudin A, Zhang J, Agarwal T, Song E, Kauffman AC, Tietjen GT, Wang Y, Jiang Z, Cheng CJ, Saltzman WM: A "top-down" approach to actuate poly(amine-co-ester) terpolymers for potent and safe mRNA delivery. Biomaterials. 2018 Sep; 2018 May 25. PMID: 29879653

Schuette D, Moore LM, Robert ME, Taddei TH, Ehrlich BE: Hepatocellular Carcinoma Outcome Is Predicted by Expression of Neuronal Calcium Sensor 1. Cancer Epidemiol Biomarkers Prev. 2018 Sep; 2018 May 22. PMID: 29789326

Lopez Sambrooks C, Baro M, Quijano A, Narayan A, Cui W, Greninger P, Egan R, Patel A, Benes CH, Saltzman WM, Contessa JN: Oligosaccharyltransferase Inhibition Overcomes Therapeutic Resistance to EGFR Tyrosine Kinase Inhibitors. Cancer Res. 2018 Sep 1; 2018 Jul 19. PMID: 30026325

Piotrowski-Daspit AS, Glaze PM, Saltzman WM: Debugging the genetic code: non-viral in vivo delivery of therapeutic genome editing technologies. Curr Opin Biomed Eng. 2018 Sep; 2018 Aug 21. PMID: 30984891

Madiraju AK, Qiu Y, Perry RJ, Rahimi Y, Zhang XM, Zhang D, Camporez JG, Cline GW, Butrico GM, Kemp BE, Casals G, Steinberg GR, Vatner DF, Petersen KF, Shulman GI: Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo. Nat Med. 2018 Sep; 2018 Jul 23. PMID: 30038219

Rauniyar N, Yu X, Cantley J, Voss EZ, Belcher J, Colangelo CM, Stone KL, Dahl N, Parikh C, Lam TT, Cantley LG: Quantification of Urinary Protein Biomarkers of Autosomal Dominant Polycystic Kidney Disease by Parallel Reaction Monitoring. Proteomics Clin Appl. 2018 Sep; 2018 May 2. PMID: 29573172

Kudalkar SN, Beloor J, Quijano E, Spasov KA, Lee WG, Cisneros JA, Saltzman WM, Kumar P, Jorgensen WL, Anderson KS: Reply to Pandey et al.: Understanding the efficacy of a potential antiretroviral drug candidate in humanized mouse model of HIV infection. Proc Natl Acad Sci U S A. 2018 Aug 28; 2018 Aug 10. PMID: 30097540

Steinhauser ML, Olenchock BA, O'Keefe J, Lun M, Pierce KA, Lee H, Pantano L, Klibanski A, Shulman GI, Clish CB, Fazeli PK: The circulating metabolome of human starvation. JCI Insight. 2018 Aug 23; 2018 Aug 23. PMID: 30135314

Pottackal J, Demb JB: Melanopsin Shows Its (Contrast-)Sensitive Side. Neuron. 2018 Aug 22. PMID: 30138585

Zhang J, Chen T, Yang X, Cheng H, Späth SS, Clavijo PE, Chen J, Silvin C, Issaeva N, Su X, Yarbrough WG, Annunziata CM, Chen Z, Van Waes C: Attenuated TRAF3 Fosters Activation of Alternative NF-κB and Reduced Expression of Antiviral Interferon, TP53, and RB to Promote HPV-Positive Head and Neck Cancers. Cancer Res. 2018 Aug 15; 2018 Jun 19. PMID: 29921694

Zhang F, Zarkada G, Han J, Li J, Dubrac A, Ola R, Genet G, Boyé K, Michon P, Künzel SE, Camporez JP, Singh AK, Fong GH, Simons M, Tso P, Fernández-Hernando C, Shulman GI, Sessa WC, Eichmann A: Lacteal junction zippering protects against diet-induced obesity. Science. 2018 Aug 10. PMID: 30093598

Flannery CA, Choe GH, Cooke KM, Fleming AG, Radford CC, Kodaman PH, Jurczak MJ, Kibbey RG, Taylor HS: Insulin Regulates Glycogen Synthesis in Human Endometrial Glands Through Increased GYS2. J Clin Endocrinol Metab. 2018 Aug 1. PMID: 29726999

Yao K, Qiu S, Wang YV, Park SJH, Mohns EJ, Mehta B, Liu X, Chang B, Zenisek D, Crair MC, Demb JB, Chen B: Restoration of vision after de novo genesis of rod photoreceptors in mammalian retinas. Nature. 2018 Aug; 2018 Aug 15. PMID: 30111842

Ravussin A, Youm YH, Sander J, Ryu S, Nguyen K, Varela L, Shulman GI, Sidorov S, Horvath TL, Schultze JL, Dixit VD: Loss of Nucleobindin-2 Causes Insulin Resistance in Obesity without Impacting Satiety or Adiposity. Cell Rep. 2018 Jul 31. PMID: 30067966

Cai Z, Zhou D, Wang M, Bak SM, Wu Y, Wu Z, Tian Y, Xiong X, Li Y, Liu W, Siahrostami S, Kuang Y, Yang XQ, Duan H, Feng Z, Wang H, Sun X: Introducing Fe2+ into Nickel-Iron Layered Double Hydroxide: Local Structure Modulated Water Oxidation Activity. Angew Chem Int Ed Engl. 2018 Jul 20; 2018 Jun 27. PMID: 29889350

Goldberg IJ, Reue K, Abumrad NA, Bickel PE, Cohen S, Fisher EA, Galis ZS, Granneman JG, Lewandowski ED, Murphy R, Olive M, Schaffer JE, Schwartz-Longacre L, Shulman GI, Walther TC, Chen J: Deciphering the Role of Lipid Droplets in Cardiovascular Disease: A Report From the 2017 National Heart, Lung, and Blood Institute Workshop. Circulation. 2018 Jul 17. PMID: 30012703

Wang Y, Nasiri AR, Damsky WE, Perry CJ, Zhang XM, Rabin-Court A, Pollak MN, Shulman GI, Perry RJ: Uncoupling Hepatic Oxidative Phosphorylation Reduces Tumor Growth in Two Murine Models of Colon Cancer. Cell Rep. 2018 Jul 3. PMID: 29972790

Kitay AM, Schneebacher MT, Schmitt A, Heschl K, Kopic S, Alfadda T, Alsaihati A, Link A, Geibel JP: Modulations in extracellular calcium lead to H+-ATPase-dependent acid secretion: a clarification of PPI failure. Am J Physiol Gastrointest Liver Physiol. 2018 Jul 1; 2018 Mar 8. PMID: 29517927

Tietjen GT, Bracaglia LG, Saltzman WM, Pober JS: Focus on Fundamentals: Achieving Effective Nanoparticle Targeting. Trends Mol Med. 2018 Jul; 2018 Jun 5. PMID: 29884540

Ricciardi AS, Bahal R, Farrelly JS, Quijano E, Bianchi AH, Luks VL, Putman R, López-Giráldez F, Coşkun S, Song E, Liu Y, Hsieh WC, Ly DH, Stitelman DH, Glazer PM, Saltzman WM: In utero nanoparticle delivery for site-specific genome editing. Nat Commun. 2018 Jun 26; 2018 Jun 26. PMID: 29946143

Santos-Sacchi J, Tan W: The Frequency Response of Outer Hair Cell Voltage-Dependent Motility Is Limited by Kinetics of Prestin. J Neurosci. 2018 Jun 13; 2018 May 21. PMID: 29899032

Han Y, Chen Y, Ahmad S, Feng Y, Zhang F, Song W, Cao F, Zhang Y, Yang X, Li J, Zhang G: High Time- and Size-Resolved Measurements of PM and Chemical Composition from Coal Combustion: Implications for the EC Formation Process. Environ Sci Technol. 2018 Jun 5; 2018 May 15. PMID: 29737847

Vatner DF, Goedeke L, Camporez JG, Lyu K, Nasiri AR, Zhang D, Bhanot S, Murray SF, Still CD, Gerhard GS, Shulman GI, Samuel VT: Angptl8 antisense oligonucleotide improves adipose lipid metabolism and prevents diet-induced NAFLD and hepatic insulin resistance in rodents. Diabetologia. 2018 Jun; 2018 Mar 1. PMID: 29497783

Zacchia M, Tian X, Zona E, Alpern RJ, Preisig PA: Acid Stimulation of the Citrate Transporter NaDC-1 Requires Pyk2 and ERK1/2 Signaling Pathways. J Am Soc Nephrol. 2018 Jun; 2018 Apr 20. PMID: 29678998

Boutagy NE, Wu J, Cai Z, Zhang W, Booth CJ, Kyriakides TC, Pfau D, Mulnix T, Liu Z, Miller EJ, Young LH, Carson RE, Huang Y, Liu C, Sinusas AJ: In Vivo Reactive Oxygen Species Detection With a Novel Positron Emission Tomography Tracer, 18F-DHMT, Allows for Early Detection of Anthracycline-Induced Cardiotoxicity in Rodents. JACC Basic Transl Sci. 2018 Jun; 2018 May 30. PMID: 30062224

Huang T, Nguyen LH, Lin TV, Gong X, Zhang L, Kim GB, Sarkisian MR, Breunig JJ, Bordey A: In utero electroporation-based translating ribosome affinity purification identifies age-dependent mRNA expression in cortical pyramidal neurons. Neurosci Res. 2018 May 29; 2018 May 29. PMID: 29857015

Zhang N, Geng T, Wang Z, Zhang R, Cao T, Camporez JP, Cai SY, Liu Y, Dandolo L, Shulman GI, Carmichael GG, Taylor HS, Huang Y: Elevated hepatic expression of H19 long noncoding RNA contributes to diabetic hyperglycemia. JCI Insight. 2018 May 17; 2018 May 17. PMID: 29769440

Wang D, Hu X, Lee SH, Chen F, Jiang K, Tu Z, Liu Z, Du J, Wang L, Yin C, Liao Y, Shang H, Martin KA, Herzog RI, Young LH, Qian L, Hwa J, Xiang Y: Diabetes Exacerbates Myocardial Ischemia/Reperfusion Injury by Down-Regulation of MicroRNA and Up-Regulation of O-GlcNAcylation. JACC Basic Transl Sci. 2018 Jun; 2018 May 16. PMID: 30062222

Xiong XJ, Yang XC, Liu W, Duan L, Wang PQ, You H, Li XK, Wang S: Therapeutic Efficacy and Safety of Traditional Chinese Medicine Classic Herbal Formula Longdanxiegan Decoction for Hypertension: A Systematic Review and Meta-Analysis. Front Pharmacol. 2018; 2018 May 8. PMID: 29867474

Shi H, Munk A, Nielsen TS, Daughtry MR, Larsson L, Li S, Høyer KF, Geisler HW, Sulek K, Kjøbsted R, Fisher T, Andersen MM, Shen Z, Hansen UK, England EM, Cheng Z, Højlund K, Wojtaszewski JFP, Yang X, Hulver MW, Helm RF, Treebak JT, Gerrard DE: Skeletal muscle O-GlcNAc transferase is important for muscle energy homeostasis and whole-body insulin sensitivity. Mol Metab. 2018 May; 2018 Feb 24. PMID: 29525407

Park SJH, Pottackal J, Ke JB, Jun NY, Rahmani P, Kim IJ, Singer JH, Demb JB: Convergence and Divergence of CRH Amacrine Cells in Mouse Retinal Circuitry. J Neurosci. 2018 Apr 11; 2018 Mar 23. PMID: 29572434

Neuman RI, van Kalmthout JAM, Pfau DJ, Menendez DM, Young LH, Forrest JN Jr: AMP-activated protein kinase and adenosine are both metabolic modulators that regulate chloride secretion in the shark rectal gland ( Squalus acanthias). Am J Physiol Cell Physiol. 2018 Apr 1; 2017 Dec 20. PMID: 29351415

Li T, Zhao Q, Yang X, Chen C, Yang K, Wu C, Zhang T, Duan Y, Xue X, Mi K, Ji X, Wang Z, Yang H: Structural insight into the Zika virus capsid encapsulating the viral genome. Cell Res. 2018 Apr; 2018 Feb 21. PMID: 29467384

Lawan A, Min K, Zhang L, Canfran-Duque A, Jurczak MJ, Camporez JPG, Nie Y, Gavin TP, Shulman GI, Fernandez-Hernando C, Bennett AM: Skeletal Muscle-Specific Deletion of MKP-1 Reveals a p38 MAPK/JNK/Akt Signaling Node That Regulates Obesity-Induced Insulin Resistance. Diabetes. 2018 Apr; 2018 Jan 9. PMID: 29317435

Aryal B, Singh AK, Zhang X, Varela L, Rotllan N, Goedeke L, Chaube B, Camporez JP, Vatner DF, Horvath TL, Shulman GI, Suárez Y, Fernández-Hernando C: Absence of ANGPTL4 in adipose tissue improves glucose tolerance and attenuates atherogenesis. JCI Insight. 2018 Mar 22; 2018 Mar 22. PMID: 29563332

Qiu Y, Perry RJ, Camporez JG, Zhang XM, Kahn M, Cline GW, Shulman GI, Vatner DF: In vivo studies on the mechanism of methylene cyclopropyl acetic acid and methylene cyclopropyl glycine-induced hypoglycemia. Biochem J. 2018 Mar 20; 2018 Mar 20. PMID: 29483297

Moore LM, Wilkinson R, Altan M, Toki M, Carvajal-Hausdorf DE, McGuire J, Ehrlich BE, Rimm DL: An assessment of neuronal calcium sensor-1 and response to neoadjuvant chemotherapy in breast cancer patients. NPJ Breast Cancer. 2018; 2018 Mar 12. PMID: 29560416

Ricciardi AS, Quijano E, Putman R, Saltzman WM, Glazer PM: Peptide Nucleic Acids as a Tool for Site-Specific Gene Editing. Molecules. 2018 Mar 11; 2018 Mar 11. PMID: 29534473

Qi S, Yang X, Zhao L, Calhoun VD, Perrone-Bizzozero N, Liu S, Jiang R, Jiang T, Sui J, Ma X: MicroRNA132 associated multimodal neuroimaging patterns in unmedicated major depressive disorder. Brain. 2018 Mar 1. PMID: 29408968

Perry RJ, Shulman GI: The Role of Leptin in Maintaining Plasma Glucose During Starvation. Postdoc J. 2018 Mar. PMID: 29682594

Price NL, Singh AK, Rotllan N, Goedeke L, Wing A, Canfrán-Duque A, Diaz-Ruiz A, Araldi E, Baldán Á, Camporez JP, Suárez Y, Rodeheffer MS, Shulman GI, de Cabo R, Fernández-Hernando C: Genetic Ablation of miR-33 Increases Food Intake, Enhances Adipose Tissue Expansion, and Promotes Obesity and Insulin Resistance. Cell Rep. 2018 Feb 20. PMID: 29466739

Ottilie S, Goldgof GM, Cheung AL, Walker JL, Vigil E, Allen KE, Antonova-Koch Y, Slayman CW, Suzuki Y, Durrant JD: Two inhibitors of yeast plasma membrane ATPase 1 (ScPma1p): toward the development of novel antifungal therapies. J Cheminform. 2018 Feb 20; 2018 Feb 20. PMID: 29464421

Ouyang X, Han SN, Zhang JY, Dioletis E, Nemeth BT, Pacher P, Feng D, Bataller R, Cabezas J, Stärkel P, Caballeria J, Pongratz RL, Cai SY, Schnabl B, Hoque R, Chen Y, Yang WH, Garcia-Martinez I, Wang FS, Gao B, Torok NJ, Kibbey RG, Mehal WZ: Digoxin Suppresses Pyruvate Kinase M2-Promoted HIF-1α Transactivation in Steatohepatitis. Cell Metab. 2018 Feb 6. PMID: 29414684

Wang Y, Chen SR, Yang X, Lee KH, Cheng YC: Structure-activity relationships of cryptopleurine analogs with E-ring modifications as anti-hepatitis C virus agents. Bioorg Med Chem. 2018 Feb 1; 2017 Dec 20. PMID: 29317151

Corbit KC, Camporez JPG, Edmunds LR, Tran JL, Vera NB, Erion DM, Deo RC, Perry RJ, Shulman GI, Jurczak MJ, Weiss EJ: Adipocyte JAK2 Regulates Hepatic Insulin Sensitivity Independently of Body Composition, Liver Lipid Content, and Hepatic Insulin Signaling. Diabetes. 2018 Feb; 2017 Dec 4. PMID: 29203511

Perry RJ, Peng L, Cline GW, Butrico GM, Wang Y, Zhang XM, Rothman DL, Petersen KF, Shulman GI: Publisher Correction: Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA). Nat Commun. 2018 Jan 31; 2018 Jan 31. PMID: 29386503

Yaghi S, Furie KL, Viscoli CM, Kamel H, Gorman M, Dearborn J, Young LH, Inzucchi SE, Lovejoy AM, Kasner SE, Conwit R, Kernan WN, IRIS Trial Investigators.: Pioglitazone Prevents Stroke in Patients With a Recent Transient Ischemic Attack or Ischemic Stroke: A Planned Secondary Analysis of the IRIS Trial (Insulin Resistance Intervention After Stroke). Circulation. 2018 Jan 30; 2017 Oct 30. PMID: 29084736

Kudalkar SN, Beloor J, Quijano E, Spasov KA, Lee WG, Cisneros JA, Saltzman WM, Kumar P, Jorgensen WL, Anderson KS: From in silico hit to long-acting late-stage preclinical candidate to combat HIV-1 infection. Proc Natl Acad Sci U S A. 2018 Jan 23; 2017 Dec 26. PMID: 29279368

Perry RJ, Wang Y, Cline GW, Rabin-Court A, Song JD, Dufour S, Zhang XM, Petersen KF, Shulman GI: Leptin Mediates a Glucose-Fatty Acid Cycle to Maintain Glucose Homeostasis in Starvation. Cell. 2018 Jan 11; 2018 Jan 4. PMID: 29307489

Perry RJ, Peng L, Cline GW, Wang Y, Rabin-Court A, Song JD, Zhang D, Zhang XM, Nozaki Y, Dufour S, Petersen KF, Shulman GI: Mechanisms by which a Very-Low-Calorie Diet Reverses Hyperglycemia in a Rat Model of Type 2 Diabetes. Cell Metab. 2018 Jan 9; 2017 Nov 9. PMID: 29129786

Samuel VT, Shulman GI: Nonalcoholic Fatty Liver Disease as a Nexus of Metabolic and Hepatic Diseases. Cell Metab. 2018 Jan 9; 2017 Aug 31. PMID: 28867301

Lemos FO, Ehrlich BE: Polycystin and calcium signaling in cell death and survival. Cell Calcium. 2018 Jan; 2017 May 24. PMID: 28601384

Jurczak MJ, Saini S, Ioja S, Costa DK, Udeh N, Zhao X, Whaley JM, Kibbey RG: SGLT2 knockout prevents hyperglycemia and is associated with reduced pancreatic β-cell death in genetically obese mice. Islets. 2018; 2018 Aug 17. PMID: 30118626

Furie KL, Viscoli CM, Gorman M, Ford GA, Young LH, Inzucchi SE, Guarino PD, Lovejoy AM, Conwit R, Tanne D, Kernan WN, IRIS Trial Investigators.: Effects of pioglitazone on cognitive function in patients with a recent ischaemic stroke or TIA: a report from the IRIS trial. J Neurol Neurosurg Psychiatry. 2018 Jan; 2017 Sep 22. PMID: 28939682

Yu P, Alves TC, Kibbey RG, Simons M: Metabolic Analysis of Lymphatic Endothelial Cells. Methods Mol Biol. 2018. PMID: 30242770

Smith AA, Yang X, Fikrig E, Pal U: Artificial Infection of Ticks with Borrelia burgdorferi Using a Microinjection Method and Their Detection In Vivo Using Quantitative PCR Targeting flaB RNA. Methods Mol Biol. 2018. PMID: 29032540

Cantley LG: Introduction: Understanding Human AKI. Semin Nephrol. 2018 Jan. PMID: 29291756

Wadia RJ, Stolar M, Grens C, Ehrlich BE, Chao HH: The prevention of chemotherapy induced peripheral neuropathy by concurrent treatment with drugs used for bipolar disease: a retrospective chart analysis in human cancer patients. Oncotarget. 2018 Jan 26; 2017 Dec 19. PMID: 29484113

Camporez JP, Wang Y, Faarkrog K, Chukijrungroat N, Petersen KF, Shulman GI: Mechanism by which arylamine N-acetyltransferase 1 ablation causes insulin resistance in mice. Proc Natl Acad Sci U S A. 2017 Dec 26; 2017 Dec 13. PMID: 29237750

Bertacco A, Dehner CA, Caturegli G, D'Amico F, Morotti R, Rodriguez MI, Mulligan DC, Kriegel MA, Geibel JP: Modulation of Intestinal Microbiome Prevents Intestinal Ischemic Injury. Front Physiol. 2017; 2017 Dec 19. PMID: 29311987

Quijano E, Bahal R, Ricciardi A, Saltzman WM, Glazer PM: Therapeutic Peptide Nucleic Acids: Principles, Limitations, and Opportunities. Yale J Biol Med. 2017 Dec; 2017 Dec 19. PMID: 29259523

Gupta A, Quijano E, Liu Y, Bahal R, Scanlon SE, Song E, Hsieh WC, Braddock DE, Ly DH, Saltzman WM, Glazer PM: Anti-tumor Activity of miniPEG-γ-Modified PNAs to Inhibit MicroRNA-210 for Cancer Therapy. Mol Ther Nucleic Acids. 2017 Dec 15; 2017 Sep 12. PMID: 29246289

Chambers AR, Pilati N, Balaram P, Large CH, Kaczmarek LK, Polley DB: Pharmacological modulation of Kv3.1 mitigates auditory midbrain temporal processing deficits following auditory nerve damage. Sci Rep. 2017 Dec 13; 2017 Dec 13. PMID: 29235497

Chi DL, Song E, Gaudin A, Saltzman WM: Improved threshold selection for the determination of volume of distribution of nanoparticles administered by convection-enhanced delivery. Comput Med Imaging Graph. 2017 Dec; 2017 Aug 24. PMID: 28927549

Seo YE, Bu T, Saltzman WM: Nanomaterials for convection-enhanced delivery of agents to treat brain tumors. Curr Opin Biomed Eng. 2017 Dec; 2017 Sep 22. PMID: 29333521

Tietjen GT, Hosgood SA, DiRito J, Cui J, Deep D, Song E, Kraehling JR, Piotrowski-Daspit AS, Kirkiles-Smith NC, Al-Lamki R, Thiru S, Bradley JA, Saeb-Parsy K, Bradley JR, Nicholson ML, Saltzman WM, Pober JS: Nanoparticle targeting to the endothelium during normothermic machine perfusion of human kidneys. Sci Transl Med. 2017 Nov 29. PMID: 29187644

Chizinga M, Rudkovskaia AA, Henderson K, Pollak J, Garcia-Tsao G, Young LH, Fares WH: Pulmonary Hypertension Prevalence and Prognosis in a Cohort of Patients with Hereditary Hemorrhagic Telangiectasia Undergoing Embolization of Pulmonary Arteriovenous Malformations. Am J Respir Crit Care Med. 2017 Nov 15. PMID: 28375020

Chen YC, Lu AY, Lu P, Yang X, Jiang CM, Mariano M, Kaehr B, Lin O, Taylor A, Sharp ID, Li LJ, Chou SS, Tung V: Structurally Deformed MoS2 for Electrochemically Stable, Thermally Resistant, and Highly Efficient Hydrogen Evolution Reaction. Adv Mater. 2017 Nov; 2017 Oct 12. PMID: 29024072

Pang XY, Wang S, Jurczak MJ, Shulman GI, Moise AR: Retinol saturase modulates lipid metabolism and the production of reactive oxygen species. Arch Biochem Biophys. 2017 Nov 1; 2017 Sep 18. PMID: 28927883

Mohideen M, Quijano E, Song E, Deng Y, Panse G, Zhang W, Clark MR, Saltzman WM: Degradable bioadhesive nanoparticles for prolonged intravaginal delivery and retention of elvitegravir. Biomaterials. 2017 Nov; 2017 Aug 15. PMID: 28829952

Montgomery TA, Xu L, Mason S, Chinnadurai A, Lee CG, Elias JA, Cantley LG: Breast Regression Protein-39/Chitinase 3-Like 1 Promotes Renal Fibrosis after Kidney Injury via Activation of Myofibroblasts. J Am Soc Nephrol. 2017 Nov; 2017 Jul 5. PMID: 28679671

Kernan WN, Viscoli CM, Dearborn JL, Kent DM, Conwit R, Fayad P, Furie KL, Gorman M, Guarino PD, Inzucchi SE, Stuart A, Young LH, Insulin Resistance Intervention After Stroke (IRIS) Trial Investigators.: Targeting Pioglitazone Hydrochloride Therapy After Stroke or Transient Ischemic Attack According to Pretreatment Risk for Stroke or Myocardial Infarction. JAMA Neurol. 2017 Nov 1. PMID: 28975241

Giehl E, Lemos FO, Huang Y, Giordano FJ, Kuo IY, Ehrlich BE: Polycystin 2-dependent cardio-protective mechanisms revealed by cardiac stress. Pflugers Arch. 2017 Nov; 2017 Jul 31. PMID: 28762163

Vijayakumar A, Aryal P, Wen J, Syed I, Vazirani RP, Moraes-Vieira PM, Camporez JP, Gallop MR, Perry RJ, Peroni OD, Shulman GI, Saghatelian A, McGraw TE, Kahn BB: Absence of Carbohydrate Response Element Binding Protein in Adipocytes Causes Systemic Insulin Resistance and Impairs Glucose Transport. Cell Rep. 2017 Oct 24. PMID: 29069585

Ferrandino G, Kaspari RR, Spadaro O, Reyna-Neyra A, Perry RJ, Cardone R, Kibbey RG, Shulman GI, Dixit VD, Carrasco N: Pathogenesis of hypothyroidism-induced NAFLD is driven by intra- and extrahepatic mechanisms. Proc Natl Acad Sci U S A. 2017 Oct 24; 2017 Oct 10. PMID: 29073114

Chen M, Lee S, Zhou ZJ: Local synaptic integration enables ON-OFF asymmetric and layer-specific visual information processing in vGluT3 amacrine cell dendrites. Proc Natl Acad Sci U S A. 2017 Oct 24; 2017 Sep 27. PMID: 28973895

Young LH, Viscoli CM, Inzucchi SE, Kernan WN: Response by Young et al to Letters Regarding Article, "Cardiac Outcomes After Ischemic Stroke or Transient Ischemic Attack: Effects of Pioglitazone in Patients With Insulin Resistance Without Diabetes Mellitus". Circulation. 2017 Oct 17. PMID: 29038213

Epstein KA, Viscoli CM, Spence JD, Young LH, Inzucchi SE, Gorman M, Gerstenhaber B, Guarino PD, Dixit A, Furie KL, Kernan WN, IRIS Trial Investigators.: Smoking cessation and outcome after ischemic stroke or TIA. Neurology. 2017 Oct 17; 2017 Sep 8. PMID: 28887378

Perry RJ, Peng L, Cline GW, Butrico GM, Wang Y, Zhang XM, Rothman DL, Petersen KF, Shulman GI: Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA). Nat Commun. 2017 Oct 6; 2017 Oct 6. PMID: 28986525

Petersen MC, Vatner DF, Shulman GI: Regulation of hepatic glucose metabolism in health and disease. Nat Rev Endocrinol. 2017 Oct; 2017 Jul 21. PMID: 28731034

Kaczmarek LK, Zhang Y: Kv3 Channels: Enablers of Rapid Firing, Neurotransmitter Release, and Neuronal Endurance. Physiol Rev. 2017 Oct 1. PMID: 28904001

Tan WJT, Song L, Graham M, Schettino A, Navaratnam D, Yarbrough WG, Santos-Sacchi J, Ivanova AV: Novel Role of the Mitochondrial Protein Fus1 in Protection from Premature Hearing Loss via Regulation of Oxidative Stress and Nutrient and Energy Sensing Pathways in the Inner Ear. Antioxid Redox Signal. 2017 Sep 10; 2017 Mar 9. PMID: 28135838

Di Pietro C, Zhang PX, O'Rourke TK, Murray TS, Wang L, Britto CJ, Koff JL, Krause DS, Egan ME, Bruscia EM: Ezrin links CFTR to TLR4 signaling to orchestrate anti-bacterial immune response in macrophages. Sci Rep. 2017 Sep 7; 2017 Sep 7. PMID: 28883468

Wang Y, Lee S, Ha Y, Lam W, Chen SR, Dutschman GE, Gullen EA, Grill SP, Cheng Y, Fürstner A, Francis S, Baker DC, Yang X, Lee KH, Cheng YC: Tylophorine Analogs Allosterically Regulates Heat Shock Cognate Protein 70 And Inhibits Hepatitis C Virus Replication. Sci Rep. 2017 Aug 30; 2017 Aug 30. PMID: 28855547

Fu M, Yang X: The sweet tooth of the circadian clock. Biochem Soc Trans. 2017 Aug 15; 2017 Jul 3. PMID: 28673939

Ruan HB, Ma Y, Torres S, Zhang B, Feriod C, Heck RM, Qian K, Fu M, Li X, Nathanson MH, Bennett AM, Nie Y, Ehrlich BE, Yang X: Calcium-dependent O-GlcNAc signaling drives liver autophagy in adaptation to starvation. Genes Dev. 2017 Aug 15; 2017 Sep 13. PMID: 28903979

Jelenik T, Kaul K, Séquaris G, Flögel U, Phielix E, Kotzka J, Knebel B, Fahlbusch P, Hörbelt T, Lehr S, Reinbeck AL, Müller-Wieland D, Esposito I, Shulman GI, Szendroedi J, Roden M: Mechanisms of Insulin Resistance in Primary and Secondary Nonalcoholic Fatty Liver. Diabetes. 2017 Aug; 2017 May 10. PMID: 28490610

Lee HY, Lee JS, Alves T, Ladiges W, Rabinovitch PS, Jurczak MJ, Choi CS, Shulman GI, Samuel VT: Mitochondrial-Targeted Catalase Protects Against High-Fat Diet-Induced Muscle Insulin Resistance by Decreasing Intramuscular Lipid Accumulation. Diabetes. 2017 Aug; 2017 May 5. PMID: 28476930

von Loeffelholz C, Lieske S, Neuschäfer-Rube F, Willmes DM, Raschzok N, Sauer IM, König J, Fromm MF, Horn P, Chatzigeorgiou A, Pathe-Neuschäfer-Rube A, Jordan J, Pfeiffer AFH, Mingrone G, Bornstein SR, Stroehle P, Harms C, Wunderlich FT, Helfand SL, Bernier M, de Cabo R, Shulman GI, Chavakis T, Püschel GP, Birkenfeld AL: The human longevity gene homolog INDY and interleukin-6 interact in hepatic lipid metabolism. Hepatology. 2017 Aug; 2017 Jun 26. PMID: 28133767

King AR, Corso CD, Chen EM, Song E, Bongiorni P, Chen Z, Sundaram RK, Bindra RS, Saltzman WM: Local DNA Repair Inhibition for Sustained Radiosensitization of High-Grade Gliomas. Mol Cancer Ther. 2017 Aug; 2017 May 31. PMID: 28566437

Tietjen GT, DiRito J, Pober JS, Saltzman WM: Quantitative microscopy-based measurements of circulating nanoparticle concentration using microliter blood volumes. Nanomedicine. 2017 Aug; 2017 Apr 13. PMID: 28412144

Zhang X, Zhu H, Yang X, Adsay VN, Jain D: Post-obstructive cyst formation in pancreas and cystic acinar transformation: Are they same? Pathol Res Pract. 2017 Aug; 2017 Apr 1. PMID: 28599853

Ornaghi S, Hsieh LS, Bordey A, Vergani P, Paidas MJ, van den Pol AN: Valnoctamide Inhibits Cytomegalovirus Infection in Developing Brain and Attenuates Neurobehavioral Dysfunctions and Brain Abnormalities. J Neurosci. 2017 Jul 19; 2017 Jun 19. PMID: 28630251

Abulizi A, Perry RJ, Camporez JPG, Jurczak MJ, Petersen KF, Aspichueta P, Shulman GI: A controlled-release mitochondrial protonophore reverses hypertriglyceridemia, nonalcoholic steatohepatitis, and diabetes in lipodystrophic mice. FASEB J. 2017 Jul; 2017 Mar 22. PMID: 28330852

Moore LM, England A, Ehrlich BE, Rimm DL: Calcium Sensor, NCS-1, Promotes Tumor Aggressiveness and Predicts Patient Survival. Mol Cancer Res. 2017 Jul; 2017 Mar 8. PMID: 28275088

Yang X, Qian K: Protein O-GlcNAcylation: emerging mechanisms and functions. Nat Rev Mol Cell Biol. 2017 Jul; 2017 May 10. PMID: 28488703

Gribkoff VK, Kaczmarek LK: The need for new approaches in CNS drug discovery: Why drugs have failed, and what can be done to improve outcomes. Neuropharmacology. 2017 Jul 1; 2016 Mar 12. PMID: 26979921

Williams KR, Colangelo CM, Hou L, Chung L, Belcher JM, Abbott T, Hall IE, Zhao H, Cantley LG, Parikh CR: Use of a Targeted Urine Proteome Assay (TUPA) to identify protein biomarkers of delayed recovery after kidney transplant. Proteomics Clin Appl. 2017 Jul; 2017 Mar 31. PMID: 28261998

Petersen MC, Shulman GI: Roles of Diacylglycerols and Ceramides in Hepatic Insulin Resistance. Trends Pharmacol Sci. 2017 Jul; 2017 May 24. PMID: 28551355

Preisig PA, Silverman J, Brown P, Petervary N: Tough decisions about protocol review. Lab Anim (NY). 2017 Jun 23. PMID: 28644450

Demb JB, Clark DA: Vision: These retinas are made for walkin'. Nature. 2017 Jun 22; 2017 Jun 7. PMID: 28607483

Ermer T, Kopp C, Asplin JR, Granja I, Perazella MA, Reichel M, Nolin TD, Eckardt KU, Aronson PS, Finkelstein FO, Knauf F: Impact of Regular or Extended Hemodialysis and Hemodialfiltration on Plasma Oxalate Concentrations in Patients With End-Stage Renal Disease. Kidney Int Rep. 2017 Nov; 2017 Jun 8. PMID: 29270514

Ter Horst KW, Gilijamse PW, Versteeg RI, Ackermans MT, Nederveen AJ, la Fleur SE, Romijn JA, Nieuwdorp M, Zhang D, Samuel VT, Vatner DF, Petersen KF, Shulman GI, Serlie MJ: Hepatic Diacylglycerol-Associated Protein Kinase Cε Translocation Links Hepatic Steatosis to Hepatic Insulin Resistance in Humans. Cell Rep. 2017 Jun 6. PMID: 28591572

AlKukhun A, Caturegli G, Munoz-Abraham AS, Judeeba S, Patron-Lozano R, Morotti R, Rodriguez-Davalos MI, Geibel JP: Use of Fluorescein Isothiocyanate-Inulin as a Marker for Intestinal Ischemic Injury. J Am Coll Surg. 2017 Jun; 2016 Dec 23. PMID: 28017811

Foer D, Zhu M, Cardone RL, Simpson C, Sullivan R, Nemiroff S, Lee G, Kibbey RG, Petersen KF, Insogna KL: Impact of gain-of-function mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) on glucose and lipid homeostasis. Osteoporos Int. 2017 Jun; 2017 Mar 10. PMID: 28283687

Song E, Gaudin A, King AR, Seo YE, Suh HW, Deng Y, Cui J, Tietjen GT, Huttner A, Saltzman WM: Surface chemistry governs cellular tropism of nanoparticles in the brain. Nat Commun. 2017 May 19; 2017 May 19. PMID: 28524852

Young LH, Viscoli CM, Curtis JP, Inzucchi SE, Schwartz GG, Lovejoy AM, Furie KL, Gorman MJ, Conwit R, Abbott JD, Jacoby DL, Kolansky DM, Pfau SE, Ling FS, Kernan WN, IRIS Investigators.: Cardiac Outcomes After Ischemic Stroke or Transient Ischemic Attack: Effects of Pioglitazone in Patients With Insulin Resistance Without Diabetes Mellitus. Circulation. 2017 May 16; 2017 Feb 28. PMID: 28246237

Yu P, Wilhelm K, Dubrac A, Tung JK, Alves TC, Fang JS, Xie Y, Zhu J, Chen Z, De Smet F, Zhang J, Jin SW, Sun L, Sun H, Kibbey RG, Hirschi KK, Hay N, Carmeliet P, Chittenden TW, Eichmann A, Potente M, Simons M: FGF-dependent metabolic control of vascular development. Nature. 2017 May 11; 2017 May 3. PMID: 28467822

Khare S, Nick JA, Zhang Y, Galeano K, Butler B, Khoshbouei H, Rayaprolu S, Hathorn T, Ranum LPW, Smithson L, Golde TE, Paucar M, Morse R, Raff M, Simon J, Nordenskjöld M, Wirdefeldt K, Rincon-Limas DE, Lewis J, Kaczmarek LK, Fernandez-Funez P, Nick HS, Waters MF: A KCNC3 mutation causes a neurodevelopmental, non-progressive SCA13 subtype associated with dominant negative effects and aberrant EGFR trafficking. PLoS One. 2017; 2017 May 3. PMID: 28467418

Wang S, Yang X: Inter-organ regulation of adipose tissue browning. Cell Mol Life Sci. 2017 May; 2016 Nov 19. PMID: 27866221

Bai JP, Moeini-Naghani I, Zhong S, Li FY, Bian S, Sigworth FJ, Santos-Sacchi J, Navaratnam D: Current carried by the Slc26 family member prestin does not flow through the transporter pathway. Sci Rep. 2017 Apr 19; 2017 Apr 19. PMID: 28422190

Egan ME: Effects of Lumacaftor/Ivacaftor in a Pediatric Cohort Homozygous for F508del-CFTR. Am J Respir Crit Care Med. 2017 Apr 1. PMID: 28362199

Inzucchi SE, Viscoli CM, Young LH, Furie KL, Gorman M, Lovejoy AM, Dagogo-Jack S, Ismail-Beigi F, Korytkowski MT, Pratley RE, Schwartz GG, Kernan WN, IRIS Trial Investigators.: Response to Comment on Inzucchi et al. Pioglitazone Prevents Diabetes in Patients With Insulin Resistance and Cerebrovascular Disease. Diabetes Care 2016;39:1684-1692. Diabetes Care. 2017 Apr. PMID: 28325804

Sharabi K, Lin H, Tavares CDJ, Dominy JE, Camporez JP, Perry RJ, Schilling R, Rines AK, Lee J, Hickey M, Bennion M, Palmer M, Nag PP, Bittker JA, Perez J, Jedrychowski MP, Ozcan U, Gygi SP, Kamenecka TM, Shulman GI, Schreiber SL, Griffin PR, Puigserver P: Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes. Cell. 2017 Mar 23. PMID: 28340340

Silverman J, Macy J, Preisig PA: The role of the IACUC in ensuring research reproducibility. Lab Anim (NY). 2017 Mar 22. PMID: 28328872

Perry RJ, Peng L, Cline GW, Petersen KF, Shulman GI: A Non-invasive Method to Assess Hepatic Acetyl-CoA In Vivo. Cell Metab. 2017 Mar 7; 2017 Jan 19. PMID: 28111213

Viscoli CM, Inzucchi SE, Young LH, Insogna KL, Conwit R, Furie KL, Gorman M, Kelly MA, Lovejoy AM, Kernan WN, IRIS Trial Investigators.: Pioglitazone and Risk for Bone Fracture: Safety Data From a Randomized Clinical Trial. J Clin Endocrinol Metab. 2017 Mar 1. PMID: 27935736

Kesarwani AK, Ramirez O, Gupta AK, Yang X, Murthy T, Minella AC, Pillai MM: Cancer-associated SF3B1 mutants recognize otherwise inaccessible cryptic 3' splice sites within RNA secondary structures. Oncogene. 2017 Feb 23; 2016 Aug 15. PMID: 27524419

Zhang Y, Ni W, Horwich AL, Kaczmarek LK: An ALS-Associated Mutant SOD1 Rapidly Suppresses KCNT1 (Slack) Na+-Activated K+ Channels in Aplysia Neurons. J Neurosci. 2017 Feb 22; 2017 Jan 24. PMID: 28119399

Huen SC, Cantley LG: Macrophages in Renal Injury and Repair. Annu Rev Physiol. 2017 Feb 10. PMID: 28192060

Corbit KC, Camporez JPG, Tran JL, Wilson CG, Lowe DA, Nordstrom SM, Ganeshan K, Perry RJ, Shulman GI, Jurczak MJ, Weiss EJ: Adipocyte JAK2 mediates growth hormone-induced hepatic insulin resistance. JCI Insight. 2017 Feb 9; 2017 Feb 9. PMID: 28194444

Feriod CN, Oliveira AG, Guerra MT, Nguyen L, Richards KM, Jurczak MJ, Ruan HB, Camporez JP, Yang X, Shulman GI, Bennett AM, Nathanson MH, Ehrlich BE: Hepatic Inositol 1,4,5 Trisphosphate Receptor Type 1 Mediates Fatty Liver. Hepatol Commun. 2017 Feb; 2016 Nov 11. PMID: 28966992

Puthumana J, Hall IE, Reese PP, Schröppel B, Weng FL, Thiessen-Philbrook H, Doshi MD, Rao V, Lee CG, Elias JA, Cantley LG, Parikh CR: YKL-40 Associates with Renal Recovery in Deceased Donor Kidney Transplantation. J Am Soc Nephrol. 2017 Feb; 2016 Jul 22. PMID: 27451287

Cocco E, Deng Y, Shapiro EM, Bortolomai I, Lopez S, Lin K, Bellone S, Cui J, Menderes G, Black JD, Schwab CL, Bonazzoli E, Yang F, Predolini F, Zammataro L, Altwerger G, de Haydu C, Clark M, Alvarenga J, Ratner E, Azodi M, Silasi DA, Schwartz PE, Litkouhi B, Saltzman WM, Santin AD: Dual-Targeting Nanoparticles for In Vivo Delivery of Suicide Genes to Chemotherapy-Resistant Ovarian Cancer Cells. Mol Cancer Ther. 2017 Feb; 2016 Dec 12. PMID: 27956521

Ferris HA, Perry RJ, Moreira GV, Shulman GI, Horton JD, Kahn CR: Loss of astrocyte cholesterol synthesis disrupts neuronal function and alters whole-body metabolism. Proc Natl Acad Sci U S A. 2017 Jan 31; 2017 Jan 17. PMID: 28096339

Padovano V, Kuo IY, Stavola LK, Aerni HR, Flaherty BJ, Chapin HC, Ma M, Somlo S, Boletta A, Ehrlich BE, Rinehart J, Caplan MJ: The polycystins are modulated by cellular oxygen-sensing pathways and regulate mitochondrial function. Mol Biol Cell. 2017 Jan 15; 2016 Nov 23. PMID: 27881662

Hsieh LS, Wen JH, Miyares L, Lombroso PJ, Bordey A: Outbred CD1 mice are as suitable as inbred C57BL/6J mice in performing social tasks. Neurosci Lett. 2017 Jan 10; 2016 Nov 18. PMID: 27871995

Kitay AM, Geibel JP: Stomach and Bone. Adv Exp Med Biol. 2017. PMID: 29101653

Kitay AM, Link A, Geibel JP: Activation of Secretagogue Independent Gastric Acid Secretion via Endothelial Nitric Oxide Synthase Stimulation in Rats. Cell Physiol Biochem. 2017; 2017 Dec 6. PMID: 29212068

Aldajani MM, Vanicek CN, Alhazzaa N, Lysyy T, Agarwal R, Geibel JP: Acute Effects of Vitamin C Exposure On Colonic Crypts: Direct Modulation of pH Regulation. Cell Physiol Biochem. 2017; 2017 Nov 13. PMID: 29132138

Knauf F, Thomson RB, Heneghan JF, Jiang Z, Adebamiro A, Thomson CL, Barone C, Asplin JR, Egan ME, Alper SL, Aronson PS: Loss of Cystic Fibrosis Transmembrane Regulator Impairs Intestinal Oxalate Secretion. J Am Soc Nephrol. 2017 Jan; 2016 Jun 16. PMID: 27313231

Stout MB, Steyn FJ, Jurczak MJ, Camporez JG, Zhu Y, Hawse JR, Jurk D, Palmer AK, Xu M, Pirtskhalava T, Evans GL, de Souza Santos R, Frank AP, White TA, Monroe DG, Singh RJ, Casaclang-Verzosa G, Miller JD, Clegg DJ, LeBrasseur NK, von Zglinicki T, Shulman GI, Tchkonia T, Kirkland JL: 17α-Estradiol Alleviates Age-related Metabolic and Inflammatory Dysfunction in Male Mice Without Inducing Feminization. J Gerontol A Biol Sci Med Sci. 2017 Jan; 2016 Jan 24. PMID: 26809497

Kaczmarek LK, Aldrich RW, Chandy KG, Grissmer S, Wei AD, Wulff H: International Union of Basic and Clinical Pharmacology. C. Nomenclature and Properties of Calcium-Activated and Sodium-Activated Potassium Channels. Pharmacol Rev. 2017 Jan; 2016 Nov 15. PMID: 28267675

Yi JS, Huang Y, Kwaczala AT, Kuo IY, Ehrlich BE, Campbell SG, Giordano FJ, Bennett AM: Low-dose dasatinib rescues cardiac function in Noonan syndrome. JCI Insight. 2016 Dec 8; 2016 Dec 8. PMID: 27942593

Thomson RB, Thomson CL, Aronson PS: N-glycosylation critically regulates function of oxalate transporter SLC26A6. Am J Physiol Cell Physiol. 2016 Dec 1; 2016 Sep 28. PMID: 27681177

Gilliland T, Dufour S, Shulman GI, Petersen KF, Emre SH: Resolution of non-alcoholic steatohepatitis after growth hormone replacement in a pediatric liver transplant patient with panhypopituitarism. Pediatr Transplant. 2016 Dec; 2016 Oct 20. PMID: 27762491

Ola R, Dubrac A, Han J, Zhang F, Fang JS, Larrivée B, Lee M, Urarte AA, Kraehling JR, Genet G, Hirschi KK, Sessa WC, Canals FV, Graupera M, Yan M, Young LH, Oh PS, Eichmann A: PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia. Nat Commun. 2016 Nov 29; 2016 Nov 29. PMID: 27897192

Bartley CM, O'Keefe RA, Blice-Baum A, Mihailescu MR, Gong X, Miyares L, Karaca E, Bordey A: Mammalian FMRP S499 Is Phosphorylated by CK2 and Promotes Secondary Phosphorylation of FMRP. eNeuro. 2016 Nov-Dec; 2016 Nov 21. PMID: 27957526

Zhang J, Cui J, Deng Y, Jiang Z, Saltzman WM: Multifunctional Poly(amine-co-ester-co-ortho ester) for Efficient and Safe Gene Delivery. ACS Biomater Sci Eng. 2016 Nov 14; 2016 Sep 26. PMID: 28649641

Cui Y, Wang YV, Park SJ, Demb JB, Butts DA: Divisive suppression explains high-precision firing and contrast adaptation in retinal ganglion cells. Elife. 2016 Nov 14; 2016 Nov 14. PMID: 27841746

Ferstl FS, Kitay AM, Trattnig RM, Alsaihati A, Geibel JP: Secretagogue-dependent and -independent transport of zinc hydration forms in rat parietal cells. Pflugers Arch. 2016 Nov; 2016 Oct 19. PMID: 27757581

Gupta A, Bahal R, Gupta M, Glazer PM, Saltzman WM: Nanotechnology for delivery of peptide nucleic acids (PNAs). J Control Release. 2016 Oct 28; 2016 Jan 8. PMID: 26776051

Clark DA, Demb JB: Parallel Computations in Insect and Mammalian Visual Motion Processing. Curr Biol. 2016 Oct 24. PMID: 27780048

Deng Y, Yang F, Cocco E, Song E, Zhang J, Cui J, Mohideen M, Bellone S, Santin AD, Saltzman WM: Improved i.p. drug delivery with bioadhesive nanoparticles. Proc Natl Acad Sci U S A. 2016 Oct 11; 2016 Sep 23. PMID: 27663731

Lin TV, Hsieh L, Kimura T, Malone TJ, Bordey A: Normalizing translation through 4E-BP prevents mTOR-driven cortical mislamination and ameliorates aberrant neuron integration. Proc Natl Acad Sci U S A. 2016 Oct 4; 2016 Sep 19. PMID: 27647922

Gaudin A, Song E, King AR, Saucier-Sawyer JK, Bindra R, Desmaële D, Couvreur P, Saltzman WM: PEGylated squalenoyl-gemcitabine nanoparticles for the treatment of glioblastoma. Biomaterials. 2016 Oct; 2016 Aug 4. PMID: 27521616

Inzucchi SE, Viscoli CM, Young LH, Furie KL, Gorman M, Lovejoy AM, Dagogo-Jack S, Ismail-Beigi F, Korytkowski MT, Pratley RE, Schwartz GG, Kernan WN, IRIS Trial Investigators.: Pioglitazone Prevents Diabetes in Patients With Insulin Resistance and Cerebrovascular Disease. Diabetes Care. 2016 Oct; 2016 Jul 27. PMID: 27465265

Pesta DH, Tsirigotis DN, Befroy DE, Caballero D, Jurczak MJ, Rahimi Y, Cline GW, Dufour S, Birkenfeld AL, Rothman DL, Carpenter TO, Insogna K, Petersen KF, Bergwitz C, Shulman GI: Hypophosphatemia promotes lower rates of muscle ATP synthesis. FASEB J. 2016 Oct; 2016 Jun 23. PMID: 27338702

Zhao L, Feng Z, Yang X, Liu J: The regulatory roles of O-GlcNAcylation in mitochondrial homeostasis and metabolic syndrome. Free Radic Res. 2016 Oct; 2016 Oct 19. PMID: 27646831

Kumamoto Y, Camporez JPG, Jurczak MJ, Shanabrough M, Horvath T, Shulman GI, Iwasaki A: CD301b(+) Mononuclear Phagocytes Maintain Positive Energy Balance through Secretion of Resistin-like Molecule Alpha. Immunity. 2016 Sep 20; 2016 Aug 23. PMID: 27566941

Jiang M, Qiu Z, Zhang S, Fan X, Cai X, Xu B, Li X, Zhou J, Zhang X, Chu Y, Wang W, Liang J, Horvath T, Yang X, Wu K, Nie Y, Fan D: Elevated O-GlcNAcylation promotes gastric cancer cells proliferation by modulating cell cycle related proteins and ERK 1/2 signaling. Oncotarget. 2016 Sep 20. PMID: 27542217

Onorati M, Li Z, Liu F, Sousa AMM, Nakagawa N, Li M, Dell'Anno MT, Gulden FO, Pochareddy S, Tebbenkamp ATN, Han W, Pletikos M, Gao T, Zhu Y, Bichsel C, Varela L, Szigeti-Buck K, Lisgo S, Zhang Y, Testen A, Gao XB, Mlakar J, Popovic M, Flamand M, Strittmatter SM, Kaczmarek LK, Anton ES, Horvath TL, Lindenbach BD, Sestan N: Zika Virus Disrupts Phospho-TBK1 Localization and Mitosis in Human Neuroepithelial Stem Cells and Radial Glia. Cell Rep. 2016 Sep 6; 2016 Aug 24. PMID: 27568284

Fehringer G, Kraft P, Pharoah PD, Eeles RA, Chatterjee N, Schumacher FR, Schildkraut JM, Lindström S, Brennan P, Bickeböller H, Houlston RS, Landi MT, Caporaso N, Risch A, Amin Al Olama A, Berndt SI, Giovannucci EL, Grönberg H, Kote-Jarai Z, Ma J, Muir K, Stampfer MJ, Stevens VL, Wiklund F, Willett WC, Goode EL, Permuth JB, Risch HA, Reid BM, Bezieau S, Brenner H, Chan AT, Chang-Claude J, Hudson TJ, Kocarnik JK, Newcomb PA, Schoen RE, Slattery ML, White E, Adank MA, Ahsan H, Aittomäki K, Baglietto L, Blomquist C, Canzian F, Czene K, Dos-Santos-Silva I, Eliassen AH, Figueroa JD, Flesch-Janys D, Fletcher O, Garcia-Closas M, Gaudet MM, Johnson N, Hall P, Hazra A, Hein R, Hofman A, Hopper JL, Irwanto A, Johansson M, Kaaks R, Kibriya MG, Lichtner P, Liu J, Lund E, Makalic E, Meindl A, Müller-Myhsok B, Muranen TA, Nevanlinna H, Peeters PH, Peto J, Prentice RL, Rahman N, Sanchez MJ, Schmidt DF, Schmutzler RK, Southey MC, Tamimi R, Travis RC, Turnbull C, Uitterlinden AG, Wang Z, Whittemore AS, Yang XR, Zheng W, Buchanan DD, Casey G, Conti DV, Edlund CK, Gallinger S, Haile RW, Jenkins M, Le Marchand L, Li L, Lindor NM, Schmit SL, Thibodeau SN, Woods MO, Rafnar T, Gudmundsson J, Stacey SN, Stefansson K, Sulem P, Chen YA, Tyrer JP, Christiani DC, Wei Y, Shen H, Hu Z, Shu XO, Shiraishi K, Takahashi A, Bossé Y, Obeidat M, Nickle D, Timens W, Freedman ML, Li Q, Seminara D, Chanock SJ, Gong J, Peters U, Gruber SB, Amos CI, Sellers TA, Easton DF, Hunter DJ, Haiman CA, Henderson BE, Hung RJ, Ovarian Cancer Association Consortium (OCAC)., PRACTICAL Consortium., Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON)., Colorectal Transdisciplinary (CORECT) Study., African American Breast Cancer Consortium (AABC) and African Ancestry Prostate Cancer Consortium (AAPC).: Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations. Cancer Res. 2016 Sep 1; 2016 Apr 20. PMID: 27197191

Nagarajan A, Petersen MC, Nasiri AR, Butrico G, Fung A, Ruan HB, Kursawe R, Caprio S, Thibodeau J, Bourgeois-Daigneault MC, Sun L, Gao G, Bhanot S, Jurczak MJ, Green MR, Shulman GI, Wajapeyee N: MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels. Nat Commun. 2016 Aug 31; 2016 Aug 31. PMID: 27577745

Fleming MR, Brown MR, Kronengold J, Zhang Y, Jenkins DP, Barcia G, Nabbout R, Bausch AE, Ruth P, Lukowski R, Navaratnam DS, Kaczmarek LK: Stimulation of Slack K(+) Channels Alters Mass at the Plasma Membrane by Triggering Dissociation of a Phosphatase-Regulatory Complex. Cell Rep. 2016 Aug 30; 2016 Aug 18. PMID: 27545877

Wang B, Boeckel GR, Huynh L, Nguyen L, Cao W, De La Cruz EM, Kaftan EJ, Ehrlich BE: Neuronal Calcium Sensor 1 Has Two Variants with Distinct Calcium Binding Characteristics. PLoS One. 2016; 2016 Aug 30. PMID: 27575489

Zhang L, Huang T, Bordey A: Tsc1 haploinsufficiency is sufficient to increase dendritic patterning and Filamin A levels. Neurosci Lett. 2016 Aug 26; 2016 Jun 21. PMID: 27345385

Zhang Y, Kaczmarek LK: Kv3.3 potassium channels and spinocerebellar ataxia. J Physiol. 2016 Aug 15; 2015 Nov 15. PMID: 26442672

Herrema H, Zhou Y, Zhang D, Lee J, Salazar Hernandez MA, Shulman GI, Ozcan U: XBP1s Is an Anti-lipogenic Protein. J Biol Chem. 2016 Aug 12; 2016 Jun 20. PMID: 27325692

Perry RJ, Cardone RL, Petersen MC, Zhang D, Fouqueray P, Hallakou-Bozec S, Bolze S, Shulman GI, Petersen KF, Kibbey RG: Imeglimin lowers glucose primarily by amplifying glucose-stimulated insulin secretion in high-fat-fed rodents. Am J Physiol Endocrinol Metab. 2016 Aug 1; 2016 Jul 12. PMID: 27406738

Belinsky GS, Sreekumar B, Andrejecsk JW, Saltzman WM, Gong J, Herzog RI, Lin S, Horsley V, Carpenter TO, Chung C: Pigment epithelium-derived factor restoration increases bone mass and improves bone plasticity in a model of osteogenesis imperfecta type VI via Wnt3a blockade. FASEB J. 2016 Aug; 2016 Apr 28. PMID: 27127101

Byun H, Kwon S, Ahn HJ, Liu H, Forrest D, Demb JB, Kim IJ: Molecular features distinguish ten neuronal types in the mouse superficial superior colliculus. J Comp Neurol. 2016 Aug 1; 2016 Jan 26. PMID: 26713509

Yang Y, Ehrlich BE: Structural studies of the C-terminal tail of polycystin-2 (PC2) reveal insights into the mechanisms used for the functional regulation of PC2. J Physiol. 2016 Aug 1; 2016 Apr 27. PMID: 26857659

Tian H, Ji X, Yang X, Zhang Z, Lu Z, Yang K, Chen C, Zhao Q, Chi H, Mu Z, Xie W, Wang Z, Lou H, Yang H, Rao Z: Structural basis of Zika virus helicase in recognizing its substrates. Protein Cell. 2016 Aug; 2016 Jul 18. PMID: 27430951

Petersen KF, Befroy DE, Dufour S, Rothman DL, Shulman GI: Assessment of Hepatic Mitochondrial Oxidation and Pyruvate Cycling in NAFLD by (13)C Magnetic Resonance Spectroscopy. Cell Metab. 2016 Jul 12. PMID: 27411016

Bartulos O, Zhuang ZW, Huang Y, Mikush N, Suh C, Bregasi A, Wang L, Chang W, Krause DS, Young LH, Pober JS, Qyang Y: ISL1 cardiovascular progenitor cells for cardiac repair after myocardial infarction. JCI Insight. 2016 Jul 7. PMID: 27525311

Costa DK, Huckestein BR, Edmunds LR, Petersen MC, Nasiri A, Butrico GM, Abulizi A, Harmon DB, Lu C, Mantell BS, Hartman DJ, Camporez JP, O'Doherty RM, Cline GW, Shulman GI, Jurczak MJ: Reduced intestinal lipid absorption and body weight-independent improvements in insulin sensitivity in high-fat diet-fed Park2 knockout mice. Am J Physiol Endocrinol Metab. 2016 Jul 1; 2016 May 10. PMID: 27166280

Ermer T, Eckardt KU, Aronson PS, Knauf F: Oxalate, inflammasome, and progression of kidney disease. Curr Opin Nephrol Hypertens. 2016 Jul. PMID: 27191349

Brown MR, El-Hassar L, Zhang Y, Alvaro G, Large CH, Kaczmarek LK: Physiological modulators of Kv3.1 channels adjust firing patterns of auditory brain stem neurons. J Neurophysiol. 2016 Jul 1; 2016 Apr 6. PMID: 27052580

Park JK, Utsumi T, Seo YE, Deng Y, Satoh A, Saltzman WM, Iwakiri Y: Cellular distribution of injected PLGA-nanoparticles in the liver. Nanomedicine. 2016 Jul; 2016 Mar 4. PMID: 26961463

Jung Y, Hsieh LS, Lee AM, Zhou Z, Coman D, Heath CJ, Hyder F, Mineur YS, Yuan Q, Goldman D, Bordey A, Picciotto MR: An epigenetic mechanism mediates developmental nicotine effects on neuronal structure and behavior. Nat Neurosci. 2016 Jul; 2016 May 30. PMID: 27239938

Saucier-Sawyer JK, Seo YE, Gaudin A, Quijano E, Song E, Sawyer AJ, Deng Y, Huttner A, Saltzman WM: Distribution of polymer nanoparticles by convection-enhanced delivery to brain tumors. J Control Release. 2016 Jun 28; 2016 Apr 8. PMID: 27063424

Lv C, Stewart WJ, Akanyeti O, Frederick C, Zhu J, Santos-Sacchi J, Sheets L, Liao JC, Zenisek D: Synaptic Ribbons Require Ribeye for Electron Density, Proper Synaptic Localization, and Recruitment of Calcium Channels. Cell Rep. 2016 Jun 21; 2016 Jun 9. PMID: 27292637

Madiraju AK, Alves T, Zhao X, Cline GW, Zhang D, Bhanot S, Samuel VT, Kibbey RG, Shulman GI: Argininosuccinate synthetase regulates hepatic AMPK linking protein catabolism and ureagenesis to hepatic lipid metabolism. Proc Natl Acad Sci U S A. 2016 Jun 14; 2016 May 31. PMID: 27247419

Goldgof GM, Durrant JD, Ottilie S, Vigil E, Allen KE, Gunawan F, Kostylev M, Henderson KA, Yang J, Schenken J, LaMonte GM, Manary MJ, Murao A, Nachon M, Stanhope R, Prescott M, McNamara CW, Slayman CW, Amaro RE, Suzuki Y, Winzeler EA: Comparative chemical genomics reveal that the spiroindolone antimalarial KAE609 (Cipargamin) is a P-type ATPase inhibitor. Sci Rep. 2016 Jun 13; 2016 Jun 13. PMID: 27291296

Perry RJ, Peng L, Barry NA, Cline GW, Zhang D, Cardone RL, Petersen KF, Kibbey RG, Goodman AL, Shulman GI: Acetate mediates a microbiome-brain-β-cell axis to promote metabolic syndrome. Nature. 2016 Jun 9. PMID: 27279214

Santos-Sacchi J, Song L: Chloride Anions Regulate Kinetics but Not Voltage-Sensor Qmax of the Solute Carrier SLC26a5. Biophys J. 2016 Jun 7. PMID: 27276272

Mortensen LS, Park SJH, Ke JB, Cooper BH, Zhang L, Imig C, Löwel S, Reim K, Brose N, Demb JB, Rhee JS, Singer JH: Complexin 3 Increases the Fidelity of Signaling in a Retinal Circuit by Regulating Exocytosis at Ribbon Synapses. Cell Rep. 2016 Jun 7; 2016 May 26. PMID: 27239031

Perry RJ, Borders CB, Cline GW, Zhang XM, Alves TC, Petersen KF, Rothman DL, Kibbey RG, Shulman GI: Propionate Increases Hepatic Pyruvate Cycling and Anaplerosis and Alters Mitochondrial Metabolism. J Biol Chem. 2016 Jun 3; 2016 Mar 21. PMID: 27002151

Vazirani RP, Verma A, Sadacca LA, Buckman MS, Picatoste B, Beg M, Torsitano C, Bruno JH, Patel RT, Simonyte K, Camporez JP, Moreira G, Falcone DJ, Accili D, Elemento O, Shulman GI, Kahn BB, McGraw TE: Disruption of Adipose Rab10-Dependent Insulin Signaling Causes Hepatic Insulin Resistance. Diabetes. 2016 Jun; 2016 Mar 25. PMID: 27207531

Hsieh LS, Wen JH, Claycomb K, Huang Y, Harrsch FA, Naegele JR, Hyder F, Buchanan GF, Bordey A: Convulsive seizures from experimental focal cortical dysplasia occur independently of cell misplacement. Nat Commun. 2016 Jun 1; 2016 Jun 1. PMID: 27249187

Platel JC, Bordey A: The multifaceted subventricular zone astrocyte: From a metabolic and pro-neurogenic role to acting as a neural stem cell. Neuroscience. 2016 May 26; 2015 Nov 3. PMID: 26546469

Moore LB, Sawyer AJ, Saucier-Sawyer J, Saltzman WM, Kyriakides TR: Nanoparticle delivery of miR-223 to attenuate macrophage fusion. Biomaterials. 2016 May; 2016 Feb 26. PMID: 26967647

Perry RJ, Petersen KF, Shulman GI: Pleotropic effects of leptin to reverse insulin resistance and diabetic ketoacidosis. Diabetologia. 2016 May; 2016 Mar 10. PMID: 26961503

Xie Z, Zhang D, Chung D, Tang Z, Huang H, Dai L, Qi S, Li J, Colak G, Chen Y, Xia C, Peng C, Ruan H, Kirkey M, Wang D, Jensen LM, Kwon OK, Lee S, Pletcher SD, Tan M, Lombard DB, White KP, Zhao H, Li J, Roeder RG, Yang X, Zhao Y: Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation. Mol Cell. 2016 Apr 21. PMID: 27105115

Demb JB, Singer JH: Mind the Gap Junctions: The Importance of Electrical Synapses to Visual Processing. Neuron. 2016 Apr 20. PMID: 27100191

Bruscia EM, Zhang PX, Barone C, Scholte BJ, Homer R, Krause DS, Egan ME: Increased susceptibility of Cftr-/- mice to LPS-induced lung remodeling. Am J Physiol Lung Cell Mol Physiol. 2016 Apr 15; 2016 Feb 5. PMID: 26851259

Mulay SR, Eberhard JN, Pfann V, Marschner JA, Darisipudi MN, Daniel C, Romoli S, Desai J, Grigorescu M, Kumar SV, Rathkolb B, Wolf E, Hrabě de Angelis M, Bäuerle T, Dietel B, Wagner CA, Amann K, Eckardt KU, Aronson PS, Anders HJ, Knauf F: Oxalate-induced chronic kidney disease with its uremic and cardiovascular complications in C57BL/6 mice. Am J Physiol Renal Physiol. 2016 Apr 15; 2016 Jan 13. PMID: 26764204

Kuo IY, Duong SL, Nguyen L, Ehrlich BE: Decreased Polycystin 2 Levels Result in Non-Renal Cardiac Dysfunction with Aging. PLoS One. 2016; 2016 Apr 15. PMID: 27081851

Priest JR, Osoegawa K, Mohammed N, Nanda V, Kundu R, Schultz K, Lammer EJ, Girirajan S, Scheetz T, Waggott D, Haddad F, Reddy S, Bernstein D, Burns T, Steimle JD, Yang XH, Moskowitz IP, Hurles M, Lifton RP, Nickerson D, Bamshad M, Eichler EE, Mital S, Sheffield V, Quertermous T, Gelb BD, Portman M, Ashley EA: De Novo and Rare Variants at Multiple Loci Support the Oligogenic Origins of Atrioventricular Septal Heart Defects. PLoS Genet. 2016 Apr; 2016 Apr 8. PMID: 27058611

Zhang Y, Zhang XF, Fleming MR, Amiri A, El-Hassar L, Surguchev AA, Hyland C, Jenkins DP, Desai R, Brown MR, Gazula VR, Waters MF, Large CH, Horvath TL, Navaratnam D, Vaccarino FM, Forscher P, Kaczmarek LK: Kv3.3 Channels Bind Hax-1 and Arp2/3 to Assemble a Stable Local Actin Network that Regulates Channel Gating. Cell. 2016 Apr 7; 2016 Mar 17. PMID: 26997484

Vyas M, Yang X, Zhang X: Gastric Hamartomatous Polyps-Review and Update. Clin Med Insights Gastroenterol. 2016; 2016 Apr 7. PMID: 27081323

Kernan WN, Viscoli CM, Furie KL, Young LH, Inzucchi SE, Gorman M, Guarino PD, Lovejoy AM, Peduzzi PN, Conwit R, Brass LM, Schwartz GG, Adams HP Jr, Berger L, Carolei A, Clark W, Coull B, Ford GA, Kleindorfer D, O'Leary JR, Parsons MW, Ringleb P, Sen S, Spence JD, Tanne D, Wang D, Winder TR, IRIS Trial Investigators.: Pioglitazone after Ischemic Stroke or Transient Ischemic Attack. N Engl J Med. 2016 Apr 7; 2016 Feb 17. PMID: 26886418

Lee S, Zhang Y, Chen M, Zhou ZJ: Segregated Glycine-Glutamate Co-transmission from vGluT3 Amacrine Cells to Contrast-Suppressed and Contrast-Enhanced Retinal Circuits. Neuron. 2016 Apr 6; 2016 Mar 17. PMID: 26996083

Xu HP, Burbridge TJ, Ye M, Chen M, Ge X, Zhou ZJ, Crair MC: Retinal Wave Patterns Are Governed by Mutual Excitation among Starburst Amacrine Cells and Drive the Refinement and Maintenance of Visual Circuits. J Neurosci. 2016 Mar 30. PMID: 27030771

Egan ME: Genetics of Cystic Fibrosis: Clinical Implications. Clin Chest Med. 2016 Mar; 2015 Dec 24. PMID: 26857764

Kursawe R, Dixit VD, Scherer PE, Santoro N, Narayan D, Gordillo R, Giannini C, Lopez X, Pierpont B, Nouws J, Shulman GI, Caprio S: A Role of the Inflammasome in the Low Storage Capacity of the Abdominal Subcutaneous Adipose Tissue in Obese Adolescents. Diabetes. 2016 Mar; 2015 Dec 30. PMID: 26718495