2012
Effect of Acute Infusion of Low‐Molecular‐Weight Polyvinylpyrrolidone on Renal Function
Yan Q, Du Z, Wan L, Beck F, Giebisch G, Wang T. Effect of Acute Infusion of Low‐Molecular‐Weight Polyvinylpyrrolidone on Renal Function. The FASEB Journal 2012, 26: 1100.2-1100.2. DOI: 10.1096/fasebj.26.1_supplement.1100.2.Peer-Reviewed Original ResearchBlood urea nitrogenGlomerular filtration rateNatriuretic effectRenal functionProximal tubular absorptionPVP storage diseaseLong-term administrationMonocyte/macrophage systemAcute infusionKaliuretic effectRenal damageRenal failureRenal injuryTubular absorptionUrine volumeFiltration rateClearance experimentsUrea nitrogenProximal tubulesInfusionNephron segmentsMacrophage systemElectrolyte absorptionPlasma expanderExcretion
2011
Renal outer medullary potassium channel knockout models reveal thick ascending limb function and dysfunction
Wang T. Renal outer medullary potassium channel knockout models reveal thick ascending limb function and dysfunction. Clinical And Experimental Nephrology 2011, 16: 49-54. PMID: 22038261, DOI: 10.1007/s10157-011-0495-0.Peer-Reviewed Original ResearchConceptsThick ascending limbIon transporter expressionRenal outer medullary potassium channelBartter's syndromeInward rectifier potassium channelPotassium channelsSmall-conductance K channelsROMK null miceMedullary thick ascending limbType II Bartter's syndromeSimilar phenotypeMammalian kidneyApical membraneK channelsROMK knockout miceKnockout modelsChannel activityChannel mutationsRenal functionLimb functionNull micePhysiological conditionsSalt wastingTransporter expressionPathophysiological conditionsGENDER DIFFERENCE IN MODULATION OF ANGIOTENSIN II TYPE 2 RECEPTOR (AT2) FUNCTION AND EXPRESSION IN AT1A RECEPTOR‐DEFICIENT MICE
Yan Q, Wan L, Du Z, Gotoh N, Wang T. GENDER DIFFERENCE IN MODULATION OF ANGIOTENSIN II TYPE 2 RECEPTOR (AT2) FUNCTION AND EXPRESSION IN AT1A RECEPTOR‐DEFICIENT MICE. The FASEB Journal 2011, 25: 835.9-835.9. DOI: 10.1096/fasebj.25.1_supplement.835.9.Peer-Reviewed Original ResearchGlomerular filtration rateUrine volumeAT2 receptorsProximal tubulesAT1A receptor-deficient miceNull miceExpression levelsReceptor-deficient miceKidneys of malesFemale null miceMale null miceAT2 inhibitorNatriuretic effectRenal functionAT2 expressionWT miceFiltration rateBolus injectionReal-time PCRRenal clearancePD123319ENaC expressionReceptor functionMiceReceptors
2008
Neutrophil gelatinase-associated lipocalin suppresses cyst growth by Pkd1 null cells in vitro and in vivo
Wei F, Karihaloo A, Yu Z, Marlier A, Seth P, Shibazaki S, Wang T, Sukhatme VP, Somlo S, Cantley LG. Neutrophil gelatinase-associated lipocalin suppresses cyst growth by Pkd1 null cells in vitro and in vivo. Kidney International 2008, 74: 1310-1318. PMID: 18974761, PMCID: PMC3793389, DOI: 10.1038/ki.2008.395.Peer-Reviewed Original ResearchConceptsNeutrophil Gelatinase-Associated LipocalinCyst growthGelatinase-associated lipocalinAutosomal dominant polycystic kidney diseaseTubular cell proliferationDominant polycystic kidney diseaseCell linesPolycystic kidney diseasePkd1 mutant miceRenal functionAdenoviral delivery systemAssociated lipocalinKidney diseaseRate of proliferationCyst enlargementProliferative responseRenal epithelial cellsProximal tubulesMutant miceEpithelial cellsFlow stimuliCell proliferationDecreased rateApical ciliaProliferationFemale ROMK null mice manifest more severe Bartter II phenotype on renal function and higher PGE2 production
Yan Q, Yang X, Cantone A, Giebisch G, Hebert S, Wang T. Female ROMK null mice manifest more severe Bartter II phenotype on renal function and higher PGE2 production. AJP Regulatory Integrative And Comparative Physiology 2008, 295: r997-r1004. PMID: 18579648, PMCID: PMC2536865, DOI: 10.1152/ajpregu.00051.2007.Peer-Reviewed Original ResearchConceptsROMK null miceFemale null miceNull miceRenal functionSurvival rateExtent of hydronephrosisDegree of hydronephrosisSeverity of hydronephrosisHigher PGE2 productionHydronephrotic miceLower GFRSyndrome pathophysiologyNg/24 hAcid-base parametersFemale micePGE2 productionHydronephrosisHigher survival rateMiceExcretionSignificant differencesUrinaryMalesSexPossible mechanismBLOOD PRESSURE AND RENAL FUNCTIONS IN MALE AND FEMALE sEH KNOCKOUT MICE
Yan Q, Raksaseri P, Weldon S, Kabcenell A, Hebert S, Wang T. BLOOD PRESSURE AND RENAL FUNCTIONS IN MALE AND FEMALE sEH KNOCKOUT MICE. The FASEB Journal 2008, 22: 479.34-479.34. DOI: 10.1096/fasebj.22.1_supplement.479.34.Peer-Reviewed Original ResearchANGIOTENSION‐INDUCED HYPERTENSION AND CHANGES IN RENAL FUNCTIONS IN MALE AND FEMALE sEH KNOCKOUT MICE
Yan Q, Raksaseri P, Weldon S, Kabcenell A, Hebert S, Wang T. ANGIOTENSION‐INDUCED HYPERTENSION AND CHANGES IN RENAL FUNCTIONS IN MALE AND FEMALE sEH KNOCKOUT MICE. The FASEB Journal 2008, 22: 941.15-941.15. DOI: 10.1096/fasebj.22.1_supplement.941.15.Peer-Reviewed Original ResearchFemale WT miceMale WT miceSEH knockout miceSEH KO miceAng IIWT miceFemale KO miceKO miceBlood pressureChronic infusionRenal functionMale WTKnockout miceMale KORenal function responseSimilar blood pressureAng II infusionSystemic blood pressureLower blood pressureGroups of miceAcute infusionII infusionFemale WTUrine volumeOsmotic minipumps
1990
Cholinergic effect on rat proximal convoluted tubule
Wang T, Chan Y. Cholinergic effect on rat proximal convoluted tubule. Pflügers Archiv - European Journal Of Physiology 1990, 415: 533-539. PMID: 2109302, DOI: 10.1007/bf02583503.Peer-Reviewed Original ResearchConceptsProximal convoluted tubulesPCT transportCholinergic effectsCholinergic receptorsCapillary perfusateInhibitory effectCarbachol-induced effectsFunctional cholinergic receptorsProximal tubular absorptionAddition of carbacholBicarbonate Ringer's solutionRenal functionTubular absorptionCholinergic agentsPeritubular capillariesRadioactive inulinSimultaneous perfusionCalcium influxHigh doseConvoluted tubulesCarbacholIonophore ABicarbonate absorptionFluid absorptionBasolateral side