2012
Genetic modifiers of hypertension in soluble guanylate cyclase α1–deficient mice
Buys ES, Raher MJ, Kirby A, Mohd S, Baron DM, Hayton SR, Tainsh LT, Sips PY, Rauwerdink KM, Yan Q, Tainsh RE, Shakartzi HR, Stevens C, Decaluwé K, da Gloria Rodrigues-Machado M, Malhotra R, Van de Voorde J, Wang T, Brouckaert P, Daly MJ, Bloch KD. Genetic modifiers of hypertension in soluble guanylate cyclase α1–deficient mice. Journal Of Clinical Investigation 2012, 122: 2316-2325. PMID: 22565307, PMCID: PMC3366402, DOI: 10.1172/jci60119.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCyclic GMPEndothelium, VascularFemaleGenetic LinkageGenome, HumanGuanylate CyclaseHumansHypertensionMaleMiceMice, KnockoutQuantitative Trait LociRatsReceptors, Cytoplasmic and NuclearReninRenin-Angiotensin SystemSecond Messenger SystemsSoluble Guanylyl CyclaseSpecies SpecificityVasodilationConceptsNitric oxideEndothelium-dependent vasorelaxationOnset of hypertensionVascular smooth muscleNO/cGMPSoluble guanylate cyclaseAdditional genetic factorsAldosterone systemRAAS inhibitionArterial pressureMale miceHypertensionSmooth muscleBlood flowGuanylate cyclaseMouse strainsΑ1 subunitGenetic factorsMiceReceptor componentsGenetic modifiersVasorelaxationRenin
2002
Use of transgenic animals to study renal acid-base transport.
Wang T, Giebisch G, Aronson PS. Use of transgenic animals to study renal acid-base transport. Journal Of Nephrology 2002, 15 Suppl 5: s151-60. PMID: 12027214.Commentaries, Editorials and LettersConceptsAcid-base transportSpecific transporter isoformsSuch knockout miceRenal acid-base transportRenal acid-base homeostasisTransgenic miceTransporter isoformsPump subunitsTransgenic animalsKnockout micePhysiological roleATPase isoformsTransport deficiencyMolecular levelAcid-base homeostasisIsoformsAdaptive mechanismsCarbonic anhydraseCompensatory-adaptive mechanismsUseful experimental modelTransportersRegulatory mediatorsNHE isoformsNitric oxideExperimental model
1997
Nitric oxide regulates HCO3- and Na+ transport by a cGMP-mediated mechanism in the kidney proximal tubule
Wang T. Nitric oxide regulates HCO3- and Na+ transport by a cGMP-mediated mechanism in the kidney proximal tubule. American Journal Of Physiology 1997, 272: f242-f248. PMID: 9124402, DOI: 10.1152/ajprenal.1997.272.2.f242.Peer-Reviewed Original ResearchConceptsSodium nitroprussideProximal tubulesKidney proximal tubulesBlood pressureL-NAMENitric oxideNitro-L-arginine methyl esterNitric oxide synthase inhibitorGlomerular filtration rateOxide synthase inhibitorGuanylate cyclase inhibitorUrine flow rateMicroM sodium nitroprussideRenal hemodynamicsFiltration rateRenal excretionRenal clearanceSynthase inhibitorCyclase inhibitorLuminal perfusateRat kidneyMicroperfusion techniqueStimulatory effectSimilar stimulationCyclic monophosphate