2008
ANGIOTENSION‐INDUCED HYPERTENSION AND CHANGES IN RENAL FUNCTIONS IN MALE AND FEMALE sEH KNOCKOUT MICE
Yan Q, Raksaseri P, Weldon S, Kabcenell A, Hebert S, Wang T. ANGIOTENSION‐INDUCED HYPERTENSION AND CHANGES IN RENAL FUNCTIONS IN MALE AND FEMALE sEH KNOCKOUT MICE. The FASEB Journal 2008, 22: 941.15-941.15. DOI: 10.1096/fasebj.22.1_supplement.941.15.Peer-Reviewed Original ResearchFemale WT miceMale WT miceSEH knockout miceSEH KO miceAng IIWT miceFemale KO miceKO miceBlood pressureChronic infusionRenal functionMale WTKnockout miceMale KORenal function responseSimilar blood pressureAng II infusionSystemic blood pressureLower blood pressureGroups of miceAcute infusionII infusionFemale WTUrine volumeOsmotic minipumps
2003
Role of PKC and calcium in modulation of effects of angiotensin II on sodium transport in proximal tubule
Du Z, Ferguson W, Wang T. Role of PKC and calcium in modulation of effects of angiotensin II on sodium transport in proximal tubule. American Journal Of Physiology. Renal Physiology 2003, 284: f688-f692. PMID: 12527554, DOI: 10.1152/ajprenal.00261.2002.Peer-Reviewed Original ResearchConceptsAng IIM ANG IIProximal tubulesFluid absorptionRole of PKCLuminal ANG IIAng II concentrationsIntracellular calcium mobilizationProximal tubule transportProximal tubular fluidTrimethoxybenzoic acid 8Modulation of effectsCAMP-independent mechanismAngiotensin IIIntracellular calciumTMB-8Calcium mobilizationTubule transportTubular fluidMicroperfusion techniqueSodium transportSuperficial segmentsRabbit kidneyPhysiological concentrationsTubules
1996
Effects of angiotensin II on electrolyte transport in the early and late distal tubule in rat kidney
Wang T, Giebisch G. Effects of angiotensin II on electrolyte transport in the early and late distal tubule in rat kidney. American Journal Of Physiology 1996, 271: f143-f149. PMID: 8760255, DOI: 10.1152/ajprenal.1996.271.1.f143.Peer-Reviewed Original ResearchConceptsLate distal tubuleEarly distal tubuleAng IIDistal tubulesRat kidneyAng II receptor antagonistsAngiotensin II stimulatesAngiotensin receptor blockersII receptor antagonistsInitial collecting tubuleLuminal administrationCortical nephronsAngiotensin IIIntravenous infusionReceptor antagonistTubular perfusateDistal nephronLuminal applicationCollecting tubuleProximal tubulesSeparate perfusionHigh dosesLow dosesHormone effectsNephron segments
1991
The role of phosphoinositide turnover in mediating the biphasic effect of angiotensin II on renal tubular transport.
Wang T, Chan Y. The role of phosphoinositide turnover in mediating the biphasic effect of angiotensin II on renal tubular transport. Journal Of Pharmacology And Experimental Therapeutics 1991, 256: 309-17. PMID: 1846421.Peer-Reviewed Original ResearchMeSH Keywords1-(5-Isoquinolinesulfonyl)-2-MethylpiperazineAngiotensin IIAnimalsBicarbonatesBiological TransportCalcium Channel BlockersDose-Response Relationship, DrugGallic AcidIsoquinolinesKidney Tubules, ProximalMalePerfusionPhosphatidylinositolsPiperazinesProtein Kinase InhibitorsRatsRats, Inbred StrainsSignal TransductionSodiumTetradecanoylphorbol AcetateConceptsM ANG IIAng IIBiphasic effectAngiotensin IIM TMBDose-dependent biphasic effectSodium transportPhosphoinositide turnoverIntracellular calcium mobilizationRenal tubular transportOriginal perfusateRat PCTLuminal perfusionCalcium mobilizationTubular transportFluid reabsorptionRat kidneyStimulatory effectJHCO3Total CO2 changesVolume markerRinger's solutionPossible roleCritical rolePrevious studies
1990
Mechanism of angiotensin II action on proximal tubular transport.
Wang T, Chan Y. Mechanism of angiotensin II action on proximal tubular transport. Journal Of Pharmacology And Experimental Therapeutics 1990, 252: 689-95. PMID: 2313594.Peer-Reviewed Original ResearchConceptsAng II actionFluid reabsorptionAng IILuminal perfusionAng II interactsAction of angiotensinAng II antagonistAngiotensin II actionM ANG IIPhosphoinositide turnoverProximal tubular transportRat proximal tubuleNa-H exchange mechanismOriginal perfusateRat PCTAngiotensin IIII antagonistLow dosePCT transportTubular transportProximal tubulesBicarbonate absorptionM amilorideStimulatory effectTotal CO2 changes