Job Opportunities

A postdoctoral position is available for an individual with an interest in understanding how the systems for translating mRNA are re-programmed during physiologic stress and disease. Our lab takes a multi-disciplinary approach to exploring these questions, and employs a wide range of biochemical, bioinformatics, and next-gen sequencing strategies. We are looking for creative and motivated candidates with a quantitative bent, and preferably a strong background in molecular biology techniques. For more information, please visit the site of Thoreen Laboratory. Applicants should send their CV, a brief statement of interests, and the names/contact information of at least one reference to Carson Thoreen, Department of Cellular and Molecular Physiology, Yale School of Medicine via email to carson.thoreen@yale.edu.

Our labs are pioneering the use of non-standard animal models, such as hibernating squirrels, tactile foraging ducks and others, to inquire into the molecular basis of mechanosensitivity, thermosensitivity and thermoregulation in vertebrates. We are seeking motivated postdocs to study general principles of temperature- and mechanosensation, and gating of heat- and mechanosensitive ion channels, including Piezo, K2P, TRP and Nav’s. We use a multidisciplinary approach ranging from biophysics, biochemistry and transcriptomics to cell and molecular biology and behavioral tests.

Candidates should have a strong background in general biochemical, biophysical, molecular or cell biological techniques. Experience with electrophysiological methods is highly desirable. Salary—Yale scale.

More information can be found on The Slav and Elena Labs at Yale website:

http://squirrel.commons.yale.edu/

Applicants should send a CV and a list of referees to:

sviatoslav.bagriantsev@yale.edu and elena.gracheva@yale.edu

Postdoc position available in the laboratory of Dr. Jesse Rinehart at the Yale Systems Biology Institute. The qualified applicant will have an NIH funded position and join a new collaborative network working at the interface of Systems Biology, Synthetic Biology, & Cancer Biology (https://news.yale.edu/2016/08/23/casbyale-launches-95m-federal-grant-battle-deadliest-cancers).

Highly qualified applicants can send a CV directly to jesse.rinehart@yale.edu.

A postdoctoral position is available in the laboratory of Jean-Ju Chung in Department of Cellular & Molecular Physiology at Yale School of Medicine in New Haven, Connecticut. The Chung lab studies cellular signaling via ion channels and membrane receptors that regulates sperm motility and fertility under normal and pathophysiological conditions using insights from human genetics and mouse models (www.jeanjuchunglab.org).

Self-driven and highly motivated PhD (or PhD candidate) with an inquisitive nature and a quantitative mind is encouraged to apply. Ideal candidates should be passionate about the Chung lab’s research interests and hold a Ph.D. in Cell Biology, Biochemistry, Immunology, or Reproductive Biology. Experience with protein biochemistry and/or mice gametes and embryos will be favorably considered.

Experience with molecular & cellular biology and imaging techniques is necessary. Excellent organization skills, written and verbal communication skills, and willingness to write grant proposals and manuscripts are necessary.

To apply, please send a single PDF file to Jean-Ju Chung at jean-ju.chung@yale.edu including:

1. A cover letter with a statement of research experience and interest
2. Curriculum Vitae (cv)
3. A list of three (3) references

A post-doctoral position is available immediately in the Karatekin lab. We study molecular mechanisms regulating neurotransmitter release and synaptic vesicle recycling using biochemical reconstitution, live cell measurements, and a range of biophysical and imaging approaches, including electrophysiology and optical tweezers (http://campuspress.yale.edu/karatekinlab/).

Building upon approaches recently developed in the lab, the candidate will

1. study how fusion pores open and dilate during neurotransmitter or hormone release in response to calcium using semi-reconstituted systems
2. dissect mechanisms contributing to kinetics and cooperativity of rapid calcium-triggered exocytosis, with a particular focus on the release machinery in photoreceptors. Techniques and tools used will include electrophysiology, nanodiscs (artificial disc-shaped phospholipid bilayers) reconstituted with SNARE and Synaptotagmin proteins, engineered cells expressing fusogens with flipped topology on their surfaces, single-particle fluorescence microscopy, and ultraviolet flash photolysis (for rapid elevation of calcium).

Problem-solving skills, analytical thinking, motivation, initiative, creativity, and good communication skills are essential. Expertise in two or more of the following areas is desirable: membrane biophysics, electrophysiology (especially coupled with UV uncaging of calcium or other compounds), cell biology/physiology, optics, molecular biology and biochemistry, quantitative analysis. Candidates with a background in physics, engineering or a related field are especially encouraged to apply.

Please send (as pdf files) a cover letter briefly describing your research interests, a curriculum vitae (including a publications list), and full contact information for three references to erdem.karatekin@yale.edu.