Nancy Carrasco, MD

Professor of Cellular And Molecular Physiology

Research Interests

Anions; Biogenesis; Biological Assay; Breast Neoplasms; Hypothyroidism; Kinetics; Medical Oncology; Neoplasm Metastasis; Thyroid Neoplasms; Amino Acid Substitution

Research Organizations

Cellular & Molecular Physiology

Liver Center

Yale Cancer Center: Genomics, Genetics, and Epigenetics

Office of Cooperative Research

Selected Publications

  • Nicola, JP., Carrasco, N*. and Amzel, LM* (2014) “Physiological Na+ concentra-tions enhance the I- affinity of the Na+/I- symporter (NIS)” Nature Comm 3;5:3948. doi: 10.1038/ncomms4948.PMID: 24888603 *co-corrresponding authors Highlighted in Science (2014), 344, 1355.
  • Asn441 plays a key role in folding and function of the Na+/I- symporter (NIS).

    Li W, Nicola JP, Amzel LM, Carrasco N. Asn441 plays a key role in folding and function of the Na+/I- symporter (NIS). FASEB Journal : Official Publication Of The Federation Of American Societies For Experimental Biology 2013, 27:3229-38.

  • Paroder V, Nicola JP, Ginter CS, and Carrasco N. (2013) “The iodide transport defect-causing mutation R124H: a d-amino group at position 124 is critical for maturation and trafficking of the Na+/I- symporter (NIS)” J. Cell Science May 20. [Epub ahead of print] PMID: 23690546
  • Mechanism of anion selectivity and stoichiometry of the Na+/I- symporter (NIS).

    Paroder-Belenitsky M, Maestas MJ, Dohán O, Nicola JP, Reyna-Neyra A, Follenzi A, Dadachova E, Eskandari S, Amzel LM, Carrasco N. Mechanism of anion selectivity and stoichiometry of the Na+/I- symporter (NIS). Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108:17933-8.

  • Roepke TK, King EC, Reyna-Neyra A, Paroder M, Purtell K, Koba W, Fine E, Lerner DJ, Carrasco N, Abbott GW (2009). "kcne2 deletion uncovers its critical role in thyroid hormone synthesis" Nature Medicine 15, 1186-1194. Epub Sep 20. Evaluated in: “Faculty of 1000.”, 2009.
  • •Dohán O, Portulano C, Basquin C, Reyna-Neyra A, Amzel LM, and Carrasco N. (2007) "The Na+/I- symporter (NIS) mediates electroneutral active transport of the environmental pollutant perchlorate" Proc Natl Acad Sci USA Dec 104, 20250-20255. Epub 2007 Dec
  • De la Vieja A, Reed M, Ginter CS, and Carrasco N. (2007) "Amino acid residues in transmembrane segment IX of the Na+/I- symporter (NIS) play a role in its Na+ dependence and are critical for transport activity" J Biol Chem 282, 25290-25298. Epub Jul 2.
  • Na+ coordination at the Na2 site of the Na+/I- symporter.

    Ferrandino G, Nicola JP, Sánchez YE, Echeverria I, Liu Y, Amzel LM, Carrasco N. Na+ coordination at the Na2 site of the Na+/I- symporter. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113:E5379-88.

  • • Nagarajah, J., Le, M., Knauf JA, Ferrandino G., Montero-Conde C., Pillarsetty N., Bolaender A., Irwin CP., Krishnamoorthy GP., Saqcena M., Larson, S., Ho AL., Seshan V., Ishii, N., Carrasco N., Rosen N., Weber WA., and Fagin JA (2016) “Sustained ERK inhibition maximizes responses of BrafV600E thyroid cancers to radioiodine” J Clin Invest 126(11):4119-4124. doi:10.1172/JCI89067

Full List of PubMed Publications

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Contact Info

Nancy Carrasco, MD
Lab Location
Carrasco LabSterling Hall of Medicine, B-Wing
333 Cedar Street, Ste BE-60

New Haven, CT 06510
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