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DTSTART:20241103T020000
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DESCRIPTION:Activity-dependent changes in synaptic strength and structure 
 are crucial for acquiring\, storing\, and retrieving information in the b
 rain. These changes are orchestrated by a complex cascade of biochemical 
 reactions involving hundreds of intracellular and extracellular signaling
  proteins at the synapse. To elucidate the operational principles of thes
 e signaling networks\, we have developed innovative 2-photon fluorescence
  lifetime imaging (2pFLIM)-based techniques\, enabling visualization of t
 he spatiotemporal dynamics of protein activity with single-synapse resolu
 tion. To bridge the gap between behavioral plasticity and signaling dynam
 ics\, we employed miniature 2-photon fluorescence lifetime imaging micros
 copy (mini-2pFLIM)\, allowing us to image signal transduction in freely b
 ehaving animals. Additionally\, we have developed various optogenetic and
  chemogenetic enzyme inhibitors targeting key kinases\, such as CaMKII an
 d PKC. This approach has allowed us to correlate the temporal dynamics of
  enzymes within synapses to behavioral plasticity. Our techniques have pr
 ovided unprecedented insights into the mechanisms underlying synaptic pla
 sticity\, circuit function\, and behavioral adaptations.\n\nSpeaker:\nRyo
 hei Yasuda\, PhD\n\nAdmission:\nFree\n\nDetails URL:\nhttps://medicine.ya
 le.edu/event/neuroscience-seminar-series-29/\n
DTEND;TZID=America/New_York:20260406T130000
DTSTAMP:20260504T114247Z
DTSTART;TZID=America/New_York:20260406T120000
GEO:41.304215;-72.931754
LOCATION:180 A/B\, 100 College Street\, New Haven\, CT\, United States
SEQUENCE:0
STATUS:Confirmed
SUMMARY:Neuroscience Seminar Series
UID:6159359e-a645-4601-841f-5b9f121e2812
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