2025
The inner core enables transient touch detection in the Pacinian corpuscle
Ziolkowski L, Nikolaev Y, Chikamoto A, Oda M, Feketa V, Monedero-Alonso D, Ardasheva S, Bae S, Xu C, Pang S, Gracheva E, Bagriantsev S. The inner core enables transient touch detection in the Pacinian corpuscle. Science Advances 2025, 11: eadt4837. PMID: 40009676, PMCID: PMC11864184, DOI: 10.1126/sciadv.adt4837.Peer-Reviewed Original Research
2023
Three-dimensional reconstructions of mechanosensory end organs suggest a unifying mechanism underlying dynamic, light touch
Handler A, Zhang Q, Pang S, Nguyen T, Iskols M, Nolan-Tamariz M, Cattel S, Plumb R, Sanchez B, Ashjian K, Shotland A, Brown B, Kabeer M, Turecek J, DeLisle M, Rankin G, Xiang W, Pavarino E, Africawala N, Santiago C, Lee W, Xu C, Ginty D. Three-dimensional reconstructions of mechanosensory end organs suggest a unifying mechanism underlying dynamic, light touch. Neuron 2023, 111: 3211-3229.e9. PMID: 37725982, PMCID: PMC10773061, DOI: 10.1016/j.neuron.2023.08.023.Peer-Reviewed Original ResearchMechanotransduction events at the physiological site of touch detection
Ziolkowski L, Gracheva E, Bagriantsev S. Mechanotransduction events at the physiological site of touch detection. ELife 2023, 12: e84179. PMID: 36607222, PMCID: PMC9833821, DOI: 10.7554/elife.84179.Peer-Reviewed Original Research
2022
The 3D ultrastructure of the chordotonal organs in the antenna of a microwasp remains complex although simplified
Diakova A, Makarova A, Pang S, Xu C, Hess H, Polilov A. The 3D ultrastructure of the chordotonal organs in the antenna of a microwasp remains complex although simplified. Scientific Reports 2022, 12: 20172. PMID: 36424494, PMCID: PMC9691716, DOI: 10.1038/s41598-022-24390-4.Peer-Reviewed Original Research
2020
Chapter Three Cell membrane mechanics and mechanosensory transduction
Martinac B, Nikolaev Y, Silvani G, Bavi N, Romanov V, Nakayama Y, Martinac A, Rohde P, Bavi O, Cox C. Chapter Three Cell membrane mechanics and mechanosensory transduction. Current Topics In Membranes 2020, 86: 83-141. PMID: 33837699, DOI: 10.1016/bs.ctm.2020.08.002.Peer-Reviewed Original ResearchConceptsCell mechanicsCell membrane mechanicsMechanosensitive ion channelsGene expressionIntracellular signalsMechanosensory transductionMolecular transducersIon channelsMechanical stimuliMembrane mechanicsCurrent knowledgeMechanical forcesMillisecond timescaleStimuli actCellsTransductionRapid progressNew toolMechanobiologyBiological cellsBetter understandingPathwayExpression
2019
Piezo2 integrates mechanical and thermal cues in vertebrate mechanoreceptors
Zheng W, Nikolaev YA, Gracheva EO, Bagriantsev SN. Piezo2 integrates mechanical and thermal cues in vertebrate mechanoreceptors. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 17547-17555. PMID: 31413193, PMCID: PMC6717272, DOI: 10.1073/pnas.1910213116.Peer-Reviewed Original ResearchA Cross-Species Analysis Reveals a General Role for Piezo2 in Mechanosensory Specialization of Trigeminal Ganglia from Tactile Specialist Birds
Schneider ER, Anderson EO, Feketa VV, Mastrotto M, Nikolaev YA, Gracheva EO, Bagriantsev SN. A Cross-Species Analysis Reveals a General Role for Piezo2 in Mechanosensory Specialization of Trigeminal Ganglia from Tactile Specialist Birds. Cell Reports 2019, 26: 1979-1987.e3. PMID: 30784581, PMCID: PMC6420409, DOI: 10.1016/j.celrep.2019.01.100.Peer-Reviewed Original ResearchConceptsTrigeminal ganglionPiezo2 ion channelsExpression of moleculesExpression of factorsPiezo2 expressionSomatosensory neuronsNeuronal subtypesSomatosensory systemSuch neuronsSpecialist birdsBird speciesMolecular variationFamily AnatidaeForaging behaviorTactile specializationNeuronsMechanoreceptorsSpecies analysisGangliaGeneral roleBehavioral phenotypesIon channelsGeneral mechanismTactile specialistsFunction of mechanoreceptors
2017
Molecular basis of tactile specialization in the duck bill
Schneider ER, Anderson EO, Mastrotto M, Matson JD, Schulz VP, Gallagher PG, LaMotte RH, Gracheva EO, Bagriantsev SN. Molecular basis of tactile specialization in the duck bill. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 13036-13041. PMID: 29109250, PMCID: PMC5724259, DOI: 10.1073/pnas.1708793114.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAvian ProteinsBeakChickensCloning, MolecularDucksEmbryo, NonmammalianGene ExpressionGenetic VectorsHEK293 CellsHumansIon ChannelsKineticsMechanoreceptorsMechanotransduction, CellularMicePatch-Clamp TechniquesRecombinant ProteinsRNA, Small InterferingSequence Homology, Amino AcidSpecies SpecificityTouchTouch PerceptionTrigeminal GanglionConceptsMolecular basisHeterologous expression systemSpecialist birdsMouse orthologPiezo2 ion channelsTactile specializationExpression systemDuck billMolecular characterizationIon channelsFeeding behaviorEdible matterPiezo2BirdsElectrophysiological characterizationSlow inactivation kineticsOrthologsVertebratesMechanoMechanotransductionKnockdownInactivation kineticsMurky watersHigh densityNeuronsMechanosensory neurons control the timing of spinal microcircuit selection during locomotion
Knafo S, Fidelin K, Prendergast A, Tseng PB, Parrin A, Dickey C, Böhm UL, Figueiredo SN, Thouvenin O, Pascal-Moussellard H, Wyart C. Mechanosensory neurons control the timing of spinal microcircuit selection during locomotion. ELife 2017, 6: e25260. PMID: 28623664, PMCID: PMC5499942, DOI: 10.7554/elife.25260.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsLocomotionMechanoreceptorsNeural PathwaysSensory Receptor CellsSpinal CordZebrafishConceptsSpinal cordMechanosensory neuronsRohon-Beard neuronsMonosynaptic inputSpinal circuitsMotor poolsCordNeuronsV2a interneuronsVertebrate spinal cordMechanosensory feedbackNumerous physiological studiesSimple locomotionPhysiological studiesActive locomotionLocomotor speedEscape responseInterneuronsZebrafish larvae
2016
CSF-contacting neurons regulate locomotion by relaying mechanical stimuli to spinal circuits
Böhm UL, Prendergast A, Djenoune L, Nunes Figueiredo S, Gomez J, Stokes C, Kaiser S, Suster M, Kawakami K, Charpentier M, Concordet JP, Rio JP, Del Bene F, Wyart C. CSF-contacting neurons regulate locomotion by relaying mechanical stimuli to spinal circuits. Nature Communications 2016, 7: 10866. PMID: 26946992, PMCID: PMC4786674, DOI: 10.1038/ncomms10866.Peer-Reviewed Original ResearchConceptsSpinal cordSpinal circuitsCentral pattern generatorCSF-cNsCerebrospinal fluid-contacting neuronsSpinal central pattern generatorVentral spinal cordLocomotor central pattern generatorCSF-contacting neuronsCentral canalSpinal bendingCordNeuronsMechanical stimuliMechanosensory organsOrgansSensory modalitiesAnimals
2014
Chemical and Physical Sensors in the Regulation of Renal Function
Pluznick JL, Caplan MJ. Chemical and Physical Sensors in the Regulation of Renal Function. Clinical Journal Of The American Society Of Nephrology 2014, 10: 1626-1635. PMID: 25280495, PMCID: PMC4559500, DOI: 10.2215/cjn.00730114.Peer-Reviewed Original Research
2012
Novel sensory signaling systems in the kidney
Pluznick JL, Caplan MJ. Novel sensory signaling systems in the kidney. Current Opinion In Nephrology & Hypertension 2012, 21: 404-409. PMID: 22569342, DOI: 10.1097/mnh.0b013e328354a6bd.Peer-Reviewed Original Research
2011
In vivo responses of cutaneous C-mechanosensitive neurons in mouse to punctate chemical stimuli that elicit itch and nociceptive sensations in humans
Ma C, Nie H, Gu Q, Sikand P, LaMotte RH. In vivo responses of cutaneous C-mechanosensitive neurons in mouse to punctate chemical stimuli that elicit itch and nociceptive sensations in humans. Journal Of Neurophysiology 2011, 107: 357-363. PMID: 21994268, PMCID: PMC3349700, DOI: 10.1152/jn.00801.2011.Peer-Reviewed Original ResearchConceptsNociceptive sensationsCowhage spiculesC-nociceptorsNociceptive neuronsReceptive fieldsCutaneous receptive fieldsNoxious mechanical stimuliC-fibre rangePeripheral neural mechanismsExtracellular electrophysiological recordingsAxonal conduction velocityMean discharge rateChemical itchElicit itchChemical stimuliMechanosensitive nociceptorsConduction velocityMechanosensitive neuronsHeat stimuliItchCell bodiesElectrophysiological recordingsVivo responseCapsaicinHistamineWagner-Meissner Corpuscle Proliferation
Barbieri AL, Jain D, Gobel S, Kenney B. Wagner-Meissner Corpuscle Proliferation. International Journal Of Surgical Pathology 2011, 20: 79-82. PMID: 21632642, DOI: 10.1177/1066896911408723.Peer-Reviewed Original Research
2005
MAPKs (ERK½, p38) and AKT Can Be Phosphorylated by Shear Stress Independently of Platelet Endothelial Cell Adhesion Molecule-1 (CD31) in Vascular Endothelial Cells*
Sumpio BE, Yun S, Cordova AC, Haga M, Zhang J, Koh Y, Madri JA. MAPKs (ERK½, p38) and AKT Can Be Phosphorylated by Shear Stress Independently of Platelet Endothelial Cell Adhesion Molecule-1 (CD31) in Vascular Endothelial Cells*. Journal Of Biological Chemistry 2005, 280: 11185-11191. PMID: 15668248, DOI: 10.1074/jbc.m414631200.Peer-Reviewed Original ResearchAnimalsCattleCell CommunicationEndothelial CellsEnzyme ActivationHumansMechanoreceptorsMiceMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3p38 Mitogen-Activated Protein KinasesPhosphorylationPlatelet Endothelial Cell Adhesion Molecule-1Protein Serine-Threonine KinasesProto-Oncogene ProteinsProto-Oncogene Proteins c-aktStress, MechanicalTyrosine
2002
Dcas Is Required for importin-α3 Nuclear Export and Mechano-Sensory Organ Cell Fate Specification in Drosophila
Tekotte H, Berdnik D, Török T, Buszczak M, Jones LM, Cooley L, Knoblich JA, Davis I. Dcas Is Required for importin-α3 Nuclear Export and Mechano-Sensory Organ Cell Fate Specification in Drosophila. Developmental Biology 2002, 244: 396-406. PMID: 11944946, DOI: 10.1006/dbio.2002.0612.Peer-Reviewed Original ResearchMeSH KeywordsActive Transport, Cell Nucleusalpha KaryopherinsAnimalsApoptosisCellular Apoptosis Susceptibility ProteinDNA HelicasesDrosophila melanogasterDrosophila ProteinsEmbryo, NonmammalianGene Expression Regulation, DevelopmentalIn Situ HybridizationMechanoreceptorsMorphogenesisPhylogenyRNA, MessengerSense OrgansConceptsNuclear exportEmbryonic central nervous systemNuclear protein importCell fate specificationSpecific developmental phenotypesHuman genetic disordersProtein importDrosophila orthologImportin alphaFate specificationExport receptorCell identityDevelopmental phenotypesHypomorphic alleleEmbryonic cellsVivo functionNotch pathwayTissue specificityCytoplasmic distributionEpidermal cellsDifferent tissuesCharacteristics of mutationsGenetic disordersMutationsPhenotypeComparison of responses to tensile and compressive stimuli in C-mechanosensitive nociceptors in rat hairy skin
Zheng Z, LaMotte R, Grigg P. Comparison of responses to tensile and compressive stimuli in C-mechanosensitive nociceptors in rat hairy skin. Somatosensory & Motor Research 2002, 19: 109-113. PMID: 12088384, DOI: 10.1080/08990220120113095.Peer-Reviewed Original Research
2001
Single-Channel Properties of Recombinant Acid-Sensitive Ion Channels Formed by the Subunits Asic2 and Asic3 from Dorsal Root Ganglion Neurons Expressed in Xenopus Oocytes
Zhang P, Canessa C. Single-Channel Properties of Recombinant Acid-Sensitive Ion Channels Formed by the Subunits Asic2 and Asic3 from Dorsal Root Ganglion Neurons Expressed in Xenopus Oocytes. Journal Of General Physiology 2001, 117: 563-572. PMID: 11382806, PMCID: PMC2232399, DOI: 10.1085/jgp.117.6.563.Peer-Reviewed Original ResearchOdor Coding in the Drosophila Antenna
de Bruyne M, Foster K, Carlson J. Odor Coding in the Drosophila Antenna. Neuron 2001, 30: 537-552. PMID: 11395013, DOI: 10.1016/s0896-6273(01)00289-6.Peer-Reviewed Original Research
2000
Endothelial cell response to different mechanical forces
Azuma N, Duzgun S, Ikeda M, Kito H, Akasaka N, Sasajima T, Sumpio B. Endothelial cell response to different mechanical forces. Journal Of Vascular Surgery 2000, 32: 789-794. PMID: 11013043, DOI: 10.1067/mva.2000.107989.Peer-Reviewed Original ResearchAnimalsAortaCattleCells, CulturedEndothelium, VascularEnzyme ActivationFocal Adhesion Kinase 1Focal Adhesion Protein-Tyrosine KinasesFocal AdhesionsHumansImmunoblottingJNK Mitogen-Activated Protein KinasesMechanoreceptorsMitogen-Activated Protein KinasesPhosphorylationProtein-Tyrosine KinasesSignal TransductionStress, Mechanical
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