2025
ATGL links insulin dysregulation to insulin resistance in adolescents with obesity and hepatosteatosis
Slusher A, Santoro N, Vash-Margita A, Galderisi A, Hu P, Tokoglu F, Li Z, Tarabra E, Strober J, Vatner D, Shulman G, Caprio S. ATGL links insulin dysregulation to insulin resistance in adolescents with obesity and hepatosteatosis. Journal Of Clinical Investigation 2025, 135: e184740. PMID: 40091831, PMCID: PMC11910223, DOI: 10.1172/jci184740.Peer-Reviewed Original ResearchConceptsHyperinsulinemic-euglycemic clampSubcutaneous adipose tissueInsulin resistanceAdipose triglyceride lipaseInsulin infusionOral glucose tolerance testAbdominal fat distributionGlucose tolerance testMeasuring abdominal fat distributionLower liver fatActivating adipose triglyceride lipaseMetabolic disease riskLiver fat contentEctopic lipid storageFUNDINGThis workAdipose tissue lipolysisInhibition of adipose tissue lipolysisSubcutaneous adipose tissue samplesFat distributionTolerance testInsulin exposureLiver fatInfusionGlycerol turnoverAdipose tissueGlobal, regional, and national prevalence of child and adolescent overweight and obesity, 1990–2021, with forecasts to 2050: a forecasting study for the Global Burden of Disease Study 2021
Collaborators G, Kerr J, Patton G, Cini K, Abate Y, Abbas N, Al Magied A, ElHafeez S, Abd-Elsalam S, Abdollahi A, Abdoun M, Abdulah D, Abdulkader R, Abdullahi A, Abeywickrama H, Abie A, Abiodun O, Abohashem S, Abtahi D, Abualruz H, Abubakar B, Abu-Gharbieh E, Abukhadijah H, Abu-Rmeileh N, Aburuz S, Abu-Zaid A, Adams L, Adane M, Addo I, Adedokun K, Adegoke N, Adesola R, Adetunji J, Adeyeoluwa T, Adiga U, Adnani Q, Afify A, Afolabi A, Afzal M, Afzal S, Agampodi S, Aghamiri S, Sobrinho C, Agyemang-Duah W, Ahinkorah B, Ahlstrom A, Ahmad A, Ahmad D, Ahmad F, Ahmad M, Ahmad N, Ahmad S, Ahmed A, Ahmed H, Ahmed L, Ahmed M, Ahmed M, Ahmed S, Ajami M, Akkaif M, Akrami A, Al Hamad H, Al Hasan S, Al Ta'ani Z, Al Thaher Y, Alalwan T, Al-Aly Z, Alam K, Al-amer R, Alansari A, Al-Ashwal F, Albashtawy M, Alemayehu B, Algammal A, Alhabib K, Alhuwail D, Ali A, Ali E, Ali M, Ali M, Ali R, Ali W, Alif M, Alimohamadi Y, Al-Jabi S, Aljofan M, Aljunid S, Alkhatib A, Almahmeed W, Al-Marwani S, Alomari M, Alqahtani S, Alqarni A, Alrawashdeh A, Alrimawi I, Alrousan S, Alshahrani N, Altaany Z, Altaf A, Alvi F, Alvis-Guzman N, Al-Wardat M, Al-Worafi Y, Aly H, Aly S, Alzoubi K, Mohammadi M, Amera T, Amiri S, Amu H, Amugsi D, Amusa G, Ananda R, Ancuceanu R, Ansari M, Ansari S, Anuoluwa B, Anuoluwa I, Anvari S, Anwar S, Anyasodor A, Arab J, Arabloo J, Arafat M, Aravkin A, Areda D, Aregawi B, Arifin H, Armocida B, Ärnlöv J, Arooj M, Arora A, Artamonov A, Artanti K, Arumugam A, Asghari-Jafarabadi M, Ashraf T, Asiamah-Asare B, Astell-Burt T, Athari S, Atorkey, Atreya A, Aumoldaeva Z, Awoke M, Awotidebe A, Aychiluhm S, Azimi A, Aziz S, Aziz S, Azzam A, Azzolino D, Babashahi M, Babu G, Badran A, Bagheri N, Bai R, Baig A, Bakkannavar S, Balakrishnan S, Baltatu O, Bam K, Banik R, Barati S, Bardhan M, Barqawi H, Barquera S, Barrow A, Barua L, Bastan M, Basu S, Bayat R, Bayih M, Bayleyegn N, Beeraka N, Behera P, Ramirez D, Bello U, Belo L, Bennett D, Bergami M, Berhe K, Berihun A, Bhadoria A, Bhala N, Bharadwaj R, Bhardwaj N, Bhardwaj P, Bhaskar S, Bhat A, Bhattacharjee P, Bhatti G, Bhatti J, Bilgin C, Bisignano C, Biswas B, Peroni B, Bjertness E, Bjørge T, Boloor A, Boppana S, Bosoka S, Bouaoud S, Boyko E, Braithwaite D, Brazo-Sayavera J, Brenner H, Bryazka D, Bugiardini R, Bui L, Bustanji Y, Butt N, Butt Z, Barsbay M, Calina D, Cámera L, Campos L, Cao S, Capodici A, Carletti C, Carvalho A, Carvalho M, Cattafesta M, Cattaruzza M, Cegolon L, Cembranel F, Cerin E, Cernigliaro A, Chadwick J, Chakraborty C, Chandrasekar E, Chang J, Chattu V, Chaudhary A, Chaurasia A, Chen A, Chen H, Chew N, Chi G, Chimoriya R, Ching P, Chitheer A, Choi D, Chong B, Chong C, Chopra H, Chopra S, Chou H, Choudhari S, Chung S, Chung S, Chutiyami M, Cogen R, Columbus A, Conrad N, Criqui M, Cruz-Martins N, da Silva A, Dadras O, Dai X, Dalakoti M, D'Amico E, Dandona L, Dandona R, D'Anna L, Danpanichkul P, Darcho S, Soltani R, Dash N, Davletov K, Dehghan A, Denova-Gutiérrez E, Molla M, Dergaa I, Desale A, Devanbu V, Devegowda D, Dhali A, Dhungel B, Diaz D, Dinu M, Chi T, do Prado C, Dodangeh M, Doegah P, Dohare S, Dokova K, Doku P, Dolatkhah N, D'Oria M, Dorostkar F, Doshi O, Doshi R, Dowou R, Du M, Dumith S, Dumuid D, Duncan B, Dutta S, Ebrahimi A, Edvardsson K, Sedeh A, Ekholuenetale M, Arab R, Bayoumy I, Eladl M, El-Ashker S, Elbarazi I, Elgendy I, Elhadi M, El-Metwally A, Elmonem M, Elnaem M, Elsheikh R, Eltaha C, Emeto T, Eslami M, Fabin N, Fadavian H, Fagbamigbe A, Fakhradiyev I, Faraji S, Farinha C, Faris M, Faris P, Kouhanjani M, Farooque U, Farrokhpour H, Fasusi S, Fazeli P, Fazylov T, Feizkhah A, Fekadu G, Feng X, Fernandez-Jimenez R, Ferreira N, Foigt N, Folayan M, Fomenkov A, Foroumadi R, Rodrigues C, Foschi M, Francis K, Franklin R, Gába A, Gadanya M, Gaidhane A, Galali Y, Gallus S, Ganesan B, Gangachannaiah S, Gebregergis M, Gebrehiwot M, Getacher L, Getie M, Ghadirian F, Ghazy R, Gil A, Gill T, Gillum R, Girmay A, Golechha M, Goleij P, Goulart A, Grada A, Grivna M, Grover A, Guan Z, Guarducci G, Gubari M, Guha A, Gulati S, Gunawardane D, Guo Z, Gupta B, Gupta R, Gupta R, Gupta V, Gutiérrez-Murillo R, Guzman-Esquivel J, Hadi N, Hadian Z, Hamdy N, Hamidi S, Hanif A, Hanifi N, Hankey G, Haq A, Haro J, Hasan F, Hashempour R, Hashempur M, Hasnain S, Hassan A, Hassan N, Hassanipour S, Rad A, Havmoeller R, Hay S, Hebert J, Hezam K, Hiraike Y, Hoang M, Holla R, Hossain A, Hosseinzadeh H, Hostiuc M, Hostiuc S, Htay Z, Hu M, Hu Y, Humayun A, Hundie T, Husseiny M, Hussien F, Huynh H, Hwang B, Ibrahim R, Ibrayeva A, Ikeda N, Ilesanmi O, Ilic I, Ilic M, Inbaraj L, Inok A, Iqbal K, Islam S, Islam F, Islam R, Islam M, Ismail N, Iso H, Isola G, Ituka M, Iwagami M, Iwu-Jaja C, Iyasu A, Jacob L, Jaffar S, Jahrami H, Jain A, Jain R, Jairoun A, Jakovljevic M, Javaid S, Jayapal S, Jayaram S, Jebasingh F, Jee S, Jema A, Jeswani B, Jonas J, Joseph N, Joshua C, Jozwiak J, Jürisson M, Kaambwa B, Kabir A, Kadashetti V, Kakkar A, Kalra S, Kanaan S, Kankam S, Kanmanthareddy A, Kanmodi K, Kantar R, Kar D, Karajizadeh M, Karakasis P, Behnagh A, Karimzadhagh S, Kassebaum N, Kauppila J, Kayode G, Kedir S, Kehagias D, Keshwani A, Kesse-Guyot E, Keykhaei M, Khajuria H, Khalili P, Khalilian A, Khalis M, Khan A, Khan M, Khan A, Khan M, Khan M, Khan M, Khan N, Khanal V, Khanmohammadi S, Khatatbeh M, Kheirkhah M, Khidri F, Khokhar M, Khosla A, Khosravi S, Khosrowjerdi M, Khusun H, Kim G, Kim J, Kim J, Kim M, Kim Y, Kimokoti R, Kisa A, Kishore L, Shivakumar K, Kokkorakis M, Kompani F, Korzh O, Kostev K, Laxminarayana S, Kretchy I, Kua C, Defo B, Kuddus M, Kulimbet M, Kulkarni V, Kumar G, Kumar V, Kundu S, Kunutsor S, Kurmi O, Kurniasari M, Kusuma D, Kytö V, La Vecchia C, Lacey B, Lahariya C, Lai D, Landires I, Larijani B, Lassi Z, Le H, Le N, Lee H, Lee M, Lee P, Lee S, Lee W, Li A, Li M, Li W, Li Y, Lim S, Lin J, Lin Q, Lindholm D, Lindstedt P, Liu J, Lo J, López-Gil J, Lorkowski S, Lucchetti G, Lugo A, Lutambi A, Feei Z, Gómez J, Maghbouli N, Mahalleh M, Mahmood N, Majeed A, Makris K, Rad E, Malekzadeh R, Malhotra K, Malik A, Malik I, Malta D, Mamun A, Manu E, Marateb H, Marino M, Marjani A, Martinez-Piedra R, Martorell M, März W, Marzouk S, Masrouri S, Mathangasinghe Y, Matozinhos F, Matthias T, Mattiello R, Maugeri A, Mazidi M, McPhail S, Mechili E, Salas M, Mehmood A, Mehrabani-Zeinabad K, Meto T, Meles H, Mendoza W, Menezes R, Mengistie E, Meo A, Mestrovic T, Mettananda C, Mettananda S, Miao H, Miller T, Ming W, Mirrakhimov E, Misganaw A, Mitiku H, Mittal M, Mohamed J, Mohamed M, Mohamed N, Mohammad T, Mohammad-Alizadeh-Charandabi S, Mohammadian-Hafshejani A, Mohammadzadeh I, Mohammed S, Mokdad A, Monasta L, Mondello S, Moni M, Namin S, Ghalibaf A, Moradi Y, Morrison S, Motappa R, Mubarik S, Mulita F, Mullany E, Munkhsaikhan Y, Murillo-Zamora E, Murray C, Musa S, Mustafa G, Muthu S, Mwita J, Myung W, Nafiu A, Nagel G, Naik G, Naik H, Nambi G, Nangia V, Nargus S, Nascimento G, Nassar M, Nauman J, Naureen Z, Navaratna S, Nawsherwan, Nayak B, Nazri-Panjaki A, Negahdary M, Negoi I, Negoi R, Nematollahi S, Nepal S, Netsere H, Ng M, Ngunjiri J, Nguyen D, Nguyen P, Phuong The Nguyen, Niazi R, Nieddu L, Niknam M, Nikolouzakis T, Nikoobar A, Nkeck J, Nomura S, Noor S, Noreen M, Noubiap J, Nouri M, Nri-Ezedi C, Nugen F, Nuñez-Samudio V, Nur A, Nyande F, Nzoputam C, Oancea B, O'Connell E, Odetokun I, Ofakunrin A, Oguta J, Oh I, Okati-Aliabad H, Okeke S, Okekunle A, Okonji O, Olagunju A, Olalusi O, Olasehinde T, Oliveira A, Oliveira G, Oluwafemi Y, Omar H, Bali A, Omer N, Ong S, Ordak M, Ortiz A, Osborne A, Osman W, Otoiu A, Oumer A, Ouyahia A, Owolabi M, Owusu I, Oyebola K, Oyelade T, A M, Padron-Monedero A, Padubidri J, Palicz T, Panda S, Panda-Jonas S, Pandey A, Pandi-Perumal S, Pant S, Pardhan S, Parekh U, Parija P, Parikh R, Park E, Passera R, Patel J, Patoulias D, Paudel S, Peprah, Pereira M, Perico N, Perna S, Petcu I, Petermann-Rocha F, Pham H, Pham T, Pirouzpanah S, Polibin R, Popovic D, Potani I, Pourghazi F, Pourshams A, Pradhan J, Pradhan P, Prasad M, Prashant A, Prates E, Puvvula J, Qattea I, Qiao Y, Radhakrishnan V, Radojˇić M, Raggi C, Rahman F, Rahman M, Rahman M, Rahman M, Rahman M, Rahmanian M, Rahmanian V, Rahmati M, Kumar R, Raimondo I, Raj J, Rajput P, Ramadan M, Ramasamy C, Ramasamy S, Ramazanu S, Rana K, Ranabhat C, Rao M, Rao S, Rashedi S, Rashidi M, Rasouli-Saravani A, Rathish D, Rauniyar S, Rautalin I, Rawaf D, Rawaf S, Redwan E, Rege S, Rehman A, Reis-Mendes A, Remuzzi G, Rezaei N, Rezaeian M, Rhee T, Rocha-Gomes J, da Silva T, Rodriguez J, Roever L, Rohloff P, Romadlon D, Rony M, Roshandel G, Rout H, Roy N, Rwegerera G, Saad A, Saber-Ayad M, Sabzmakan L, Sadarangani K, Saddik B, Sadeghi M, Saeed U, Sagoe D, Sharif-Askari F, Sahebkar A, Sahoo S, Sajadi S, Sajid M, Salami A, Salaroli L, Saleem S, Saleh M, Salem M, Salihu D, Salimi S, Samy A, Santric-Milicevic M, Sarkar T, Sarmadi M, Sarode G, Sarode S, Sassano M, Saulam J, Sawhney M, Saxena S, Saya G, Schinckus C, Schmidt M, Schuermans A, Selvaraj S, Sendekie A, Sengupta P, Senol Y, Senthilkumaran S, Sepanlou S, Sethi Y, Seylani A, Shafie M, Shah S, Shahid S, Shahwan M, Shamim M, Shams-Beyranvand M, Shamsutdinova A, Shanawaz M, Shannawaz M, Sharath M, Sharifan A, Sharma M, Sharma U, Sharma V, Sheida F, Shenoy R, Shetty P, Shiferaw D, Shin M, Lapari M, Shiri R, Shittu A, Shool S, Shorofi S, Shrestha G, Shrestha R, Shuval K, Si Y, Sibuyi N, Siddig E, Siervo M, Silva D, Silva L, Singh A, Singh B, Singh H, Singh J, Singh K, Singh L, Singh M, Singh P, Singh S, Skryabina A, Smith A, Smith G, Soliman S, Soraneh S, Spartalis M, Srichawla B, Stanikzai M, Starodubova A, Straif K, Stubbs P, Subramaniyan V, Odidi M, Sulkowski A, Meo A, Sun Z, Sunny S, Sunuwar D, Swain C, Szarpak L, Y S, Tabarés-Seisdedos R, Tabatabaei S, Malazy O, Tabatabaeizadeh S, Tabatabai S, Tabche C, Tabish M, Taiba J, Tampa M, Tamuzi J, Tan K, Tanwar M, Tariq S, Tat N, Temsah M, Temsah R, Teramoto M, Terefa D, Tewari J, Thangaraju P, Thapar R, Thavamani A, Thirunavukkarasu S, Thomas J, Tiruneh S, Tiruye T, Titova M, Tiwari K, Tomo S, Tonelli M, Touvier M, Tovani-Palone M, Trabelsi K, Tran N, Tran T, Duc N, Trico D, Truyen T, Tsegay G, Tumurkhuu M, Tye S, Udoakang A, Ullah A, Ullah S, Ullah S, Umair M, Umar L, Umar U, Unim B, Upadhya D, Upadhyay E, Usman J, Ustunsoz D, Vaezghasemi M, Vaithinathan A, Van den Eynde J, Varghese J, Vasankari T, Vaziri S, Vellingiri B, Venketasubramanian N, Verma M, Verras G, Villalobos-Daniel V, Vladimirov S, Vlassov V, Vollset S, Vukovic R, Wahiduzzaman M, Wang C, Wang S, Wang X, Wang Y, Weerakoon K, Wei F, Wicaksana A, Wickramasinghe D, Wickramasinghe N, Willeit P, Wojewodzic M, Xia Q, Xiao G, Xie W, Xu S, Xu X, Yahya G, Yamagishi K, Yano Y, Yao H, Yarahmadi A, Yaribeygi H, Ye P, Yesuf S, Yin D, Yon D, Yonemoto N, Yu C, Yuan C, Yuce D, Yunusa I, Zamagni G, Zastrozhin M, Zeariya M, Zhang C, Zhang H, Zhang J, Zhang L, Zhang X, Zhang Z, Zhao H, Zheng D, Zhong A, Zhong C, Zhou J, Zhu B, Zhumagaliuly A, Zielińska M, Zitoun O, Zoghi G, Zou Z, Zyoud S, Gakidou E, Sawyer S, Azzopardi P. Global, regional, and national prevalence of child and adolescent overweight and obesity, 1990–2021, with forecasts to 2050: a forecasting study for the Global Burden of Disease Study 2021. The Lancet 2025, 405: 785-812. PMID: 40049185, PMCID: PMC11920006, DOI: 10.1016/s0140-6736(25)00397-6.Peer-Reviewed Original ResearchConceptsHigh-income North AmericaSouthern sub-Saharan AfricaExcess body massObesity prevalenceAged 5Non-communicable diseases in adulthoodGlobal burdenGlobal Burden of Disease StudyBurden of Disease StudyGlobal Burden of DiseaseSub-Saharan AfricaCentral Latin AmericaNational prevalence of childrenRisk Factors StudySpatiotemporal Gaussian process regression modelingBurden of diseaseMales aged 5Prevalence of childrenConsequences of obesityOverweight prevalenceAdolescent overweightAge-standardisedBody massIndividuals aged 5Females aged 5Single cell analysis identifies distinct CD4 + T cells associated with the pathobiology of pediatric obesity related asthma
Thompson D, Wabara Y, Duran S, Reichenbach A, Chen L, Collado K, Yon C, Greally DMed J, Rastogi D. Single cell analysis identifies distinct CD4 + T cells associated with the pathobiology of pediatric obesity related asthma. Scientific Reports 2025, 15: 6844. PMID: 40000680, PMCID: PMC11861978, DOI: 10.1038/s41598-025-88423-4.Peer-Reviewed Original ResearchConceptsCD4+ T cellsT cell subtypesT cellsSteroid resistanceTh1 inflammationObese asthmaTh1 responseCentral memory T cellsObese asthma phenotypeEffector T cellsMemory T cellsObesity-related asthmaCD4+ T cell subtypesPediatric obesity-related asthmaT helper 1Healthy-weight controlsPulmonary function deficitsCD4Th1Asthma phenotypesGlucocorticoid receptorSingle-cell transcriptomicsFunctional deficitsInflammationSteroids
2024
Daily glucose variability is associated with intrahepatic fat content, β cell sensitivity, and biomarkers of glycolysis in youth with obesity
Barbieri E, Bonet J, Fox D, Nelson R, Nelson M, Nelson L, Fernandez C, Van Name M, Samuels S, Caprio S, Sabati M, Galderisi A, Sherr J, Man C, Santoro N. Daily glucose variability is associated with intrahepatic fat content, β cell sensitivity, and biomarkers of glycolysis in youth with obesity. Obesity 2024, 33: 116-124. PMID: 39658509, PMCID: PMC11666407, DOI: 10.1002/oby.24175.Peer-Reviewed Original ResearchConceptsIntrahepatic fat contentDaily glucose variabilityLiver proton density fat fractionProton density fat fractionGlucose variabilityInsulin sensitivityOral glucose tolerance testFat fractionInsulin secretionAssociated with insulin resistanceFirst-phase insulin secretionAssociated with 2-h glucoseGlucose tolerance testGlucose standard deviationMagnetic resonance imagingOral minimal modelCoefficient of variationBasal insulin secretionPediatric obesityPostprandial glucoseTolerance testCell sensitivityInsulin resistanceObesityResonance imagingThe association of higher offspring early‐childhood weight gain with prepregnancy metabolic and bariatric surgery
Hilaire M, Babcock A, White G, Masson C, Salem R, Reddy U, Gallagher D, LeDuc C, Thaker V. The association of higher offspring early‐childhood weight gain with prepregnancy metabolic and bariatric surgery. Obesity 2024, 32: 2012-2023. PMID: 39497631, PMCID: PMC11694145, DOI: 10.1002/oby.24166.Peer-Reviewed Original ResearchConceptsOffspring growth trajectoriesBariatric surgeryHypertensive disorders of pregnancyWorld Health Organization Child Growth StandardsRoux-en-Y gastric bypassWeight gainHigher BMI z-scoreEarly-life weight gainNon-MB groupDisorders of pregnancyGestational diabetes mellitusGestational weight gainLow birth weightBMI z-scoreChild Growth StandardsScore-matched controlsPrepregnancy BMIGestational outcomesHypertensive disordersSleeve gastrectomyGastric bypassBirth weightPrepregnancyDiabetes mellitusGrowth standardsNeighborhood Food Access in Early Life and Trajectories of Child Body Mass Index and Obesity
Aris I, Wu A, Lin P, Zhang M, Farid H, Hedderson M, Zhu Y, Ferrara A, Chehab R, Barrett E, Carnell S, Camargo C, Chu S, Mirzakhani H, Kelly R, Comstock S, Strakovsky R, O’Connor T, Ganiban J, Dunlop A, Dabelea D, Breton C, Bastain T, Farzan S, Call C, Hartert T, Snyder B, Santarossa S, Cassidy-Bushrow A, O’Shea T, McCormack L, Karagas M, McEvoy C, Alshawabkeh A, Zimmerman E, Wright R, McCann M, Wright R, Coull B, Amutah-Onukagha N, Hacker M, James-Todd T, Oken E, Smith P, Newby L, Adair L, Jacobson L, Catellier D, McGrath M, Douglas C, Duggal P, Knapp E, Kress A, Blackwell C, Mansolf M, Lai J, Ho E, Cella D, Gershon R, Macy M, Das S, Freedman J, Mallal S, McLean J, Shah R, Shilts M, Alshawabkeh A, Cordero J, Meeker J, Trasande L, Camargo C, Hasegawa K, Zhu Z, Sullivan A, Dabelea D, Perng W, Bekelman T, Wilkening G, Magzamen S, Moore B, Starling A, Rinehart D, Koinis Mitchell D, D'Sa V, Deoni S, Mueller H, Duarte C, Monk C, Canino G, Posner J, Murray T, Lugo-Candelas C, Dunlop A, Brennan P, Hockett C, Elliott A, Ferrara A, Croen L, Hedderson M, Ainsworth J, Bacharier L, Bendixsen C, Gern J, Gold D, Hartert T, Jackson D, Johnson C, Joseph C, Kattan M, Khurana Hershey G, Lemanske, Jr. R, Lynch S, Miller R, O’Connor G, Ober C, Ownby D, Rivera-Spoljaric K, Ryan P, Seroogy C, Singh A, Wood R, Zoratti E, Habre R, Farzan S, Gilliland F, Hertz-Picciotto I, Bennett D, Schweitzer J, Schmidt R, LaSalle J, Hipwell A, Keenan K, Karr C, Bush N, LeWinn K, Sathyanarayana S, Zhao Q, Tylavsky F, Carroll K, Loftus C, Leve L, Ganiban J, Neiderhiser J, Weiss S, Litonjua A, McEvoy C, Spindel E, Tepper R, Newschaffer C, Lyall K, Volk H, Landa R, Ozonoff S, Piven J, Hazlett H, Pandey J, Schultz R, Dager S, Botteron K, Messinger D, Stone W, Ames J, O'Connor T, Miller R, Oken E, Hacker M, James-Todd T, O'Shea T, Fry R, Frazier J, Singh R, Rollins C, Montgomery A, Vaidya R, Joseph R, Washburn L, Gogcu S, Bear K, Rollins J, Hooper S, Taylor G, Jackson W, Thompson A, Daniels J, Hernandez M, Lu K, Msall M, Lenski M, Obeid R, Pastyrnak S, Jensen E, Sakai C, Santos H, Kerver J, Paneth N, Barone C, Elliott M, Ruden D, Fussman C, Herbstman J, Margolis A, Schantz S, Geiger S, Aguiar A, Tabb K, Strakovsky R, Woodruff T, Morello-Frosch R, Padula A, Stanford J, Porucznik C, Giardino A, Wright R, Wright R, Collett B, Baumann-Blackmore N, Gangnon R, McKennan C, Wilson J, Altman M, Aschner J, Stroustrup A, Merhar S, Moore P, Pryhuber G, Hudak M, Reynolds Lyndaker A, Lampland A, Rochelson B, Jan S, Blitz M, Katzow M, Brown Z, Chiuzan C, Rafael T, Lewis D, Meirowitz N, Poindexter B, Gebretsadik T, Osmundson S, Straughen J, Eapen A, Cassidy-Bushrow A, Wegienka G, Sitarik A, Woodcroft K, Urquhart A, Levin A, Johnson-Hooper T, Davidson B, Ma T, Barrett E, Blaser M, Dominguez-Bello M, Horton D, Jimenez M, Rosen T, Palomares K, Avalos L, Zhu Y, Hunt K, Newman R, Bloom M, Alkis M, Roberts J, Mumford S, Burris H, DeMauro S, Yee L, Hamvas A, Olidipo A, Haddad A, Eiland L, Spillane N, Suri K, Fisher S, Goldstein J, Mithal L, DeRegnier R, Maitre N, Nguyen R, JaKa M, Sidebottom A, Paidas M, Potter J, Ruby N, Duthely L, Jayakumar A, Young K, Maldonado I, Miller M, Slaughter J, Keim S, Lynch C, Venkatesh K, Whitworth K, Symanski E, Northrup T, Mendez-Figueroa H, Mosquera R, Karagas M, Madan J, MacKenzie D, Lewis J, Rennie B, Leventhal B, Kim Y, Bishop S, Nozadi S, Luo L, Lester B, Marsit C, Everson T, Loncar C, McGowan E, Sheinkopf S, Carter B, Check J, Helderman J, Neal C, Smith L. Neighborhood Food Access in Early Life and Trajectories of Child Body Mass Index and Obesity. JAMA Pediatrics 2024, 178: 1172-1182. PMID: 39283628, PMCID: PMC11406455, DOI: 10.1001/jamapediatrics.2024.3459.Peer-Reviewed Original ResearchConceptsChild body mass indexLow food accessBody mass indexNeighborhood food accessChild obesityObesity riskLow-incomeFood accessAccess neighborhoodsAssociated with higher BMI z-scoreHigher BMI z-scoreBody mass index z-scoreHigher risk of obesityPrevent child obesityHigher obesity riskGeocoded residential addressesIndividual sociodemographic characteristicsBMI z-scoreRisk of obesityZ-scoreImprove food accessLow-income neighborhoodsExposure in early lifeSevere obesityEarly lifeInterplay between preclinical indices of obesity and neural signatures of fluid intelligence in youth
Ward T, Schantell M, Dietz S, Ende G, Rice D, Coutant A, Arif Y, Wang Y, Calhoun V, Stephen J, Heinrichs-Graham E, Taylor B, Wilson T. Interplay between preclinical indices of obesity and neural signatures of fluid intelligence in youth. Communications Biology 2024, 7: 1285. PMID: 39379610, PMCID: PMC11461743, DOI: 10.1038/s42003-024-06924-w.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBody Mass IndexBrainChildCognitionFemaleHumansIntelligenceMagnetoencephalographyMaleObesityPediatric ObesityConceptsAbstract reasoning taskFluid intelligenceAbstract reasoningBrain regionsNeural activityReasoning tasksLeft dorsolateral prefrontal cortexLeft temporoparietal junctionDorsolateral prefrontal cortexHigher-order cognitionWhole-brain correlationHigh-density magnetoencephalographySignificant oscillatory responsesYouth aged 9Prefrontal cortexTemporoparietal junctionNeural signaturesTheta oscillationsResponse scaleWhole-brainNeurobehavioral functionNeural dynamicsAged 9CognitionReaction timeImproving access to first‐line treatment for pediatric obesity: Lessons from the dissemination of SmartMoves
Finn E, Keller C, Gowey M, Savoye M, Samuels S, Fleisch A, Rogers V, Grey M, Damschroder L, Beck A, Sharifi M. Improving access to first‐line treatment for pediatric obesity: Lessons from the dissemination of SmartMoves. Obesity 2024, 32: 1745-1756. PMID: 39192771, PMCID: PMC11875074, DOI: 10.1002/oby.24107.Peer-Reviewed Original ResearchConceptsConstant comparative methodInterviewed key informantsHealth behaviorsObesity programsSufficient staffingInsufficient staffingPediatric obesityFunding insecurityLifestyle treatmentImprove accessOrganizational prioritiesProgram componentsProgram fitPromote fidelityKey informantsUS sitesIncreased prevalenceAdequate fundingSurvey findingsStaffingParticipantsInterviewsCOVID-19 pandemicDominant barriersObesityCost‐effectiveness of a primary care‐based Healthy Weight Clinic compared with usual care
Sharifi M, Fiechtner L, Barrett J, O'Connor G, Perkins M, Reiner J, Luo M, Taveras E, Gortmaker S. Cost‐effectiveness of a primary care‐based Healthy Weight Clinic compared with usual care. Obesity 2024, 32: 1734-1744. PMID: 39192764, PMCID: PMC11361715, DOI: 10.1002/oby.24111.Peer-Reviewed Original ResearchConceptsHealthy weight clinicHealth care sectorObesity prevalenceIntervention costsCare sectorReducing obesity disparitiesNational implementationHealth care costsObesity disparitiesUsual careBMI changeCare costsFQHCsCost-effectiveSocietal perspectiveWhite populationHealthHealthyObesityQALYEstimated costInterventionClinicChildrenGreater reductionsA systems thinking framework for understanding rising childhood obesity in the Caribbean
Guariguata L, Burlar A, Greaves N, Harewood H, Khan R, Rosario-Rosado R, Jones W, Roy B, Hassan S. A systems thinking framework for understanding rising childhood obesity in the Caribbean. Health Research Policy And Systems 2024, 22: 115. PMID: 39169406, PMCID: PMC11337753, DOI: 10.1186/s12961-024-01201-y.Peer-Reviewed Original ResearchConceptsChildhood obesityReduce rates of childhood obesityComplexity of childhood obesityRising childhood obesity ratesRates of childhood obesityChildhood obesity ratesObesity ratesCommercial determinantsSystems thinking frameworkMulti-disciplinary stakeholdersConclusionsDespite differencesObesityObjectiveThe aimPersonal experienceVirtual meetingsMulti-facetedChildhoodPolicy solutionsReinforcing loopsPuerto RicoPotential areasStakeholdersInterventionUS Virgin IslandsFacilitationAltered extracellular matrix dynamics is associated with insulin resistance in adolescent children with obesity
Slusher A, Nouws J, Tokoglu F, Vash‐Margita A, Matthews M, Fitch M, Shankaran M, Hellerstein M, Caprio S. Altered extracellular matrix dynamics is associated with insulin resistance in adolescent children with obesity. Obesity 2024, 32: 593-602. PMID: 38410080, PMCID: PMC11034857, DOI: 10.1002/oby.23974.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentChildCollagenExtracellular MatrixHumansInsulinInsulin ResistanceIntra-Abdominal FatLipidsPediatric ObesitySubcutaneous FatConceptsSubcutaneous adipose tissueLiver fat contentInsulin resistanceInsulin sensitivityEctopic storage of lipidOral glucose tolerance testGluteal subcutaneous adipose tissueExtracellular matrix dynamicsMagnetic resonance imaging scansAdipose tissueBody fat distribution patternsFibrogenesis in vivoAdipocyte turnoverAssociated with insulin resistanceGlucose tolerance testFat distribution patternsWhole-body IRAdipose tissue insulin signalingTissue insulin signalingTolerance testGluteal fatImaging scansPathophysiological pathwaysAssociated with ratioObesity
2023
High-frequency variants in PKA signaling-related genes within a large pediatric cohort with obesity or metabolic abnormalities
Bloyd M, Sinaii N, Faucz F, Iben J, Coon S, Caprio S, Santoro N, Stratakis C, London E. High-frequency variants in PKA signaling-related genes within a large pediatric cohort with obesity or metabolic abnormalities. Frontiers In Endocrinology 2023, 14: 1272939. PMID: 38027204, PMCID: PMC10679389, DOI: 10.3389/fendo.2023.1272939.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultChildDiabetes Mellitus, Type 2Genome-Wide Association StudyHumansMutationPediatric ObesityConceptsGenome-wide association studiesSignaling-related genesProtein kinaseHigh-frequency variantsCAMP-dependent protein kinaseLarge-scale genome-wide association studiesNew genetic associationsPDE11A geneGenomic DNAAssociation studiesMonogenic obesityTargeted exome sequencingGenesGenetic variantsEnergy metabolismGenetic associationExome sequencingNovel variantsVariant searchMetabolic characteristicsVariantsKinaseType II diabetesLociSequencingEffects of short‐term supervised exercise training on liver fat in adolescents with obesity: a randomized controlled trial
Tas E, Landes R, Diaz E, Bai S, Ou X, Buchmann R, Na X, Muzumdar R, Børsheim E, Dranoff J. Effects of short‐term supervised exercise training on liver fat in adolescents with obesity: a randomized controlled trial. Obesity 2023, 31: 2740-2749. PMID: 37731271, PMCID: PMC11519784, DOI: 10.1002/oby.23887.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentCardiovascular DiseasesExerciseHumansLiverMetabolic DiseasesOverweightPediatric ObesityConceptsHigh-intensity interval trainingCardiorespiratory fitnessOral glucose tolerance testDual-energy X-ray absorptiometryAttenuation parameter (CAP) scoreIntrahepatic triglyceride contentSerum alanine aminotransferaseGlucose tolerance testSteatotic liver diseaseX-ray absorptiometryLiver magnetic resonanceCardiometabolic markersCardiometabolic healthExercise trainingHIIT protocolsLiver diseaseLiver fatExercise protocolTolerance testCRF testAlanine aminotransferaseInterval trainingMRI-PDFFTriglyceride contentObesityAssociation between age at menarche and cardiometabolic risk among Samoan adults
Oyama S, Duckham R, Pomer A, Rivara A, Kershaw E, Wood A, Fidow U, Naseri T, Reupena M, Viali S, McGarvey S, Hawley N. Association between age at menarche and cardiometabolic risk among Samoan adults. American Journal Of Human Biology 2023, 36: e23982. PMID: 37668413, PMCID: PMC10845161, DOI: 10.1002/ajhb.23982.Peer-Reviewed Original ResearchConceptsCardiometabolic riskOne-year increaseSubsequent cardiometabolic riskOdds of hypertensionHigher total cholesterolOdds of diabetesOdds of obesityEarly life exposureFat-free massCardiometabolic morbiditySerum lipidsBlood pressureMedian ageMetabolic syndromeTotal cholesterolProspective studyChildhood adiposityInsulin resistanceObesity prevalenceLife exposureSamoan adultsLean massEarly menarcheLogistic regressionMenarcheThe lncOb rs10487505 polymorphism impairs insulin sensitivity and glucose tolerance in children and adolescents with obesity
Umano G, Cirillo G, Sanchez G, Rondinelli G, Foderini M, Ferrara S, Di Sessa A, Marzuillo P, Papparella A, Santoro N, del Giudice E. The lncOb rs10487505 polymorphism impairs insulin sensitivity and glucose tolerance in children and adolescents with obesity. Obesity 2023, 31: 2359-2364. PMID: 37550829, DOI: 10.1002/oby.23835.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBody Mass IndexChildGlucoseHumansInsulinInsulin ResistanceLeptinPediatric ObesityPrediabetic StateRetrospective StudiesConceptsHomeostasis model assessmentInsulin resistanceDisposition indexLower whole-body insulin sensitivity indexModel assessmentWhole-body insulin sensitivity indexRisk of prediabetesHigher fasting insulinLower disposition indexPlasma leptin levelsInsulin sensitivity indexBMI z-scoreLeptin plasma levelsLeptin gene transcriptionFasting insulinGlucose toleranceLeptin levelsCC patientsRetrospective studyPlasma levelsAnthropometrical evaluationInsulin sensitivityHormone levelsHigh prevalenceHigh riskSex-Specific Differences in Left Ventricular Mass and Volumes with Body Mass Index among Children Aged 6 to 8: A Cross-Sectional Study in China
Xiao H, Shu W, Li M, Xu L, Amaerjiang N, Zunong J, Vermund S, Huang D, Chong M, Hu Y. Sex-Specific Differences in Left Ventricular Mass and Volumes with Body Mass Index among Children Aged 6 to 8: A Cross-Sectional Study in China. Nutrients 2023, 15: 3066. PMID: 37447393, PMCID: PMC10347080, DOI: 10.3390/nu15133066.Peer-Reviewed Original ResearchConceptsBody mass indexLeft ventricular massVisceral fat areaHigher body mass indexBlood pressureWaist circumferenceMass indexVentricular massStroke volumeFat massElevated body mass indexHigher left ventricular massVentricle end-diastolic volumeGreater LV hypertrophyCardiovascular risk factorsSex differencesDiastolic blood pressureSystolic blood pressureOverweight/obesityLeft ventricle structureEnd-diastolic volumeEnd-systolic volumeCross-sectional studyChildren Aged 6LV hypertrophyBreastfeeding and the Obesity Pandemic
Pérez-Escamilla R. Breastfeeding and the Obesity Pandemic. American Journal Of Clinical Nutrition 2023, 118: 1-2. PMID: 37210290, DOI: 10.1016/j.ajcnut.2023.04.035.Peer-Reviewed Original ResearchComparison of Metabolic Response to Colonic Fermentation in Lean Youth vs Youth With Obesity
Galuppo B, Umano G, Li Z, Van Name M, Samuels S, Kien C, Cline G, Wagner D, Barbieri E, Tricò D, Santoro N. Comparison of Metabolic Response to Colonic Fermentation in Lean Youth vs Youth With Obesity. JAMA Network Open 2023, 6: e2312530. PMID: 37159195, PMCID: PMC10170343, DOI: 10.1001/jamanetworkopen.2023.12530.Peer-Reviewed Original ResearchConceptsInsulin sensitivity indexCross-sectional studyFree fatty acidsColonic fermentationActive glucagon-like peptide-1Plasma free fatty acidsGlucagon-like peptide-1Indigestible dietary carbohydratesReduction of ghrelinActive GLP-1Health care burdenBody mass indexMetabolic responseInsulin-resistant groupLean youthObese insulinOIS groupPYY responseAnorexigenic responsePediatric obesityMass indexTyrosine tyrosineInsulin resistanceIntravenous infusionHormone secretionAssociation of Body Mass Index and Waist Circumference With Imaging Metrics of Brain Integrity and Functional Connectivity in Children Aged 9 to 10 Years in the US, 2016-2018
Kaltenhauser S, Weber C, Lin H, Mozayan A, Malhotra A, Constable R, Acosta J, Falcone G, Taylor S, Ment L, Sheth K, Payabvash S. Association of Body Mass Index and Waist Circumference With Imaging Metrics of Brain Integrity and Functional Connectivity in Children Aged 9 to 10 Years in the US, 2016-2018. JAMA Network Open 2023, 6: e2314193. PMID: 37200030, PMCID: PMC10196880, DOI: 10.1001/jamanetworkopen.2023.14193.Peer-Reviewed Original ResearchConceptsBody mass indexHigher body mass indexWaist circumferenceBMI z-scoreCross-sectional studyBrain healthCross-sectional analysisFunctional connectivityMass indexMean ageInterval developmentCorpus callosumAssociation of BMIHigher baseline body mass indexBaseline cross-sectional analysisBaseline body mass indexBrain integrityResting-state functional connectivityLongitudinal analysisFuture treatment trialsABCD studyLower microstructural integrityCognitive Development StudyAdolescent Brain Cognitive Development (ABCD) studyCardiovascular implicationsChampioning the use of people‐first language in childhood overweight and obesity to address weight bias and stigma: A joint statement from the European‐Childhood‐Obesity‐Group (ECOG), the European‐Coalition‐for‐People‐Living‐with‐Obesity (ECPO), the International‐Paediatric‐Association (IPA), Obesity‐Canada, the European‐Association‐for‐the‐Study‐of‐Obesity Childhood‐Obesity‐Task‐Force (EASO‐COTF), Obesity Action Coalition (OAC), The Obesity Society (TOS) and the World‐Obesity‐Federation (WOF)
Weghuber D, Khandpur N, Boyland E, Mazur A, Frelut M, Forslund A, Vlachopapadopoulou E, Erhardt É, Vania A, Molnar D, Ring‐Dimitriou S, Caroli M, Mooney V, Forhan M, Ramos‐Salas X, Pulungan A, Holms J, O'Malley G, Baker J, Jastreboff A, Baur L, Thivel D. Championing the use of people‐first language in childhood overweight and obesity to address weight bias and stigma: A joint statement from the European‐Childhood‐Obesity‐Group (ECOG), the European‐Coalition‐for‐People‐Living‐with‐Obesity (ECPO), the International‐Paediatric‐Association (IPA), Obesity‐Canada, the European‐Association‐for‐the‐Study‐of‐Obesity Childhood‐Obesity‐Task‐Force (EASO‐COTF), Obesity Action Coalition (OAC), The Obesity Society (TOS) and the World‐Obesity‐Federation (WOF). Pediatric Obesity 2023, 18: e13024. PMID: 37002830, DOI: 10.1111/ijpo.13024.Peer-Reviewed Original Research
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