2025
Using vascular biomarkers to assess heart failure event risk in hospitalized patients with and without AKI
Shi A, Andrawis A, Biswas A, Wilson F, Obeid W, Philbrook H, Go A, Ikizler T, Siew E, Chinchilli V, Hsu C, Garg A, Reeves W, Prince D, Bhatraju P, Coca S, Liu K, Kimmel P, Kaufman J, Wurfel M, Himmelfarb J, Parikh C, Mansour S. Using vascular biomarkers to assess heart failure event risk in hospitalized patients with and without AKI. BMC Nephrology 2025, 26: 271. PMID: 40457292, PMCID: PMC12131712, DOI: 10.1186/s12882-025-04169-1.Peer-Reviewed Original ResearchConceptsArea under the curveRisk of HF eventsHeart failureHF eventsHospitalized patientsPrediction of HFVascular biomarkersClinical modelHigher risk of HF eventsPrediction of HF eventsLevels of injury markersRates of heart failureDormant phenotypeAssociated with higher riskCox regression analysisHeart failure eventsCardiovascular disease risk factorsPost-hospitalizationDisease risk factorsSerum creatinineAKI patientsStratify patientsInjury markersLung diseaseClinical centersHospital and Clinician Practice Variation in Cardiac Surgery and Postoperative Acute Kidney Injury
Mathis M, Mentz G, Cao J, Balczewski E, Janda A, Likosky D, Schonberger R, Hawkins R, Heung M, Ailawadi G, Ladhania R, Sjoding M, Kheterpal S, Singh K, Sundt T, Fitzsimons M, Shann K, Kumar V, Yarboro L, Naik B, Tibayan F, Aziz M, Mulligan M, Jelacic S, Kaneko T, Graetz T, Assi R, Mallidi H, Querejeta-Roca G, Shook D, Tsai C, Jewell E, Wanderer J, Freundlich R, Rock P, Douville N, Fisher C, Pace N, Domino K, Wagener G, King C, O'Reilly-Shah V, Bardia A, Clark D. Hospital and Clinician Practice Variation in Cardiac Surgery and Postoperative Acute Kidney Injury. JAMA Network Open 2025, 8: e258342. PMID: 40314957, PMCID: PMC12048843, DOI: 10.1001/jamanetworkopen.2025.8342.Peer-Reviewed Original ResearchConceptsAcute kidney injuryClinician-level variationAssociated with acute kidney injuryAcute kidney injury ratesCardiac surgeryIntraclass correlation coefficientAdult patientsKidney injuryCohort studyCohort study of adult patientsResuscitation practicesPostoperative acute kidney injuryOperating room practiceStudy of adult patientsAssociated with increased morbidityCardiac surgical proceduresCardiac surgical databasePractice variationRBC transfusion ratesFluid volume administrationHospital-level variationMultilevel mixed-effects modelsPatient-level characteristicsRisk-adjustment modelsHealth care costsAdding insult to injury: the spectrum of tubulointerstitial responses in acute kidney injury
Baker M, Cantley L. Adding insult to injury: the spectrum of tubulointerstitial responses in acute kidney injury. Journal Of Clinical Investigation 2025, 135: e188358. PMID: 40091836, PMCID: PMC11910233, DOI: 10.1172/jci188358.Peer-Reviewed Original ResearchConceptsAcute kidney injuryTubular epithelial cellsKidney injuryTubular cellsCases of acute kidney injuryImmune-mediated processPersistence of inflammationBiphasic immune responseChronic kidney diseaseCell deathTubular cell injuryLymphocyte subsetsTubular repairCell cycle arrestOutflow obstructionTEC differentiationPreclinical findingsLymphocytic infiltrationProinflammatory macrophagesKidney diseaseModulate inflammationImmune responseActivated macrophagesMetabolic reprogrammingTubular castsPostdischarge Care of Acute Kidney Injury Survivors: An Opportunity for Targeted Nurse and Pharmacist Interventions
Manis M, Wallace J, Boyd E, Abebe K, Fried L, Palevsky P, Conway P, Horwitz E, Liu K, Parikh C, Poggio E, Siew E, Neyra J, Weir M, Wilson F, Kane-Gill S. Postdischarge Care of Acute Kidney Injury Survivors: An Opportunity for Targeted Nurse and Pharmacist Interventions. Advances In Kidney Disease And Health 2025, 32: 154-161. PMID: 40222802, PMCID: PMC12120554, DOI: 10.1053/j.akdh.2025.01.005.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAftercareHumansNurse's RolePatient Care TeamPatient DischargePharmacistsProfessional RoleSurvivorsConceptsPost-AKI carePostdischarge careElements of follow-up carePatient care goalsHealth care providersFollow-up careReview of medicationsAcute kidney injury survivorsPostdischarge follow-upTargeted nursingCare goalsCare providersPharmacist interventionsPost-AKIPrevent progression of kidney diseaseCare EvaluationAcute kidney injury episodesInterdisciplinary teamPromote kidney recoveryCarePopulation of individualsBundle approachEpisodes of acute kidney injuryNursesPatient monitoring devicesAssociation of Causative Pathogens With Acute Kidney Injury in Adult Patients With Community-Onset Sepsis
Pant P, Chihara S, Krishnamoorthy V, Treggiari M, Messina J, Privratsky J, Raghunathan K, Ohnuma T. Association of Causative Pathogens With Acute Kidney Injury in Adult Patients With Community-Onset Sepsis. Critical Care Explorations 2025, 7: e1219. PMID: 39937578, PMCID: PMC11826047, DOI: 10.1097/cce.0000000000001219.Peer-Reviewed Original ResearchConceptsAcute kidney injuryOdds of acute kidney injuryDevelopment of acute kidney injuryCommunity-onset sepsisAdult patientsKidney injuryAssociated with increased odds of AKICausative pathogenPINC AI Healthcare DatabaseAcute kidney injury riskMultilevel logistic regressionGlobal Outcomes serum creatinine criteriaAssociated with decreased oddsAssociated with increased oddsSerum creatinine criteriaStage 1 AKIStage 3 AKIStage 2 AKIRetrospective cohort studyCritically ill patientsDay of admissionE. coli infectionCommunity-onsetCreatinine criteriaMedian age
2024
Rhabdomyolysis in Severe Fever With Thrombocytopenia Syndrome: Associations With Acute Kidney Injury and Mortality
Zhang Z, Hu X, Du Q, Liu J, Chen X, Mo P, Luo M, Jiang Q, Deng L, Xiong Y. Rhabdomyolysis in Severe Fever With Thrombocytopenia Syndrome: Associations With Acute Kidney Injury and Mortality. Journal Of Medical Virology 2024, 96: e70095. PMID: 39624019, DOI: 10.1002/jmv.70095.Peer-Reviewed Original ResearchConceptsAcute kidney injuryKidney injuryRhabdomyolysis groupLaboratory parametersClinical characteristicsLevels of laboratory parametersThrombocytopenia syndromeMultivariate binary logistic regression analysisCumulative survival rateHigh viral loadMortality of patientsSevere feverBinary logistic regression analysisLogistic regression analysisAbdominal painConsecutive patientsSFTS patientsSerum levelsViral loadChest distressAdverse outcomesRhabdomyolysisSurvival ratePatientsSystem injurySex, Acute Kidney Injury, and Age: A Prospective Cohort Study
Golestaneh L, Basalely A, Linkermann A, El-Achkar T, Kim R, Neugarten J. Sex, Acute Kidney Injury, and Age: A Prospective Cohort Study. American Journal Of Kidney Diseases 2024, 85: 329-338.e1. PMID: 39447957, DOI: 10.1053/j.ajkd.2024.10.003.Peer-Reviewed Original ResearchConceptsRisk of acute kidney injuryAcute kidney injuryFemale sex hormonesSex hormonesKidney injuryRelative risk of acute kidney injuryOdds of acute kidney injuryAnimal models of kidney diseaseRisk factorsAcute kidney injury incidenceHospital-acquired acute kidney injuryWomen of fertile ageModels of kidney diseaseAbstractText Label="PLAIN-LANGUAGE SUMMARYAge groupsEquation logistic regressionSeverity of illnessPostmenopausal womenKDIGO definitionAbstractText Label="RATIONALEObstetric diagnosisAge categoriesMale sexCounts of hospitalizationsMontefiore Health SystemThe prognostic utility of galectin-3 in patients undergoing cardiac surgery: a scoping review
Shah A, Ding Y, Walji D, Rabinovich G, Pelletier M, El-Diasty M. The prognostic utility of galectin-3 in patients undergoing cardiac surgery: a scoping review. Biomarkers 2024, 29: 485-493. PMID: 39422445, DOI: 10.1080/1354750x.2024.2415073.Peer-Reviewed Original ResearchConceptsAssociated with acute kidney injuryPostoperative atrial fibrillationGal-3 levelsLeft ventricular reverse remodelingCardiac surgeryAdverse outcomesGal-3Clinical risk prediction scorePreoperative plasma levelsVentricular reverse remodelingEuroSCORE II modelPlasma Gal-3 levelsPostoperative adverse outcomesAcute kidney injuryGalectin-3Group of patientsPredicting adverse outcomesRisk prediction scorePostoperative morbidityReverse remodelingPostoperative mortalityElectronic database searchPrognostic utilityAdult patientsKidney injuryPlasma proteomics of acute tubular injury
Schmidt I, Surapaneni A, Zhao R, Upadhyay D, Yeo W, Schlosser P, Huynh C, Srivastava A, Palsson R, Kim T, Stillman I, Barwinska D, Barasch J, Eadon M, El-Achkar T, Henderson J, Moledina D, Rosas S, Claudel S, Verma A, Wen Y, Lindenmayer M, Huber T, Parikh S, Shapiro J, Rovin B, Stanaway I, Sathe N, Bhatraju P, Coresh J, Rhee E, Grams M, Waikar S. Plasma proteomics of acute tubular injury. Nature Communications 2024, 15: 7368. PMID: 39191768, PMCID: PMC11349760, DOI: 10.1038/s41467-024-51304-x.Peer-Reviewed Original ResearchConceptsAcute tubular injuryAcute kidney injuryPathway analysisOrganelle stress responsesSingle-cell RNA sequencingKidney Precision Medicine ProjectKidney diseaseSOMAscan proteomics platformProgression to kidney failureRNA sequencingBiological pathwaysGene expressionStress responseNon-invasive biomarkersProteomics platformMannose receptor 1Kidney injuryTubular injuryImmune regulationReceptor 1Macrophage mannose receptor 1Host responseBiomarker proteinsPrecision Medicine ProjectKidney failureImproving Access to Kidney Transplant: Could Kidneys with AKI Help Narrow the Gap?
Aklilu A, Djamali A. Improving Access to Kidney Transplant: Could Kidneys with AKI Help Narrow the Gap? Kidney360 2024, 5: 933-935. PMID: 39052470, PMCID: PMC11296545, DOI: 10.34067/kid.0000000000000476.Peer-Reviewed Original ResearchThe Use of Kidney Disease Improving Global Outcomes AKI Definitions in AKI Research: COMMENTARY
Wilson F. The Use of Kidney Disease Improving Global Outcomes AKI Definitions in AKI Research: COMMENTARY. Kidney360 2024, 5: 948-949. PMID: 38833314, PMCID: PMC11296550, DOI: 10.34067/kid.0000000000000457.Peer-Reviewed Original ResearchAcute Kidney InjuryHumansThe Use of Kidney Disease Improving Global Outcomes AKI Definitions in Retrospective AKI Research: CON
Tamargo C, Parikh C. The Use of Kidney Disease Improving Global Outcomes AKI Definitions in Retrospective AKI Research: CON. Kidney360 2024, 5: 944-947. PMID: 38833306, PMCID: PMC11296551, DOI: 10.34067/kid.0000000000000355.Peer-Reviewed Original ResearchAcute Kidney Injury, Systemic Inflammation, and Long-Term Cognitive Function
Bhatraju P, Zelnick L, Stanaway I, Ikizler T, Menez S, Chinchilli V, Coca S, Kaufman J, Kimmel P, Parikh C, Go A, Siew E, Wurfel M, Himmelfarb J. Acute Kidney Injury, Systemic Inflammation, and Long-Term Cognitive Function. Clinical Journal Of The American Society Of Nephrology 2024, 19: 829-836. PMID: 38728094, PMCID: PMC11254015, DOI: 10.2215/cjn.0000000000000473.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryBiomarkersCognitionCognitive DysfunctionHumansInflammationTime FactorsConceptsLong-term cognitive impairmentRisk of long-term cognitive impairmentCognitive impairmentCognitive functionCognitive declineSoluble TNF receptor-1 concentrationsAssociated with poorer cognitive functionModified Mini-Mental Status ExaminationLong-term cognitive functionPoorer cognitive functionMini-Mental Status ExaminationLong-term cognitive declineSystemic inflammationCognitive testsCognitive dysfunctionSerial evaluationMediation analysisPersistent systemic inflammationSystemic inflammatory biomarkersAcute kidney injuryBaseline kidney functionComplication of CKDAssociated with long-term cognitive declineEpisode of AKITNF receptor 1Mitochondria-mediated ferroptosis induced by CARD9 ablation prevents MDSCs-dependent antifungal immunity
Zhang Z, Li P, Chen Y, Chen Y, Wang X, Shen S, Zhao Y, Zhu Y, Wang T. Mitochondria-mediated ferroptosis induced by CARD9 ablation prevents MDSCs-dependent antifungal immunity. Cell Communication And Signaling 2024, 22: 210. PMID: 38566195, PMCID: PMC10986078, DOI: 10.1186/s12964-024-01581-2.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAnimalsAntifungal AgentsCandidiasisFerroptosisMiceMice, KnockoutMyeloid-Derived Suppressor CellsConceptsMitochondrial oxidative phosphorylationDisseminated candidiasisC. tropicalisMyeloid-derived suppressor cellsAntifungal immunityOxidative phosphorylationAcute kidney injuryMolecular mechanismsExpression of solute carrier family 7 memberExpression of mitochondrial proteinsInhibition of mitochondrial oxidative phosphorylationKidney injurySolute carrier family 7 memberSusceptible to ferroptosisRNA sequencing analysisCandida tropicalisQuantitative real-time PCRHost antifungal immunityMitochondrial proteinsC-type lectin receptorsIncreased susceptibility to acute kidney injuryProportion of myeloid-derived suppressor cellsCARD9Susceptibility to acute kidney injuryReal-time PCRAre biomarkers in acute kidney injury ready for prime time? The time is right for a second look
Parikh C, Coca S. Are biomarkers in acute kidney injury ready for prime time? The time is right for a second look. Kidney International 2024, 105: 675-678. PMID: 38519236, DOI: 10.1016/j.kint.2024.01.018.Peer-Reviewed Original ResearchHepatorenal Syndrome Type 1: Diagnosis and Treatment
Belcher J. Hepatorenal Syndrome Type 1: Diagnosis and Treatment. Advances In Kidney Disease And Health 2024, 31: 100-110. PMID: 38649214, DOI: 10.1053/j.akdh.2023.05.001.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryBiomarkersDiagnosis, DifferentialHepatorenal SyndromeHumansLipocalin-2LypressinTerlipressinVasoconstrictor AgentsConceptsAcute kidney injuryHepatorenal syndromeKidney injuryFunctional acute kidney injuryUrinary biomarkers of kidney injuryAssociated with significant morbidityFractional excretion of sodiumNeutrophil gelatinase-associated lipocalinDiagnostic criteriaBiomarkers of kidney injuryMultiple urinary biomarkersOptimal dosing strategiesExcretion of sodiumPoint-of-care ultrasoundAccurate differential diagnosisAnalog of vasopressinSets of diagnostic criteriaAdvanced cirrhosisAlbumin administrationSignificant morbidityVolume resuscitationTherapeutic optionsDosing strategiesFractional excretionDifferential diagnosisPHENOTYPING REPAIR AFTER ACUTE KIDNEY INJURY: PRECISION MEDICINE TO CLINICAL TRIALS.
Parikh C, Hernandez J. PHENOTYPING REPAIR AFTER ACUTE KIDNEY INJURY: PRECISION MEDICINE TO CLINICAL TRIALS. Transactions Of The American Clinical And Climatological Association 2024, 134: 37-46. PMID: 39135588, PMCID: PMC11316880.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryBiomarkersClinical Trials as TopicHumansKidneyPhenotypePrecision MedicineProteomicsConceptsAcute kidney injuryChronic kidney diseaseKidney injuryEpisodes of acute kidney injuryAssociated with long-term riskLong-term risk of readmissionLong-term sequelaeRepair biomarkersRisk of readmissionSubclinical inflammationPreclinical studiesUrine biomarkersResearch biopsiesDeceased donor kidneysClinical trialsKidney diseaseBlood pressureMedical managementDonor kidneysPragmatic clinical trialsKidney tissueTherapeutic developmentOrgan allocationPrecision medicineKidney
2023
APOBEC-1 deletion enhances cisplatin-induced acute kidney injury
Guo X, Blanc V, Davidson N, Velazquez H, Chen T, Moledina D, Moeckel G, Safirstein R, Desir G. APOBEC-1 deletion enhances cisplatin-induced acute kidney injury. Scientific Reports 2023, 13: 22255. PMID: 38097707, PMCID: PMC10721635, DOI: 10.1038/s41598-023-49575-3.Peer-Reviewed Original ResearchAnalysis of the human kidney transcriptome and plasma proteome identifies markers of proximal tubule maladaptation to injury
Wen Y, Su E, Xu L, Menez S, Moledina D, Obeid W, Palevsky P, Mansour S, Devarajan P, Cantley L, Cahan P, Parikh C, Project K, Injury T. Analysis of the human kidney transcriptome and plasma proteome identifies markers of proximal tubule maladaptation to injury. Science Translational Medicine 2023, 15: eade7287. PMID: 38091407, PMCID: PMC11405121, DOI: 10.1126/scitranslmed.ade7287.Peer-Reviewed Original ResearchAGA Clinical Practice Update on the Use of Vasoactive Drugs and Intravenous Albumin in Cirrhosis: Expert Review
Garcia-Tsao G, Abraldes J, Rich N, Wong V. AGA Clinical Practice Update on the Use of Vasoactive Drugs and Intravenous Albumin in Cirrhosis: Expert Review. Gastroenterology 2023, 166: 202-210. PMID: 37978969, DOI: 10.1053/j.gastro.2023.10.016.Peer-Reviewed Original ResearchConceptsSpontaneous bacterial peritonitisAcute kidney injuryLarge-volume paracentesisEffective arterial blood volumeVasoactive drugsVariceal hemorrhageArterial blood volumeHRS-AKIUncomplicated ascitesIntravenous albuminVolume statusPractice UpdateBlood volumeChronic liver failure grade 3Best practice advice statementsClinical Practice Updates CommitteeEnd-stage liver diseaseAGA Clinical Practice UpdateForms of AKIIntensive care unit monitoringAGA Governing BoardCombination of vasoconstrictorsInitial endoscopic hemostasisPatient's volume statusClinical Practice Update
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