2025
Timing of repeat epinephrine to inform paediatric anaphylaxis observation periods: a retrospective cohort study
Dribin T, Sampson H, Zhang Y, Boyd S, Zhang N, Michelson K, Neuman M, Brousseau D, Mistry R, Freedman S, Aronson P, Bergmann K, Boswell B, Chinta S, Chua W, Cohen A, Cohen J, Daggett A, Davis J, Freeman J, Khanna K, Knoles C, Kwan K, Larsen C, Lee J, Lubell T, Metcalf A, Moake M, Nesiama J, Ngo T, Pulcini C, Russo C, Singh N, Srivastava G, Strutt J, Thapar V, Vander Wyst C, Walsh P, Wolnerman Y, Schnadower D, Academy of Pediatrics P, Kanngiesser A, McGarghan F, Dulchavsky A, Costalez J, DesPain A, Armanious M, Haghnazarian E, Brown-Whitehorn T, Weigert R, Dayan P, Meltzer J, Chowdhury N, Benedetti J, Sinziana C, Handorf A, Ruthford M, Devens M, Mecham C, Holland J, Casas T, Brown J, Panda P, Morrow A, Maready M, Nathani Y, Stevens M, Abraham G, Yen K, Cooper-Sood J, Woolf S. Timing of repeat epinephrine to inform paediatric anaphylaxis observation periods: a retrospective cohort study. The Lancet Child & Adolescent Health 2025, 9: 484-496. PMID: 40506197, DOI: 10.1016/s2352-4642(25)00139-7.Peer-Reviewed Original ResearchConceptsElectronic medical recordsEmergency departmentRetrospective cohort studyCohort studyMedical recordsDocumentation of symptomsCardiovascular involvementHealth-care facilitiesEpinephrine doseAcute allergic reactionsNational Institutes of HealthCumulative incidenceNational Center for Advancing Translational SciencesInstitutes of HealthChildren aged 6 monthsClinical ModificationHospital wardsIncidence rateICD-10Observation periodPrimary outcomeAllergic reactionsSecondary to medicationsInitiation to discontinuationKaplan-Meier analysisPediatric Nonfatal Firearm Injury Health Care Utilization.
Du J, Andrews A, Gastineau K, Lee L, Ranney M, Sacks C, Song Z, Fleegler E, Pulcini C. Pediatric Nonfatal Firearm Injury Health Care Utilization. 2025, 156 PMID: 40555422, DOI: 10.1542/peds.2024-070424.Peer-Reviewed Original ResearchConceptsFirearm injuriesHealth care outcomesHealth care useHealth care utilizationMental health diagnosesPediatric firearm injuriesHealth care spendingCare outcomesCare useInjury preventionCare utilizationPostinjury careInjured childrenHealth diagnosisCare spendingPrevention effortsHealth impactsIntervention effortsHealthLongitudinal researchChildrenPostinjuryCost-effectiveFirearmUnited StatesValidation of a food security experience scale among indigenous populations in Brazil
Segall-Corrêa A, Luz V, do Amaral Azevedo M, Ferreira B, Emperaire L, Gruppi D, Marín-Leon L, Licio J, Pérez-Escamilla R. Validation of a food security experience scale among indigenous populations in Brazil. International Journal For Equity In Health 2025, 24: 175. PMID: 40517230, PMCID: PMC12167585, DOI: 10.1186/s12939-025-02515-1.Peer-Reviewed Original ResearchConceptsSevere food insecurityFood insecurityIndigenous populationGood/very good healthPoor health statusIndigenous householdsPsychometrically valid scaleIndigenous organizationsIndigenous peoplesNutrition insecurityHealth statusRural communitiesGood healthHouseholdsBivariate analysisInsecurityNutrition securityLinguistic diversityRasch modelUrban areasIncomeMeasurement scaleExperiences ScaleMethodsA totalMitigate foodGermline-encoded recognition of peanut underlies development of convergent antibodies in humans
Marini-Rapoport O, Andrieux L, Keswani T, Zong G, Duchen D, Yaari G, Min J, Lytle I, Rosenberg A, Fucile C, Kobie J, Piepenbrink M, Sun T, Martin V, Yuan Q, Shreffler W, Seppo A, Järvinen K, Loeffler J, Ward A, Kleinstein S, Pedersen L, Fernández-Quintero M, Mueller G, Patil S. Germline-encoded recognition of peanut underlies development of convergent antibodies in humans. Science Translational Medicine 2025, 17: eadw4148. PMID: 40498852, DOI: 10.1126/scitranslmed.adw4148.Peer-Reviewed Original ResearchConceptsGene rearrangementsAllergen-specific IgG antibodiesPeanut-allergic childrenContext of food allergyGermline antibody repertoireDietary antigensAntibody gene rearrangementsPublic epitopesFood allergySerum IgGIgG antibodiesAntibody specificityImmunoglobulin GDiverse cohortAntibodiesAntibody repertoireAra h 2IgG recognitionEpitope-paratope interactionH-2AntigenGermlineIgGPeanut allergen Ara h 2Antigenicity of food proteinsA case-control study of early-life residential exposure to tetrachloroethylene and risks of childhood cancer and birth defects
Rhee J, Michalski A, Kuliszewski M, Musco J, Adler C, Xie S, Friesen M, Insaf T, Purdue M. A case-control study of early-life residential exposure to tetrachloroethylene and risks of childhood cancer and birth defects. Environment International 2025, 201: 109600. PMID: 40516285, DOI: 10.1016/j.envint.2025.109600.Peer-Reviewed Original ResearchConceptsRisk of childhood cancerCase-control studyChildhood cancerNew York CityNew York State Cancer RegistryBureau of Vital StatisticsOdds ratioCases of childhood cancerState Cancer RegistryNon-whiteConfidence intervalsUnconditional logistic regressionComputed odds ratiosBirth Defects RegistryBirth defectsCancer RegistryExposure-response effectTetrachloroethylene exposureBirth certificatesVital statisticsResidential exposureInvestigate associationsCollege-educatedLogistic regressionStrong associationsElectrophysiological indices of reading intervention response: A systematic review
Lee B, Landi N. Electrophysiological indices of reading intervention response: A systematic review. Advances In Child Development And Behavior 2025, 68: 105-131. PMID: 40581393, DOI: 10.1016/bs.acdb.2025.03.001.Peer-Reviewed Original ResearchConceptsEvent-related potentialsReading disabilityNeural systemsEvent-related potential componentRegional activity changesNeural functionPre-post intervention changesCognitive neuroscience toolsPre- to post-interventionMagnetic resonance imagingIntervention-associated changesBrain basisRD readersTD readersReading interventionReading improvementTemporal dynamicsIntervention changesActivity changesNeuroscience toolsReview of studiesPost-interventionNeural signalsSystematic review of studiesSystematic reviewDigital Health Interventions Targeting Psychological Health in Parents of Children With Autism Spectrum Disorder: Protocol for a Scoping Review
Ji B, Batubara I, Batten J, Peng X, Chen S, Ni Z. Digital Health Interventions Targeting Psychological Health in Parents of Children With Autism Spectrum Disorder: Protocol for a Scoping Review. JMIR Research Protocols 2025, 14: e68677. PMID: 40466097, PMCID: PMC12177426, DOI: 10.2196/68677.Peer-Reviewed Original ResearchConceptsDigital health interventionsParents of childrenINTERNATIONAL REGISTERED REPORT IDENTIFIERParental psychological healthPsychological healthScoping reviewAutism spectrum disorderDevelopment of practice guidelinesPsychological health outcomesHealth of parentsEnglish-language studiesPsychological health of parentsWeb of SciencePublic health concernHealth outcomesHealth interventionsSpectrum disorderEvidence synthesisParticipant characteristicsIntervention specificsPsychological outcomesPractice guidelinesStudy designData extractionOvid MEDLINEPerinatal Exposures to Ambient Fine Particulate Matter and Outdoor Artificial Light at Night and Risk of Pediatric Papillary Thyroid Cancer
Deziel N, Wang R, Warren J, Dinauer C, Ogilvie J, Clark C, Zhong C, Wiemels J, Morimoto L, Metayer C, Ma X. Perinatal Exposures to Ambient Fine Particulate Matter and Outdoor Artificial Light at Night and Risk of Pediatric Papillary Thyroid Cancer. Environmental Health Perspectives 2025, 133: 057026. PMID: 40209106, PMCID: PMC12121722, DOI: 10.1289/ehp14849.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAir PollutantsCaliforniaCarcinoma, PapillaryCase-Control StudiesChildChild, PreschoolEnvironmental ExposureFemaleHumansInfantInfant, NewbornLightingMaleParticulate MatterPregnancyPrenatal Exposure Delayed EffectsRisk FactorsThyroid Cancer, PapillaryThyroid NeoplasmsYoung AdultConceptsThyroid cancer riskOutdoor artificial lightAmbient fine particulate matterCancer riskOdds ratioAge groupsConfidence intervalsExposure to ambient fine particulate matterIndividual-level exposuresAssociated with thyroid cancerPediatric thyroid cancer incidenceControls frequency-matchedPapillary thyroid cancer riskThyroid cancer incidenceFine particulate matterCalifornia birth cohortOutdoor air pollutionAerodynamic diameter <Case-control studyHypothesized risk factorsStatistically significant associationCancer incidenceThyroid cancerExposure tertilesFrequency-matchedAmerican Society of Hematology/International Society on Thrombosis and Haemostasis 2024 updated guidelines for treatment of venous thromboembolism in pediatric patients
Monagle P, Azzam M, Bercovitz R, Betensky M, Bhat R, Biss T, Branchford B, Brandão L, Chan A, Faustino E, Jaffray J, Jones S, Kawtharany H, Kerlin B, Kucine N, Kumar R, Male C, Pelland-Marcotte M, Raffini L, Raulji C, Sartain S, Takemoto C, Tarango C, van Ommen C, Velez M, Vesely S, Wiernikowski J, Williams S, Wilson H, Woods G, Zia A, Mustafa R. American Society of Hematology/International Society on Thrombosis and Haemostasis 2024 updated guidelines for treatment of venous thromboembolism in pediatric patients. Blood Advances 2025, 9: 2587-2636. PMID: 40423983, DOI: 10.1182/bloodadvances.2024015328.Peer-Reviewed Original ResearchConceptsPediatric venous thromboembolismGRADE Evidence-to-Decision frameworksEvidence-to-decision frameworkMultidisciplinary guideline panelHealth care professionalsGuideline development processAmerican Society of HematologyUniversity of Kansas Health SystemVenous thromboembolismEvidence-based guidelinesCare professionalsPatient representativesHealth systemPediatric patientsGuideline panelTreatment of pediatric venous thromboembolismManagement of pediatric patientsPediatric guidelinesTreatment of venous thromboembolismTreatment trialsInternational Society on ThrombosisAmerican SocietyGuidelinesImplementation guidancePotential biasInvestigating the familiality of trichotillomania and excoriation disorder
Chen D, Farhat L, Lebowitz E, Silverman W, Bloch M, Fernandez T, Olfson E. Investigating the familiality of trichotillomania and excoriation disorder. Psychiatry Research 2025, 350: 116560. PMID: 40449230, PMCID: PMC12179820, DOI: 10.1016/j.psychres.2025.116560.Peer-Reviewed Original ResearchConceptsFamily history of mental health disordersFirst-degreeHistory of mental health disordersSelf-reported family historyExcoriation disorderFamily history of individualsMental health historyMental health disordersFamily history of anxietyHistory of anxietyCross-sectional survey responsesFirst-degree relativesHealth historyHealth disordersFamily historySurvey responsesAged 4Etiological underpinningsTrichotillomaniaAnxietyDepressionIndividualsHistory of individualsDisordersEnvironmental factorsSocio‐ecological domains and adolescent mental health: An application of the dual‐factor model
Rose T, Lambert S, Liu C, Raghunathan R, Musci R, Sullivan A, Lyall K, Elliott A, McEvoy C, Frazier J, Shipp G, Koinis‐Mitchell D, Ganiban J, Smith P, Newby L, Adair L, Jacobson L, Catellier D, McGrath M, Douglas C, Duggal P, Knapp E, Kress A, Blackwell C, Mansolf M, Lai J, Ho E, Cella D, Gershon R, Macy M, Das S, Freedman J, Mallal S, McLean J, Shah R, Shilts M, Alshawabkeh A, Cordero J, Meeker J, Trasande L, Camargo C, Hasegawa K, Zhu Z, Sullivan A, Dabelea D, Perng W, Bekelman T, Wilkening G, Magzamen S, Moore B, Starling A, Rinehart D, Mitchell D, D’Sa V, Deoni S, Mueller H, Duarte C, Monk C, Canino G, Posner J, Murray T, Lugo‐Candelas C, Dunlop A, Brennan P, Hockett C, Elliott A, Ferrara A, Croen L, Hedderson M, Ainsworth J, Bacharier L, Bendixsen C, Gern J, Gold D, Hartert T, Jackson D, Johnson C, Joseph C, Kattan M, Hershey G, Lemanske R, Lynch S, Miller R, O’Connor G, Ober C, Ownby D, Rivera‐Spoljaric K, Ryan P, Seroogy C, Singh A, Wood R, Zoratti E, Habre R, Farzan S, Gilliland F, Hertz‐Picciotto I, Bennett D, Schweitzer J, Schmidt R, LaSalle J, Hipwell A, Karr C, Bush N, LeWinn K, Sathyanarayana S, Zhao Q, Tylavsky F, Carroll K, Loftus C, Leve L, Ganiban J, Neiderhiser J, Weiss S, Litonjua A, McEvoy C, Spindel E, Tepper R, Newschaffer C, Lyall K, Volk H, Landa R, Ozonoff S, Piven J, Hazlett H, Pandey J, Schultz R, Dager S, Botteron K, Messinger D, Stone W, Ames J, O’Connor T, Miller R, Oken E, Hacker M, James‐Todd T, O’Shea T, Fry R, Frazier J, Singh R, Rollins C, Montgomery A, Vaidya R, Joseph R, Washburn L, Gogcu S, Bear K, Rollins J, Hooper S, Taylor G, Jackson W, Thompson A, Daniels J, Hernandez M, Lu K, Msall M, Lenski M, Obeid R, Pastyrnak S, Jensen E, Sakai C, Santos H, Kerver J, Paneth N, Barone C, Elliott M, Ruden D, Fussman C, Herbstman J, Margolis A, Schantz S, Geiger S, Aguiar A, Tabb K, Strakovsky R, Woodruff T, Morello‐Frosch R, Padula A, Stanford J, Porucznik C, Giardino A, Wright R, Wright R, Collett B, Baumann‐Blackmore N, Gangnon R, Jackson D, McKennan C, Wilson J, Altman M, Aschner J, Stroustrup A, Merhar S, Moore P, Pryhuber G, Hudak M, Lyndaker A, Lampland A, Rochelson B, Jan S, Blitz M, Katzow M, Brown Z, Chiuzan C, Rafael T, Lewis D, Meirowitz N, Poindexter B, Gebretsadik T, Osmundson S, Straughen J, Eapen A, Cassidy‐Bushrow A, Wegienka G, Sitarik A, Woodcroft K, Urquhart A, Levin A, Johnson‐Hooper T, Davidson B, Ma T, Barrett E, Blaser M, Dominguez‐Bello M, Horton D, Jimenez M, Rosen T, Palomares K, Avalos L, Zhu Y, Hunt K, Newman R, Bloom M, Alkis M, Roberts J, Mumford S, Burris H, DeMauro S, Yee L, Hamvas A, Olidipo A, Haddad A, Eiland L, Spillane N, Suri K, Fisher S, Goldstein J, Mithal L, DeRegnier R, Maitre N, Nguyen R, JaKa M, Sidebottom A, Paidas M, Potter J, Ruby N, Duthely L, Jayakumar A, Young K, Maldonado I, Miller M, Slaughter J, Keim S, Lynch C, Venkatesh K, Whitworth K, Symanski E, Northrup T, Mendez‐Figueroa H, Mosquera R, Karagas M, Madan J, MacKenzie D, Lewis J, Rennie B, Leventhal B, Kim Y, Bishop S, Nozadi S, Luo L, Lester B, Marsit C, Everson T, Loncar C, McGowan E, Sheinkopf S, Carter B, Check J, Helderman J, Neal C, Smith L. Socio‐ecological domains and adolescent mental health: An application of the dual‐factor model. Journal Of Research On Adolescence 2025, 35: e70029. PMID: 40400085, PMCID: PMC12095899, DOI: 10.1111/jora.70029.Peer-Reviewed Original ResearchConceptsMental health groupDual-factor modelMental healthHealth groupsDual-factor model of mental healthComprehensive assessment of mental healthAssessment of mental healthModel of mental healthChild health outcomesNon-Hispanic whitesPositive mental healthLatent profile analysisLatent regression analysesNo significant moderatorsMental health profilesAdolescent mental healthSocio-ecological domainsCross-sectional dataSocioecological domainsHealth outcomesHealth profileSignificant moderatorEnvironmental influencesHealthDual factorsFeasibility of machine learning–based modeling and prediction to assess osteosarcoma outcomes
Zhao Q, Hu W, Xia Y, Dai S, Wu X, Chen J, Yuan X, Zhong T, Xi X, Wang Q. Feasibility of machine learning–based modeling and prediction to assess osteosarcoma outcomes. Scientific Reports 2025, 15: 17386. PMID: 40389469, PMCID: PMC12089500, DOI: 10.1038/s41598-025-00179-z.Peer-Reviewed Original ResearchConceptsGene signatureLow-risk score groupIncreased metastasis riskLow-risk patientsSensitive to immunotherapyUnivariate Cox regression analysisReduced immune infiltrationCox regression analysisPersonalized therapeutic strategiesAggressive bone malignancyOsteosarcoma outcomesPersonalized treatment strategiesHigh-risk scoreOverall survivalHigher mortality rateProlonged survivalMetastasis riskMulticenter cohortImmune infiltrationPoor prognosisRisk stratificationC-indexDrug sensitivityClinical managementPrognostic toolThe hidden burden: self-reported irritability in adolescent girls signals higher psychiatric risk
Vidal-Ribas P, Krebs G, Silver J, Tseng W, Ford T, Stringaris A. The hidden burden: self-reported irritability in adolescent girls signals higher psychiatric risk. BMC Public Health 2025, 25: 1832. PMID: 40389896, PMCID: PMC12087224, DOI: 10.1186/s12889-025-23076-6.Peer-Reviewed Original ResearchConceptsSelf-reported irritabilityPrevalence of irritabilityIrritable moodParent reportAssociations of irritabilityMental Health of ChildrenLevels of irritabilityAssessment of irritabilityAdolescent femalesMental health problemsPediatric irritabilityPsychopathological symptomsTemper outburstsHealth of ChildrenPsychiatric disordersPsychiatric riskDevelopmental trajectoriesEmotional problemsSelf-reportMoodMental healthAdolescent malesLongitudinally Designed StudyChildren aged 5BackgroundMost researchPlace-based approaches to improve the mental health and wellbeing of children and young people: a rapid realist review
March A, Allen K, Davies K, Harris J, Bethel A, Kennedy L, Malhotra T, Stemp R, Alexandrescu B, Hobbs T, Fonagy P, Pilling S, Berry V. Place-based approaches to improve the mental health and wellbeing of children and young people: a rapid realist review. Systematic Reviews 2025, 14: 115. PMID: 40390084, PMCID: PMC12090407, DOI: 10.1186/s13643-025-02838-8.Peer-Reviewed Original ResearchConceptsContext-mechanism-outcome configurationsImprove young people's mental health.Young people's mental healthPlace-based approachMental healthRealist reviewPeople's mental healthWellbeing of childrenYoung Person's Advisory GroupImprove mental healthMental health servicesYoung peopleYoung people's needsPublic health concernHealth servicesPreventive interventionsResultsFifteen articlesCommunity stakeholdersGrey literatureWellbeing outcomesConclusionsThis reviewIsolated interventionAdvisory GroupExpert panelIntermediate outcomesLongitudinal and Geographic Trends in Perceived Racial Discrimination Among Adolescents in the United States: The Adolescent Brain Cognitive Development Study
Fields C, Black C, Calhoun A, Rosenblatt M, Rodriguez R, Aina J, Thind J, Grayson J, Khalifa F, Assari S, Zhou X, Nagata J, Gee D. Longitudinal and Geographic Trends in Perceived Racial Discrimination Among Adolescents in the United States: The Adolescent Brain Cognitive Development Study. Journal Of Adolescent Health 2025, 77: 118-127. PMID: 40382724, DOI: 10.1016/j.jadohealth.2025.03.014.Peer-Reviewed Original ResearchConceptsNon-Hispanic youthPerceived discriminationDevelopment studiesHigher levels of perceived discriminationAmerican Community SurveyAnti-Black biasLevels of perceived discriminationPacific IslandersPerceived Discrimination ScaleWhite non-Hispanic youthNeighborhood segregationBlack householdsBlack youthContext-specific approachImmigrant backgroundPerceived racial discriminationRacial discriminationCommunity SurveyRacial biasYouthGeographic variationStructural contextAdolescent Brain Cognitive Development StudyNational representativesRacial/ethnic groupsSocial and mental health pathways to institutional trust: A cohort study
Paquin V, Miconi D, Aversa S, Johnson-Lafleur J, Côté S, Geoffroy M, Gülöksüz S. Social and mental health pathways to institutional trust: A cohort study. Social Science & Medicine 2025, 379: 118199. PMID: 40382867, DOI: 10.1016/j.socscimed.2025.118199.Peer-Reviewed Original ResearchConceptsFactor associated with lower levelsMental health factorsSocial connectednessHealth factorsMental healthContext of mental health problemsMental health pathwayQuebec Longitudinal Study of Child DevelopmentLongitudinal Study of Child DevelopmentEarly-life factorsLower household incomeMental health problemsSocio-economic disadvantageHistory of depressionAssociated with greater trustPromote social connectednessStudy of Child DevelopmentPsychotic experiencesAssociated with institutional trustHealth pathwaysRacial minority statusPerceived stressProfessional helpMaternal history of depressionEarly lifeDelandistrogene Moxeparvovec Gene Therapy in Individuals With Duchenne Muscular Dystrophy: Evidence in Focus
Oskoui M, Caller T, Parsons J, Servais L, Butterfield R, Bharadwaj J, Rose S, Tolchin B, Puskala Hamel K, Silsbee H, Dowling J. Delandistrogene Moxeparvovec Gene Therapy in Individuals With Duchenne Muscular Dystrophy: Evidence in Focus. Neurology 2025, 104: e213604. PMID: 40367405, DOI: 10.1212/wnl.0000000000213604.Peer-Reviewed Original ResearchConceptsDuchenne muscular dystrophyFood and Drug AdministrationClinical trialsImmune-related side effectsMuscular dystrophyFood and Drug Administration approvalFunctional motor outcomePhase 3 clinical trialsTreatment groupsNorth Star Ambulatory Assessment scoresUS Food and Drug AdministrationMotor outcomeClinical trial dataRisk of biasClass I studiesGene therapyTreated patientsAmerican Academy of NeurologyLiver toxicityPrimary outcomeLiver injurySide effectsDrug AdministrationSafety outcomesDose exposureExploring the link between grandmaternal air pollution exposure and Grandchild’s ASD risk: A multigenerational population-based study in California
O'Sharkey K, Chow T, Mitra S, Thompson L, Su J, Cockburn M, Liew Z, Ritz B. Exploring the link between grandmaternal air pollution exposure and Grandchild’s ASD risk: A multigenerational population-based study in California. Environment International 2025, 200: 109526. PMID: 40378475, DOI: 10.1016/j.envint.2025.109526.Peer-Reviewed Original ResearchConceptsAir pollutionLand-use regression modelsExposure to air pollutionAP exposureAir pollution exposureMaternal pregnancy exposuresPopulation-based cohortPopulation-based studyMultigenerational exposurePollution exposureLand-useIncreased ASD riskPregnancy exposurePollutionASD riskInfluence ASD riskMaternal pregnancyExposure levelsInfant exposureLogistic regressionMaternal exposureRisk factorsRegression modelsIncreased prevalenceEnvironmental factorsSleep tracking and sleep hygiene counseling improve fatigue in pediatric patients with inflammatory bowel disease
Kuzoian S, Jerson B, Brimacombe M, Schneeberg L, Hyams J. Sleep tracking and sleep hygiene counseling improve fatigue in pediatric patients with inflammatory bowel disease. Journal Of Pediatric Gastroenterology And Nutrition 2025, 81: 62-68. PMID: 40341610, DOI: 10.1002/jpn3.70066.Peer-Reviewed Original ResearchConceptsSleep hygiene counselingIntervention groupFatigue scoresSleep behaviour changeHygiene counselingSleep logsBehavioral changesSleep improvement interventionsInflammatory bowel diseasePresence of fatigueRandomized controlled trialsSleep/rest fatigueIntervention implementationAssessed 2 weeksPediatric QualityFatigue ScaleImprovement interventionsSleep counselingReduce fatigueSleep trackingImprove fatigueIn-personImprove sleepInadequate sleepCounselingAltered brain activation during memory retrieval mediates the relationship between developmental trauma and psychotic symptom severity
Mason A, Palmer W, Cao H, Addington J, Bearden C, Cadenhead K, Cornblatt B, Perkins D, Mathalon D, Walker E, Woods S, Cannon T. Altered brain activation during memory retrieval mediates the relationship between developmental trauma and psychotic symptom severity. Schizophrenia Research 2025, 281: 115-121. PMID: 40328092, DOI: 10.1016/j.schres.2025.04.034.Peer-Reviewed Original ResearchConceptsInferior parietal lobe activityPsychotic symptom severityParietal lobe activityDevelopmental traumaDelusion severityHallucination severityMemory taskNeurocognitive measuresMemory processesMemory performanceSymptom severityScale of Psychosis-risk SymptomsNorth American Prodrome Longitudinal StudyPoorer episodic memory performanceRisk of psychotic symptomsPaired-associate memory taskAssociated with memory processingMemory-associated regionsTrauma-exposed individualsEpisodic memory processesEpisodic memory tasksPsychosis-risk symptomsClinical high riskEpisodic memory performanceSubclinical delusions
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