2025
The inner core enables transient touch detection in the Pacinian corpuscle
Ziolkowski L, Nikolaev Y, Chikamoto A, Oda M, Feketa V, Monedero-Alonso D, Ardasheva S, Bae S, Xu C, Pang S, Gracheva E, Bagriantsev S. The inner core enables transient touch detection in the Pacinian corpuscle. Science Advances 2025, 11: eadt4837. PMID: 40009676, PMCID: PMC11864184, DOI: 10.1126/sciadv.adt4837.Peer-Reviewed Original ResearchSupportive Touch in Psychedelic Assisted Therapy
Neitzke-Spruill L, Beit C, Averill L, McGuire A. Supportive Touch in Psychedelic Assisted Therapy. The American Journal Of Bioethics 2025, 25: 29-39. PMID: 39804300, DOI: 10.1080/15265161.2024.2433428.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderPsychedelic-assisted therapyTreating post-traumatic stress disorderPsychedelic assisted therapyMDMA-ATStress disorderPsychological interventionsUnlicensed therapistsIncidents of misconductPsychedelicsCases of misconductFuture abuseSexual misconductHarm reductionAssisted therapyClinical contextMisconductWhole clothU.S. Food and Drug AdministrationMDMADrug AdministrationTherapistsAbuseDisordersFood and Drug Administration
2023
3D architecture and a bicellular mechanism of touch detection in mechanosensory corpuscle
Nikolaev Y, Ziolkowski L, Pang S, Li W, Feketa V, Xu C, Gracheva E, Bagriantsev S. 3D architecture and a bicellular mechanism of touch detection in mechanosensory corpuscle. Science Advances 2023, 9: eadi4147. PMID: 37703368, PMCID: PMC10499330, DOI: 10.1126/sciadv.adi4147.Peer-Reviewed Original ResearchMechanotransduction events at the physiological site of touch detection
Ziolkowski L, Gracheva E, Bagriantsev S. Mechanotransduction events at the physiological site of touch detection. ELife 2023, 12: e84179. PMID: 36607222, PMCID: PMC9833821, DOI: 10.7554/elife.84179.Peer-Reviewed Original Research
2022
Gabrb3 is required for the functional integration of pyramidal neuron subtypes in the somatosensory cortex
Babij R, Ferrer C, Donatelle A, Wacks S, Buch A, Niemeyer J, Ma H, Duan Z, Fetcho R, Che A, Otsuka T, Schwartz T, Huang B, Liston C, De Marco García N. Gabrb3 is required for the functional integration of pyramidal neuron subtypes in the somatosensory cortex. Neuron 2022, 111: 256-274.e10. PMID: 36446382, PMCID: PMC9852093, DOI: 10.1016/j.neuron.2022.10.037.Peer-Reviewed Original ResearchConceptsAssociated with autism spectrum disorderNeuronal subtypesAngelman syndromePyramidal neuron subtypesAssociated with neurodevelopmental disordersGABAergic synapsesWidefield calcium imagingPyramidal neuronsAutism spectrum disorderNeonatal stageTwo-photonCalcium imagingResponse to tactile stimulationGABRB3Developmental decreaseSomatosensory cortexAtypical connectivityNetwork synchronyFunctional connectivitySpectrum disorderInterhemispheric circuitInhibitory functionSensory processingNeurodevelopmental disordersASD subjectsMore than a feeling: Scalp EEG and eye signals in conscious tactile perception
Gusso MM, Christison-Lagay KL, Zuckerman D, Chandrasekaran G, Kronemer SI, Ding JZ, Freedman NC, Nohama P, Blumenfeld H. More than a feeling: Scalp EEG and eye signals in conscious tactile perception. Consciousness And Cognition 2022, 105: 103411. PMID: 36156359, DOI: 10.1016/j.concog.2022.103411.Peer-Reviewed Original ResearchConceptsEye metricsHigh-density scalp EEGConscious tactile perceptionPerception taskReport taskNeural basisConscious perceptionPhysiological arousalVisual stimuliMicrosaccade rateTactile perceptionTactile stimuliScalp EEGSensory perceptionP300 eventEye signalsPerceptionPresent behaviorPupil diameterStimuliTaskEmpirical studyEEGConsciousnessNeuroscience
2021
Sensational channels
Gracheva EO, Bagriantsev SN. Sensational channels. Cell 2021, 184: 6213-6216. PMID: 34942094, DOI: 10.1016/j.cell.2021.11.034.Peer-Reviewed Original ResearchLow-touch, team-based care for co-morbidity management in cancer patients: the ONE TEAM randomized controlled trial
Zullig LL, Shahsahebi M, Neely B, Hyslop T, Avecilla RAV, Griffin BM, Clayton-Stiglbauer K, Coles T, Owen L, Reeve BB, Shah K, Shelby RA, Sutton L, Dinan MA, Zafar SY, Shah NP, Dent S, Oeffinger KC. Low-touch, team-based care for co-morbidity management in cancer patients: the ONE TEAM randomized controlled trial. BMC Primary Care 2021, 22: 234. PMID: 34794388, PMCID: PMC8600877, DOI: 10.1186/s12875-021-01569-8.Peer-Reviewed Original ResearchConceptsPrimary care providersCancer survivorsCardiovascular diseaseMedication adherenceCancer specialistsCare providersPrimary care clinic levelInformation Set (HEDIS) quality measuresPharmacy refill dataPrimary care clinicsHealthcare Effectiveness DataHistory of cancerPrimary care physiciansProvider-level interventionsCo-morbidity managementPatient-provider communicationPrimary care teamsBlood pressure measurementsTeam-based careEducation-only controlSequential multiple assignmentCVD comorbidityRefill dataCare clinicsCare physiciansBrain Gene Expression Pattern Correlated with the Differential Brain Activation by Pain and Touch in Humans
Tang J, Su Q, Zhang X, Qin W, Liu H, Liang M, Yu C. Brain Gene Expression Pattern Correlated with the Differential Brain Activation by Pain and Touch in Humans. Cerebral Cortex 2021, 31: 3506-3521. PMID: 33693675, DOI: 10.1093/cercor/bhab028.Peer-Reviewed Original ResearchConceptsInhibitory synaptic transmissionAddiction-related pathwaysPain-related genesExpression patternsNeural responsesPainful activitiesActivity patternsPainDifferential brain activationAllen Human Brain AtlasBrain activation patternsCortical levelHuman brainGene expression patternsHuman Brain AtlasBrainBrain gene expression patternsTouch sensationBrain activityIdentification of genesNeural activityGenesTactile stimuliExpressionTactile activities
2019
A Cross-Species Analysis Reveals a General Role for Piezo2 in Mechanosensory Specialization of Trigeminal Ganglia from Tactile Specialist Birds
Schneider ER, Anderson EO, Feketa VV, Mastrotto M, Nikolaev YA, Gracheva EO, Bagriantsev SN. A Cross-Species Analysis Reveals a General Role for Piezo2 in Mechanosensory Specialization of Trigeminal Ganglia from Tactile Specialist Birds. Cell Reports 2019, 26: 1979-1987.e3. PMID: 30784581, PMCID: PMC6420409, DOI: 10.1016/j.celrep.2019.01.100.Peer-Reviewed Original ResearchConceptsTrigeminal ganglionPiezo2 ion channelsExpression of moleculesExpression of factorsPiezo2 expressionSomatosensory neuronsNeuronal subtypesSomatosensory systemSuch neuronsSpecialist birdsBird speciesMolecular variationFamily AnatidaeForaging behaviorTactile specializationNeuronsMechanoreceptorsSpecies analysisGangliaGeneral roleBehavioral phenotypesIon channelsGeneral mechanismTactile specialistsFunction of mechanoreceptors
2018
Layer I Interneurons Sharpen Sensory Maps during Neonatal Development
Che A, Babij R, Iannone A, Fetcho R, Ferrer M, Liston C, Fishell G, De Marco García N. Layer I Interneurons Sharpen Sensory Maps during Neonatal Development. Neuron 2018, 99: 98-116.e7. PMID: 29937280, PMCID: PMC6152945, DOI: 10.1016/j.neuron.2018.06.002.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornCalciumCell Adhesion Molecules, NeuronalCerebral CortexExtracellular Matrix ProteinsGene Knockdown TechniquesInterneuronsMiceNerve Tissue ProteinsNeural PathwaysOptogeneticsPatch-Clamp TechniquesPhysical StimulationPyramidal CellsReceptors, N-Methyl-D-AspartateReceptors, Serotonin, 5-HT3Reelin ProteinSensory DeprivationSerine EndopeptidasesSomatosensory CortexTouchVibrissaeConceptsNMDA receptorsWhisker-dependent behaviorsSpontaneous calcium transientsDiverse neuronal typesPostnatal day 6Barrel map formationLayer IIntrinsic neuronal activityCalcium transientsSerotonin receptorsBarrel cortexWhisker stimulationInterneuron typesLongitudinal calcium imagingMouse pupsNeonatal developmentSensory mapsWhisker responsesCalcium imagingNeonatal mammalsNeuronal activityInterneuronsNeuron typesThalamic inputDay 6
2017
Molecular basis of tactile specialization in the duck bill
Schneider ER, Anderson EO, Mastrotto M, Matson JD, Schulz VP, Gallagher PG, LaMotte RH, Gracheva EO, Bagriantsev SN. Molecular basis of tactile specialization in the duck bill. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 13036-13041. PMID: 29109250, PMCID: PMC5724259, DOI: 10.1073/pnas.1708793114.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAvian ProteinsBeakChickensCloning, MolecularDucksEmbryo, NonmammalianGene ExpressionGenetic VectorsHEK293 CellsHumansIon ChannelsKineticsMechanoreceptorsMechanotransduction, CellularMicePatch-Clamp TechniquesRecombinant ProteinsRNA, Small InterferingSequence Homology, Amino AcidSpecies SpecificityTouchTouch PerceptionTrigeminal GanglionConceptsMolecular basisHeterologous expression systemSpecialist birdsMouse orthologPiezo2 ion channelsTactile specializationExpression systemDuck billMolecular characterizationIon channelsFeeding behaviorEdible matterPiezo2BirdsElectrophysiological characterizationSlow inactivation kineticsOrthologsVertebratesMechanoMechanotransductionKnockdownInactivation kineticsMurky watersHigh densityNeuronsPsychological Characteristics and Pain Frequency Are Associated With Experimental Pain Sensitivity in Pediatric Patients With Sickle Cell Disease
Bakshi N, Lukombo I, Shnol H, Belfer I, Krishnamurti L. Psychological Characteristics and Pain Frequency Are Associated With Experimental Pain Sensitivity in Pediatric Patients With Sickle Cell Disease. Journal Of Pain 2017, 18: 1216-1228. PMID: 28602692, DOI: 10.1016/j.jpain.2017.05.005.Peer-Reviewed Original ResearchConceptsSickle cell diseaseExperimental pain stimuliExperimental pain sensitivityPain sensitivityPain stimuliChronic painExperimental painCell diseasePsychological characteristicsQuantitative sensory testing methodsPsychological factorsChronic SCD painMechanical temporal summationVaso-occlusive painQuantitative sensory testingSubset of patientsPain-related outcomesStudy of patientsCross-sectional assessmentChildren ages 8SCD painPain burdenPain frequencyPediatric patientsPain processingStimulation of 5-HT2A Receptors Recovers Sensory Responsiveness in Acute Spinal Neonatal Rats
Swann H, Kauer S, Allmond J, Brumley M. Stimulation of 5-HT2A Receptors Recovers Sensory Responsiveness in Acute Spinal Neonatal Rats. Behavioral Neuroscience 2017, 131: 92-98. PMID: 28004950, PMCID: PMC5269442, DOI: 10.1037/bne0000176.Peer-Reviewed Original ResearchConceptsSpinal cord injurySpinal ratsTail pinchMotor activityCord injurySensory stimulationNeonatal ratsSensory afferent stimulationRecovery of functionHind limb movementsTail pinchingAfferent stimulationReceptor agonistSpinal cordRat pupsAdult rodentsMotor circuitsQuipazineSupine postureRatsBaseline periodIntact levelsLevel of activityStimulationInjury
2016
The role of empathy in the neural responses to observed human social touch
Peled-Avron L, Levy-Gigi E, Richter-Levin G, Korem N, Shamay-Tsoory S. The role of empathy in the neural responses to observed human social touch. Cognitive, Affective, & Behavioral Neuroscience 2016, 16: 802-813. PMID: 27165338, DOI: 10.3758/s13415-016-0432-5.Peer-Reviewed Original ResearchConceptsHuman social touchNeural responsesSocial touchEmpathic traitsEmpathic participantsElectrophysiological responsesMore pleasant emotionsRole of empathyGreater mu suppressionLevel of empathyPleasant emotionsSensorimotor resonanceEmotional contagionMu suppressionPersonal distressObserved touchNeural markersTactile stimuliInanimate objectsElectroencephalography (EEG) activityInterindividual differencesEmotionsHuman interactionEmpathyParticipantsDendritic spine remodeling following early and late Rac1 inhibition after spinal cord injury: evidence for a pain biomarker
Zhao P, Hill M, Liu S, Chen L, Bangalore L, Waxman SG, Tan AM. Dendritic spine remodeling following early and late Rac1 inhibition after spinal cord injury: evidence for a pain biomarker. Journal Of Neurophysiology 2016, 115: 2893-2910. PMID: 26936986, PMCID: PMC4922610, DOI: 10.1152/jn.01057.2015.Peer-Reviewed Original ResearchConceptsSpinal cord injuryNeuropathic painDendritic spine dysgenesisDendritic spinesCord injurySpine dysgenesisDorsal horn neuronsSpine profilesDendritic spine remodelingEffective clinical translationSensory dysfunctionSignificant complicationsNociceptive systemPain biomarkersSpine remodelingClinical conditionsPreclinical studiesRac1 activityEffective treatmentPainDrug responsivenessStructural biomarkersDisease statesRac1 inhibitionBiomarkers
2014
Neuronal mechanism for acute mechanosensitivity in tactile-foraging waterfowl
Schneider ER, Mastrotto M, Laursen WJ, Schulz VP, Goodman JB, Funk OH, Gallagher PG, Gracheva EO, Bagriantsev SN. Neuronal mechanism for acute mechanosensitivity in tactile-foraging waterfowl. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 14941-14946. PMID: 25246547, PMCID: PMC4205607, DOI: 10.1073/pnas.1413656111.Peer-Reviewed Original ResearchConceptsTrigeminal ganglionIon channel Piezo2Light mechanical stimuliMechanoreceptive neuronsTG neuronsPrimary afferentsMechanical stimuliTrigeminal afferentsNeuronal excitationEnd organsNeuronal mechanismsDirect mechanical stimulationCellular mechanismsMechanical stimulationAfferentsNeuronsLow thresholdNumerical expansionGangliaStimuli
2013
Facial allotransplantation: A 3-year follow-up report
Diaz-Siso J, Parker M, Bueno E, Sisk G, Pribaz J, Eriksson E, Annino D, Tullius S, Pomahac B. Facial allotransplantation: A 3-year follow-up report. Journal Of Plastic Reconstructive & Aesthetic Surgery 2013, 66: 1458-1463. PMID: 23911716, DOI: 10.1016/j.bjps.2013.06.046.Peer-Reviewed Original ResearchConceptsQuality of lifeFunctional recoveryFace transplantationFirst postoperative yearPatients' functional recoveryPost-operative monthHigh-voltage burnsSatisfactory aesthetic resultsFace transplant patientsSevere facial defectsImmunosuppression dosesSteroid therapyPostoperative yearTransplant patientsMale patientsNormal sensationImmunologic complicationsWomen's HospitalMotor functionSurgical techniquePatient reportsReconstructive surgeryClose monitoringMultidisciplinary teamOccupational therapyBrain mechanisms for prepulse inhibition in adults with Tourette syndrome: Initial findings
Zebardast N, Crowley MJ, Bloch MH, Mayes LC, Vander Wyk BV, Leckman JF, Pelphrey KA, Swain JE. Brain mechanisms for prepulse inhibition in adults with Tourette syndrome: Initial findings. Psychiatry Research 2013, 214: 33-41. PMID: 23916249, PMCID: PMC3932431, DOI: 10.1016/j.pscychresns.2013.05.009.Peer-Reviewed Original ResearchConceptsTourette syndromeFunctional magnetic resonance imagingHealthy subjectsTic severityWhole-brain functional magnetic resonance imagingYale Global Tic Severity ScaleTactile startle responseCase-control study designTic Severity ScaleCortical-striatal circuitsBrain activityMagnetic resonance imagingMultiple brain regionsLeft middle frontal gyrusMiddle frontal gyrusDegree of PPIPulse-alone stimuliBlock-design fMRI paradigmTic symptomsNeuropathological dataHealthy controlsPrepulse inhibitionDevelopmental neuropsychiatric disordersSensorimotor gatingLeft caudateFunctional MRI and neural responses in a rat model of Alzheimer's disease
Sanganahalli BG, Herman P, Behar KL, Blumenfeld H, Rothman DL, Hyder F. Functional MRI and neural responses in a rat model of Alzheimer's disease. NeuroImage 2013, 79: 404-411. PMID: 23648961, PMCID: PMC3700380, DOI: 10.1016/j.neuroimage.2013.04.099.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseFunctional magnetic resonance imagingCerebral cortexAD brainSomatosensory cortexRat modelCortical functionNeural responsesAge-matched healthy controlsAD rat modelContralateral somatosensory cortexSensory-evoked responsesHigh-field functional magnetic resonance imagingBrain functional responsesMagnetic resonance imagingAD ratsControl ratsHealthy controlsThalamic responsesNormal ratsCortical responsesAD modelSubcortical functionBrain plaquesElectrical stimulation
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