2025
DSP-1, the major fibronectin type-II protein of donkey seminal plasma is a small heat-shock protein and exhibits chaperone-like activity against thermal and oxidative stress
Alim S, Cheppali S, Pawar S, Swamy M. DSP-1, the major fibronectin type-II protein of donkey seminal plasma is a small heat-shock protein and exhibits chaperone-like activity against thermal and oxidative stress. Biochimica Et Biophysica Acta (BBA) - Proteins And Proteomics 2025, 1873: 141064. PMID: 39956303, DOI: 10.1016/j.bbapap.2025.141064.Peer-Reviewed Original ResearchConceptsChaperone-like activitySeminal plasmaFibronectin type IITetramer to monomersSperm capacitationSurface hydrophobicityMolecular chaperonesClient proteinsHeat shock proteinsBiophysical studiesAlcohol dehydrogenaseOxidative stressPhysiological ligandsShock proteinsProteinHead group moietySHspsBinding of phosphorylcholineCholine phospholipidsBindingFibronectinDehydrogenaseChaperoneSpermMammals
2023
LRRC23 truncation impairs radial spoke 3 head assembly and sperm motility underlying male infertility
Hwang J, Chai P, Nawaz S, Choi J, Lopez-Giraldez F, Hussain S, Bilguvar K, Mane S, Lifton R, Ahmad W, Zhang K, Chung J. LRRC23 truncation impairs radial spoke 3 head assembly and sperm motility underlying male infertility. ELife 2023, 12: rp90095. PMID: 38091523, PMCID: PMC10721216, DOI: 10.7554/elife.90095.Peer-Reviewed Original ResearchContrasting effects of molecular crowding on the membrane-perturbing and chaperone-like activities of major bovine seminal plasma protein, PDC-109
Singh B, Cheppali S, Saha I, Swamy M. Contrasting effects of molecular crowding on the membrane-perturbing and chaperone-like activities of major bovine seminal plasma protein, PDC-109. International Journal Of Biological Macromolecules 2023, 254: 127573. PMID: 37923045, DOI: 10.1016/j.ijbiomac.2023.127573.Peer-Reviewed Original ResearchConceptsChaperone-like activityPDC-109Effects of molecular crowdingMembrane destabilizationMolecular crowdingBovine seminal plasma proteinSperm cell surfaceSeminal plasma proteinsBovine seminal plasmaAcrosome reactionClient proteinsProtein stabilityMicroenvironment of proteinsSeminal plasmaMembrane-perturbingProtein oligomersReduced surface hydrophobicityOligomeric proteinsLipid effluxCell surfaceCrowding agentsProteinIsothermal titration calorimetric studiesTitration calorimetric studiesFunctional activityA CUG-initiated CATSPERθ functions in the CatSper channel assembly and serves as a checkpoint for flagellar trafficking
Huang X, Miyata H, Wang H, Mori G, Iida-Norita R, Ikawa M, Percudani R, Chung J. A CUG-initiated CATSPERθ functions in the CatSper channel assembly and serves as a checkpoint for flagellar trafficking. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2304409120. PMID: 37725640, PMCID: PMC10523455, DOI: 10.1073/pnas.2304409120.Peer-Reviewed Original ResearchConceptsChannel assemblySperm flagellaTransmembrane domain-containing proteinsSperm tail formationDomain-containing proteinsCatSper channel complexMale fertilityFlagellar traffickingMacromolecular complexesTail formationPhysiological roleSuccessful fertilizationCalcium signalingCatSper channelsFlagellaGenetic abrogationChannel complexNormal expressionDimer formationSpermatid cellsProteinCheckpointHyperactivated motilityAssemblyPotential roleAttitudes towards disposition of cryopreserved sperm in the event of death.
Buller D, Harnisch B, Lyall V, Goltzman M, Neuber E, Bartolucci A, Honig S. Attitudes towards disposition of cryopreserved sperm in the event of death. Canadian Journal Of Urology 2023, 30: 11613-11618. PMID: 37633289.Peer-Reviewed Original ResearchConceptsInfertility diagnosisMale factor infertility diagnosisRetrospective cohort studyInsurance coverageDemographic characteristicsEtiology of infertilityCases of deathCommercial insurance coverageRace/ethnicityCohort studyMale patientsInfertility etiologyFertility centerPatient preferencesDuration of marriagePatientsSubsequent deathFuture deathsFinal analysisConsent formEvent of deathMarital statusDeathReproductive technologiesSignificant differencesThree-dimensional imaging of vascular development in the mouse epididymis.
Damon-Soubeyrand C, Bongiovanni A, Chorfa A, Goubely C, Pirot N, Pardanaud L, Piboin-Fragner L, Vachias C, Bravard S, Guiton R, Thomas J, Saez F, Kocer A, Tardivel M, Drevet J, Henry-Berger J. Three-dimensional imaging of vascular development in the mouse epididymis. ELife 2023, 12 PMID: 37310207, PMCID: PMC10264076, DOI: 10.7554/elife.82748.Peer-Reviewed Original ResearchConceptsProtection of spermatozoaComplex immune functionsAccessory tubulesVascular developmentMouse epididymisCellular levelSecretory roleImportant playersMale fertilityMale reproductive systemOrgan clearingMature adult miceReproductive systemTransgenic mouse modelFunctional maturationPeripheral toleranceBlood markersImmune responseLymphatic networkImmune functionKey determinantMouse modelSurvival of spermatozoaAdult miceImmune systemMolecular Biology of Cytoplasmic Incompatibility Caused by Wolbachia Endosymbionts
Hochstrasser M. Molecular Biology of Cytoplasmic Incompatibility Caused by Wolbachia Endosymbionts. Annual Review Of Microbiology 2023, 77: 299-316. PMID: 37285552, DOI: 10.1146/annurev-micro-041020-024616.Peer-Reviewed Original ResearchConceptsCytoplasmic incompatibilityMale killingHost ubiquitin systemEndosymbiotic bacteriaFemale germlineEukaryotic cellsCognate partnersEmbryonic lethalityBicistronic operonUbiquitin systemDownstream genesWolbachia endosymbiontReproductive advantageCI inductionMolecular biologyInfected femalesEndosymbiontsInfections of malesReproductive alterationsDeubiquitylaseDeubiquitylasesOperonParthenogenesisArthropodsGermlineVitamin D and infertility
Simpson S, Pal L. Vitamin D and infertility. Current Opinion In Obstetrics & Gynecology 2023, 35: 300-305. PMID: 37266579, DOI: 10.1097/gco.0000000000000887.Peer-Reviewed Original ResearchConceptsPolycystic ovarian syndromeVitamin DGynaecological disordersVitamin D serum levelsOvarian reserve parametersD serum levelsVitamin D deficiencyVitamin D statusDiminished ovarian reserveCommon gynaecological disorderReproductive health burdenHigher pregnancy rateD deficiencyD statusOvarian reserveOvarian syndromeInfertile womenSerum levelsUterine myomaMenstrual regularityEndometriosis patientsInsulin levelsUterine fibroidsHealth burdenPregnancy rateDOT1L promotes spermatid differentiation by regulating expression of genes required for histone-to-protamine replacement
Malla A, Rainsford S, Smith Z, Lesch B. DOT1L promotes spermatid differentiation by regulating expression of genes required for histone-to-protamine replacement. Development 2023, 150 PMID: 37082969, PMCID: PMC10259660, DOI: 10.1242/dev.201497.Peer-Reviewed Original ResearchConceptsHistone replacementMale sterilityProtamine exchangeSpermatid differentiationHistone H3 lysine 79Chromatin remodeling factorsRNA polymerase IIH3 lysine 79Expression of genesMature sperm headSperm headPostmeiotic germ cellsHistone methyltransferase DOT1LPolymerase IILysine 79Embryonic lethalityRemodeling factorsProtamine transitionProtamine replacementTranscriptional dysregulationMethyltransferase DOT1LIndispensable regulatorDOT1LHistonesGerm cellsHuman Uterine Lavage: First Live Births from In Vivo Conceived Genetically Screened Blastocysts
Najmabadi S, Rivas J, Angle M, Nadal A, Bastu E, Munné S, Carson S, Buster J, Nakajima S. Human Uterine Lavage: First Live Births from In Vivo Conceived Genetically Screened Blastocysts. Advances In Therapy 2023, 40: 2534-2541. PMID: 36988819, DOI: 10.1007/s12325-023-02486-1.Peer-Reviewed Original ResearchConceptsFirst live birthEmbryo transfer proceduresLive birthsUterine lavageIntrauterine inseminationEuploid blastocystsOvarian stimulation cyclesObservational case seriesBlastocyst implantation ratePreimplantation genetic testingSets of twinsInfertile womenCase seriesLavage catheterImplantation rateTransfer procedureFertility centerOocyte aspirationStimulation cyclesInfertile couplesLavage procedureSurgical proceduresEmbryo implantationMethodsIn vivoOocyte donorsThe impact of air pollution and endocrine disruptors on reproduction and assisted reproduction
Seli D, Taylor H. The impact of air pollution and endocrine disruptors on reproduction and assisted reproduction. Current Opinion In Obstetrics & Gynecology 2023, 35: 210-215. PMID: 36924404, DOI: 10.1097/gco.0000000000000868.Peer-Reviewed Original ResearchConceptsDiminished ovarian reserveOvarian reserveInfertility treatmentAbnormal semen parametersAssisted reproduction outcomesHuman reproductive healthEstrogen-like activityFemale reproductive functionEndocrine disruptorsPregnancy rateUterine leiomyomaReproductive healthReproduction outcomesReproductive functionSemen parametersClinical implicationsLarge-scale studiesAssisted reproductionSperm concentrationPatientsAir pollutionHealth impactsEndocrineTreatmentBisphenol A
2022
CatSper Calcium Channels: 20 Years On
Hwang J, Chung J. CatSper Calcium Channels: 20 Years On. Physiology 2022, 38: 125-140. PMID: 36512352, PMCID: PMC10085559, DOI: 10.1152/physiol.00028.2022.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsSelenoprotein TXNRD3 supports male fertility via the redox regulation of spermatogenesis
Dou Q, Turanov AA, Mariotti M, Hwang JY, Wang H, Lee SG, Paulo JA, Yim SH, Gygi SP, Chung JJ, Gladyshev VN. Selenoprotein TXNRD3 supports male fertility via the redox regulation of spermatogenesis. Journal Of Biological Chemistry 2022, 298: 102183. PMID: 35753352, PMCID: PMC9352919, DOI: 10.1016/j.jbc.2022.102183.Peer-Reviewed Original ResearchConceptsThioredoxin/glutathione reductaseThiol redox controlSperm quality controlThiol redox statusGene duplicationThiol oxidoreductasesRedox regulationProteomic analysisRedox controlGross phenotypeThioredoxin reductaseSperm maturationMovement phenotypesSperm cellsRedox statusMale reproductionKnockout animalsMale fertilityGlutathione reductaseCritical roleReductasePhenotypeTXNRD3Knockout miceSpermatogenesisHomeostatic Model Assessment for Insulin Resistance Is Associated With Late Miscarriage in Non-Dyslipidemic Women Undergoing Fresh IVF/ICSI Embryo Transfer
Yang T, Yang Y, Zhang Q, Liu D, Liu N, Li Y, Yao Z, Zhang Y, Tian F, Zhao J, Li Y. Homeostatic Model Assessment for Insulin Resistance Is Associated With Late Miscarriage in Non-Dyslipidemic Women Undergoing Fresh IVF/ICSI Embryo Transfer. Frontiers In Endocrinology 2022, 13: 880518. PMID: 35784578, PMCID: PMC9247267, DOI: 10.3389/fendo.2022.880518.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeAssisted reproductive technologyMiscarriage rateIVF/ICSI-ETAssociated with late miscarriageInfertile womenFertilization/intracytoplasmic sperm injection-embryo transferIVF/ICSI-embryo transferPolycystic ovary syndrome groupNon-PCOS groupNon-PCOS populationHOMA-IR groupReproductive Medicine CenterLate miscarriagePCOS womenHOMA-IRHomeostatic model assessmentIncreased HOMA-IRReproductive technologyCentral South UniversityEmbryo transferPercentage of macrosomiaInsulin resistanceSubgroup analysisModel assessmentRedox regulation by TXNRD3 during epididymal maturation underlies capacitation-associated mitochondrial activity and sperm motility in mice
Wang H, Dou Q, Jeong KJ, Choi J, Gladyshev VN, Chung JJ. Redox regulation by TXNRD3 during epididymal maturation underlies capacitation-associated mitochondrial activity and sperm motility in mice. Journal Of Biological Chemistry 2022, 298: 102077. PMID: 35643315, PMCID: PMC9218152, DOI: 10.1016/j.jbc.2022.102077.Peer-Reviewed Original ResearchConceptsRedox regulationRedox homeostasisMolecular mechanismsSperm maturationMitochondrial sheath formationCell imaging analysisThioredoxin glutathione reductaseSperm developmentMammalian spermatozoaEpididymal transitMitochondrial ultrastructureMitochondrial activityRedox statusMale fertilityCapacitationHomeostasisMaturationRegulationMotilityFamily membersFertilizationSperm morphologySperm motilityMitochondriaBioenergeticsBiomarkers of Stress and Male Fertility
Spitzer TL, Trussell JC, Coward RM, Hansen KR, Barnhart KT, Cedars MI, Diamond MP, Krawetz SA, Sun F, Zhang H, Santoro N, Steiner AZ. Biomarkers of Stress and Male Fertility. Reproductive Sciences 2022, 29: 1262-1270. PMID: 35106743, PMCID: PMC9078052, DOI: 10.1007/s43032-022-00853-x.Peer-Reviewed Original ResearchConceptsLive birth rateSemen parametersSalivary levelsSperm countPregnancy/live birth rateBirth rateTotal motile sperm countMale factor infertilityMotile sperm countDNA fragmentationTotal sperm countSalivary cortisol levelsMale fertilityStress-related biomarkersChi-square testingSalivary alpha-amylaseInfertility trialsCohort studyHighest quintileIntrauterine inseminationPregnancy rateUpper quintileInfertile menPhysiologic measuresBiomarkers of stress
2021
The relationship of plasma antioxidant levels to semen parameters: the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial
Knudtson JF, Sun F, Coward RM, Hansen KR, Barnhart KT, Smith J, Legro RS, Diamond MP, Krawetz SA, Zhang H, Usadi R, Baker VL, Santoro N, Steiner AZ. The relationship of plasma antioxidant levels to semen parameters: the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial. Journal Of Assisted Reproduction And Genetics 2021, 38: 3005-3013. PMID: 34455507, PMCID: PMC8609082, DOI: 10.1007/s10815-021-02301-2.Peer-Reviewed Original ResearchConceptsPlasma antioxidant levelsLive birthsClinical trialsSemen parametersAntioxidant levelsVitamin ERank sum testSecondary analysisClinical outcomesNormal rangeBaseline plasma valuesVitamin E levelsWilcoxon rank sum testMale fertilityConclusionsAmong menPrimary endpointDNA fragmentationResultsAt baselineSerum levelsFertility centerE levelsMethodsThis studyMale infertilityFertility outcomesPlasma valuesMale vitamin D status and male factor infertility
Banks N, Sun F, Krawetz SA, Coward RM, Masson P, Smith JF, Trussell JC, Santoro N, Zhang H, Steiner AZ. Male vitamin D status and male factor infertility. Fertility And Sterility 2021, 116: 973-979. PMID: 34289935, PMCID: PMC8561776, DOI: 10.1016/j.fertnstert.2021.06.035.Peer-Reviewed Original ResearchMeSH KeywordsAbortion, SpontaneousAdultBiomarkersClomipheneDietary SupplementsDouble-Blind MethodFemaleFertilityFertility Agents, FemaleHumansInfertility, MaleInsemination, Artificial, HomologousLive BirthMalePregnancyPregnancy RateProspective StudiesRisk FactorsSemenSemen AnalysisTime FactorsTreatment OutcomeUnited StatesVitamin DVitamin D DeficiencyConceptsVitamin D deficiencyLive birth rateMale factor infertilityD deficiencyFactor infertilityD levelsSemen parametersMild male factor infertilityMale partnersVitamin D levelsVitamin D statusRate of miscarriageFemale partnersSperm concentrationBirth rateClinical pregnancyClomiphene citrateD statusDNA fragmentationCumulative pregnancySperm DNA fragmentationVitamin DFertility centerIntrauterine inseminationMonth 4
2019
Repeated semen exposure decreases cervicovaginal SIVmac251 infection in rhesus macaques
Abdulhaqq S, Martinez M, Kang G, Rodriguez I, Nichols S, Beaumont D, Joseph J, Azzoni L, Yin X, Wise M, Weiner D, Liu Q, Foulkes A, Münch J, Kirchhoff F, Coutifaris C, Tomaras G, Sariol C, Marx P, Li Q, Kraiselburd E, Montaner L. Repeated semen exposure decreases cervicovaginal SIVmac251 infection in rhesus macaques. Nature Communications 2019, 10: 3753. PMID: 31434895, PMCID: PMC6704120, DOI: 10.1038/s41467-019-11814-5.Peer-Reviewed Original ResearchConceptsCD4+ T cellsFemale reproductive tractSemen exposureT cellsIncreased infiltration of CD4+ T cellsMale-to-female HIV transmissionCirculating CD4+ T cellsInfiltration of CD4+ T cellsExposure to semenEffect of semenNon-human primatesExpression of Mx1Anti-HIV mechanismsCervicovaginal mucosaSIVmac251 challengeSIVmac251 infectionCCR5 expressionIn vivo evidenceHIV acquisitionHIV infectionHIV transmissionAssociated with activationIncreased infiltrationRhesus macaquesReproductive tractEvaluation of different testing tools for the identification of non-gonococcal Neisseria spp. isolated from Lebanese male semen: a strong and significant association with infertility
Khoder M, Osman M, Diene S, Okdah L, Lalaoui R, Al Achkar M, Mallat H, Hamze M, Rolain J. Evaluation of different testing tools for the identification of non-gonococcal Neisseria spp. isolated from Lebanese male semen: a strong and significant association with infertility. Journal Of Medical Microbiology 2019, 68: 1012-1020. PMID: 31172907, DOI: 10.1099/jmm.0.000990.Peer-Reviewed Original ResearchConceptsNeisseria sppSignificant associationRetrospective study designCross-sectional retrospective study designCritical treatment decisionsSymptoms of infertilityLarge-scale epidemiological investigationsAntimicrobial susceptibility testingStrains of NeisseriaUrogenital infectionsInfertile patientsNeisseria infectionsTreatment decisionsNormal seminogramMale infertilityControl groupLebanese menEpidemiological investigationsInfertilitySusceptibility testingLebanese populationAPI NHPatientsStudy designAnalytical profile index
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