2025
Adding insult to injury: the spectrum of tubulointerstitial responses in acute kidney injury
Baker M, Cantley L. Adding insult to injury: the spectrum of tubulointerstitial responses in acute kidney injury. Journal Of Clinical Investigation 2025, 135: e188358. PMID: 40091836, PMCID: PMC11910233, DOI: 10.1172/jci188358.Peer-Reviewed Original ResearchConceptsAcute kidney injuryTubular epithelial cellsKidney injuryTubular cellsCases of acute kidney injuryImmune-mediated processPersistence of inflammationBiphasic immune responseChronic kidney diseaseCell deathTubular cell injuryLymphocyte subsetsTubular repairCell cycle arrestOutflow obstructionTEC differentiationPreclinical findingsLymphocytic infiltrationProinflammatory macrophagesKidney diseaseModulate inflammationImmune responseActivated macrophagesMetabolic reprogrammingTubular casts
2011
Use of mouse hematopoietic stem and progenitor cells to treat acute kidney injury
Li L, Black R, Ma Z, Yang Q, Wang A, Lin F. Use of mouse hematopoietic stem and progenitor cells to treat acute kidney injury. American Journal Of Physiology. Renal Physiology 2011, 302: f9-f19. PMID: 21937606, PMCID: PMC3251347, DOI: 10.1152/ajprenal.00377.2011.Peer-Reviewed Original ResearchConceptsAcute kidney injuryKidney injuryMouse hematopoietic stemProgenitor cellsHematopoietic stemEpithelial marker E-cadherinRenal ischemic injuryTubular cell deathCell fate conversionMarker E-cadherinEmbryonic kidney organ cultureHistone deacetylase inhibitorsKidney organ culturesIschemic injuryKidney functionPostischemic kidneyTubular repairRenal capsuleRenal repairRenotrophic factorIGF-1Intravenous injectionEffective treatmentFate conversionEpithelial proliferation
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