2025
Sedation for moderate‐to‐severe traumatic brain injury in adults
Williamson D, Dryden L, Cheng W, Hutton B, Skidmore B, Mehta S, Golan E, Turgeon A, Adhikari N, Rose L, Burry L. Sedation for moderate‐to‐severe traumatic brain injury in adults. Cochrane Database Of Systematic Reviews 2025, 2025: cd012639. PMID: 40326601, PMCID: PMC12053465, DOI: 10.1002/14651858.cd012639.pub2.Peer-Reviewed Original ResearchEarly Pupil Abnormality Frequency Predicts Poor Outcomes and Enhances International Mission for Prognosis and Analysis of Clinical Trials in Traumatic Brain Injury (IMPACT) Model Prognostication in Traumatic Brain Injury
Veerapaneni D, Sakthiyendran N, Du Y, Mallinger L, Reinert A, Kim S, Nguyen C, Daneshmand A, Abdalkader M, Mohammed S, Dupuis J, Sheth K, Gilmore E, Greer D, Ong C. Early Pupil Abnormality Frequency Predicts Poor Outcomes and Enhances International Mission for Prognosis and Analysis of Clinical Trials in Traumatic Brain Injury (IMPACT) Model Prognostication in Traumatic Brain Injury. Critical Care Explorations 2025, 7: e1257. PMID: 40299976, PMCID: PMC12043342, DOI: 10.1097/cce.0000000000001257.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryNeurological Pupil indexUnfavorable discharge dispositionPrimary diagnosis of traumatic brain injuryDischarge dispositionPupil abnormalitiesAcute care settingInternational Mission for PrognosisDiagnosis of traumatic brain injuryQuantitative pupillometryTraumatic brain injury severityBrain injuryMultivariate logistic regressionAnalysis of clinical trialsCare settingsAssociated with unfavorable discharge outcomesTraumatic brain injury prognostic modelsClinical trialsDischarge outcomesUnfavorable discharge outcomesPrognostic modelPupillary assessmentAssociated with unfavorable outcomesDynamic prognostic informationInclusion criteriaAAN Position
Najib U, Cheng E, Halker Singh R, Ayub N, Nelson S, Bushard P, Jordan J, Sico J, Turbes M, Anderson W. AAN Position. Neurology 2025, 104: e213544. PMID: 40193721, DOI: 10.1212/wnl.0000000000213544.Peer-Reviewed Original ResearchConceptsAmerican Academy of NeurologySafety of opioid prescribingElectronic prescribing of controlled substancesLow back painPrescribing of controlled substancesMisused prescription medicationsPrescribing of opioidsPrescription monitoring programsElectronic prescribingCare teamBack painPrescription medicationsPatient's painOpioid prescribingPrescribing practicesUpstream approachTraumatic brain injuryChronic painOpioid misusePosition statementFinding alternative therapiesPrescribingTeam's needsAmerican AcademyPain disordersExploring Calcium Channels as Potential Therapeutic Targets in Blast Traumatic Brain Injury
Wachtler N, O’Brien R, Ehrlich B, McGuone D. Exploring Calcium Channels as Potential Therapeutic Targets in Blast Traumatic Brain Injury. Pharmaceuticals 2025, 18: 223. PMID: 40006037, PMCID: PMC11859800, DOI: 10.3390/ph18020223.Peer-Reviewed Original ResearchCalcium signalingCalcium channelsTherapeutic strategiesCalcium homeostasisFunction of calcium channelsDysregulated calcium signalingModulation of injuryTraumatic brain injuryBrain injuryLoss of calcium homeostasisBlast-related traumatic brain injuryDevelopment of neuroprotective interventionsIntracellular calcium dynamicsPlasma membrane stabilityExtracellular calciumBlast traumatic brain injuryPreclinical modelsTherapeutic outcomesNeuroprotective interventionsMembrane abnormalitiesPharmacological inhibitorsNeuronal somataExclusion criteriaCalcium dynamicsSecondary injuryQualitative Analysis of Symptoms from the Central Thalamic Deep Brain Stimulation Trial for Traumatic Brain Injury
Gerber L, Shulman K, Wright M, Schiff N, Fins J. Qualitative Analysis of Symptoms from the Central Thalamic Deep Brain Stimulation Trial for Traumatic Brain Injury. NeuroRehabilitation An International Interdisciplinary Journal 2025, 56: 143-151. PMID: 40260721, DOI: 10.1177/10538135241296732.Peer-Reviewed Original ResearchStudy of deep brain stimulationTraumatic brain injuryDeep brain stimulation trialsDeep brain stimulationBrain injuryRandomized feasibility studySecondary qualitative analysisFamily membersSelf-regulationChronic traumatic brain injurySemi-structured interviewsBrain stimulationFamily perspectiveStimulation trialsTrial participantsExecutive controlResults SubjectsSymptom assessmentOutcome measuresQualitative analysisCognitive symptomsAnalysis of symptomsNarrative dataQualitative dataPost-injury
2024
Occurrence of Opioid-Related Neurocognitive Symptoms Associated With Long-term Opioid Therapy
León C, Sung M, Reisman J, Liu W, Kerns R, Gordon K, Mitra A, Kwon S, Yu H, Becker W, Li W. Occurrence of Opioid-Related Neurocognitive Symptoms Associated With Long-term Opioid Therapy. The Clinical Journal Of Pain 2024, 41: e1266. PMID: 39682036, PMCID: PMC11729567, DOI: 10.1097/ajp.0000000000001266.Peer-Reviewed Original ResearchLong-term opioid therapyElectronic health recordsIncidence rate ratiosOpioid-related harmsSubstance use disordersNeurocognitive symptomsHazard ratioPatients prescribed long-term opioid therapyVeterans Health AdministrationCalculated incidence ratesAssociated with increased likelihoodChronic obstructive pulmonary diseasePost-traumatic stress disorderHealth recordsProportional hazards modelRetrospective cohort studyObstructive pulmonary diseaseHealth AdministrationRate ratiosIncidence rateCohort studyTraumatic brain injuryClinical notesExtract dataHazards modelUnnecessary Scans Lead to Unnecessary Re-scans: Evaluating Clinical Management of Low and Intermediate Risk Pediatric Traumatic Brain Injuries
Rivero R, Curran I, Hellmann Z, Carroll M, Hornick M, Solomon D, DiLuna M, Morrell P, Christison-Lagay E. Unnecessary Scans Lead to Unnecessary Re-scans: Evaluating Clinical Management of Low and Intermediate Risk Pediatric Traumatic Brain Injuries. Journal Of Pediatric Surgery 2024, 60: 162097. PMID: 39693726, DOI: 10.1016/j.jpedsurg.2024.162097.Peer-Reviewed Original ResearchPediatric Emergency Care Applied Research NetworkPECARN guidelinesPediatric Emergency Care Applied Research Network criteriaClinically important traumatic brain injuryComputed tomographyRisk patientsCross-sectional imagingIntermediate risk group patientsHead traumaIntracranial injuryIntermediate risk patientsRisk group patientsLow-risk injuriesLow-risk patientsRetrospective cohort studyClinically significant progressionEvaluate clinical managementIncreased hospital costsMild head traumaPenetrating head traumaLength of stayTraumatic brain injuryNon-accidental traumaBrain injuryRetrospective reviewPrehospital Trauma Compendium: Fluid Resuscitation in Trauma – a Position Statement and Resource Document of NAEMSP
McMullan J, Curry B, Calhoun D, Forde F, Gray J, Lardaro T, Larrimore A, LeBlanc D, Li J, Morgan S, Neth M, Sams W, Lyng J. Prehospital Trauma Compendium: Fluid Resuscitation in Trauma – a Position Statement and Resource Document of NAEMSP. Prehospital Emergency Care 2024, ahead-of-print: 1-11. PMID: 39576138, DOI: 10.1080/10903127.2024.2433146.Peer-Reviewed Original ResearchEmergency medical servicesPrehospital trauma careTraumatic brain injuryTrauma carePrehospital trauma managementFluid usePrehospital providersIV fluidsVolume crystalloid resuscitationMedical servicesClinical careCrystalloid solutionTrauma resuscitationPosition statementCareWithholding fluidsBlood product administrationIndividual riskPolytrauma patientsTrauma managementMedical compatibilityIsotonic crystalloid solutionsResuscitationFluid resuscitationCrystalloid resuscitationGenetic vulnerability and adverse mental health outcomes following mild traumatic brain injury: a meta-analysis of CENTER-TBI and TRACK-TBI cohorts
Kals M, Wilson L, Levey D, Parodi L, Steyerberg E, Richardson S, He F, Sun X, Jain S, Palotie A, Ripatti S, Rosand J, Manley G, Maas A, Stein M, Menon D, Consortium T, Ackerlund C, Adams H, Amrein K, Andelic N, Andreassen L, Anke A, Antoni A, Audibert G, Azouvi P, Azzolini M, Bartels R, Barzó P, Beauvais R, Beer R, Bellander B, Belli A, Benali H, Berardino M, Beretta L, Blaabjerg M, Bragge P, Brazinova A, Brinck V, Brooker J, Brorsson C, Buki A, Bullinger M, Cabeleira M, Caccioppola A, Calappi E, Calvi M, Cameron P, Lozano G, Carbonara M, Castaño-León A, Cavallo S, Chevallard G, Chieregato A, Citerio G, Clusmann H, Coburn M, Coles J, Cooper J, Correia M, Čović A, Curry N, Czeiter E, Czosnyka M, Dahyot-Fizelier C, Dark P, Dawes H, De Keyser V, Degos V, Della Corte F, Boogert H, Depreitere B, Đilvesi Đ, Dixit A, Donoghue E, Dreier J, Dulière G, Ercole A, Esser P, Ezer E, Fabricius M, Feigin V, Foks K, Frisvold S, Furmanov A, Gagliardo P, Galanaud D, Gantner D, Gao G, George P, Ghuysen A, Giga L, Glocker B, Golubović J, Gomez P, Gratz J, Gravesteijn B, Grossi F, Gruen R, Gupta D, Haagsma J, Haitsma I, Helbok R, Helseth E, Horton L, Huijben J, Hutchinson P, Jacobs B, Jankowski S, Jarrett M, Jiang J, Johnson F, Jones K, Karan M, Kolias A, Kompanje E, Kondziella D, Koskinen L, Kovács N, Kowark A, Lagares A, Lanyon L, Laureys S, Lecky F, Ledoux D, Lefering R, Legrand V, Lejeune A, Levi L, Lightfoot R, Lingsma H, Maegele M, Majdan M, Manara A, Maréchal H, Martino C, Mattern J, McFadyen C, McMahon C, Melegh B, Menovsky T, Mikolic A, Misset B, Muraleedharan V, Murray L, Negru A, Nelson D, Newcombe V, Nieboer D, Nyirádi J, Oresic M, Ortolano F, Otesile O, Parizel P, Payen J, Perera N, Perlbarg V, Persona P, Peul W, Piippo-Karjalainen A, Pirinen M, Pisica D, Ples H, Polinder S, Pomposo I, Posti J, Puybasset L, Rădoi A, Ragauskas A, Raj R, Rambadagalla M, Rehorčíková V, Helmrich I, Rhodes J, Richter S, Rocka S, Roe C, Roise O, Rosenfeld J, Rosenlund C, Rosenthal G, Rossaint R, Rossi S, Rueckert D, Rusnák M, Sahuquillo J, Sakowitz O, Sanchez-Porras R, Sandor J, Schäfer N, Schmidt S, Schoechl H, Schoonman G, Schou R, Schwendenwein E, Sewalt C, Singh R, Skandsen T, Smielewski P, Sorinola A, Stamatakis E, Stanworth S, Stevens R, Stewart W, Stocchetti N, Sundström N, Takala R, Tamás V, Tamosuitis T, Taylor M, Ao B, Tenovuo O, Theadom A, Thibaut A, Thomas M, Tibboel D, Timmers M, Tolias C, Trapani T, Tudora C, Unterberg A, Vajkoczy P, Valeinis E, Vallance S, Vámos Z, van der Jagt M, van der Naalt J, Van der Steen G, van Dijck J, van Erp I, van Essen T, Van Hecke W, van Heugten C, Van Praag D, van Veen E, van Wijk R, Vyvere T, Vargiolu A, Vega E, Velt K, Verheyden J, Vespa P, Vik A, Vilcinis R, Volovici V, von Steinbüchel N, Voormolen D, Vulekovic P, Whitehouse D, Wiegers E, Williams G, Wolf S, Yang Z, Ylén P, Younsi A, Zeiler F, Ziverte A, Zoerle T, Adeoye O, Badjatia N, Barber J, Bergin M, Boase K, Bodien Y, Chesnut R, Corrigan J, Crawford K, Diaz-Arrastia R, Dikmen S, Duhaime A, Ellenbogen R, Feeser V, Ferguson A, Foreman B, Gaudette E, Giacino J, Gonzalez L, Gopinath S, Grandhi R, Gullapalli R, Hemphill C, Hotz G, Huie R, Jha R, Keene D, Kitagawa R, Korley F, Kramer J, Kreitzer N, Levin H, Lindsell C, Machamer J, Madden C, Martin A, McAllister T, McCrea M, Merchant R, Mukherjee P, Nelson L, Ngwenya L, Noel F, Nolan A, Okonkwo D, Palacios E, Perl D, Puccio A, Rabinowitz M, Robertson C, Rodgers R, Rosenthal E, Sander A, Sandsmark D, Schneider A, Schnyer D, Seabury S, Sherer M, Sugar G, Temkin N, Toga A, Torres-Espin A, Valadka A, Vassar M, Wang K, Wang V, Yue J, Yuh E, Zafonte R. Genetic vulnerability and adverse mental health outcomes following mild traumatic brain injury: a meta-analysis of CENTER-TBI and TRACK-TBI cohorts. EClinicalMedicine 2024, 78: 102956. PMID: 39720422, PMCID: PMC11667043, DOI: 10.1016/j.eclinm.2024.102956.Peer-Reviewed Original ResearchPost-traumatic stress disorderMild traumatic brain injuryPolygenic risk scoresPTSD-PRSMDD-PRSTraumatic brain injuryTRACK-TBIProportion of outcome variancePost-traumatic Stress Disorder Checklist-5Odds of post-traumatic stress disorderAdverse mental health outcomesAssociations of polygenic risk scoresBrain injuryPatient Health Questionnaire-9Mental health outcomesOdds ratioMonths post-injuryRisk of depressionDisorder-specificDepressive disorderStress disorderChecklist-5Genetic vulnerabilityOutcome varianceCohort of African AmericansTraumatic Brain Injury in US Veterans: Prevalence and Associations With Physical, Mental, and Cognitive Health
Karr J, Rippey C, Hubert T, Stein M, Adams T, Pietrzak R. Traumatic Brain Injury in US Veterans: Prevalence and Associations With Physical, Mental, and Cognitive Health. Archives Of Physical Medicine And Rehabilitation 2024, 106: 537-547. PMID: 39613218, DOI: 10.1016/j.apmr.2024.11.010.Peer-Reviewed Original ResearchPosttraumatic stress disorderAlcohol use disorderDrug use disordersTraumatic brain injuryActivities of daily livingInstrumental activities of daily livingU.S. veteransAnxiety disordersSuicidal ideationUse disorderHealth conditionsPrevalence of traumatic brain injuryU.S. military veteransBrain injuryActivities of daily living disabilitySelf-reported health professional diagnosisOdds of mild cognitive impairmentU.S. veteran populationMental health conditionsMild cognitive impairmentPhysical health conditionsDepressive disorderStress disorderAssociated with higher oddsSuicide attemptsThe association between female sex and depression following traumatic brain injury: A systematic review and meta-analysis
Sandhu M, Schonwald A, Boyko M, Jafar T, Freedman I, Woeste J, Kurup A, Funaro M, Zlotnik A, Gruenbaum S, Elsamadicy A, Reynolds R, Gruenbaum B. The association between female sex and depression following traumatic brain injury: A systematic review and meta-analysis. Neuroscience & Biobehavioral Reviews 2024, 168: 105952. PMID: 39603437, DOI: 10.1016/j.neubiorev.2024.105952.Peer-Reviewed Original ResearchPost-TBI depressionTraumatic brain injurySpectrum of TBI severityBrain injuryDiagnosis of depressionNeurobehavioral symptomsTBI severitySystematic reviewDepressionMeta-analysisStatistically significant differenceMedian ageFemale patientsPooled analysisFemale sexRisk factorsSevere casesParticipantsPotential associationSignificant differenceSexSeverityRiskInjurySubjectsChronic headaches after traumatic brain injury: Diagnostic complexity associated with increased cost
McGeary D, Swan A, Kennedy E, Dismuke-Greer C, McGeary C, Sico J, Amuan M, Manhapra A, Bouldin E, Watson P, Kenney K, Myers M, Werner J, Mitchell J, Carlson K, Delgado R, Esmaeili A, Pugh M. Chronic headaches after traumatic brain injury: Diagnostic complexity associated with increased cost. NeuroRehabilitation An International Interdisciplinary Journal 2024, 55: 303-317. PMID: 39422976, PMCID: PMC11613006, DOI: 10.3233/nre-230277.Peer-Reviewed Original ResearchTraumatic brain injuryChronic headacheTraumatic brain injury diagnosisPost-9/11-era veteransPost-traumatic headacheAssociated with higher costsCare burdenBrain injuryHealthcare costsHeadache diagnosisEra veteransClinical characteristicsHeadache disordersHigher expendituresCareVeteransIndividual headachesHigh costHeadacheIntensive treatmentRefractory headacheOutcomesDiagnosisInjuryConfoundingTibolone treatment after traumatic brain injury exerts a sex-specific and Y chromosome-dependent regulation of methylation and demethylation enzymes and estrogen receptors in the cerebral cortex
Pinto-Benito D, Bautista-Abad A, Lagunas N, Ontiveros N, Ganchala D, Garcia-Segura L, Arevalo M, Grassi D. Tibolone treatment after traumatic brain injury exerts a sex-specific and Y chromosome-dependent regulation of methylation and demethylation enzymes and estrogen receptors in the cerebral cortex. Biochimica Et Biophysica Acta (BBA) - Molecular Basis Of Disease 2024, 1871: 167532. PMID: 39366643, DOI: 10.1016/j.bbadis.2024.167532.Peer-Reviewed Original ResearchRepetitive Mild Closed-Head Injury Induced Synapse Loss and Increased Local BOLD-fMRI Signal Homogeneity
Markicevic M, Mandino F, Toyonaga T, Cai Z, Fesharaki-Zadeh A, Shen X, Strittmatter S, Lake E. Repetitive Mild Closed-Head Injury Induced Synapse Loss and Increased Local BOLD-fMRI Signal Homogeneity. Journal Of Neurotrauma 2024, 41: 2528-2544. PMID: 39096127, PMCID: PMC11698675, DOI: 10.1089/neu.2024.0095.Peer-Reviewed Original ResearchChronic variable stressRegional homogeneityFunctional brain abnormalitiesSynapse densityMild closed-head injuryClosed-head injuryTraumatic brain injuryTreat traumatic brain injuryNeurobiological alterationsMild head injuryVariable stressBrain abnormalitiesPositron emission tomographyMultimodal studiesSynaptic densityMagnetic resonance imagingBrain imagingBrain injuryInduce synapse lossFMRIInjured miceMouse modelEmission tomographyResonance imagingCompensatory mechanismsMild Traumatic Brain Injury in U.S. Military Veterans: Results from the National Health and Resilience in Veterans Study
Meshberg-Cohen S, Cook J, Fischer I, Pietrzak R. Mild Traumatic Brain Injury in U.S. Military Veterans: Results from the National Health and Resilience in Veterans Study. Psychiatry 2024, 87: 314-328. PMID: 39186319, DOI: 10.1080/00332747.2024.2392226.Peer-Reviewed Original ResearchMild traumatic brain injuryNational Health and ResilienceU.S. military veteransPsychosocial functioningTraumatic brain injuryVeterans StudyMilitary veteransCurrent posttraumatic stress disorderOutcomes of mild traumatic brain injuryLifetime psychiatric conditionsGeneralized anxiety disorderComorbid psychiatric diagnosesPosttraumatic stress disorderPoor psychosocial functioningMild traumatic brain injury eventDrug use disordersBrain injuryPrevention of disabilityAssociated with increased oddsAnxiety disordersDepressive disorderStress disorderPsychiatric diagnosisMTBI symptomsPsychiatric characteristicsMicroglia: The Drunken Gardeners of Early Adversity
Ahmed S, Polis B, Kaffman A. Microglia: The Drunken Gardeners of Early Adversity. Biomolecules 2024, 14: 964. PMID: 39199352, PMCID: PMC11353196, DOI: 10.3390/biom14080964.Peer-Reviewed Original ResearchEarly life adversityAbnormal immune responseImpact of early life adversityHistory of early life adversityRodent studiesImmune responseNegative childhood experiencesConditions in adulthoodLevels of inflammatory cytokinesLong-term alterationsRefractory responses to treatmentAbnormal brain developmentMicroglial functionResponse to treatmentTraumatic brain injuryResident immune cellsStress reactivityEarly adversityLife adversitySubstance useChildhood experiencesMicroglial inflammatory responseImmune cellsIn adulthoodPeriod of developmentNarrative Discourse Performance in Traumatic Brain Injury: Does Story Comprehension Predict Story Retelling?
Lê K, Coelho C, Feinn R. Narrative Discourse Performance in Traumatic Brain Injury: Does Story Comprehension Predict Story Retelling? Journal Of Speech Language And Hearing Research 2024, 67: 2685-2697. PMID: 39052432, PMCID: PMC11305611, DOI: 10.1044/2024_jslhr-23-00681.Peer-Reviewed Original ResearchConceptsStructure Building FrameworkTraumatic brain injuryDiscourse comprehensionDiscourse Comprehension TestStory comprehension taskStory retelling taskComprehensive measureBrain injuryModerate-to-large correlationsDiscourse measuresDiscourse performanceRetelling taskStory comprehensionStory retellingComprehension taskDiscourse productionPreliminary supportDiscourse interventionCognitive processesStory grammarStory completionGrammar performanceSpoken languageMultiple regression analysisDiscourse modelSelf-Assembled Fibroblast Growth Factor Nanoparticles as a Therapeutic for Oxidant-Induced Neuronal and Skin Cell Injury
Kumar S, Chu A, Theis T, Rastogi S, Costea D, Banerjee R, Das B, Yarmush M, Hsia H, Cohen R, Schachner M, Berthiaume F. Self-Assembled Fibroblast Growth Factor Nanoparticles as a Therapeutic for Oxidant-Induced Neuronal and Skin Cell Injury. ACS Applied Bio Materials 2024, 7: 5158-5170. PMID: 39038169, DOI: 10.1021/acsabm.4c00135.Peer-Reviewed Original ResearchSpinal cord injuryFGF-2Cell injuryTraumatic brain injurySkin wound healingResponses in vivoInflammatory response in vivoWound healingPressure woundsOxidant-mediated injuryFibroblast growth factor-2Growth factor 2Delayed injuryLocal inflammationNanoparticle sizeChronic skin woundsSecondary complicationsCultured neuronal cellsEndothelial cellsGrowth factorPromote neurite outgrowthCord injuryNeurological sensationsRecombinant fusion proteinNanoparticlesAssociation of early dexmedetomidine exposure with brain injury biomarker levels following moderate – Severe traumatic brain injury: A TRACK-TBI study
Wongsripuemtet P, Ohnuma T, Temkin N, Barber J, Komisarow J, Manley G, Hatfield J, Treggiari M, Colton K, Sasannejad C, Chaikittisilpa N, Ivins-O’Keefe K, Grandhi R, Laskowitz D, Mathew J, Hernandez A, James M, Raghunathan K, Miller J, Vavilala M, Krishnamoorthy V, investigators T. Association of early dexmedetomidine exposure with brain injury biomarker levels following moderate – Severe traumatic brain injury: A TRACK-TBI study. Journal Of Clinical Neuroscience 2024, 126: 338-347. PMID: 39029302, DOI: 10.1016/j.jocn.2024.07.003.Peer-Reviewed Original ResearchConceptsC-reactive proteinNeuron-specific enolaseGlial fibrillary acidic proteinBiomarker levelsUbiquitin C-terminal hydrolase-L1Traumatic brain injuryDexmedetomidine exposureInjury biomarkersSevere traumatic brain injuryTRACK-TBIS100 calcium-binding protein BInflammatory biomarkers C-reactive proteinCalcium-binding protein BHs-CRP levelsLevel 1 trauma centerRetrospective cohort studyCritically ill TBI patientsAlpha-2 agonistsBrain injuryBrain injury biomarkersBiomarkers C-reactive proteinModulate autonomic functionGlasgow Coma Scale score 3No significant associationSecondary brain injuryAssociation of Early Dexmedetomidine Utilization With Clinical Outcomes After Moderate-Severe Traumatic Brain Injury: A Retrospective Cohort Study
Liu S, Kelly-Hedrick M, Komisarow J, Hatfield J, Ohnuma T, Treggiari M, Colton K, Arulraja E, Vavilala M, Laskowitz D, Mathew J, Hernandez A, James M, Raghunathan K, Krishnamoorthy V. Association of Early Dexmedetomidine Utilization With Clinical Outcomes After Moderate-Severe Traumatic Brain Injury: A Retrospective Cohort Study. Anesthesia & Analgesia 2024, 139: 366-374. PMID: 38335145, PMCID: PMC11250935, DOI: 10.1213/ane.0000000000006869.Peer-Reviewed Original ResearchLength of stayTraumatic brain injuryImprove patient outcomesModerate-severe TBIRetrospective cohort studyMechanical ventilationMechanically ventilated patientsDexmedetomidine exposureDay of admissionCohort studyHospital mortalityOdds of hospital mortalityPatient outcomesAssociated with reduced oddsCohort of critically ill adult patientsPrimary outcome of hospital mortalityReduce length of stayHospital costsAssociated with oddsOutcome of hospital mortalityCritically ill adult patientsDay of ICU admissionHospital length of stayIll adult patientsPublic health problem
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