2025
Molecular Components of Vesicle Cycling at the Rod Photoreceptor Ribbon Synapse
Hanke-Gogokhia C, Zapadka T, Finkelstein S, Arshavsky V, Demb J. Molecular Components of Vesicle Cycling at the Rod Photoreceptor Ribbon Synapse. Advances In Experimental Medicine And Biology 2025, 1468: 325-330. PMID: 39930217, DOI: 10.1007/978-3-031-76550-6_54.Peer-Reviewed Original ResearchConceptsSynaptic vesicle exocytosisSynaptic vesicle recyclingPhotoreceptor ribbon synapseVesicle exocytosisVesicle recyclingVesicle cycleVesicle releaseRibbon synapseProtein synthesisProperties of synaptic transmissionMolecular componentsMouse rodsSynaptic terminalsRod cellsProteinVesiclesRod photoreceptorsDim lightSynaptic transmissionInner segmentsCellsExocytosisEndocytosisOuter segmentsEnergy production
2023
Nonquantal transmission at the vestibular hair cell–calyx synapse: KLV currents modulate fast electrical and slow K+ potentials
Govindaraju A, Quraishi I, Lysakowski A, Eatock R, Raphael R. Nonquantal transmission at the vestibular hair cell–calyx synapse: KLV currents modulate fast electrical and slow K+ potentials. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2207466120. PMID: 36595693, PMCID: PMC9926171, DOI: 10.1073/pnas.2207466120.Peer-Reviewed Original ResearchConceptsNonquantal transmissionAfferent neuronsHair cellsPresynaptic hair cellsPrimary afferent neuronsAction potential latencyVestibular hair cellsCalyx afferentsPotential latencySynaptic terminalsVestibular signalsSynaptic cleftNeural circuitsHead positionPossible roleGap junctionsNeuronsSynapsesSynapseCleftCellsCalyxAfferentsα-Synuclein Pathology and Reduced Neurogenesis in the Olfactory System Affect Olfaction in a Mouse Model of Parkinson's Disease
Martin-Lopez E, Vidyadhara D, Liberia T, Meller S, Harmon L, Hsu R, Spence N, Brennan B, Han K, Yücel B, Chandra S, Greer C. α-Synuclein Pathology and Reduced Neurogenesis in the Olfactory System Affect Olfaction in a Mouse Model of Parkinson's Disease. Journal Of Neuroscience 2023, 43: 1051-1071. PMID: 36596700, PMCID: PMC9908323, DOI: 10.1523/jneurosci.1526-22.2022.Peer-Reviewed Original ResearchConceptsΑ-syn tg miceΑ-Syn pathologyOlfactory bulb neurogenesisProjection neuronsParkinson's diseaseOlfactory dysfunctionMutant α-synucleinOlfactory deficitsOlfactory pathwaySyn pathologyBehavioral deficitsMouse modelΑ-synucleinOB granule cellsΑ-synuclein pathologyOlfactory systemMonths of ageReduced neurogenesisFunctional deficitsPeriglomerular cellsMotor progressionPathologic changesMultiple symptomsSynaptic terminalsGranule cells
2019
Phosphorylation of human placental aromatase CYP19A1.
Ghosh D, Egbuta C, Kanyo J, Lam TT. Phosphorylation of human placental aromatase CYP19A1. Biochemical Journal 2019, 476: 3313-3331. PMID: 31652308, PMCID: PMC7069221, DOI: 10.1042/bcj20190633.Peer-Reviewed Original ResearchConceptsAromatase CYP19A1Protein-level regulationPhosphorylation/dephosphorylationMultiple phosphorylation sitesNon-genomic signaling pathwaysPost-translational modificationsNon-genomic signalingTranscriptional activatorPhosphorylation sitesProline residuesSignaling pathwaysHistidine residuesPhosphorylationLevel regulationAromatase inhibitor resistanceInhibitor resistanceMembrane interfaceRegulationReproductive systemStructural dataAromatase activityActive siteResiduesGenotoxic effectsSynaptic terminalsTherapeutic Potential of Agonists and Antagonists of A1, A2a, A2b and A3 Adenosine Receptors.
Jamwal S, Mittal A, Kumar P, Alhayani DM, Al-Aboudi A. Therapeutic Potential of Agonists and Antagonists of A1, A2a, A2b and A3 Adenosine Receptors. Current Pharmaceutical Design 2019, 25: 2892-2905. PMID: 31333104, DOI: 10.2174/1381612825666190716112319.Peer-Reviewed Original ResearchConceptsCentral nervous systemNervous systemFast excitatory postsynaptic currentsCerebral blood flowExcitatory postsynaptic currentsPeripheral nervous systemAntagonists of A1Pharmacology of adenosineA3 adenosine receptorAutonomic gangliaPostsynaptic currentsReceptor agonistMetabolic dysfunctionBlood flowNeuronal activityOcular diseasesSynaptic terminalsTherapeutic strategiesAdenosine receptorsTherapeutic potentialChemical transmissionATP actsExtracellular concentrationReceptors vizNerve signals
2015
A marginal band of microtubules transports and organizes mitochondria in retinal bipolar synaptic terminals
Graffe M, Zenisek D, Taraska J. A marginal band of microtubules transports and organizes mitochondria in retinal bipolar synaptic terminals. Journal Of Cell Biology 2015, 210: 2102oia145. DOI: 10.1083/jcb.2102oia145.Peer-Reviewed Original ResearchSynaptic terminals
2010
P/Q and N Channels Control Baseline and Spike-Triggered Calcium Levels in Neocortical Axons and Synaptic Boutons
Yu Y, Maureira C, Liu X, McCormick D. P/Q and N Channels Control Baseline and Spike-Triggered Calcium Levels in Neocortical Axons and Synaptic Boutons. Journal Of Neuroscience 2010, 30: 11858-11869. PMID: 20810905, PMCID: PMC2947942, DOI: 10.1523/jneurosci.2651-10.2010.Peer-Reviewed Original ResearchConceptsAxon initial segmentNeuronal excitabilityPyramidal cellsCalcium concentrationPresynaptic terminalsWhole-cell patch-clamp recordingsPrefrontal cortical pyramidal cellsOmega-agatoxin IVAOmega-conotoxin GVIACortical pyramidal cellsPatch-clamp recordingsBaseline calcium concentrationAction potential repolarizationAction potential generationNeocortical axonsVoltage-activated ion channelsCalcium currentCortical axonsSynaptic terminalsCalcium levelsCalcium channelsSynaptic boutonsSuprathreshold depolarizationElectrophysiological propertiesSubthreshold depolarizationFgfr2 Is Required for the Development of the Medial Prefrontal Cortex and Its Connections with Limbic Circuits
Stevens HE, Smith KM, Maragnoli ME, Fagel D, Borok E, Shanabrough M, Horvath TL, Vaccarino FM. Fgfr2 Is Required for the Development of the Medial Prefrontal Cortex and Its Connections with Limbic Circuits. Journal Of Neuroscience 2010, 30: 5590-5602. PMID: 20410112, PMCID: PMC2868832, DOI: 10.1523/jneurosci.5837-09.2010.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexCerebral cortexFibroblast growth factor receptorCKO miceExcitatory neuronsPrefrontal cortexCortical neuron developmentEntire cerebral cortexRadial glial cellsSpecific fibroblast growth factor receptorsGrowth factor receptorGABAergic neuronsLimbic circuitsCortical neuronsGlial cellsSubcortical stationsBed nucleusCortical developmentLimbic systemStria terminalisSynaptic terminalsSecondary decreaseNeuronal precursorsVentricular zoneNeuron development
2009
Imaging Exocytosis in Retinal Bipolar Cells with TIRF Microscopy
Joselevitch C, Zenisek D. Imaging Exocytosis in Retinal Bipolar Cells with TIRF Microscopy. Journal Of Visualized Experiments 2009, 1305. PMID: 19513018, PMCID: PMC2794884, DOI: 10.3791/1305.Peer-Reviewed Original ResearchConceptsRetinal bipolar cellsBipolar cellsSynaptic vesiclesTotal internal reflectance fluorescence microscopyLarge axon terminalsBipolar cell terminalsPatch pipette solutionTIRF microscopyImaging ExocytosisGlutamatergic vesiclesAxon terminalsGoldfish retinaSynaptic releaseSynaptic terminalsPipette solutionCell membraneCell terminalsFluorescence microscopyVesiclesRinger's solutionExocytosisCellsIndex substanceActive zoneEndocytosis
2001
Synaptic Release of Neurotransmitters
B.Levitan I, Kaczmarek L. Synaptic Release of Neurotransmitters. 2001, 195-222. DOI: 10.1093/oso/9780195145236.003.0009.Peer-Reviewed Original ResearchChemical communicationSecretion of proteinsVertebrate neuromuscular junctionSpecific chemical signalsEvolutionary pressureMembranous vesiclesChemical signalsEndocrine cellsRecipient cellsCell typesNeuronal cellsSecretory cellsMessenger substancesExtracellular spaceMuscle cellsLong axonsCellsNeuromuscular junctionTarget cellsChemical transmittersSynaptic terminalsSynaptic releaseGiant synapseSynaptic junctionsExocytosis
2000
Overexpression of Human Amyloid Precursor Protein in Drosophila
Yagi Y, Tomita S, Nakamura M, Suzuki T. Overexpression of Human Amyloid Precursor Protein in Drosophila. Archives Of Biochemistry And Biophysics 2000, 4: 43-49. PMID: 11152627, DOI: 10.1006/mcbr.2000.0248.Peer-Reviewed Original ResearchConceptsHuman APPHuman amyloid precursor proteinAPP expression levelsExpression of APPPrecursor proteinAmyloid precursor proteinBeta-amyloid peptideSynaptic terminalsHuman neuronsAlzheimer's diseaseNeural cellsApp functionsExpression levelsDiseasePhysiological functionsProtein transport systemWing blister phenotypePhenotypeWing phenotypeImaginal discsCuticle secretionNeuronsWing tissueProteinSecretionThe Role of Mitochondria in Presynaptic Calcium Handling at a Ribbon Synapse
Zenisek D, Matthews G. The Role of Mitochondria in Presynaptic Calcium Handling at a Ribbon Synapse. Neuron 2000, 25: 229-237. PMID: 10707986, DOI: 10.1016/s0896-6273(00)80885-5.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsCalciumCalcium-Transporting ATPasesCarbonyl Cyanide m-Chlorophenyl HydrazoneFluorescent DyesFura-2GoldfishLanthanumMembrane PotentialsMitochondriaPatch-Clamp TechniquesPotassiumRetinaRhodamine 123SodiumSynapsesSynaptic TransmissionUncoupling AgentsVision, OcularConceptsSynaptic terminalsCalcium handlingBipolar cell synaptic terminalsCalcium clearance mechanismsRetinal bipolar neuronsSingle synaptic terminalsClearance of Ca2Patch-clamp techniqueATP-dependent Ca2Bipolar neuronsRibbon synapseClamp techniqueClearance mechanismsCalcium uptakeLarge Ca2Role of mitochondriaMitochondrial uptakeCa2Mitochondria actMembrane extrusionNeuronsUptake
1999
Illusive transience of parvalbumin expression duringembryonic development of the primate spinal cord
Knyihár‐csillik E, Rakic P, Csillik B. Illusive transience of parvalbumin expression duringembryonic development of the primate spinal cord. International Journal Of Developmental Neuroscience 1999, 17: 79-97. PMID: 10221668, DOI: 10.1016/s0736-5748(98)00090-2.Peer-Reviewed Original ResearchConceptsNerve cellsSpinal cordLarge dorsal root ganglion cellsDorsal root ganglion cellsYoung adult macaque monkeysPrimate spinal cordUpper dorsal hornDorsal root axonsPrimary sensory neuronsSpinal reflex pathwaysElectron microscopic immunohistochemical techniquesAdult macaque monkeysParvalbumin-positive terminalsLong axonal processesDorsal hornMonkey fetusesDorsal columnsReflex pathwaysGanglion cellsClarke's nucleusAxon terminalsIntercellular networkMotoneuron poolSensory neuronsSynaptic terminals
1998
Calcium action potentials in retinal bipolar neurons
ZENISEK D, MATTHEWS G. Calcium action potentials in retinal bipolar neurons. Visual Neuroscience 1998, 15: 69-75. PMID: 9456506, DOI: 10.1017/s0952523898151064.Peer-Reviewed Original ResearchConceptsBipolar neuronsSynaptic terminalsAction potentialsCalcium-dependent action potentialsCalcium channel blockersRetinal bipolar neuronsCalcium action potentialsPerforated-patch recordingsNeurotransmitter GABAIntracellular calciumGoldfish retinaIntraterminal calciumCalcium channelsCalcium transientsRegenerative depolarizationTransient increaseNeuronsElectrical excitabilityFish retinaCalcium actionSpontaneous increaseRetinaElectrical recordingsExternal applicationCalcium
1997
Static and Dynamic Membrane Properties of Large-Terminal Bipolar Cells From Goldfish Retina: Experimental Test of a Compartment Model
Mennerick S, Zenisek D, Matthews G. Static and Dynamic Membrane Properties of Large-Terminal Bipolar Cells From Goldfish Retina: Experimental Test of a Compartment Model. Journal Of Neurophysiology 1997, 78: 51-62. PMID: 9242260, DOI: 10.1152/jn.1997.78.1.51.Peer-Reviewed Original ResearchConceptsBipolar neuronsGoldfish retinaSynaptic terminalsBipolar cellsIntact goldfish retinaDepolarization-evoked increaseSingle synaptic terminalsSynaptic transmitter releaseWhole-cell recordingsSoma/dendritesMorphological correlatesElectrotonic architectureTwo-compartment modelTransmitter releaseBiexponential time courseCell recordingsPatch pipetteNeuronsCompartment modelRetinaLines of evidenceTime courseSomaCellsFunctional Repair of Myelinated Fibers in the Spinal Cord by Transplantation of Glial Cells
Waxman S, Kocsis J. Functional Repair of Myelinated Fibers in the Spinal Cord by Transplantation of Glial Cells. Altschul Symposia Series 1997, 283-298. DOI: 10.1007/978-1-4615-5949-8_28.Peer-Reviewed Original ResearchConduction velocityMyelinated axonsMyelin sheathNon-myelinated fibresClinical deficitsMyelin damageConduction abnormalitiesDemyelinated axonsSpinal cordGlial cellsMyelinated fibersConduction blockSynaptic terminalsAction potentialsRefractory periodCell bodiesDemyelinated fibersAxonsFunctional repair
1989
Neuropeptide Y-Containing Neurons are Situated Predominantly Outside Cytochrome Oxidase Puffs in Macaque Visual Cortex
Kuljis R, Rakic P. Neuropeptide Y-Containing Neurons are Situated Predominantly Outside Cytochrome Oxidase Puffs in Macaque Visual Cortex. Visual Neuroscience 1989, 2: 57-62. PMID: 2562144, DOI: 10.1017/s0952523800004326.Peer-Reviewed Original ResearchConceptsNeuropeptide YVisual cortexLayers II/IIINumber of NPYLocal circuit neuronsCortico-cortical connectivityCytochrome oxidase histochemistryPrimary visual cortexReceptive field propertiesMacaque visual cortexCircuit neuronsInhibitory GABASynaptic terminalsInterpuffsImmunocytochemical methodsNeuronsEqual volumeCortexPuffsGABA
1986
Origin and ultrastructural identification of dorsal column nuclear synaptic terminals in the basilar pontine gray of rats
Kosinski R, Azizi S, Border B, Mihailoff B. Origin and ultrastructural identification of dorsal column nuclear synaptic terminals in the basilar pontine gray of rats. The Journal Of Comparative Neurology 1986, 253: 92-104. PMID: 2432100, DOI: 10.1002/cne.902530108.Peer-Reviewed Original ResearchConceptsCell of originDense coresDorsal column nucleiBasilar pontine nucleiFilamentous formsDegenerating terminalsSynaptic vesiclesMedullary reticular formationExternal cuneate nucleusBasilar pontine grayAsymmetric synaptic contactsArea postremaPontine neuronsDCN cellsDegenerating axon terminalsPontine nucleiRound synaptic vesiclesDendritic shaftsSynaptic contactsCuneate nucleusReticular formationVesiclesAxon terminalsSynaptic terminalsFormer group
1982
Retrograde axon reaction following section of asynaptic nerve fibers
Waxman S, Anderson M. Retrograde axon reaction following section of asynaptic nerve fibers. Cell And Tissue Research 1982, 223: 487-492. PMID: 7093992, DOI: 10.1007/bf00218470.Peer-Reviewed Original ResearchThe Role of Neuronal-Glial Cell Interaction During Brain Development
Rakic P. The Role of Neuronal-Glial Cell Interaction During Brain Development. Dahlem Workshop Report 1982, 25-38. DOI: 10.1007/978-3-642-68466-1_4.Peer-Reviewed Original ResearchRadial glial cellsGlial cellsNeuronal-glial cell interactionsGlial-specific markersGlial cell classesRecent immunocytochemical studiesSite of originBrain abnormalitiesSynaptic terminalsGlial precursorsNervous systemPrimate brainGlial fibersImmunocytochemical studyBrain developmentDifferentiating neuronsCell classesBrain surfaceDegenerating cellsSpecific markersVentricular surfaceCellular mechanismsProliferative zonePossible involvementNormal developmental processes
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