2025
IP18-28 IS A FRESH SEMEN ANALYSIS NECESSARY FOR A POST VASECTOMY SEMEN ANALYSIS?: ASSESSMENT OF STABILITY OF SPERM CONCENTRATION OVER A 10-DAY TIME FRAME AS A MODEL FOR POST VASECTOMY SEMEN ANALYSIS USING THE FELLOW SYSTEM
McCahill E, Honig S, Reddy S, Fernandez A, Schroeder T, Kaur I, Chen E, Belarmino A, Mehta A, Civello D, Kenfield S, Nolte D, Smith J, Rotker K. IP18-28 IS A FRESH SEMEN ANALYSIS NECESSARY FOR A POST VASECTOMY SEMEN ANALYSIS?: ASSESSMENT OF STABILITY OF SPERM CONCENTRATION OVER A 10-DAY TIME FRAME AS A MODEL FOR POST VASECTOMY SEMEN ANALYSIS USING THE FELLOW SYSTEM. Journal Of Urology 2025, 213: e976. DOI: 10.1097/01.ju.0001110060.12139.1b.28.Peer-Reviewed Original ResearchEffects of Hot Night Exposure on Human Semen Quality: A Multicenter Population-Based Study
Dai T, Xu T, Wang Q, Ni H, Song C, Li Y, Li F, Meng T, Sheng H, Wang L, Cai X, Xiao L, Yu X, Zeng Q, Guo P, Zhang X. Effects of Hot Night Exposure on Human Semen Quality: A Multicenter Population-Based Study. Biomedical And Environmental Sciences 2025, 38: 178-193. PMID: 40159171, DOI: 10.3967/bes2024.131.Peer-Reviewed Original ResearchConceptsSperm progressive motilitySemen qualityProgressive motilityDecreased total motilitySemen quality parametersHuman Sperm BankHuman semen qualityTotal motilitySperm motilitySemen collectionNight exposureMotilityMulticenter population-based studySperm donorsSemenPopulation-based studySpermMulticenter studySperm bankingInverse associationMulticenterExposure-response relationshipHNESpermatogenesisLinear mixed modelsDSP-1, the major fibronectin type-II protein of donkey seminal plasma is a small heat-shock protein and exhibits chaperone-like activity against thermal and oxidative stress
Alim S, Cheppali S, Pawar S, Swamy M. DSP-1, the major fibronectin type-II protein of donkey seminal plasma is a small heat-shock protein and exhibits chaperone-like activity against thermal and oxidative stress. Biochimica Et Biophysica Acta (BBA) - Proteins And Proteomics 2025, 1873: 141064. PMID: 39956303, DOI: 10.1016/j.bbapap.2025.141064.Peer-Reviewed Original ResearchConceptsChaperone-like activitySeminal plasmaFibronectin type IITetramer to monomersSperm capacitationSurface hydrophobicityMolecular chaperonesClient proteinsHeat shock proteinsBiophysical studiesAlcohol dehydrogenaseOxidative stressPhysiological ligandsShock proteinsProteinHead group moietySHspsBinding of phosphorylcholineCholine phospholipidsBindingFibronectinDehydrogenaseChaperoneSpermMammals
2024
Physalia gonodendra are not yet sexually mature when released
Oguchi K, Yamamoto G, Kohtsuka H, Dunn C. Physalia gonodendra are not yet sexually mature when released. Scientific Reports 2024, 14: 23011. PMID: 39362967, PMCID: PMC11450099, DOI: 10.1038/s41598-024-73611-5.Peer-Reviewed Original ResearchConceptsGerm cell maturationGene expression analysisGerm cell markersReproductive ecologySexual reproductionHaploid cellsGerm cellsReproductive biologyGonophoresExpression analysisRelated genesLife cycleGenesCell maturationGermConsistent with other studiesFlow cytometryPhysalia utriculusExpressionCnidariaCell markersCellsPhysaliaSpermHydrozoaStress increases sperm respiration and motility in mice and men
Moon N, Morgan C, Marx-Rattner R, Jeng A, Johnson R, Chikezie I, Mannella C, Sammel M, Epperson C, Bale T. Stress increases sperm respiration and motility in mice and men. Nature Communications 2024, 15: 7900. PMID: 39261485, PMCID: PMC11391062, DOI: 10.1038/s41467-024-52319-0.Peer-Reviewed Original ResearchConceptsEpididymal epithelial cellsIncreased mitochondrial respirationIn vitro stress modelsCells secrete extracellular vesiclesSperm RNASperm respirationMouse spermSperm maturationDNA regionsSperm functionTranslational signaling pathwaysSperm motilitySemen qualitySpermMitochondrial respirationMetabolic pathwaysSignaling pathwayEnvironmental stressorsExtracellular vesiclesHuman cohort studiesEpithelial cellsMotilityCellular mechanismsEmbryo developmentCohort studySperm Chromatin Structure Analysis and Clinical Correlations
Vaughan D, Sakkas D. Sperm Chromatin Structure Analysis and Clinical Correlations. 2024 DOI: 10.1016/b978-0-443-21477-6.00048-1.Peer-Reviewed Original ResearchThe Preparation of Sperm
Sakkas D. The Preparation of Sperm. 2024 DOI: 10.1016/b978-0-443-21477-6.00268-6.Peer-Reviewed Original Research
2023
A novel homozygous nonsense variant of AK7 is associated with multiple morphological abnormalities of the sperm flagella
Chang T, Tang H, Zhou X, He J, Liu N, Li Y, Xiang W, Yao Z. A novel homozygous nonsense variant of AK7 is associated with multiple morphological abnormalities of the sperm flagella. Reproductive BioMedicine Online 2023, 48: 103765. PMID: 38492416, DOI: 10.1016/j.rbmo.2023.103765.Peer-Reviewed Original ResearchConceptsHomozygous nonsense variantMultiple morphological abnormalitiesWhole-exome sequencingSperm flagellaAssociated with multiple morphological abnormalitiesMitochondrial function of spermatozoaFlagella-associated proteinsFunction of spermatozoaPotential gene variantsMitochondrial metabolic dysfunctionSperm ultrastructureFlagellar assemblyPatient's spermatozoaFlagellar defectsRate of apoptosisConcentration of reactive oxygen speciesMale infertilitySanger sequencingReactive oxygen speciesMitochondrial functionSpermSpermatozoaMutated genesFunctional associationDisease phenotypeAssessing mail-in cryopreservation for fertility preservation.
Belarmino A, Morris J, Kenfield S, Colin D, Griscom B, Honig S, Dupree J, Samplaski M, Halpern J, Behr B, Lamb D, Matthews W, Smith J. Assessing mail-in cryopreservation for fertility preservation. Journal Of Clinical Oncology 2023, 41: 1525-1525. DOI: 10.1200/jco.2023.41.16_suppl.1525.Peer-Reviewed Original ResearchTotal motile countIntrauterine insemination cyclesSperm recovery rateIntrauterine inseminationIn vitro fertilizationMotile spermMotile countSemen analysisLower patient costsFresh semen samplesHealthy adult volunteersHours post-collectionPrimary endpointPre-freezingFertility preservationSemen samplesOncology patientsSemen volumeSperm bankingAdult volunteersCancer treatmentReceipt of samplesPatient costsCryopreservationSperm
2022
CatSper Calcium Channels: 20 Years On
Hwang J, Chung J. CatSper Calcium Channels: 20 Years On. Physiology 2022, 38: 125-140. PMID: 36512352, PMCID: PMC10085559, DOI: 10.1152/physiol.00028.2022.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements3D structure and in situ arrangements of CatSper channel in the sperm flagellum
Zhao Y, Wang H, Wiesehoefer C, Shah NB, Reetz E, Hwang JY, Huang X, Wang TE, Lishko PV, Davies KM, Wennemuth G, Nicastro D, Chung JJ. 3D structure and in situ arrangements of CatSper channel in the sperm flagellum. Nature Communications 2022, 13: 3439. PMID: 35715406, PMCID: PMC9205950, DOI: 10.1038/s41467-022-31050-8.Peer-Reviewed Original ResearchConceptsCatSper complexSperm flagellaCryo-electron tomographyHigher-order organizationMammalian spermIntracellular domainStructural basisExtracellular domainTetrameric channelChannel CatSperSuccessful fertilizationFlagellar movementCatSper channelsChannel poreSitu mapSitu arrangementHuman sperm flagellumPrimary Ca2CatSperDimer formationFlagellaCentral roleSpermAtomic modelSperm motilityCatSper and its CaM‐like Ca2+ sensor EFCAB9 are necessary for the path chirality of sperm
Wiesehöfer C, Wiesehöfer M, Dankert JT, Chung J, von Ostau N, Singer BB, Wennemuth G. CatSper and its CaM‐like Ca2+ sensor EFCAB9 are necessary for the path chirality of sperm. The FASEB Journal 2022, 36: e22288. PMID: 35438819, PMCID: PMC9835897, DOI: 10.1096/fj.202101656rr.Peer-Reviewed Original ResearchConceptsNNC 55Exposure of spermMotility changesPharmacological inhibitionLateral head excursionCatSper activationIntracellular CaPhysiological stimuliCatSper channelsProtein 2Zona pellucida protein 2Zona pellucida glycoproteinsCapacitation stateCatSperHead excursionMouse spermPellucida glycoproteinsSpermSuccessful fertilizationMibefradilHigh frequency
2021
The mutational landscape of human somatic and germline cells
Moore L, Cagan A, Coorens T, Neville M, Sanghvi R, Sanders M, Oliver T, Leongamornlert D, Ellis P, Noorani A, Mitchell T, Butler T, Hooks Y, Warren A, Jorgensen M, Dawson K, Menzies A, O’Neill L, Latimer C, Teng M, van Boxtel R, Iacobuzio-Donahue C, Martincorena I, Heer R, Campbell P, Fitzgerald R, Stratton M, Rahbari R. The mutational landscape of human somatic and germline cells. Nature 2021, 597: 381-386. PMID: 34433962, DOI: 10.1038/s41586-021-03822-7.Peer-Reviewed Original ResearchConceptsCell typesMutational landscapeRate of mutationLow rate of cell divisionRate of cell divisionBasal spermatogoniaGermline cellsGenetic variationCell divisionHuman cellsMutational signaturesGermlineAcquired mutationsMutationsSpermatogoniaHuman populationCellsIndividual's lifetimeSBS5/40SpermSBS18Stem cellsSBS1LandscapeTypeMolecular Evolution of CatSper in Mammals and Function of Sperm Hyperactivation in Gray Short-Tailed Opossum
Hwang JY, Maziarz J, Wagner GP, Chung JJ. Molecular Evolution of CatSper in Mammals and Function of Sperm Hyperactivation in Gray Short-Tailed Opossum. Cells 2021, 10: 1047. PMID: 33946695, PMCID: PMC8147001, DOI: 10.3390/cells10051047.Peer-Reviewed Original ResearchConceptsMolecular evolutionHigh sequence divergenceSperm-specific ion channelIQ-like motifSequence divergenceCatSper activityCatSper subunitsMolecular regulationFertilization environmentSperm hyperactivationCatSper proteinsAmerican marsupialsCatSper functionSequence analysisMarsupialsFemale reproductive tractGray Short-Tailed OpossumsEutheriansSperm flagellaCatSper channelsIon channelsCatSperCurrent understandingOpossumSperm
2020
3D in situ imaging of female reproductive tract reveals molecular signatures of fertilizing spermatozoa in mice
Ded L, Hwang JY, Miki K, Shi HF, Chung JJ. 3D in situ imaging of female reproductive tract reveals molecular signatures of fertilizing spermatozoa in mice. ELife 2020, 9: e62043. PMID: 33078708, PMCID: PMC7707823, DOI: 10.7554/elife.62043.Peer-Reviewed Original ResearchConceptsFemale reproductive tractFemale tractCalcium channel complexSitu molecular imagingReproductive tractMolecular insightsSuccessful fertilizationCatSper channelsMolecular signaturesSperm cellsSperm selectionChannel complexMouse spermatozoaFertilization siteSpermSperm migrationSpermatozoaMammalsPhosphorylationCatSper1ProteinSitu imagingAcrosomeUtero-tubal junctionSelectionThe Association Between Race, Obesity, and Sperm Quality Among Men Attending a University Physician Practice in Washington, DC
McCray N, Young H, Irwig M, Frankfurter D, Schwartz A, Witmyer J, Hynes M, Jayanthi V, Marcus M, Patel M, Perry M. The Association Between Race, Obesity, and Sperm Quality Among Men Attending a University Physician Practice in Washington, DC. American Journal Of Men's Health 2020, 14: 1557988320925985. PMID: 32602769, PMCID: PMC7328221, DOI: 10.1177/1557988320925985.Peer-Reviewed Original ResearchConceptsBody mass indexSperm healthPhysician practicesAssociated with low sperm motilitySperm countWorld Health OrganizationLow sperm motilitySample of U.S. menMen of colorLow sperm countNon-Hispanic menStudy sample sizeSperm motilitySperm concentrationSperm qualitySemen samplesSperm parametersSemen qualityObesity ratesSpermEpidemiological literatureU.S. menHispanic menMass indexAndrological healthSperm Go to (Transcription) Extremes
Lesch BJ. Sperm Go to (Transcription) Extremes. Cell 2020, 180: 212-213. PMID: 31978338, DOI: 10.1016/j.cell.2019.12.033.Commentaries, Editorials and Letters
2019
The Impact of Single and Multiple Sperm Abnormalities and Low-Level Leukocytospermia on Sperm DNA
Alshahrani S, Ahmad G, Khan H, Ayaz A, Ali A. The Impact of Single and Multiple Sperm Abnormalities and Low-Level Leukocytospermia on Sperm DNA. Journal Of Men's Health 2019, 15: e51-e58. DOI: 10.22374/jomh.v15i2.144.Peer-Reviewed Original ResearchStandard sperm parametersSperm parametersDNA damageAnalysis of semen characteristicsCohort of infertile menSperm DNA testingSperm DNA damageDNA fragmentation analysisLevel of leukocytospermiaNick end labelingSperm motilityInfertile menSemen characteristicsSpermSperm abnormalitiesSperm DNASemen abnormalitiesPercentage of DNA damageRetrospective analysisFragment analysisDNAAbnormal parametersART treatmentEnd labelingDNA testingIntergenerational epigenetic inheritance of cancer susceptibility in mammals
Lesch BJ, Tothova Z, Morgan EA, Liao Z, Bronson RT, Ebert BL, Page DC. Intergenerational epigenetic inheritance of cancer susceptibility in mammals. ELife 2019, 8: e39380. PMID: 30963999, PMCID: PMC6456297, DOI: 10.7554/elife.39380.Peer-Reviewed Original ResearchConceptsGerm lineEpigenetic changesParental germ lineIntergenerational epigenetic inheritanceRegulation of genesPaternal germ lineCancer susceptibilityChromatin regulatorsEpigenetic inheritanceH3K27me3 marksHypermethylated regionsDNA methylationSomatic tissuesMale gametesElevated tumor incidenceCancer initiationGenetic variantsGermline deletionMutantsHeritabilityDeletionSuccessive generationsSpermOffspringWild-type mice
2017
The Usefulness of Sperm Viability Testing in Reproductive Technology: The Hypo-Osmotic Swelling Test, Laser and Motility Stimulants
Sakkas D. The Usefulness of Sperm Viability Testing in Reproductive Technology: The Hypo-Osmotic Swelling Test, Laser and Motility Stimulants. 2017, 1-8. DOI: 10.4324/9781315151632-1.Peer-Reviewed Original ResearchHypo-osmotic swelling testPoor sperm parametersSperm viability testsMale fertility statusIn vitro fertilizationProgressive motilitySperm concentrationSperm numberSperm parametersSemen volumeAutosomal recessive diseaseSpermMotility stimulationWorld Health OrganizationRecessive diseaseMotilitySwelling testStandard World Health OrganizationWorld Health Organization recommendationsKartagener's syndromeAssess viabilityIntact membranesHeterogeneous groupReproductive technologyViability test
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply